Conserved Protein Domain Family
Zn_ADH9

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cd08269: Zn_ADH9 
Alcohol dehydrogenases of the MDR family
The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P)-binding Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability.
Statistics
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PSSM-Id: 176230
View PSSM: cd08269
Aligned: 12 rows
Threshold Bit Score: 318.532
Threshold Setting Gi: 41409689
Created: 21-Jan-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative NAD(P)catalytic Zn
Feature 1:putative NAD(P) binding site [chemical binding site]
Evidence:
  • Comment:MDR family binds NAD(P) as a cofactor
  • Comment:defined by comparison to MDR alcohol dehydrogenase like family

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                          ###  #                                        
YP_003022335  10 ITGPGRSRVEKVARPs---AGRGEVVVRVEGCGVCASNLPlw---qGRPWFSYpa----qPGSPGHEGWGRVh------- 72  Geobacter sp. M21
YP_002978944  17 ITGPGDVSVEERPLPq---PRPGQVRIRLEGSGVCASNLGp----wAGPEWMSfp---tePGGLGHEGWGRId------- 79  Rhizobium legum...
YP_002547406  22 FTGPGQINIVSNTLPq---PGRSQVRIRLEGCGVLACDPLsld-rqGRMPTSAe------PVGLDGEGWGVId------- 84  Agrobacterium v...
YP_002491601  10 LAGPRRIELAEVERPr---PGPGEVLVRLHGCGVCGSNLApw---qGRAWFTYpf----aPGVPGHEGWGVVe------- 72  Anaeromyxobacte...
YP_001380397  21 MTAPGRFEVREAPRPa---PGQGQVLVAVDGSGICGSNLPvf---eGRPWFAYpl----aPGAPGHEGWGRVv------- 83  Anaeromyxobacte...
YP_003322571   6 LLAPRKFDLIDCPIPe---PGPREVLVRVAVCGVCTSELDvw---dGRAGDVQf------PRFPGHEVAGIVe------- 66  Thermobaculum t...
YP_001541490   8 LVSAGLVRIEEHESPk---PREGEVLIKVKAAGICSGDIYaf---kGLPVWFTl------PAPFGHEPVGDVv------- 68  Caldivirga maqu...
XP_001750391  18 YREPGHMVMEQTPRPtlegCMPGTVLLEALYTTICGSDMLyi--nqPREIDHC-------AGASIHEAIARIvdlvptde 88  Monosiga brevic...
NP_962525      6 IVAPYRFEPTTIDDKtpecLADGQVLLRFSAAGVCGSDLPafrgarGRLPGDDgrsgpekDGFPIHEIAGEVia------ 79  Mycobacterium a...
YP_001853870   6 VPTSGNVLVKQWPDPr--aSQDGQFVVRVVAASVCGSDLHsv--lhGTLHERApe----lAGYPGHEGVGVVte------ 71  Kocuria rhizoph...
YP_708712     12 LVGPGELVIEEHPIPe---VRERDVLVKVDRGAICGSDLHav--ydGLGFLVNqsk--peAGGPGHEGVGTVve------ 78  Rhodococcus sp....
YP_002538686  10 ITGPGQAGLTEIPIPd---PGSGDLLIRVEGCGVCPSNLPlw---qGRPWFTYpa----pPGNPGHEGWGTVe------- 72  Geobacter sp. F...
Feature 1                                                                                        
YP_003022335  73 ---------------------rLGDGVeg---------vaVGDRVTfls----ynaFAQYDKVQae---alVRIPPsl-- 113 Geobacter sp. M21
YP_002978944  80 ---------------------aLGDGVsg---------laLGDRVAalt----yhaYATHDIADed---mvVSLPRaf-- 120 Rhizobium legum...
YP_002547406  85 ---------------------aIGPNVrs---------lsVGDRVAslv----rsaYASHHLADad---svISLPPll-- 125 Agrobacterium v...
YP_002491601  73 ---------------------rLGAGVdg---------lvEGQRVAlls----gaaFAQYDLAAad---rvLPIPEal-- 113 Anaeromyxobacte...
YP_001380397  84 ---------------------aAGPGAega--------ftAGARVAfls----gaaFAEYEAVDaa---aaLAVPAal-- 125 Anaeromyxobacte...
YP_003322571  67 ---------------------kLGSDVke---------fhPGDRVAvwvt---ergFSDYVLADvnhcfrlQNVPI---- 109 Thermobaculum t...
YP_001541490  69 ---------------------eVGPNVtg---------fkPGDKVIaig----spaYADYLVAKas---svAKIPSni-- 109 Caldivirga maqu...
XP_001750391  89 peldnpfglttdqivlalpsnyLHSGIfrdvpperaqalrEGVKCTg--------gMSQYFIGHas---hcYPIPSk--- 154 Monosiga brevic...
NP_962525     80 ---------------------sRHPAHr------------PGDRVVgwas--gfdgLMERVVSDgdg--laPYDPAls-- 120 Mycobacterium a...
