Conserved Protein Domain Family
FDH_like_ADH3

?
cd08287: FDH_like_ADH3 
formaldehyde dehydrogenase (FDH)-like
This group contains proteins identified as alcohol dehydrogenases and glutathione-dependant formaldehyde dehydrogenases (FDH) of the zinc-dependent/medium chain alcohol dehydrogenase family. The MDR family uses NAD(H) as a cofactor in the interconversion of alcohols and aldehydes, or ketones. FDH converts formaldehyde and NAD to formate and NADH. The initial step in this process the spontaneous formation of a S-(hydroxymethyl)glutathione adduct from formaldehyde and glutathione, followed by FDH-mediated oxidation (and detoxification) of the adduct to S-formylglutathione. The medium chain alcohol dehydrogenase family (MDR) has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit.
Statistics
?
PSSM-Id: 176247
View PSSM: cd08287
Aligned: 17 rows
Threshold Bit Score: 498.372
Threshold Setting Gi: 269957773
Created: 14-May-2009
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
Feature 1:NAD(P) binding site [chemical binding site]
Evidence:
  • Comment:defined by comparison to related dehydrogenases

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                              ##  #                                     
YP_715012      1 MRATLLEDVGKIALREFPDPvvqrPTDAVVRVTASCICGSDLHPYRGktp-svfPKRIGHEFVGVVEDIGDEVtTVRPGD 79  Frankia alni AC...
NP_281175      1 MRAAVYQGPGEIAVEEVPKPdiesPEDAVIRVTHTAVCGSDLWFYRGdsd-reaGSRVGHEPMGIVEEVGDDVtSVAPGD 79  Halobacterium s...
NP_827624      1 MRATTIHAPYDMRVEDVPEPvvrqPTDAVVRVLRACICGSDLWAYRGeaa-rqpGQRIGHEFLGIVEETGSEVtGVRRGD 79  Streptomyces av...
NP_722179      1 MKTAVFVKAGQMAIETIEKPsvieVDDAIIRVVRACVCGSDLWSYRGdddkathSANSGHEIIGIVDEVGSAInTVKKGD 80  Streptococcus m...
YP_444847     38 MRAAVFHEPGDIRVEDVPDPsieaPTDAILRITRTAICGSDLWFYRGhrd-yeaGWRTGHEPMGVVEDVGSEVrSLEPGD 116 Salinibacter ru...
NP_267705      1 MKSVYFVEKNKMQVREFPKAqlvkETDAIIKIVRACVCGSDLWWFRGise--rqPGPVGHEAIGLIEEVGTGVkNFKVGD 78  Lactococcus lac...
YP_923863      1 MRATTIHGLRDIRVSEVPDPaitaPTDAIVKVVAGCICGSDLWPYRGend-irpGATIGHECVGVVEEVGAEVrSVRPGD 79  Nocardioides sp...
CAJ88160       1 MRGAVIHAPGDVRFETVDDArilkPTDAVIRTAVTCVCGSDLWPYRGaep-tehAHPMGHEYVGFVEEVGGDVtSVRPGQ 79  Streptomyces am...
ACU53234       1 MRAAVFHRPGLITVDERPDPrvlePTDAVVRVVRGCVCGSDLWYWRGlse--rgPGSIGHEFIGVVEEIGSAIdGLRPGM 78  Acidimicrobium ...
YP_003289461   2 MRATVLYGPKDVRLEQVPDPkilePTDAIIRVLVACICGSDLWPYRGydpvpeeGRPMGHEAVGVVEAVGKEVrTVKPGD 81  Rhodothermus ma...
Feature 1             #                                                                         #
YP_715012     80 VVVAPFLISDGTCRYCRAGLHTSCENgsvwgtddgsgarsdACQGDRIRAPLADGTLVRVGTelp---ealLPDVLALSD 156 Frankia alni AC...
NP_281175     80 RVIAPFAISCGECEFCRQGLYTSCVEdeswg-----seangGGQGEYVKCPFADGTLVRVPDryad-dedvLESLLPLTD 153 Halobacterium s...
