Conserved Protein Domain Family
MDR7

?
cd08276: MDR7 
Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family
This group is a member of the medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, but lacks the zinc-binding sites of the zinc-dependent alcohol dehydrogenases. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P)-binding Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.
Statistics
?
PSSM-Id: 176237
View PSSM: cd08276
Aligned: 109 rows
Threshold Bit Score: 234.353
Threshold Setting Gi: 262096681
Created: 1-May-2009
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
putative NAD(P)
Feature 1:putative NAD(P) binding site [chemical binding site]
Evidence:
  • Comment:MDR family binds NAD(P) as a cofactor
  • Comment:defined by comparison to MDR alcohol dehydrogenase like family

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                                        ###  #                          
EAL23377       7 MKRYVLVhr---ndLSGITFEq--GAPLPQIKks--tEILINIKALSLNARDLQIAT-NQYPAphpipdgiVPVSDASGE 78  Cryptococcus ne...
XP_456332      4 QTVFRINkg---tsYEDISVNk-eEIPVPAAN-----EVLIKVKAVSLNYRDIAIST-GAYPFpvk--rdvVPCSDASGE 71  Debaryomyces ha...
CAP97062       4 QNVLRLTaq---gsWENLVHS---KEPIPSAGk---hEVLIAVKSVSLNFRDIAIAT-GKYPFpvk--dqvVPGSDAAGD 71  Penicillium chr...
XP_001904225   7 YKAFRRT-------TGDLPRTi-vPSTEPMVQelaphDVLLKIHAVSLNFRDVGMLN-GRYPVdvi--ergIPCSDAAAE 75  Podospora anser...
XP_388230      7 YSAWRRSqgtmgshANPLTINlhnNEELPKDLas--hDVVIKIHAVSLNRRDFTMLN-GEYPVple--sggVPCSDAAGE 81  Gibberella zeae...
EEQ32114       7 SKAFRRSr-----gAGNKTLEp-vTEKIPSTLkp--hDVLIRIHAVSLNYRDVAMLH-GKYPIkfl--drgIPASDCAAE 75  Microsporum can...
EEU33753       7 CRAFRRTe-----pPYPLAVVp-sTETLPDTLgp--rDVVIRVHAVSLNFRDVAMLHeGRYPApae--pqgISASDCAAE 76  Nectria haemato...
XP_001548395   8 YKAFRRTvd---ttPTTLEQT---TEEIPATLsp--nDVLIKIHAVSLNYRDVAMMH-GKYPVevi--dhgVPASDCAAE 76  Botryotinia fuc...
XP_001800234   7 YRAWRRSat---pfPRTLKLS---NETLPEALdt--sDVLIRIHAVSLNYRDVAMLQeGKYPAtvd--dggVSASDCAAE 76  Phaeosphaeria n...
XP_001227925  16 HLAFRRSpgt-gteQTPLPLQlttEPTLPPSGhlgphDVLVRVRAVSLNYRDALMLR-GTYPGgavl-psgIVASDCAGE 92  Chaetomium glob...
Feature 1                                                                                     #  
EAL23377      79 IAAVGDDVTdFKVGDRVTPIIfqghhqdedvtldsmnrgIGGARNGvAAEYFVCdqsEAVKIPksf--shQDASTLAIAY 156 Cryptococcus ne...
XP_456332     72 VVSFGHNVRgFEVGDKVVSNFditnlygp---qqdweggLGGPIDGvLREYVTLpyeSVVKAPsslklsfELLASLVCTG 148 Debaryomyces ha...
CAP97062      72 IVETGEGVSgFKRGDKVIISFdpttlygp---ikdwgngLGGPVDGvLREYIAVpaqAVVKLPanstlsyAQWASVVCTG 148 Penicillium chr...
XP_001904225  76 VAAIGSAVKdFAIGDHVSVNFdlghlvag---ddepmqaLGGDVDGvLREYAVFedkELVQLPkhl--swEEASTIACAG 150 Podospora anser...
