Conserved Protein Domain Family
C2D_MCTP_PRT_plant

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cd08379: C2D_MCTP_PRT_plant 
C2 domain fourth repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP); plant subset
MCTPs are involved in Ca2+ signaling at the membrane. Plant-MCTPs are composed of a variable N-terminal sequence, four C2 domains, two transmembrane regions (TMRs), and a short C-terminal sequence. It is one of four protein classes that are anchored to membranes via a transmembrane region; the others being synaptotagmins, extended synaptotagmins, and ferlins. MCTPs are the only membrane-bound C2 domain proteins that contain two functional TMRs. MCTPs are unique in that they bind Ca2+ but not phospholipids. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. This cd contains the fourth C2 repeat, C2D, and has a type-II topology.
Statistics
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PSSM-Id: 176025
View PSSM: cd08379
Aligned: 9 rows
Threshold Bit Score: 160.265
Threshold Setting Gi: 270235722
Created: 11-Oct-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative Ca2+
Feature 1:putative Ca2+ binding site [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                               #     #                                                   
BAD27694      367 LVELGIREAIl-----tATRTRDGRGSCDAYCVAKYgvkWYRTRTVTds----iSPRF---HQQYHWEVHDHCt------ 428  Japanese rice
ABA96012      485 RVHLGILRAT-------GLPLRMGKSTVNPYCVAKYgdkWVRTRTILdg----pEHVF---NEQHTWSVYDIAt------ 544  Japanese rice
ABR16393      345 ILQVGILSAQnl----lPMKTKDGRGTTDAYCVAKYgqkWVRTRTLIdt----lNPKW---NEQYTWEVYDPCt------ 407  Sitka spruce
AAD55273      670 ILELGILGARgl---lpMKAKNGGKGSTDAYCVAKYgkkWVRTRTITds----fDPRW---HEQYTWQVYDPCt------ 733  thale cress
XP_001780504  319 VLEVGIHGANnl---lpMKTTKDNRGSTDAYCVAKYgpkWIRTRTIFes----fNPRW---NEQYTWEVYDPCt------ 382  Physcomitrell...
NP_191731     359 KLEIGILGATg------LKGSDEKKQTIDSYVVAKYgnkWARTRTVVns----vSPKW---NEQYSWDVYEKCt------ 419  thale cress
CBI24847      240 ILEVGILGAQgl----lPMKMKDSRGSTDAYCVARYgqkWGQFEIHElgrlgraEPPLrkeVVEYMLDVDSHMwsmrrsk 315  wine grape
XP_001417134  452 HLHGGNTSKAvgkltldVLEAKDLEGAPDTYVMVKTgpyWSRLSDQKaq----sNPQW---NVRLRYPIIEPSe------ 518  Ostreococcus ...
XP_002504419  516 HLHGGNATAEvgrmtvdVLRATDLPKDTTTFAVVKMgpyWTRLPGVEns----sKPAW---KQRLRYPVFEPSa------ 582  Micromonas sp...
Feature 1                            # #                   #                                      
BAD27694      429 ------------VLTVAVFHNSqigdkggl----vagdpvkDVLLGKVRIRLStLETGRTYAYAYPLMSLHGGg--VKKM 490  Japanese rice
ABA96012      545 ------------VLTAGVFDHFpht-------------rkaHREIGKVQIHLScLETDRVYAHSYPLIILNRRg--FKKA 597  Japanese rice
ABR16393      408 ------------VITVGVFDNChlqggeke----ksaaspkDARIGKVRIRLStLETDRVYTHAYPLLVLHPSg--VKKM 469  Sitka spruce
AAD55273      734 ------------VLTVGVFDNWrmfsda--------sddrpDTRIGKIRIRVStLESNKVYTNSYPLLVLLPSg--MKKM 791  thale cress
XP_001780504  383 ------------VLTVGVFDNRhsfpv---------ggapkDLPIGKVRIRLStLESDRVYTNAYPLLVVTPQg--VKKM 439  Physcomitrell...
NP_191731     420 ------------VLTLGIYDNRqiled---------knkanDVPIGKVRIPLNrVQSDWIYTCSYPILKLGSSg--LKKM 476  thale cress
CBI24847      316 anffrimsllsgVITMSRWFGNvchwknpitslswaeavqpDELDEEFDTFPTsRSQDRVYMRYDRLRSVAGRi--QTVV 393  wine grape
XP_001417134  519 ------------PVTVGVFNLSd------------------GSMIGKIRCVLSgLDDGLRYEDDFPLKTVNRSg-vVVTN 567  Ostreococcus ...
XP_002504419  583 ------------RCTVALFEGTas----------------sCKFLGRVKLQLStMEDGVRYAGSFQLMARDPSsgeIKKT 634  Micromonas sp...
Feature 1               
BAD27694      491 GELRLA 496  Japanese rice
ABA96012      598 GELQIA 603  Japanese rice
ABR16393      470 GELHLA 475  Sitka spruce
AAD55273      792 GEIEVA 797  thale cress
XP_001780504  440 GELEMA 445  Physcomitrella patens subsp. patens
NP_191731     477 GELQLA 482  thale cress
CBI24847      394 GDLATQ 399  wine grape
XP_001417134  568 GTLRCS 573  Ostreococcus lucimarinus CCE9901
XP_002504419  635 CKLECG 640  Micromonas sp. RCC299

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