NP_827624     80 LVVAPFMWSDGVCDYCREGLTTSCEHggfwg-----svghdGGQGEAVRVPYADGTLVQLPKdaas-dehlLSALLTLSD 153 Streptomyces av...
NP_722179     81 FVIAPFTHGCGHCAACRAGFEGGCQGhdrst------nfssGYQAEYVRYAHADWSLVKIPGqpsdysegmIASLLALAD 154 Streptococcus m...
YP_444847    117 RVLAPFAISDGTCEFCRQGLHTSCVHgnvwa------aehdGAQGEAVRAPQADGTLVKIPEraeg-daslLRALFPLTD 189 Salinibacter ru...
NP_267705     79 FVIVPFTHGCGHCPICLAGFEANCPNakdg--------vngGYQGEFYRAINTDGALVKIPGqpsdysddqLASLTALAD 150 Lactococcus lac...
YP_923863     80 FVIVPFDHCDNTCPHCLAGAQSACVNlgf----------tvSGQAEYARVTQADGSLVATQGtpd---aglVPSLLTLSD 146 Nocardioides sp...
CAJ88160      80 FVVGSFATSDNTCANCRNGFQSNCLNref----------msTCQAEYVRIPNAQGTLVATDDvpd---erfWPGLLAVSD 146 Streptomyces am...
ACU53234      79 LVIAPFAFADLACPNCQWGATVNCVHgglfg-----dgtidGGQGEAVRVPLAETTLVPVPGtsws--daeLASFLALSD 151 Acidimicrobium ...
YP_003289461  82 VVLMPFAISDGSCEFCHEGLTTACVHvgffgy----spgvgGAQAEAVRIPLADGTLYRVPVsedd--relLPHLLTLTD 155 Rhodothermus ma...
Feature 1           #                   # ###                   ##   #                           
YP_715012    157 VMGTGHHAAVCAGVgpGSTVVVVGDGAVGLCAVLAARRLGAERVVAMSRtpsRQKLAAEFGATDIVAGRGAEGIAQVGEL 236 Frankia alni AC...
NP_281175    154 VMGTGHHAAVSAGVgeGDTAVVVGDGAVGLCGVLAAQRLGAERIIAMGHhedRLELAAEFGATDTISARGDDAIERARDL 233 Halobacterium s...
NP_827624    154 VMGTGHHAALGAGArpGATVAVVGDGAVGLCAVLAAKRLGAERIIALGRhevRTDIARRFGATDVVAERGEAAVEAVREL 233 Streptomyces av...
NP_722179    155 VMPTGYHAARVANVqkGDTVAVVGDGAVGLCAVIAAKMRGAKRIIIMSRhkdRQELALEFGATDIVEERGEEGVAKVLEL 234 Streptococcus m...
YP_444847    190 VMGTGHHAAVSAGVeaGSTCVVVGDGAVGLCAVLAAQRLGAERIIAMGHheeRLEKARGFGATDIVSSRGEEAVEEVREM 269 Salinibacter ru...
NP_267705    151 VMPTGFHAAKAADVheGDTVVVFGDGAVGLCAVISAKLLGAKRIIAMSRhedRAALARDFGATDIIDERGEEAIQKIMSL 230 Lactococcus lac...
YP_923863    147 VLPTGWHAAVSAGVreGGTAVVVGDGAVGLCGVLAASVLGAETIVAMSRhepRQELARRFGATHIVAERGDEGTAAIMEI 226 Nocardioides sp...
CAJ88160     147 VMGTGWWAADAAQVepGSTAVVVGDGAVGLCAVIAAKEMGAERIIAMSRhepRQKLAREFGATDIVTERGDEGVARIKDL 226 Streptomyces am...
ACU53234     152 VMPTGHHAAVSAGVtkGSTVAVIGDGAVGLSAVLAAHRLGAERIVALSShadRQVVARAFGATDIVAQRGAEAVATVLEM 231 Acidimicrobium ...
YP_003289461 156 VMGTGHHAAVTARVgpGKIAAVIGDGAVGLCGVLAARRLGAERIILLGHhpdRLELGRAFGATDVVTERGEAAVERVLEL 235 Rhodothermus ma...
