1JQB,1YKF,2OUI,2NVB,1Y9A


Conserved Protein Domain Family
NADP_ADH

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cd08285: NADP_ADH 
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NADP(H)-dependent alcohol dehydrogenases
This group is predominated by atypical alcohol dehydrogenases; they exist as tetramers and exhibit specificity for NADP(H) as a cofactor in the interconversion of alcohols and aldehydes, or ketones. Like other zinc-dependent alcohol dehydrogenases (ADH) of the medium chain alcohol dehydrogenase/reductase family (MDR), tetrameric ADHs have a catalytic zinc that resides between the catalytic and NAD(H)binding domains; however, they do not have and a structural zinc in a lobe of the catalytic domain. The medium chain alcohol dehydrogenase family (MDR) has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit.
Statistics
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PSSM-Id: 176245
View PSSM: cd08285
Aligned: 27 rows
Threshold Bit Score: 495.223
Threshold Setting Gi: 15838328
Created: 14-May-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:NADP binding site [chemical binding site]
Evidence:
  • Structure:1YKF: Thermoanaerobacter brockii alcohol dehydrogenase binds NADP, contacts at 4A
    View structure with Cn3D
  • Structure:2NVB: Thermoanaerobacter brockii alcohol dehydrogenase binds NADP, contacts at 4A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                          ##                                         
1JQB_A      1 MKGFAMLGINKLGWIEKERPvaGSYDAIVRPLAVSPCTSDIHTVFEGalgdrkNMILGHEAVGEVVEVGSEVKDFKPGDR 80  Clostridium beijer...
1YKF_A      1 MKGFAMLSIGKVGWIEKEKPapGPFDAIVRPLAVAPCTSDIHTVFEGaigerhNMILGHEAVGEVVEVGSEVKDFKPGDR 80  Thermoanaerobacter...
P14940      5 MKAAVFVEPGRIELADKPIPdiGPNDALVRITTTTICGTDVHILKGEypv-akGLTVGHEPVGIIEKLGSAVTGYREGQR 83  Wautersia eutropha
NP_250809   5 MKAAVFIQPGRIELVDKPIPdvGPNDALVRITTTTLCGTDVHILKGEypv-apGLTVGHEPVGIIEKLGSAVVGYREGQR 83  Pseudomonas aerugi...
NP_435872   4 MKAAIFVAPGRIVLDEKQIPdvGPLDALMRITTTTICGTDVHILRGEypv-arGLTIGHEPVGVIEKLGSAVRGYSEGQR 82  Sinorhizobium meli...
NP_757848  10 MKALVFVEKNKIQIVNKPIPtvGPNDALIKVTTTTICGTDIHIVKGEypv-kpGLTIGHEAVGILAAVGDEVTGFELGER 88  Mycoplasma penetra...
AAP39869   14 MKAAVFKGKNRIVLDEKPVPvpKHSEALIKITTTTICGTDIHILKGEypv-aeGLTIGHEPIGVIESFGDGVTGFKKGQR 92  Phytomonas sp. ADU...
YP_481337   5 MQALAFLGIGKAGVIEKPIPkpGPTDAIVRTTSALICTSDVHTVRGAipv-peGRALGHEAVGVVHDLGAAVTGFEAGER 83  Frankia sp. CcI3
YP_634919   1 MRANVFQAVNRFGIEEVERPraGAGEAVIRMTMTTVCGTDLHIVRGEypv-rpGLVIGHEPVGVIEELGPGVTDYRPGQR 79  Myxococcus xanthus...
BAF43793    5 MKTFTMLEVGKTAIVEKPIPtpGPNEALVKTTAALICTSDVHTVKGAlpv-enGRTLGHESVGVIAALGSAVTGFTEGQR 83  Gordonia sp. TY-5
Feature 1                                                                                     
1JQB_A     81 VIVPCTTPDWRSLEVQAGFQQHSNGMl--------------AGWKFSNfKDGVFGEYFHVNDADMNLAILPKdmpLENAV 146 Clostridium beijer...
1YKF_A     81 VVVPAITPDWRTSEVQRGYHQHSGGMl--------------AGWKFSNvKDGVFGEFFHVNDADMNLAHLPKeipLEAAV 146 Thermoanaerobacter...
