Conserved Protein Domain Family
FDH_like_1

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cd08283: FDH_like_1 
Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1
Members identified as glutathione-dependent formaldehyde dehydrogenase(FDH), a member of the zinc-dependent/medium chain alcohol dehydrogenase family. FDH converts formaldehyde and NAD(P) to formate and NAD(P)H. The initial step in this process the spontaneous formation of a S-(hydroxymethyl)glutathione adduct from formaldehyde and glutathione, followed by FDH-mediated oxidation (and detoxification) of the adduct to S-formylglutathione. MDH family uses NAD(H) as a cofactor in the interconversion of alcohols and aldehydes, or ketones. Like many zinc-dependent alcohol dehydrogenases (ADH) of the medium chain alcohol dehydrogenase/reductase family (MDR), these FDHs form dimers, with 4 zinc ions per dimer. The medium chain alcohol dehydrogenase family (MDR) has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit.
Statistics
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PSSM-Id: 176243
View PSSM: cd08283
Aligned: 45 rows
Threshold Bit Score: 508.615
Threshold Setting Gi: 159039174
Created: 22-Dec-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:NAD binding site [chemical binding site]
Evidence:
  • Comment:defined by comparison to related dehydrogenases

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                             # ##  #                                    
P77316         1 MKALTYHGPHHVQVENVPDPGVeqADDIILRITATAIC-GSDLHLYRGkipq---------vkhGDIFGHEFMGEVVETG 70  Escherichia coli
XP_001831301  32 MRALAWFGTKDVRMIDAPIPKVtePDDVILKVTATTIC-GSDLHLYHGeima---------lqkGEILGHEFMGVVDSVG 101 Coprinopsis cin...
EAA63788      41 IRATVWQGKNSVGIVEMPKPRVvdAGDVIVRVTGSTVC-GSDLHLYHDylsdrahagvipqlqkGDVLGHECCGVIESVG 119 Aspergillus nid...
XP_458867      1 MMALQWFGKEDVAVGKVPIPAItnDTDVIAKVTGTTIC-GSDLHLYHGeime---------lkkGDVLGHEWCGIIEDVG 70  Debaryomyces ha...
EAK86513      24 MLALTFHGTQDVRLTEVRTPTItdPTDVVVRSTGVTIC-GSDLHLYHNkipd---------lkkGDILGHEGTGVVEHVG 93  Ustilago maydis...
XP_001903861  46 MKALAWMGKNDVRVIETSKPKIvdDHDVILKVTGSTVC-GSDVHLMHGvvvq---------vekGDILGHEFCGVVESVG 115 Podospora anser...
EED14616      22 MKAALWMGRRKIEIAEVAKPSItePSDAIVHITHTTIC-GSDLYIYEGdldr--------ymekGRIMGHEAIGIVEKIG 92  Talaromyces sti...
XP_002175184  36 MSAVTWQGPKSVAVEKVPKPTIthENDVIVKITACSICsGSDSHIFSGeinp---------tkkGSIMGHEGCGVIVERG 106 Schizosaccharom...
XP_001701046   1 MRAVTWHGPKKIVMEERPRPMItdPTDAVLRVTSSAIC-GSDLHLYLGsapg---------mqrGDVLGHEFMGFVEEVG 70  Chlamydomonas r...
XP_002566144  61 MKAAQWMGTRNVEVGVVPKPQItdPGDVIVQITHCTIS-GSDIHLYEGqlkd--------amekGDILGQEAIGMIEEVG 131 Penicillium chr...
Feature 1                       #                                                                
P77316        71 KDVkNLQKGDRVVIPFVIACGDCFFCrlqqYAACENtnagkgaalnkkqipapaALFGYSHLYGGVpGGQAEYVRVPKGN 150 Escherichia coli
XP_001831301 102 PSVkNLEPGQRVVASFQIACGECEFCkkkiSSMCDRtnpsslqk--amygttdaGFFGYSHFAGGFpGGQAEYVRVPKGN 179 Coprinopsis cin...
EAA63788     120 PEStKYKPGQRVVVSFPIACGTCKRCkaqlYSQCENtnentitn--amygkrtaGIFGYSHFTGGFaGGQAEYLRVPYGD 197 Aspergillus nid...
XP_458867     71 PSVqNFKKGDRVVSSFQIACGECFYCrdnlSSMCDKtstsrvqe--lmygtavsGIYGYSHFTGGYaGGQAEYVRAPRAD 148 Debaryomyces ha...
EAK86513      94 AQItKFKVGDRVVASFSIACGTCEQCkaklFTMCDRtntsakmd--elygqklgGILGYSHLLGGYaGTQAEYFRVPFGD 171 Ustilago maydis...
