2JQZ


Conserved Protein Domain Family
C2_Smurf-like

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cd08382: C2_Smurf-like 
Click on image for an interactive view with Cn3D
C2 domain present in Smad ubiquitination-related factor (Smurf)-like proteins
A single C2 domain is found in Smurf proteins, C2-WW-HECT-domain E3s, which play an important role in the downregulation of the TGF-beta signaling pathway. Smurf proteins also regulate cell shape, motility, and polarity by degrading small guanosine triphosphatases (GTPases). C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. Members here have type-II topology.
Statistics
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PSSM-Id: 176028
View PSSM: cd08382
Aligned: 18 rows
Threshold Bit Score: 150.15
Threshold Setting Gi: 730684
Created: 2-Jun-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative Ca2+
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:putative Ca2+ binding pocket [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                        #     #                                                    # #   
2JQZ_A          4 KLRLTVLCAKNLVKKDffRLPDPFAKVVVdgsgQCHSTDTVKntlDPKWNQHYDLYIgk------sdSVTISVWNHKKIH 77   human
Q9V853         14 KVRITILCARNLARKDlfRLPDPFAKVQVdgtgQVYSTEISKsslDPKWNAHYDLFLgi------gdAITITVWNQRKIH 87   fruit fly
XP_001876290   13 SIRVKLYSANGLAKREllSLPDPFAVLTVdg-eQTSTTAIAKkslAPVWNEHFDVTVrq------ssMIAIQIFDHRKFR 85   Laccaria bico...
T49744          6 DSGLPVIAADGLYKRDvfRFPDPFAVATIng-eQTKTTQVSKrtlNPYWNEHFDFWLiqrskvnedsILAVQVFDQKKFK 84   Neurospora cr...
XP_001750778   80 LVRVCVSSADNLARKSmlRMPDPFALVSId--nEQFQSAVARrtlSPQWLTERDMFMnp------ssILTIYVFDAKRYR 151  Monosiga brev...
Q92462          9 RIRVTIVAADGLYKRDvfRFPDPFAVLTVdg-eQTHTTTAIKktlNPYWNETFEVNVtd------nsTIAIQVFDQKKFK 81   fission yeast
P39940          4 SISVKLVAAESLYKRDvfRSPDPFAVLTIdg-yQTKSTSAAKktlNPYWNETFKFDDine-----nsILTIQVFDQKKFK 77   baker's yeast
XP_002175690    7 KIRFSIVSADGLSKRDlfRTPDPFAVLTIdg-eQTRTTKVVKkslNPYWNESFDINVrp------ssSILVRIFDQKRYK 79   Schizosacchar...
NP_593926       7 EVQLTILHVEGLWKNGllRSLKPYLLISVdd-dQFIKTNVASgtlRLSWGFTQKLTVsp------qsIILLQLFDEKQKN 79   fission yeast
XP_001833620    8 KIRITVVAADGLSKRDvfRLPDPFAVITVda-eQTHTTSVIKktlNPYWNESFDITVqd------ssIVAVQIFDQRKFK 80   Coprinopsis c...
Feature 1              # #                                                      
2JQZ_A         78 KkqgaGFLGCVRLlsNAINRLKDt--------gYQRLDLcklgpn--dndtvrGQIVVSLQS 129  human
Q9V853         88 Kg--sGFLGCVRIpaFNIQSLKGa--------gFQRLDLgklspd--ddelvrGQIIISLLS 137  fruit fly
XP_001876290   86 Krd-qGFLGVINIpaAEALSYAAs---------QQGPITrdltms--snnlpvYGKISFSFS 135  Laccaria bicolor S238N-H82
T49744         85 Kkd-qGFLGVINVriGDVIELAPd--------aEDQMLTrdlkks--tdnlvvHGKLIINLS 135  Neurospora crassa
XP_001750778  152 PrdwaGFLGMAVIeaNAFLDSTTlgeg---atkVLNFRLrkrvp-----ddlvTGTICVKVR 205  Monosiga brevicollis MX1
Q92462         82 Kkg-qGFLGVINLrvGDVLDLAIg---------GDEMLTrdlkks--nentvvHGKIIINLS 131  fission yeast
P39940         78 Kkd-qGFLGVVNVrvGDVLGHLDedtatssgrpREETITrdlkks--ndgmavSGRLIVVLS 136  baker's yeast
XP_002175690   80 Kkd-qGFLGLVTFrvQEVVNLSSs---------RETLVTrqlrkssnssslsvQGELILKLC 131  Schizosaccharomyces japonicus y...
NP_593926      80 Ets-dGFVGLGAAvvNSFLPFNNpkd-----dyKTRITLrsps-------gsyRGSVVCLFK 128  fission yeast
XP_001833620   81 Rkd-qGFLGVVNVrvADVLDLELg---------GHEMLTldlkrs--ndnlivHGKLIIYLS 130  Coprinopsis cinerea okayama7#130

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