YP_001853870  72 ---------------------sRSPRFp------------VGTAVLclppgelggtFAELMLLDee---haVALPPeadp 115 Kocuria rhizoph...
YP_708712     79 ---------------------tRSERFq------------VGDRVLiln----vgsFAEYTVVSed---wlLTLPEdq-- 116 Rhodococcus sp....
YP_002538686  73 ---------------------aTGHGVkg---------faEGDRVTfls----sqaYAEYDLVPae---aaVKLPSsl-- 113 Geobacter sp. F...
Feature 1                          #   #                         ######                  ##   #  
YP_003022335 114 --dGFPFp---------gEPVGCAMNVFR-RSAIe-----pGQTVAVIGAGFLGAIFISLAAARGAR-VIALSRRGfALE 175 Geobacter sp. M21
YP_002978944 121 --dGQPFp---------gEPLGCAMNIFR-RSRVe-----aGQTVAIIGIGFLGALLTQLVSGAGAR-VIAISRRPfSLE 182 Rhizobium legum...
YP_002547406 126 --dGMPFp---------gRSLSRAMNIFR-RGDIk-----aGQRVAIIGIDFVGALLVQLASRAKAH-VTAISRRPaSLA 187 Agrobacterium v...
YP_002491601 114 -tgPFPG-----------EALGCAVNVFR-RAAIg-----qGDTVAVVGAGFLGLMVLRLAALAGAR-VLALSRREtSLA 174 Anaeromyxobacte...
YP_001380397 126 --gDLPFp---------gEPVACGVNVFR-RARIv-----rGDVVAVVGIGFIGAVVARLAAAAGAR-VLAVGRRPfALD 187 Anaeromyxobacte...
YP_003322571 110 ---DQALi----------EPLACAVNAVE-LTNVs-----lGDDVLVVGAGYMGSLVLKLLKLQGVArLIVADIRPeVLK 170 Thermobaculum t...
YP_001541490 110 -pyEYAIg----------EPLAAIVNVIR-VTQPr-----lGDYVAVVGSGYMGLLLTQALRGMGFSeLAVFDIIDdRLK 172 Caldivirga maqu...
XP_001750391 155 ---DKWGpgvelhhltaaQPLGTILWMGR-QLPNl-----lHKTVLVLGQGQNGQLATHLMASMGARrIIAADVLPeRLA 225 Monosiga brevic...
NP_962525    121 --pAQAVe---------lQPLACVLYACEqLGELa------GKHVAIIGQGSIGLLFSYVAKAAGARrVTGVDPID-RRD 182 Mycobacterium a...
YP_001853870 116 edlTQMRrym------maQQMGTCLYAMN-LYWPtevparrAGTCVVMGAGSAGLFFLQDALARGFErVVVSDREEsRLA 188 Kocuria rhizoph...
YP_708712    117 -sfARMIm---------aQQLGVCLYGMD-RFWPrdr--eaGKVATLIGAGSIGLNFLQLLKLWGFEtVIVSDLEQaRLD 183 Rhodococcus sp....
YP_002538686 114 --dGKAFp---------gEPVGCAVNVFR-RSQIr-----aDQTVAVIGAGFLGIIFTALAAAQGAN-VVAITRRRaSLD 175 Geobacter sp. F...
Feature 1                                      #             ## #                    ##          
YP_003022335 176 LARRCGAAetvpl------ddhrKVLDRVRE-LTGDKGCDRVVEATGYqw-pLDVAGELVRerGRIVIAGFHq-DGMRQV 246 Geobacter sp. M21
YP_002978944 183 IAKRMGAAetvsm------ddhwRIIEAVRE-LTNGAFCHRVIEAVGKqw-pLDLAGELTAerGRLVVAGYHq-DGPRQV 253 Rhizobium legum...
YP_002547406 188 VAKRMGAAkaftidehgaaddsvRIIETVHE-LTGGYLCDRVIDVTGEsg-lIDLADKLTNaaGRLIMAGRQq-SDPREG 264 Agrobacterium v...
YP_002491601 175 LARRLGADeaipt------gdpgAAEARVRD-LTGGRLCRVVVEAIGSqe-aLDLASRLVAegGRLAIAGYHq-DGPRTV 245 Anaeromyxobacte...
YP_001380397 188 LAGALGAEpvpw-------gergAVVEEIRR-RTGGALCDVAVEAVGLqa-pLDLASDLVResGRLVVAGFHq-DGLRTV 257 Anaeromyxobacte...
YP_003322571 171 LASNIGAThlid-------lareDIKHTVAD-LTDGKGVDAVFEVTGHqa-pLNFIGDIVRmhGKIAIVGYHq-GEPRCI 240 Thermobaculum t...
YP_001541490 173 LAKEFGATatvn--------ptvDDVDKVTKeLTNGNGFNVVFEVSGNpn-gVDLATRIIGrrGRLSIVSYH--SLPVQV 241 Caldivirga maqu...