P14940     84 VIAGAICPNFNSYAAQDGVASQDGSYlmasgqcgchgykatAGWRFGNmIDGTQAEYVLVPDAQANLTPIPDgltDEQVL 163 Wautersia eutropha
NP_250809  84 VIAGAICPNFNSYAAQDGVPSQDGSYlvesgrcachgykatAGWRFGNlIDGTQAEYVLVPDAQANLAPIPDglsDEQVL 163 Pseudomonas aerugi...
NP_435872  83 VIAGAICTSGHSNAALCGCHAQDGPGtkhg-------wkgmGGWKFGNtIDGSQAEYVLVPDAMANLAPVPDglaDEQVL 155 Sinorhizobium meli...
NP_757848  89 VLAGAITPSGYTAACQSGQSSQDGIGtkyg-------ykptAGWKFGNiMDGCQAEYVLVKNAMANLARVPNaltDEQVL 161 Mycoplasma penetra...
AAP39869   93 VVIGAITPCSSCSSCMEGIRSQCGSKl-------------mGGWKFGNtIDGSQAEYLIVPDAAANMYPIPDgitDEQVL 159 Phytomonas sp. ADU...
YP_481337  84 VAVGALTPCFHCGPCQRGFSTQCQGMl--------------GGYKFTTqRDGNMAEYFLVNNAAANLARIPAdlpDEKAV 149 Frankia sp. CcI3
YP_634919  80 VLVGAITPCGQCRACLSSHLSQCGHGagy---------ealGGWRMGNtQDGAQAEYIRIPAAQANLAPIPDgltDEQVI 150 Myxococcus xanthus...
BAF43793   84 VAVNAVTPCFECSYCQRGFTSQCGGLl--------------GGYKYTAqVDGNMAEYFLVPAAQGNLAPIPDelsDDAAV 149 Gordonia sp. TY-5
Feature 1        #   #                   #####                    ##                 #        
1JQB_A    147 MITDMMTTGFHGAELADIEMGSSVVVIGIGAVGLMGIAGAKLRGAGRIIGVGSRpICVEAAKFYGATDILNYKNGHIeDQ 226 Clostridium beijer...
1YKF_A    147 MIPDMMTTGFHGAELADIELGATVAVLGIGPVGLMAVAGAKLRGAGRIIAVGSRpVCVDAAKYYGATDIVNYKDGPIeSQ 226 Thermoanaerobacter...
P14940    164 MCPDIMSTGFKGAENANIRIGHTVAVFAQGPIGLCATAGARLCGATTIIAIDGNdHRLEIARKMGADVVLNFRNCDVvDE 243 Wautersia eutropha
NP_250809 164 MCPDIMSTGFKGAENANIRIGDSVAIFAQGPIGLCATAGARLLGASTIIAIDGNaHRLDIARGMGADVTLNFRECDViEE 243 Pseudomonas aerugi...
NP_435872 156 MCPDIMSTGFSGAESGAVRVGDAVAVFAQGPIGLCATAGARLIGATTIIAVESVpARMEMARRMGADDVVDFTVSDPtAE 235 Sinorhizobium meli...
NP_757848 162 MCPDIMSTGFSGPENANIKLGDYVGVIAQGPIGLCATTGAKLMGASIIIAIDGNdRRLEIAKELGATHTINFRNVDVvQE 241 Mycoplasma penetra...
AAP39869  160 MCPDIMSTGFSGPESAGVKVGDTVVIYAQGPIGLGATAGAKMMGATKVIVVDRFpERLALAKKLGADYTLDFTKCNPiEE 239 Phytomonas sp. ADU...
YP_481337 150 YATDMLSTGFGGAENAQLRLGESVAIFAQGPVGLSATIGCRLLGAGLIIAVEGRpERQELARRFGADVVVDPAAGDVvNQ 229 Frankia sp. CcI3
YP_634919 151 LLSDIASTGFSGAEAGSVRIGDAVVVFAQGPIGLCASIGARLMGASLVVGVDGDeARMKMAQRMGVDVVLDHRQQDVvAE 230 Myxococcus xanthus...