XP_001903861 116 PSItKLAVGDRVVNSFCISCGECSYCkdklPTACEKtnastlha--klyggrmgGIFGYSHLTGGYaGGQAEYVRIPLAE 193 Podospora anser...
EED14616      93 SSVsRLQVGDRVIILPIIACGQCRYCekqqFSLCDNtngskeme--akygyrlsGILGSSELMGGYsGDQAEYCRVPNAD 170 Talaromyces sti...
XP_002175184 107 PAVkNLYVGDRVVIAFDIACGQCPYCkrqeFVACDAtndsklmd--kmygahhcAIFGYSDMMGNVpGTQAEYVRVPFAD 184 Schizosaccharom...
XP_001701046  71 PEVkHVKKGDRVVACFDIACGHCRSCsrgaFSGCDItnpskdqe--mmygartaGMFGYAHVTGGYeGGQTDYVRVPFAD 148 Chlamydomonas r...
XP_002566144 132 PDVkSLKVGDRVIILPVISCGTCQYCqrqqYSLCDNtnpskeme--aayghrlgGKLGYSRLCGGYpGNQAEYCRVPHAD 209 Penicillium chr...
Feature 1                           #   #                  ## ###                     ###     #  
P77316       151 vGPFKVPPllsDDKALFLSDILPTAWQAAKNAqiqqGSSVAVYGAGPVGLLTIACARLLGa---EQIFVVDHh--pYRLH 225 Escherichia coli
XP_001831301 180 vNLLPVPDdlaDEQVLFLSDILPTSYHAVVDTgveeGDTVAVWGLGPVGMYVAKFALLKGa---SKVIGIDQv--pERLE 254 Coprinopsis cin...
EAA63788     198 vNLLPIPDdvpDEKALFLSDVISTSWHCVVDTgvnkGDIVAVWGAGPIGQMAVDFAFYHGa---ERVILIDGgdgaWRLE 274 Aspergillus nid...
XP_458867    149 yNLLKIPDkvpDEKALYLSDIVPTSYHSVVCAdvkkGDTVAIWGLGPIGLCALRWAQLRGa---KRVVGIDNv--eSRLA 223 Debaryomyces ha...
EAK86513     172 vNCFHVPDsvsDETALLMADVTLTAYHSVVDIkfqeGETAAIWGAGPIGQLIAQWLLKVFg--aRKVMLIDNv--aPRLH 247 Ustilago maydis...
XP_001903861 194 nNLLKIPDnvpDEKALYLSDVLPTSYHSVVYTgvneGDTVAIWGLGPIGFMACFWAKKKGa---KRVIGIDSn---WRTE 267 Podospora anser...
EED14616     171 lTCIKAPDdisPKKLLGLADVTASAWHGCELAevgkGDIVAVWGCGAVGLSIQRLAKLRGa---SKVFAVDKd--qTRLQ 245 Talaromyces sti...
XP_002175184 185 vNCYKIPAnlpDRKALYASDVLCTSLHAVDMAeinkNDTLAIWGLGPIGLLAARWAQIRGa---RSIIGIDSv--pERLE 259 Schizosaccharom...
XP_001701046 149 vNLLHVPKdlpDNKLLLLSDIMSTAWFANELGsvgpDTTVAIWGAGPGTCQRASVSASQRvrgaPRIILIDNqh-tCRLA 227 Chlamydomonas r...
XP_002566144 210 lSCVKAPEyidARKLLGLANVVTTAWHALELAevqeGDVLGVWGCGPIGLATQRLAKMRGa---KKVFAIDKd--pQRLR 284 Penicillium chr...
Feature 1                      #                            ###                         #        
P77316       226 FAAdry--gaIPINFDeds---dpaQSIIEQTAGhrGVDAVIDAVGFEAKGSttetvltnl--klegssgkALRQCIAAV 298 Escherichia coli
XP_001831301 255 FAEqsl--giETINFKehk---dvpARIREIIGEk-GVDVCIDAGSFHEPKSfthkvqkfl--mletdapeTINEMLLAV 326 Coprinopsis cin...
EAA63788     275 YVKskl-pkvEVIDFTnlpkgesvsSHLRKITDH--NLDVCLECVGGEYAKGwihffeqmv--gaetdtseIVNEMITAV 349 Aspergillus nid...
XP_458867    224 KAQsm---gcKVLNFKdid----vvKEILNIVPG--GVDSSIDAAGFRYANKlthniqrtl--gletdtseVINEAIKAT 292 Debaryomyces ha...
EAK86513     248 WAQerl-nglETINFDqtp---qvaEEVMHKVAG--GVDVSFDAAGFRYAKSlkhqtmqtl--gvetdtpeIINEAIRAT 319 Ustilago maydis...