XP_001750391 226 ISTHMGATdivqid----pedsaKAVAEVQR-LTSGAGADVVLEMVGHqdstINLCIEMVApsGLIMAFGVPgnSLYGSF 300 Monosiga brevic...
NP_962525    183 VARAFGVDdp-----------vrATSDRWVSqLDPADRADVVIETVGHqvatLAHAIDAAApgGTVFYFGVAd-DDTYPI 250 Mycobacterium a...
YP_001853870 189 IARELGAVtvrv--------peeSLAEVVSE-LTDGAGADLVIEAVGSdt-lRAEAVNIVAhrGIVGWFGLYesFDPAPV 258 Kocuria rhizoph...
YP_708712    184 VARELGATevvl-------apaeSVVEMTRK-LTGGLGADLVVEAAGYde-tRAQSVEAVRedGRIGFFGYPesYEPSPF 254 Rhodococcus sp....
YP_002538686 176 LAKKYGAAesvtl------ddhqGIIDRLNK-ITGGKGCDRVIEATGHqw-pLDLAGELVGerGTLVIAGYHq-DGPRQV 246 Geobacter sp. F...
Feature 1                      ###                                                               
YP_003022335 247 NVQLWNWKGVDVINAHErdpkvy--------legmlAGIEAVDAGLFal----deLITHTYALeHLGEAYRaldQRPDGF 314 Geobacter sp. M21
YP_002978944 254 NMQLWNWRGIDVINAHErdpriy--------vsgmrEAIAAMISGRLdp----ssLYTHVYPLeGLGEALDatrDRPDGF 321 Rhizobium legum...
YP_002547406 265 IIQSWKKREAAVIQTDKhshgigpdisqeicvdgmlEAVAAIMDGRLdp----tsLYTHRYRLeELGQALIaarDQPDGF 340 Agrobacterium v...
YP_002491601 246 DMQSWNWRGIDVVNAHErdpavq--------regvlAAARLVAEGRLdp-----gPLYRSFPLdRLADAFQameERPDGF 312 Anaeromyxobacte...
YP_001380397 258 DLCAWNWKGLDVVNGHErrrevm--------mdamrGAAEAVADGTLdl----arLVTHAFPLeAIGEAFAalrDRPDGF 325 Anaeromyxobacte...
YP_003322571 241 PLGQWNYKALQIVNCHFrdpkii--------lrgmsIGVNLMENGLLtm----gdLITHRFPLgSINDAFAtaeRKPDGF 308 Thermobaculum t...
YP_001541490 242 NFRIWDAKGIDLVMAVParsgeey------atidlrIAAKLLERGVFnq----ekLITHEWRLdQLQEALEyasKKPKEY 311 Caldivirga maqu...
XP_001750391 301 AFATLFRKNAKLQGSVFpcah-----------edfpFAVELLAQGRIkag---piFNTDPFSLeHAPDAFSkslYAKHTV 366 Monosiga brevic...
NP_962525    251 SMRTMLRNNLTLKSGVTldrr-----------rmleLAGKFAAEHPWll----gaYLTHTFGVdEVQDAFElacRPVADR 315 Mycobacterium a...
YP_001853870 259 PVYEVFRKCVRLQGSVAaqsepg--------lisfhEAVRRIHAGEVevdyclgpVHTLEETL-DVLRRAE---RGGDGE 326 Kocuria rhizoph...
YP_708712    255 PFGDAFWKGPISIEIVKgaqrik-------glphfhEAIKLISDGTIpv----dhLLDAEYPLdDITTAFEa--ARARKH 321 Rhodococcus sp....
YP_002538686 247 NLQQWNWKGIDVINAHErdrkvy--------legirEGIRAAESGLFrl----ddLVTHDFSLrELDKAYAaitERPEGF 314 Geobacter sp. F...
Feature 1              
YP_003022335 315 LKGIIR 320 Geobacter sp. M21
YP_002978944 322 LKAMVT 327 Rhizobium leguminosarum bv. trifolii WSM1325
YP_002547406 341 MKALVI 346 Agrobacterium vitis S4
YP_002491601 313 VKALVT 318 Anaeromyxobacter dehalogenans 2CP-1
YP_001380397 326 LKGVVR 331 Anaeromyxobacter sp. Fw109-5
YP_003322571 309 IKSVVS 314 Thermobaculum terrenum ATCC BAA-798
YP_001541490 312 IKGVII 317 Caldivirga maquilingensis IC-167
XP_001750391 367 MKVIIE 372 Monosiga brevicollis MX1
NP_962525    316 IKIAIA 321 Mycobacterium avium subsp. paratuberculosis K-10
YP_001853870 327 VKFTIV 332 Kocuria rhizophila DC2201
YP_708712    322 IKVQLV 327 Rhodococcus sp. RHA1
YP_002538686 315 IKGIIR 320 Geobacter sp. FRC-32

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