3JZY


Conserved Protein Domain Family
C2_Intersectin

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cd08375: C2_Intersectin 
Click on image for an interactive view with Cn3D
C2 domain present in Intersectin
A single instance of the C2 domain is located C terminally in the intersectin protein. Intersectin functions as a scaffolding protein, providing a link between the actin cytoskeleton and the components of endocytosis and plays a role in signal transduction. In addition to C2, intersectin contains several additional domains including: Eps15 homology domains, SH3 domains, a RhoGEF domain, and a PH domain. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. The members here have topology I.
Statistics
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PSSM-Id: 176021
View PSSM: cd08375
Aligned: 10 rows
Threshold Bit Score: 222.645
Threshold Setting Gi: 193716197
Created: 3-Jun-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative Ca2+
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:putative Ca2+ binding site [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                #                                        
3JZY_A        373 EKAYQARSQKTSgi--gRLMVHVIEATELKack-pnGKSNPYCEISMGSqSYTTRTIQDTLNPKWNFNCQFFIkdlyqDV 449  human
XP_002123219 1520 EKAYQARTQRSAgi--gRLMVTIIEGCNLVkt--snGRHDPYCEVTMGEqSHTTKTVQDTLNPKWGSQMQFYVkdvnlDV 1595 Ciona intesti...
XP_001636713  225 QKMHRTRSIRTSgi--gKLVVTIVEGVDLKssd-psGMSDPYCEVSMGSqEHKTRVCPQTLNPKWNSTMTFTVkdmeqDV 301  starlet sea a...
XP_001176623   64 EKLQRARSQRSKgv--gRLMVVIIEGYDLKpsnsvtGRADPYCEVSMGSqEHKTKVVPDNLNPIWDSSMQFIVrdleqDV 141  purple urchin
XP_416715    1577 EKAYLVRSQRATgi--gRLMVNIVEGIELKpcr-shGKSNPYCEVTMGSqCHITKTMQDTLNPKWNSNCQFFIkdleqDV 1653 chicken
XP_002408358  461 QMKVSAKMQKQSgv--gRLLVVVVEGRNLRngs-pqGQIDSYCEVNMASqEHKTHVVSSTTSPQWNTSMQFLVrdlrqDV 537  black-legged ...
XP_393062    1602 LKTITVRRRPVQg----KLRLIVKEAEDLVil--kkGKCNTFCKVSMGSqEQRTGIVSGTDCPLWDTSMQFQVkdlyeDT 1675 honey bee
XP_001947769 1381 NQKQLMESKKADfgacgRVLVFVMDGRKLQtp--klGKKAAFCEVSMGS-RKQCTQVSESPDPKWDSSMQFLVkdiqdDI 1457 pea aphid
NP_997065    1582 EKAYLVRSQRATgi--gRLMVNIVEGIELKpcr-snGKSNPYCEVTMGSqCHVTKTLQDTLNPKWNSNCQFFIkdleqDV 1658 zebrafish
XP_002590626 1103 EKAHQARMLRSTgv--gRLLVVIQEGHRLQpcn-snGRSDPYCEVSMGVqEHKTKVIPGTLNPKWNSSMQFFVydieqDV 1179 Florida lancelet
Feature 1               # #     #                                            
3JZY_A        450 LCLTLFDRDQFsPDDFLGRTEIPVakirt-eqeskGPMTRRLLLHEvptGEVWVRFDLQ 507  human
XP_002123219 1596 LCISVFQRYMFsPDDFLGRTEMKLseiqreastskEPITKRLLLHEvdaGEVVVKLSLQ 1654 Ciona intestinalis
XP_001636713  302 LCITVFDRDFFsPNDFLGRTEVSLasll---kkgkGPWHERLLLHEvttGEVLVKLELH 357  starlet sea anemone
XP_001176623  142 LCITVYDRDFFsPNDFLGRTEVRVadilk-etqgrGPMTKSLLLHEvstGEVKVKLTLH 199  purple urchin
XP_416715    1654 LCITVFERDQFsPDDFLGRTEIRVadikk-dqgskGPVTKCLLLHEvptGEIVVRLDLQ 1711 chicken
XP_002408358  538 LCVTVFNKELFsPNDFLGRTEVRVwdiaqetreshGPITKQLRLYEvdqGEVLIRLDLQ 596  black-legged tick
XP_393062    1676 LCITVFDKGYYsPDEFLGRAEIRVadimrdskdscGPIQKRIGLHEvekGSVVLKLDLR 1734 honey bee
XP_001947769 1458 LCVTVFNKGHYsPDEFLGRSEIRVseiiqstknsrGPLTKHLQLREvqtGVITLKLDLC 1516 pea aphid
NP_997065    1659 LCVTVFERDQFsPDDFLGRTEIRLadikk-dqgskGPITKRLLLHEvptGEIVVRLDLQ 1716 zebrafish
XP_002590626 1180 LCITVFDRDFFsPNDFLGRTEIRVadilkertegkGPLVKKLVLHEvptGEVQVKLDLQ 1238 Florida lancelet

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