3F6Q,2CU8,2EHE,2IYB,1WIG,1X3H,2CO8,1V6G,1X64,1X6A,1IBI,1U5S,1J2O,2COR,1X4K,2D8Z,1X68,2D8X,2DJ7,1X61,2DAR,2CUP,2RGT,2DLO,2RGT,1RUT,2EGQ,2DFY


Conserved Protein Domain Family
LIM
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cd08368: LIM 
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LIM is a small protein-protein interaction domain, containing two zinc fingers.
LIM domains are identified in a diverse group of proteins with wide variety of biological functions, including gene expression regulation, cell fate determination, cytoskeleton organization, tumor formation and development. LIM domains function as adaptors or scaffolds to support the assembly of multimeric protein complexes. They perform their functions through interactions with other protein partners. LIM domains are 50-60 amino acids in size and share two characteristic highly conserved zinc finger motifs. The two zinc fingers contain eight conserved residues, mostly cysteines and histidines, which coordinately bond to two zinc atoms. The consensus sequence of LIM domain has been defined as C-x(2)-C-x(16,23)-H-x(2)-[CH]-x(2)-C-x(2)-C-x(16,21)-C-x(2,3)-[CHD] (where X denotes any amino acid).
Links
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Statistics
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PSSM-Id: 259829
Aligned: 397 rows
Threshold Bit Score: 34.6007
Created: 17-Nov-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Zn binding site
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Structure:3F6Q_B: Human PINCH1 LIM1 domain binds Zn
  • Comment: The two zinc fingers contain eight conserved residues, mostly cysteines and histidines, which coordinately bond to two zinc atoms. The Zn binding residues of LIM domain are highly conserved.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #  #                  #  #  #  #                    #  # 
3F6Q_B         14 CERCKGGFapaekivnsngELYHEQCFVCAQCFQQFpe---glFYEFEgRKYCEhDF 67   human
XP_001641741  499 CGACHNLIegntkfvaydeKYFHRECFTCCKCNKPLag---ekFRIRDgEKICLpCD 552  starlet sea anemone
XP_002733044  271 CHGCKEKLetkwi--eamdKPWHPGCFKCAGCKKALeg---esFFKKNdNPYCGdCV 322  Saccoglossus kowalevskii
XP_002163384  438 CFKCKELIrgssi--kfegNMYHTKCFFCENCKKELgg---aqFYKYEtNPYCDdCF 489  green hydra
XP_001641741  440 CVKCNQVIktssv--qhagSTYHSECFTCHHCDKPLag---spFTKQEgRNVCQnCY 491  starlet sea anemone
XP_002733051  261 CHGCKEAIenkwi--kalgYAWHHGCFKCKGCEKSLeg---esFFKKNeDPYCEkCA 312  Saccoglossus kowalevskii
XP_002738354  129 CKGCKDKIetqwv--eamgHTWHPGCFACKGCKLPLqa---gsFYKKDdKPYCEkCI 180  Saccoglossus kowalevskii
XP_454063      14 CVRCTNHItmgha-yelggNRWHTHCFSCYKCDKPLscd-sdfLVLGTsDLICFeCS 68   Kluyveromyces lactis NRRL Y-1140
XP_002175616   28 CITCEKLLsegvf-ltvnnNFYHGNCFRCEKCGKTLavrdavaFTNSN-QPICKdCV 82   Schizosaccharomyces japonicus yFS275
XP_001742996  171 CAHCYKLLiggka-llcndSYYHPKCFCCQHCHQPItt---trFLLTNgQPVCYdCC 223  Monosiga brevicollis MX1

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