XP_388230     82 VVATGNAVSqFSVGDRVVPIPpi--------------gdHYPDNDGwHWNIGVQe-pGMLREYai----cQERDLFPLPD 142 Gibberella zeae...
EEQ32114      76 VVAVGSEVKdFEIGDHVAPIFdvmnind----teeekaaLGGHVDGvLRQYAVFdrnVLFHLPkyl--swEEVATHPFNS 149 Microsporum can...
EEU33753      77 VVAVGDEVKqFKIGDHAAPVFnmsnldgt--erdieavaLGGDGPGvLREFAVFedkFLVKLPqhl--swEEASTLACAG 152 Nectria haemato...
XP_001548395  77 VMKVGSNVHdFKVGDRVAPIFdnnnfds----trdensvLGGDIDGvLREYAVFhqdVLFHLP-------KHLSWEEAST 145 Botryotinia fuc...
XP_001800234  77 VVAIGRGVErFALGDHVAPTIgleilt-------geerdVGDVILG-STGPGTL---REYAVF-------HEKVLVKLPQ 138 Phaeosphaeria n...
XP_001227925  93 VVAVGGGVTrFAVGERVVPTF------------------VRGGSLG-EGGVPLT---LGGEVD-------GVLREFAVFG 143 Chaetomium glob...
Feature 1         #                                              ######                 ##   #   
EAL23377     157 ATAWSSLYshhp-------------------------rlqsGDTVLCLGTGGVSLCAAQIALISGakvIVTSSSqSKLDR 211 Cryptococcus ne...
XP_456332    149 TTAWNALYgnnq--------------------------lkpGQIVLLQGTGGVSMTGLLLAKAAGaitILTSSSdEKLER 202 Debaryomyces ha...
CAP97062     149 TTAWNSLYgnnp--------------------------lkpGQTVLFQGTGGVSITGLMLAKAAGartIITSSSdEKLQH 202 Penicillium chr...
XP_001904225 151 VTAWTALDnlk---------------------------apnPRSALLQGTGGVSLFALLICLAAGikpIITSSSdKKLEE 203 Podospora anser...
XP_388230    143 NLSWEEATwtaldc---------------------mktmpkDGVVLLQGTGGISMIALMLCLGAGvqpIITSSSdDKLET 201 Gibberella zeae...
EEQ32114     150 MNVNTEVLirsigsmyhlcwynsmeiivyasltrhcstssiNFLPPFLGTGGVSMFALLICLAAGirpIITSSSdQKLDR 229 Microsporum can...
EEU33753     153 LTAWTSLDslks--------------------------pneDTTVLLQGTGGVSMFALLICLAAGikpIITSSSdAKLER 206 Nectria haemato...
XP_001548395 146 ITCAGVTA---------------------------------WNALDMPRNKGTALLQGIKPIITS---SSDKKL-DIAKA 188 Botryotinia fuc...
XP_001800234 139 HLTWEEVSf--------------------------------DNIDQATGTGGVSLMTLLICIAAGikpIITSSSdDKLEK 186 Phaeosphaeria n...
XP_001227925 144 EEGLVRLP---------------------------------GHFVVGGGVRHWAVLRSRLGKAVGapdSLDKNK-SVLIQ 189 Chaetomium glob...
Feature 1                             #                        ## #                   ##         
EAL23377     212 VVDLlkplvkgnfaDTIHTIDYSRiDKWDEEVRRItegkGANFVIEIGGRgtIGKSIRSTRr-GGLVAVSGYLSTykdip 290 Cryptococcus ne...
XP_456332    203 IKAKy---------GVDYTVNYKKfPKWGEAVNQMigknRVDYIFENGGSgnIEQSIECIAy-GGQIGIIGFLNVakqs- 271 Debaryomyces ha...
CAP97062     203 VKAQy---------DVDYTINYKTtPDWAAEAQKItdgqGVDFILENGGSgtIKQSLDAIAf-GGVISVIGFLSAakqe- 271 Penicillium chr...
