Conserved Protein Domain Family
C2B_MCTP_PRT

?
cd08376: C2B_MCTP_PRT 
C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
MCTPs are involved in Ca2+ signaling at the membrane. MCTP is composed of a variable N-terminal sequence, three C2 domains, two transmembrane regions (TMRs), and a short C-terminal sequence. It is one of four protein classes that are anchored to membranes via a transmembrane region; the others being synaptotagmins, extended synaptotagmins, and ferlins. MCTPs are the only membrane-bound C2 domain proteins that contain two functional TMRs. MCTPs are unique in that they bind Ca2+ but not phospholipids. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. This cd contains the second C2 repeat, C2B, and has a type-II topology.
Statistics
?
PSSM-Id: 176022
View PSSM: cd08376
Aligned: 21 rows
Threshold Bit Score: 135.461
Threshold Setting Gi: 189521049
Created: 21-Oct-2009
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
putative Ca2+
Feature 1:putative Ca2+ binding site [ion binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                             #                                                          
XP_424705    165 IVSITLIEGRELKAMdanGLSDPYVKFRLGHQKYKSKIMPkt-----------------------lNPQWREQFDFHLye 221  chicken
CAG03086     407 VVSITLVEARELCWDs--QGGQLFVCFKLGEQIYKSKNQVkv-----------------------pRPQWRERFTLNLfl 461  Tetraodon nigr...
CAG13085       8 VLRITLVEGQDLPQY---GQGDIYVRFRLGDQKYKSKNLCiq-----------------------aNPQWREQFDFNQfe 61   Tetraodon nigr...
CAG05381     177 IVNIALIEGRNLIPMdpnGLSDPYVKFRLGNQKYKSKVSFhgfffsfwragidptgvfaqtvpktlSPQWREQFDLHLye 256  Tetraodon nigr...
NP_001015768 166 IVSITLIEGQELKAMdanGLSDPYVKFRLGHQKYKSKTLPkt-----------------------lNPQWREQIDMHIfe 222  western clawed...
Q6DN14       471 IVSITLIEGRDLKAMdsnGLSDPYVKFRLGHQKYKSKIMPkt-----------------------lNPQWREQFDFHLye 527  human
Q6DN12       357 IISITLLEGKNVSGG---SMTEMFVQLKLGDQRYKSKTLCks-----------------------aNPQWQEHFDFHYfs 410  human
XP_001749528 365 LVTVDVIEAWDLQPWddnGLADPYVRLSIRKQKRKSKVCNkt-----------------------lHPVWKQRFEFAVhd 421  Monosiga brevi...
XP_002120929 275 IATVQLVSGSNLPARdanGFSDPYVKLMLGKWKKKSKVCYkt-----------------------lNPLWKEEFTIQLcn 331  Ciona intestin...
XP_690994    177 LYTITLVDGRDLPKD---GQGDLFVRFKLGDQKFKSKSRSkk-----------------------vITEWRERFDFYQfp 230  zebrafish
Feature 1                   # #     #                                       
XP_424705    222 erggIIDITVWDKDagkkDDFIGRCQVDlstlskeqthKLEMLLeegegCLVLLVTLTA 280  chicken
CAG03086     462 esshILEVELWLKEgrrnEECLGTCQVDlsavpasqrqLFTVALnpsrgVLVFLLAVNS 520  Tetraodon nigroviridis
CAG13085      62 dnqePLQVEVFSKRgrktEESWGMFEIDlsrlpinerqLYNHVLdsgrgRLLCLVTLRP 120  Tetraodon nigroviridis
CAG05381     257 esggVLEITVWDKDtgrrDDFIGRCMLDlstlakehthHLELPLeeargFVVLLVTLTA 315  Tetraodon nigroviridis
NP_001015768 223 eqggVIEITVWDKDagkrDDFIGRCHVDlstlskeqthKLKLKLeegegWLVLLVTLTA 281  western clawed frog
Q6DN14       528 erggVIDITAWDKDagkrDDFIGRCQVDlsalsreqthKLELQLeegegHLVLLVTLTA 586  human
Q6DN12       411 drmgILDIEVWGKDnkkhEERLGTCKVDisalplkqanCLELPLdsclgALLMLVTLTP 469  human
XP_001749528 422 atsnLLKIELYDRDpgmsDELMGHCEIDltklsmdhthSLKKSLgkpedGEIYLQVTVT 480  Monosiga brevicollis MX1
XP_002120929 332 ketsMLDVTVWDKDsyrkDDFIGRCDLDlwnlerevthSLKLNLldttgSLLFLITVHG 390  Ciona intestinalis
XP_690994    231 dassLLEIEVVLKDgrksEESYGLSEINlselplnestLFSCDLepgrgKVVFLITPKA 289  zebrafish

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap