Conserved Protein Domain Family
FDH_like_2

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cd08284: FDH_like_2 
Glutathione-dependent formaldehyde dehydrogenase related proteins, child 2
Glutathione-dependent formaldehyde dehydrogenases (FDHs) are members of the zinc-dependent/medium chain alcohol dehydrogenase family. Formaldehyde dehydrogenase (FDH) is a member of the zinc-dependent/medium chain alcohol dehydrogenase family. FDH converts formaldehyde and NAD to formate and NADH. The initial step in this process the spontaneous formation of a S-(hydroxymethyl)glutathione adduct from formaldehyde and glutathione, followed by FDH-mediated oxidation (and detoxification) of the adduct to S-formylglutathione. These tetrameric FDHs have a catalytic zinc that resides between the catalytic and NAD(H)binding domains and a structural zinc in a lobe of the catalytic domain. The medium chain alcohol dehydrogenase family (MDR) has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit.
Statistics
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PSSM-Id: 176244
View PSSM: cd08284
Aligned: 19 rows
Threshold Bit Score: 413.577
Threshold Setting Gi: 124263033
Created: 14-May-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:NAD(P) binding site [chemical binding site]
Evidence:
  • Comment:defined by comparison to related dehydrogenases

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
NP_421633      1 MKALRYHGA-RDVRYESMDDPTPqsDRDAIVQVTACSICGSDLHIYHGhgfsedlGFCVGHEAVGEVVEVGRGVqRLKVG 79  Caulobacter cre...
XP_001702676   1 MTALVLSKE-EDVKFVEVPCPSIvhAGDAIIKVTACSVCGSDLHPYHGrergiapNTIVGHEFVGVVVAKGPEVkDLDLG 79  Chlamydomonas r...
CAJ88611       1 MRALQWHGTrRVAVADDLPVPRIedPRDAVVRVVRSAICGTDLHPYRGeiagftpGTVTGHEFTGVVEAVGPEVhGLRTG 80  Streptomyces am...
YP_001261944   5 MKALIHLGP-GRIGYESVPDPILpdRQGALVRTTMCGLCGSDLHLYHGapa--hgSYCIGHEAVGEVVEVGSEVrDFRVG 81  Sphingomonas wi...
ACD50896       1 MRAVVFENK-ERVAVKEVNAPRLqhPLDALVRVHLAGICGSDLHLYHGkip-vlpGSVLGHEFVGQVEAVGEGIqDLQPG 78  Thermus sp. ATN1
YP_001411652   1 MKALGYHGE-RDIRYDDFPDPVLmgQDGAIVKMKSCGICGSDLHIYHGhgfskdtGYCVGHEAVGEVVEVGRDVrTLKVG 79  Parvibaculum la...
CAB10037       1 MRAVVIDGA-GSVRVNTQPDPALpgPDGVVVAVTAAGICGSDLHFYEGeyp-ftePVALGHEAVGTIVEAGPQVrTVGVG 78  Mycobacterium t...
EAK86047       7 MKAVVIQGP-EQVAVLERPIPKPg-KGEVVVKVNLAALCGSDLHIYRGhqavpryDFVLGHEFVGEIHEAGEGIkNWKRG 84  Ustilago maydis...
EEU38105       1 MKAVVFKGP-FQVHVVTKPVPQIrePTDAILKVSSTALCGSDLHYYRGhqk-stpGFICGHETVGHIVALGASVdGFQIG 78  Nectria haemato...
YP_003201705   1 MKAVVFAGD-GQVRVDSVPTPTIsqPQDALVRVRRAAVCGTDLHAVAHpdg-lpvGTVLGHEFAGEVIEVGPAVqTHQPG 78  Nakamurella mul...
Feature 1              #                                                                         
NP_421633     80 DKVMLPAa---vGCGRCRSCLSGVIQTCENgqgacy------------glsarLQGSQAEAVRVPAADmNAVPVPDgvSM 144 Caulobacter cre...
XP_001702676  80 DRVASPFt---sCCGQCFYCERGATCRCDHtqahlfgwvsegeeqlppeqrrgLQGSQAQYVRVPLASgTLLKLPDdvSD 156 Chlamydomonas r...
CAJ88611      81 DRVVASDi---iACGRCRPCHAGWHYQCHRvglfgyd---------tvvgaraYAGGHAEYVRVPFADvVLLPIPDdvGD 148 Streptomyces am...
YP_001261944  82 DRVLLPAi---lGCGRCDPCRAGDVYLCRTqsapmiy----------gqgfpgIGGSQAEAVAVPNADrNLWRLPPglSD 148 Sphingomonas wi...
ACD50896      79 DWVVGPFh---iACGTCPYCRRHQYNLCERggvygy-----------gpmfgnLQGAQAEILRVPFSNvNLRKLPPnlSP 144 Thermus sp. ATN1
YP_001411652  80 DEVMMSAavrsgGCGRCPACRAGTPAKCAKqiwgcy------------glstnLQGCQAEGIAIPWADnNATRIPEgiST 147 Parvibaculum la...
CAB10037      79 DLVMVSSv---aGCGVCPGCETHDPVMCFSgpmif--------------gagvLGGAQADLLAVPAADfQVLKIPEgiTT 141 Mycobacterium t...
EAK86047      85 DKVVSPFt---iSCGDCFFCNRNQTGRCTQsrvf---------------gsvpLDGAQAEYVLVPLADtTLYPIPDd-VP 145 Ustilago maydis...
EEU38105      79 DHVVVPFs---tACGDCFYCDQGQSSRCSKgvlfgs-----------atptftVDGGHAEFIRVPHAAsSLMRAPAsiPK 144 Nectria haemato...
YP_003201705  79 TIVYGSDf---tACGHCWWCRAGDHWECPQrrffgtg----------tafgpaLPGAQAQLLRVPFADtALRAVPAglSL 145 Nakamurella mul...
Feature 1                ##  #                         # ##                      ##   #          
NP_421633    145 DQALMM-TDALATAWFGARNAev------rpGASVAVIGLGPIGLMAVESAYVMGa--HVVYAIDPLpaRRALAEe---- 211 Caulobacter cre...
XP_001702676 157 EAGLLL-GDILSTAFFCAERGev------gdGATVAVLGCGPVGLLAVMAAKHLGa--SQIFAVDAVpeRLAVAAelgaq 227 Chlamydomonas r...
CAJ88611     149 ERALFI-GDVLATGYACAMGAqv------rpGDTVAVVGCGPVGLLALEAAWTLGa--ARVLAVDPLesRRRRAAe---- 215 Streptomyces am...
YP_001261944 149 EVGIML-TDNLATAWFCARRArv------rpGDVVAVIGLGPVGQQAVMAAKAMGa--ERVLGIDLLrsRRAAAAl---- 215 Sphingomonas wi...
ACD50896     145 ERAIFA-GDILSTAYGGLIQGql------rpGDSVAVIGAGPVGLMAIEVAQVLGa--SKILAIDRIpeRLERAAs---- 211 Thermus sp. ATN1
YP_001411652 148 DQALLL-TDNLPTAYMGAKNAdi------gpGKTVAIVGLGPIGLMAVQSAFVLGa--ARVFAIDLVkeRRDAAAa---- 214 Parvibaculum la...
CAB10037     142 EQALLL-TDNLATGWAAAQRAdi------sfGSAVAVIGLGAVGLCALRSAFIHGa--ATVFAVDRVkgRLQRAAt---- 208 Mycobacterium t...
EAK86047     146 EEIMLLtADIFPTGYFVANNAytmlneaerkDVTAVVIGCGPVGLCAITAACSFF---KTVYAVDSVpeRLAEAKk---- 218 Ustilago maydis...
EEU38105     145 EMLVLM-ADVFPTGYFAASRFlkdlp-qaqeDPVAVVLGCGPVGICAIASAIYLTggrAKIFAVDSVpdRLREAEk---- 218 Nectria haemato...
YP_003201705 146 DAAVFL-GDTLATGYAAVSRAql------raGGTVAVLGGGPVGQLISLAAQACGa--GVVVVVEPVadRRELAAa---- 212 Nakamurella mul...
Feature 1                                                                          ##    #       
NP_421633    212 ------------------------aGAIALHPDea-------------lARVREDTKGRGLDCVIEAVGGeaTVDAALRL 254 Caulobacter cre...
XP_001702676 228 plllgstrpahasgeadeereakrqKAEAGESAaaetpsmssggadevvAAVKAATEGRGVDTVLEAVGSnsALRLGYDL 307 Chlamydomonas r...
CAJ88611     216 ------------------------rGAHPVPGGpd------------aaWEIADLTDGRGADAVLEAVGTddALLTALDA 259 Streptomyces am...
YP_001261944 216 ------------------------lGAEPIEAAdv-------------vQAAIELTGGDGPDVVLDANGSavTIGLAIGM 258 Sphingomonas wi...
ACD50896     212 ------------------------lGAIPINAEqen-----------pvRRVRSETNDEGPDLVLEAVGGaaTLSLALEM 256 Thermus sp. ATN1
YP_001411652 215 ------------------------lGAIPLSPEta-------------iEEVREATDGAMVECSVEAVGIdkTIELAIAV 257 Parvibaculum la...
CAB10037     209 ------------------------wGATPIPSPa--------------aETILAATRGRGADSVIDAVGTdaSMSDALNA 250 Mycobacterium t...
EAK86047     219 ------------------------hGAIPLHLTddd-----------pvKTVKEATGGRGADVALEVVGAgpALDLAVSI 263 Ustilago maydis...
EEU38105     219 ------------------------lGAVPINLSdn------------pvHKVKNASSGRGADVVMEVVGRadALELAFDL 262 Nectria haemato...
YP_003201705 213 ------------------------qGAVVAEPEla-------------rTLIDRVTDGRGADAVIDAVGGprALDTACAL 255 Nakamurella mul...
Feature 1                 # #                      ###                                           
NP_421633    255 VRPRGVVSVIGVQQaKRFAFPleRAFGAGLTFRVGTCSvpeELPALFPLVRSGrlr-----------------pekYISH 317 Caulobacter cre...
XP_001702676 308 VRPMGTISSVGVNTsAEFPFSpvDAYNRNITFRSGRCParaYMTKLMGLVREPpaaaaagaaptaaagksalpwrrIFTH 387 Chlamydomonas r...
CAJ88611     260 VRPRGVVCAVGAHAsDAMPLPtrLAFAKEVTLRFAVGDpisDREPLMNLVRGGrid-----------------ptfVVSH 322 Streptomyces am...
YP_001261944 259 VRKGGRVSVVGLSEsPQIDFPiiGSMLKNLDFHIGVCSvqaELPALFGAIEAGridtg--------------aleaLVTH 324 Sphingomonas wi...
ACD50896     257 VRPGGRVSAVGVDNaPSFPFPlaSGLVKDLTFRIGLANvhlYIDAVLALLASGrlq-----------------perIVSH 319 Thermus sp. ATN1
YP_001411652 258 AGRNASISVFGANQnQAFKYPlwTAFNKSLTFRVAGCFvqsHWPELIPLVQAGrlt-----------------pekFITH 320 Parvibaculum la...
CAB10037     251 VRPGGTVSVVGVHDlQPFPVPalTCLLRSITLRMTMAPvqrTWPELIPLLQSGrld-----------------vdgIFTT 313 Mycobacterium t...
EAK86047     264 VRNFGVISSCGIHT-HTVTLQgpDLYNKNLRFQFGRCPvraVFDPAVKLLSKHhdl-----------------fasFIQH 325 Ustilago maydis...
EEU38105     263 IRPFGKISSVGVHN-EQISFPgfALYSKNVTMAFGRCPvrsLVEETAPVLAKLkdq-----------------lafLCKK 324 Nectria haemato...
YP_003201705 256 VRRRGSVISVGVHRdLAWSLPvaRAFADELTLRFVIGDamrDGDALVDLVRSGaid-----------------ptvLVSD 318 Nakamurella mul...
Feature 1                     #              
NP_421633    318 RLPLSDGPEAYRLFESReagalKMVLTP 345 Caulobacter crescentus CB15
XP_001702676 388 RMPLSQGPQAYDMFARRadgviKIVLDP 415 Chlamydomonas reinhardtii
CAJ88611     323 RMPLAEAPEAFRLFDSGaa--gKVVLIP 348 Streptomyces ambofaciens ATCC 23877
YP_001261944 325 RMGLSEGAEGYARFDAReggigKVVFDP 352 Sphingomonas wittichii RW1
ACD50896     320 YLPLEEAPRGYELFDRKea--lKVLLVV 345 Thermus sp. ATN1
YP_001411652 321 RMSLKDGAEAYRIFDGKldnvmKVVLAP 348 Parvibaculum lavamentivorans DS-1
CAB10037     314 TLPLDEAAKGYATARARsgeelRFCLRP 341 Mycobacterium tuberculosis H37Rv
EAK86047     326 TRPIEDAPEYYKLFNDRkv--lKTVFKM 351 Ustilago maydis 521
EEU38105     325 EIPLDQAPEAFKLFETQka--hKFLFKM 350 Nectria haematococca mpVI 77-13-4
YP_003201705 319 TVGLDDVPEAYRRMADRrt--lKTLIAV 344 Nakamurella multipartita DSM 44233

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