BAF43793  150 YACDMLSTGLMGAEHAQIEIGDTVAIFAQGAVGLCATIGAKLRGAGRIIAVESRpERIALAQRFGADDIVDFTDGDPvAQ 229 Gordonia sp. TY-5
Feature 1                    ###                    ###                                       
1JQB_A    227 VMKLTNGkGVDRVIMAGGGseTLSQAVKMVKPGGIISNINYHGs-GDALLIPrvEWGCGMAHKTIKGGLCPGGRLRAERL 305 Clostridium beijer...
1YKF_A    227 IMNLTEGkGVDAAIIAGGNadIMATAVKIVKPGGTIANVNYFGe-GEVLPVPrlEWGCGMAHKTIKGGLCPGGRLRMERL 305 Thermoanaerobacter...
P14940    244 VMKLTGGrGVDASIEALGTqaTFEQSLRVLKPGGTLSSLGVYSs-DLTIPLS--AFAAGLGDHKINTALCPGGKERMRRL 320 Wautersia eutropha
NP_250809 244 ILKLTGGrGVDASIEALGTqsTFETALRVLKPGGTLSSLGVYSe-DLTIPLS--AFAAGLGDHRINTALCPGGKERMRRL 320 Pseudomonas aerugi...
NP_435872 236 IMRLTDGrGVDVAIEALGRqeTFEGALRVLRPGGTLSSLGVYSg-DLRIPLD--GFLAGLGDHTIRTTLCPGGKERMRRL 312 Sinorhizobium meli...
NP_757848 242 VNRITDGrMLDSAIECLGSqsTFEQGFRLLRAGGTLSSLGVYSs-DIKLPLD--ALAAGLGDHKISFALCPGGSERMRRL 318 Mycoplasma penetra...
AAP39869  240 VMRLTGGrGVDVAIEALGLqsTFESCLRCLKPGGVLSSLGVYSd-DLRLPND--AFAAGLGDFKIVTTLCPGGKERMRRL 316 Phytomonas sp. ADU...
YP_481337 230 ILDLTGGvGVDGAIEALGHpqTFEDCIRVTKPGGRISNIGYHGenPAPLQIPlePFGLGMSDKKILTSLCPGGSDRLERI 309 Frankia sp. CcI3
YP_634919 231 VKRLTGG-GADVAIEALGTqqTFESALRCLRPAGTLSSLGVYSg-KLQLPYD--AFSAGLGDYRIVTTLCPGGKERMRRL 306 Myxococcus xanthus...
BAF43793  230 IMDLTGGvGVDASIEALGFpqTFEAALACLKAGGTLSNIGYHGenPAPLPLDltAWGLGMGDKTIRTGLCTGGSDRMSRL 309 Gordonia sp. TY-5
Feature 1                                                   
1JQB_A    306 RDMVVYNRVDlsKLVTHVYHGFDHIEEALLLMKDKpkDLIKAVVIL 351 Clostridium beijerinckii
1YKF_A    306 IDLVFYKRVDpsKLVTHVFRGFDNIEKAFMLMKDKpkDLIKPVVIL 351 Thermoanaerobacter brockii
P14940    321 INVIESGRVDl-GALVTHQYRLDDIVAAYDLFANQrdGVLKIAIKP 365 Wautersia eutropha
NP_250809 321 LNIVASGRVNl-GPLVSHEYRLDDIVAAYDLFANQrdNVLKVAIKP 365 Pseudomonas aeruginosa PAO1
NP_435872 313 MEVIASGRVDt-RPLVTHRFKLDQIEEAYDLFANQrdGVLKVAINP 357 Sinorhizobium meliloti 1021
NP_757848 319 MSLIENKRVDl-RSLVTHTLPFDRIAEGYNIFANQkdGVLKVAIKV 363 Mycoplasma penetrans HF-2
AAP39869  317 LSVIESGRVDm-RPMVTHTFKLDEIEKAYDLFGNQrdGVLKVAIKP 361 Phytomonas sp. ADU-2003
YP_481337 310 FTLMRSGRVDp-TPMTTHEFGFDEIERAFSMMETKedGVIKPLIRF 354 Frankia sp. CcI3
YP_634919 307 MDLVHHKRVDl-SPLITHRFKLADIQEAYALFGERrdGVFKVAIQP 351 Myxococcus xanthus DK 1622
BAF43793  310 FTLMTTGKVDp-TVMTTHRFGFDDVEEAFVMMAEKrdNIVKPLITF 354 Gordonia sp. TY-5

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