XP_001903861 268 YAKski-pglETINYAtlesgqtvpTKIHEMVPG--GVDVSIDASGGEYAKGwahklemai--gaeqdtseMINECLYAT 342 Podospora anser...
EED14616     246 IAKsfgmipvDVVAHPnv------sDYILSVQPH--GLDCGIEASGFRSINTpkhaamrym--kaetdsgdTVHAVLKST 315 Talaromyces sti...
XP_002175184 260 LAAskl--kiHVIDRSkvk---dipAKIMEIVPG--GVDAAIEASGFRFTSSfrhtverai--gmetdscdMITECCQAV 330 Schizosaccharom...
XP_001701046 228 CTHaht--htHTHTHThth----vkEALERLVPG--GPDVCIEAVGFHYCKSlvhavmvkvrtlmetdtadILNELIYCC 299 Chlamydomonas r...
XP_002566144 285 IAEdf---gmTPVDVDshp---dvaEYILSVQDH--GLDRSIEASGYRCVGKqeypamqai--glekdssdTLAAIIKAT 354 Penicillium chr...
Feature 1                ###                      ###                                          # 
P77316       299 RRGGIVSVPGVYAgfiHGFLFGDAFDKGLSFKMGQThv--haWLGELLPLIEKGL-LKPEEIVTHYMPFEEAARGYEIFE 375 Escherichia coli
XP_001831301 327 RKMGRCGIIAVYAgyaNGVNVGALMEKGIRLIGNGQapvhlyWKDILENYIKTGK-LDPTFIISHRVGLEDLPALYAAFD 405 Coprinopsis cin...
EAA63788     350 RPFGRVGLTGVYAgytNHFNIGSLMQTGVRLIGNGQapv-qkYWGDLMNLIQKGD-IDPLRMVSHRFRLEDIDKVYSLFN 427 Aspergillus nid...
XP_458867    293 RKFGTIALVADYAgfaNQFLIGGLMEKGITLRGCGQapv-qkYWHELLEKVEAGL-FDPTFILTHRFPIEEFKELYQAFD 370 Debaryomyces ha...
EAK86513     320 RKFGRISVIADYVgqcNEFLIGAMMEKGILLKGNGQapv-qaYMEQVFEDYIVPGkFDPTLILTHRFKLEDIAKVYKAFD 398 Ustilago maydis...
XP_001903861 343 KKFGRVGIIGDYVgftNHFNVGALMELGIYLIGCGQapv-qrYWEELLEMVEKGE-IDPTIMLTHRFKIDDIAKAYKLQE 420 Podospora anser...
EED14616     316 RKGGRIALIGDFFwgtNDFPIGMLMEKGITVRGGQHfg--pkYYPHLLNLVIEGK-YDPSWMFTYDDEFENISEDYRLFS 392 Talaromyces sti...
XP_002175184 331 RKYGRISVIADYIgfaDRFPIGHIMMKHLTLRSGQCpc--qcYFKQVFDALESGK-IDPDFIVTDVVKFNDLPKAYEKLF 407 Schizosaccharom...
XP_001701046 300 RKGGTIACIGVYVglvNGFNIGALMEKGLTLKAGQTpv--qkYWGHLLEMVKSGK-LDPTMIITHELPIEDAPHAYKIFN 376 Chlamydomonas r...
XP_002566144 355 RKGGNVALVGDFFfttRDFPIGPLMQKALTVRGGQTwp--qrYFPFLMDLAVQGK-IDTSWMFTYVDEFENIAEMYKKFS 431 Penicillium chr...
Feature 1                            
P77316       376 KRee-------eCRKVILVP 388 Escherichia coli
XP_001831301 406 ARta-------gVEKVVVDT 418 Coprinopsis cinerea okayama7#130
EAA63788     428 ERng-------gVQKVYLET 440 Aspergillus nidulans FGSC A4
XP_458867    371 KKkg-------gIGKVFVQT 383 Debaryomyces hansenii CBS767
EAK86513     399 EKridehkggipIIKTFIET 418 Ustilago maydis 521
XP_001903861 421 KRee-------gLVKCFVET 433 Podospora anserina DSM 980
EED14616     393 RHqi------pgGLKVCLTT 406 Talaromyces stipitatus ATCC 10500
XP_002175184 408 YKkd-------gMVKIYCEP 420 Schizosaccharomyces japonicus yFS275
XP_001701046 377 DKt--------dGCIKVVLK 388 Chlamydomonas reinhardtii
XP_002566144 432 LHev------pgKLKVCLVT 445 Penicillium chrysogenum Wisconsin 54-1255

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