1ICH


Conserved Protein Domain Family
Death_TNFR1

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cd08313: Death_TNFR1 
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Death domain of Tumor Necrosis Factor Receptor 1
Death Domain (DD) found in tumor necrosis factor receptor-1 (TNFR-1). TNFR-1 has many names including TNFRSF1A, CD120a, p55, p60, and TNFR60. It activates two major intracellular signaling pathways that lead to the activation of the transcription factor NF-kB and the induction of cell death. Upon binding of its ligand TNF, TNFR-1 trimerizes which leads to the recruitment of an adaptor protein named TNFR-associated death domain protein (TRADD) through a DD/DD interaction. Mutations in the TNFRSF1A gene causes TNFR-associated periodic syndrome (TRAPS), a rare disorder characterized recurrent fever, myalgia, abdominal pain, conjunctivitis and skin eruptions. DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including CARD (Caspase activation and recruitment domain), DED (Death Effector Domain), and PYRIN. They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes.
Statistics
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PSSM-Id: 176729
View PSSM: cd08313
Aligned: 7 rows
Threshold Bit Score: 110.172
Threshold Setting Gi: 119591951
Created: 24-Feb-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1ICH_A        15 TLYAVVENVPPLRWKEFVKRLgLSDHEIDRLELQngrclREAQYSMLATWRRRtpr------reaTLELLGRVLRDMdlL 88  human
CAF97843     296 LIYSVLDLVPVSQVKQLVRSLgVRDTEIEQVELDnr-scREAHYQMLRAWAERgprtdv-llhppLLQHLLSELRKMhlE 373 Tetraodon nigro...
CAG32132     331 ILYTVVDHVPPSRWKEFVRRLgLTENDLERIEMEhr-hlRDAQYEMVSLWKLQmgh-------aaTVEHISCVLNQMelS 402 chicken
AAH68424     293 FFYFVLDEVPIGRFKELVRRLgVSEQNIDRAEHDhr-ncKDAQYQMLKVWSDGgsgggnnvvpydQIQMLMSTLKDMclV 371 zebrafish
NP_001108251 330 ELYTLVDSIPMPRWKEFARRLgLSDNDIERSETDnr-ryRDAQYDMLLTWKERvgr------cgaKRDAVCKVLREMelA 402 African clawed ...
NP_001135245 312 LIYSVLDQVPPRHVKELVRSLgVSDIVIERAENDhlrdtKEAQYQMLRVWAKGnaqgggevlarpLLYHLLDKLRDMdlG 391 Atlantic salmon
EAW71545     469 QLYDVMDAVPARRWKEFVRTLgLREAEIEAVEVEig-rfRDQQYEMLKRWRQQqp---------aGLGAVYAALERMglD 538 human
1ICH_A        89 GCLEDIE 95  human
CAF97843     374 HAAEELE 380 Tetraodon nigroviridis
CAG32132     403 GCSEAIQ 409 chicken
AAH68424     372 SCADNIE 378 zebrafish
NP_001108251 403 ACIEKIQ 409 African clawed frog
NP_001135245 392 GTAEELE 398 Atlantic salmon
EAW71545     539 GCVEDLR 545 human
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