Feature 1                   ##    #                                            ###               
YP_715012    237 LGD-GADAVLECVGSqeSLEQAAAVAHPGGRLGCVGAPLg--NLPLG----PLFMKNVRLAGGVAPARa-YLPELLDDVL 308 Frankia alni AC...
NP_281175    234 THG-GANHVMECVGAasAMDSAIAIARPGGTVGYVGVPYgveDGGLDv--fTMFSDNITIRGGVAPVRa-YAEELMADVL 309 Halobacterium s...
NP_827624    234 TRGqGAHCVVEAVGTeqSMRTAVDITRDGGAIGFVGVPHg-sGTGLDl--gVMFDRNIALRGGVAPVRa-YIPELLPDIL 309 Streptomyces av...
NP_722179    235 TNGdGVDAALECVGTqlSTETALAIARPGASIGRVGVPHt-kDINLS----DYFFQNAIIAGGPASVTtyDKSVLLKAVL 309 Streptococcus m...
YP_444847    270 TRG-GARHVMECVGAasAIETAISVCRPGGTIGYVGVPFgaeDGGLDm--fRLFRENITLQGGIAPVRa-YIPELMDDVL 345 Salinibacter ru...
NP_267705    231 TNGyGADAALECVGTkqAIESAFQAVRAGGRVGRVGVPH---DVDYNewidSLFWKNIQLGGGVASVArwDKEILLEAVL 307 Lactococcus lac...
YP_923863    227 TGGvGADAVLECVGTdqAMRTAFSTARPGSTVGFVGVPH---GVELPv--rEMFQRNIGLAGGMAPTRr-YIPELLELVL 300 Nocardioides sp...
CAJ88160     227 TGGiGADSVLECVGTaqAMRQALHSARPGGSVGFVGVPH---EVAVDg--qELFFSHVGLRGGPAPVRr-YLPDLIEQVL 300 Streptomyces am...
ACU53234     232 TGGiGADAVLECVGTqeAMETAAAIARPGSIVGGVGVPH---GVMPAt---ALFGRNVGWRGGPAPVRi-YLPELLEDVL 304 Acidimicrobium ...
YP_003289461 236 TGGfGAHSVLECVGTeeAVETAVQIARPGGAIGRVGVPHh-eGIPAG----VTFFKNVIVAGGPAPTRa-YMPELVPDVL 309 Rhodothermus ma...
Feature 1                                              
YP_715012    309 AGrVRPGRIFDLELPLDEVAEGYRAMDERrAIKVLLRP 346 Frankia alni ACN14a
NP_281175    310 QGtLDPSPIFTKTVDLDGVPEGYAAMDDReAIKVLVKA 347 Halobacterium sp. NRC-1
NP_827624    310 AGrIDPSPVFDRTVDLEGVPEGYKAMDERtALKVLVTN 347 Streptomyces avermitilis MA-4680
NP_722179    310 DGeINPGKVFTQSYSLDDIDQAYKDMQERkTIKSMVVV 347 Streptococcus mutans UA159
YP_444847    346 DGtLDPSPVFDTTIGLEEVPDGYAAMDEReSIKVMVEL 383 Salinibacter ruber DSM 13855
NP_267705    308 SGeINPGRVFTAEFSLDEIQKAYEAMDQRtAIKSLLRI 345 Lactococcus lactis subsp. lactis Il1403
YP_923863    301 ADrIEPGLVFDSTLPLDQVAEGYRAMDERqAIKVLIEP 338 Nocardioides sp. JS614
CAJ88160     301 SGrIDPGKVFDLTLPLDQVAEGYKAMDERrAIKTLLTP 338 Streptomyces ambofaciens ATCC 23877
ACU53234     305 GGtIDPGRVFTYETDLDGVVEAYRAMDERrAIKSILRV 342 Acidimicrobium ferrooxidans DSM 10331
YP_003289461 310 EGrIEPGRVFDLTLPLDRVAEGYRAMDERrAIKVMLEP 347 Rhodothermus marinus DSM 4252

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap