2AC0,2GEQ,1T4W


Conserved Protein Domain Family
P53

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cd08367: P53 
Click on image for an interactive view with Cn3D
P53 DNA-binding domain
P53 is a tumor suppressor gene product; mutations in p53 or lack of expression are found associated with a large fraction of all human cancers. P53 is activated by DNA damage and acts as a regulator of gene expression that ultimatively blocks progression through the cell cycle. P53 binds to DNA as a tetrameric transcription factor. In its inactive form, p53 is bound to the ring finger protein Mdm2, which promotes its ubiquitinylation and subsequent proteosomal degradation. Phosphorylation of p53 disrupts the Mdm2-p53 complex, while the stable and active p53 binds to regulatory regions of its target genes, such as the cyclin-kinase inhibitor p21, which complexes and inactivates cdk2 and other cyclin complexes.
Statistics
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PSSM-Id: 176262
View PSSM: cd08367
Aligned: 35 rows
Threshold Bit Score: 146.26
Threshold Setting Gi: 221131137
Created: 18-Nov-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
2AC0_A        16 FRLGFLHsgt-aksVTCTYSPa---lNKMFCQl--aKTCPVQLWVdstp---ppgTRVRAMAIYKqsq--------hmtE 78  human
1T4W_A         4 MEIDVLKqkv-aksSDMAFAIsseheKYLWTKm--gCLVPIQVKWkldkrhfnsnLSLRIRFVKYdkkenveyairnprS 80  Caenorhabditis ...
XP_001844341 141 FRVNLPSdas--dkTSWMYSDk---lQKLFVKm--gNTCTFNVQLmasp---evtTVVRAMVVCSspe--------dqhH 202 southern house ...
XP_001658484 154 FNVDLNGets--gkSSWMFSSr---lNKVFVKm--gQACTFNISYqalt---hqeLFVRAMMVCSape--------dmhY 215 yellow fever mo...
NP_996267    203 FSMVLDEpp----kSLWMYSIp---lNKLYIRmnkaFNVDVQFKSkmp----iqpLNLRVFLCFSnd----------vsA 261 fruit fly
XP_002433759  93 FRVVFVKpegvrnsTSWTYSNa---kRKLYTNm--nEFCSVHFITerap---prgSVVCVVGVFLdse--------frrH 156 black-legged tick
XP_313590    102 FTVIPSStq----gSGFIFSEq---lQKLFLKt--dSICSFDIACqlptflpptgWYVRVMLVSLape--------sqhE 164 Anopheles gambi...
XP_001844338  74 FKVTLEKsg---snDFHVFSQk---lNRIFTSt--gKSLTFNMAMnph-----tpLLVRIMLVCSnq----------lfQ 130 southern house ...
XP_001844340 128 FKVRIAEtg---rnESYTYSNv---lNKIYTSi--eKHCTFEASFnfcs---tilPIIRVMMVCAna----------pfQ 186 southern house ...
XP_001844339  56 FKVKLDItg---kgDSYEISDa---lDRIYTS----TDRSITFDIvykpe-hgsnLSVRIMLVGSnl----------lhH 114 southern house ...
Feature 1                                                                                        
2AC0_A        79 VVRRCPHHERCSDsd-------gLAPPq----HLIRVEGNl-RVEYLDdr----nTFRHSVVVPYEppe----vgSDCTT 138 human
1T4W_A        81 DVMKCRSHTEREQ----------HFPFd----SFFYIRNSehEFSYSA-------EKGSTFTLIMYp-------gAVQAN 132 Caenorhabditis ...
XP_001844341 203 PVSRCDNHRCSDNq---------DIPDdi-kmHVIRCKNE--QVSYVGtkdgkvfEERLAILVPMEh--------TNRAG 262 southern house ...
XP_001658484 216 PVYRCENHRGSDNvnpk---lpnEVKA-----HVMRCFNP--SARYVGtengvafKDRLAVIIPLGmts----qeQVALN 281 yellow fever mo...
NP_996267    262 PVVRCQNHLSVEPl---------TANNakmreSLLRSENP--NSVYCGnaqgkgiSERFSVVVPLNmsrsvtrsgLTRQT 330 fruit fly
XP_002433759 157 NVERCTAHARLEDgsnqlpsgkhPFPC-----FWIRCDHP--RTRYCLde---anGGRQCLCLPFEape---aasNDPFT 223 black-legged tick
XP_313590    165 SITRCHKHIAHDTgp-------eEIRK-----HVVRCKNE--QHEYVGadngpffEDRYAVRVPLDd-------eVLCVK 223 Anopheles gambi...
XP_001844338 131 PLSRCSYHIRGDNt---------TFRD-----HVVTHRDS--AARYVGtangiyqRERLAILVPIEe--------IGQKS 186 southern house ...
XP_001844340 187 PLSRCAYHTKNDTt---------ANKN-----HVVLRRDG--SAEYIGtpegetfRDRLALKIAMGd--------SCRKN 242 southern house ...
XP_001844339 115 PLARCSYHRKGDNt---------TFKD-----HVVRHKDA--SAEYVGtatgmlyPERLAILVPLDq--------SGLKS 170 southern house ...
Feature 1               # #       #                          # ###  #         
2AC0_A       139 IHYNYMCNSSCmg-gMNRRPILTIITLEDs-sGNLLGRNSF-EVRVCACPGRDRRTEEENL 196 human
1T4W_A       133 FDIIFMCQEKCldldDRRKTMCLAVFLDDe-nGNEILHAYIkQVRIVAYPRRDWKNFCERE 192 Caenorhabditis elegans
XP_001844341 263 ITLEFVCQNSCr--nINRRATALVFTLEDq-tGRILGRQMF-QIKICTNIKRDKLNEENAV 319 southern house mosquito
XP_001658484 282 VSLEFVCQNSCr--iINRRTTAIIFTLEDv-hGQILGKKSL-HLKVCSCPKRDKMKEEETV 338 yellow fever mosquito
NP_996267    331 LAFKFVCQNSC----IGRKETSLVFCLEKa-cGDIVGQHVI-HVKICTCPKRDRIQDERQL 385 fruit fly
XP_002433759 224 YHLAFMCRNSCpg-sPGRKATEVVFILQSp-eGRDIARRVI-EVKVCACPCRDRRHDEQAA 281 black-legged tick
XP_313590    224 IMLQFVCQNTCf--rLDQRRTGLVFTLENd-qGNIWARRVV-PVKICINYRRDMQNEQNSA 280 Anopheles gambiae str. PEST
XP_001844338 187 ISLEFKCLSSCy--kIRKIATALVFTLEDensNSVLGRQIF-NVHVSKNYKRDMEVAEKNG 244 southern house mosquito
XP_001844340 243 ITLEFKCLSSCy--kIKKVSTALVFTLEDpvgGQLLGREII-PIQISKNFKRDMETAEKAA 300 southern house mosquito
XP_001844339 171 ITLDFVCLNSCh--kIRKLKLALVFTLEDqddKKIVGRQIF-HLQVSKNFKRDMEVAEKGP 228 southern house mosquito

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