2RD0,3DBS


Conserved Protein Domain Family
C2_PI3K_like

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cd08380: C2_PI3K_like 
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C2 domain present in phosphatidylinositol 3-kinases (PI3Ks)
C2 domain present in all classes of PI3Ks. PI3Ks (AKA phosphatidylinositol (PtdIns) 3-kinases) regulate cell processes such as cell growth, differentiation, proliferation, and motility. PI3Ks work on phosphorylation of phosphatidylinositol, phosphatidylinositide (4)P (PtdIns (4)P),2 or PtdIns(4,5)P2. Specifically they phosphorylate the D3 hydroxyl group of phosphoinositol lipids on the inositol ring. There are 3 classes of PI3Ks based on structure, regulation, and specificity. All classes contain a C2 domain, a PIK domain, and a kinase catalytic domain. In addition some PI3Ks contain a Ras-binding domain and/or a p85-binding domain. Class II PI3Ks contain both of these as well as a PX domain, and a C-terminal C2 domain containing a nuclear localization signal. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. This cd contains members with the first C2 repeat, C2A, and a type-I topology, as well as some with a single C2 repeat.
Statistics
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PSSM-Id: 176026
View PSSM: cd08380
Aligned: 28 rows
Threshold Bit Score: 96.2764
Threshold Setting Gi: 261330704
Created: 13-Oct-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2RD0_A        353 KSLwvinsALRIKILCAtyvnv---------nirdiDKIYVRTGIYHGgep--lcDNVNTQRVpc-------sNPRW-NE 413  human
XP_001022838  506 KLLkdaqmDTSITNHGIdgvafmgglekkfglnctpYLVSLKVMLFHGsn---clRTVETKKQpf------ckSIRF-NE 575  Tetrahymena t...
XP_002678075  140 LNLwdlvqPTRVEIIGIenlniqp-----eksqsgnSYLYICCELFHGgtp--ltKGRFTRMIpl------htSPQW-NQ 205  Naegleria gru...
XP_002157809  291 ICLwdispKTLFKVNIFaakgi----------hnaqMWKEIHCGIFHGgee--vcKVQSTNKLqq------stTPHW-NE 351  green hydra
XP_001032162  831 CSYf---qQLCQKYDINfa----------------pYLIQVQVKLMYGnra-lavKKETQKIPfs-------rSPRW-DE 882  Tetrahymena t...
EEZ97307      470 KYVsdvmeSLVIRVCAIyrpnv----------ewkhDSFMVAAQIYHGtrp-mghPVLSQPCVkt------esDHKW-PA 531  red flour beetle
XP_002186929   29 KREqk-syKALLEDPMLkfsgl---------yqetcSDLYVTCQVFAEgkp-lalPIRTSYKAfs-------tRWNW-NE 89   zebra finch
NP_001128289  686 DHLqftifAAHGIPTGWvscf-----------ekyyLVCSLIHNGKDKfkp-vqsKKVGTYKSff-------yLVKW-DE 745  western clawe...
EET00678       19 KATpt-ifLQHIILDGSllaghm--------lhgfyPDLHMVFRLMAPpst-llaPPMNSPVQstiickrttlKYFWsSQ 88   Giardia intes...
XP_001451414  424 KQLskgtfNPHFFNHGPqgtanmeclmqkyeldiqpYLISVQVLLMYGqtpltkfSIVNSQKVpf-------rQNTWfYQ 496  Paramecium te...
2RD0_A        414 WLNYDiyipd-------lpraaRLCLSICSVKgrkga---------keehCPLAWGNINLFdytdTLVSGKMALNLwpvp 477  human
XP_001022838  576 WVTFDnlkisq------ipleaRICMNIILHSddq------------nehQIIGSTSFSLFdqddKYRQGLNALNVwpiq 637  Tetrahymena t...
XP_002678075  206 FVIFNdvllcd------lpretKICFTIFSRQmnetdqsldspncisgkdTPLGYVIIPMFdfkgLLKQGEFHSIMkpng 279  Naegleria gru...
XP_002157809  352 FLEFDlpvad-------iprmaRLCFSIVGYQqndrk---------krkpVCIGWVNMPIFnykaYLKTGTCALYCwqys 415  green hydra
XP_001032162  883 WIKFPlikisq------lplesRICFDIIVYSvtg------------ldsQIIGSTNFYIFdqfcKFTQGISPLNIwpfy 944  Tetrahymena t...
EEZ97307      532 RIIIDhwfdmidihisalaresRLKLVIYGRTmepsddaq---nepkytqEEIGWASVQFFtydgTMVQGNIILSIwppd 608  red flour beetle
XP_002186929   90 WLKLPvkypd-------lprnaQVALTIWDVYgpg-------------kaVPVGGTTVSLFgkygMFRQGMHDLKVwpnv 149  zebra finch
NP_001128289  746 LIIFPiqisq-------lplesILQLTLYGILnpnsggspd-ankqrkgpEMLGRVSLPLFtfrrMLIGGTKLLHLwtsf 817  western clawe...
EET00678       89 QVTFPisvsn-------lpqaaYFHISIYAND------------------TVIGTTELPIYnehfALRCMMHTCLIkpaa 143  Giardia intes...
XP_001451414  497 DVSFQglkisq------lpmelRLCFNIVLHSsng-------------eeQIIGSTITELFdengKLKQGRLHLNVwpfy 557  Paramecium te...
2RD0_A        478 hgledllnp-----igvtgsnpnketpCLELEFDWFSSVV 512  human
XP_001022838  638 nrlccmsqywg-ltdkslkpkqanekeMQDFISKNFTRVF 676  Tetrahymena thermophila
XP_002678075  280 rampysi---------pienignetsiFINYRLDSHSDSV 310  Naegleria gruberi strain NEG-M
XP_002157809  416 igrknenqnfl-nplgtvassgdengaCLIIKLTEFAHPV 454  green hydra
XP_001032162  945 asddrlacagqyygltqplsdenkrdqRDHNKWEEFKARE 984  Tetrahymena thermophila
EEZ97307      609 sqflhgappaf-gthptpdhpmmdiqiAGGHPKTEFPKVP 647  red flour beetle
XP_002186929  150 eadgseptkt---pgrtsstvsedqmsRLAKLTKSHRQGH 186  zebra finch
NP_001128289  818 htgpapagt------trktnqmqrivlQVDFPLPAFDIVY 851  western clawed frog
EET00678      144 yidnqi------------ggqlppvelALELALPHSEDRT 171  Giardia intestinalis ATCC 50581
XP_001451414  558 kcdtriacmneyygaalpnqertpyytQLVIGMPTFIEDV 597  Paramecium tetraurelia strain d4-2
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