XP_001904225 204 IRKLs---------SDVGTINYKTvSDQVSEVKRLtdgkGVDFVINNTGPasLPEDISFLRsrGGVVSLVGFLAGfngd- 273 Podospora anser...
XP_388230    202 IRKIs---------PRILGINYKTtHDQVAEVKRLtngrGVDYVLNNTGIpsVIDDIEMLRerDGTVSLVGALGGfesv- 271 Gibberella zeae...
EEQ32114     230 VRALgk-------pGEVDTINYRThPNWEEEVLRLtrgrGVDFVIETVGPrtIAQSIASLAr-RGSITIVGFLGGfdvk- 300 Microsporum can...
EEU33753     207 VKQLg---------RDVQGINYKKhPDVAAEALRLtggkGVDYVVNNTGPasIPSDLQSLRkkHGTISLVGFLEGfead- 276 Nectria haemato...
XP_001548395 189 VGEA----------GEVETINYRTyPKWEEEALKLangrGVDIVVDNVGPtqAAQSLTALAr-RGVLSLVGFLGGfkae- 256 Botryotinia fuc...
XP_001800234 187 IKTId---------PAIRGINYKT-ADVATEVLKLtggkGVDVILNNIGI--SSIPENLKV--VRQNGSVALVGFl---- 248 Phaeosphaeria n...
XP_001227925 190 VTKLd--------tPDLASYNYRTnPDQVAEVQRLtggkGVDYVVNNNGPpgIPADIDSLVpsDGVISIVGFLGGrsad- 260 Chaetomium glob...
Feature 1                             ###                                                        
EAL23377     291 keileedLAQTILYSGSYVRGVFVCNREDEKRMISALE--VGNVKPVID-KVFDFENLk--EAYQYMADGKHFGKICVTV 365 Cryptococcus ne...
XP_456332    272 ---empdAVALALSKGCVMRGIAVGSKQLLEELMRFVN--SKGLSIPVD-KSFKFSKPeviEAYKHLQSGSQVGKVCVTL 345 Debaryomyces ha...
CAP97062     272 ---empdVAGLALAKGAVVRGIMVGSKQQMEDAAQFIG--LHNLSVAVE-KTFKFGRDevvEALNYLASGQHIGKVCIDF 345 Penicillium chr...
XP_001904225 274 ---wqpsAIMALMSKFAKLKGIGVGSKQDFVELNQFLAekKVSLAPLVD-RVFTFDESp--AAFDYLYSGSHVGKVIIKV 347 Podospora anser...
XP_388230    272 ---wkhsELIKLMTKRAKLKGVVLGTKAEFRDMVQFIAdkNVSLTLAINeRSFAFKDAk--DAYDLLESNNFCGKIVIKV 346 Gibberella zeae...
EEQ32114     301 ---sfpdTITPLLTKTATIRGGAVGSKIDHQNLSSFLSekRISLKPILDkTVFSFDDSq--AAFDYLYEAKHMGKVVIRM 375 Microsporum can...
EEU33753     277 ---wkpsLLLTVLSKAAKIQGIQVGSKKQFEELNKFLDekKVRLDSIVD-KTFAFEDSa--AAFDYLYSGAHTGKVVIKI 350 Nectria haemato...
XP_001548395 257 ---qipdLFSPTLHKSLVIRGIAVGDKKDHQDLCGFLElkKISLKGIVDpGVFSFKDSq-aAFDALYDGTKHQGKIVIRI 332 Botryotinia fuc...
XP_001800234 249 -------GGFSADYSPNVLSAIMIKAYFEALNAFLGEK--QVKMDPIID-RIFTFDEAp--AAYEYLALGSHVGKVVIKV 316 Phaeosphaeria n...
XP_001227925 261 ---wnpgKLLALIAKTARLQGIAAGSKLDFEALNSFLDekQVRLDPLVDdKVFNFKDSq--AALDYLWSGKHMGKVVIRV 335 Chaetomium glob...

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap