Conserved Protein Domain Family
MDR1

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cd08267: MDR1 
Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family
This group is a member of the medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, but lacks the zinc-binding sites of the zinc-dependent alcohol dehydrogenases. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P)-binding Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.
Statistics
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PSSM-Id: 176228
View PSSM: cd08267
Aligned: 113 rows
Threshold Bit Score: 165.467
Threshold Setting Gi: 115398227
Created: 2-Dec-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative NAD(P)
Feature 1:putative NAD(P) binding site [chemical binding site]
Evidence:
  • Comment:MDR family binds NAD(P) as a cofactor
  • Comment:defined by comparison to MDR alcohol dehydrogenase like family
  • Comment:[AG]XXGXXG nucleotide-binding motif

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                        ###  #                          
Q9SV68         9 LQYNSYGGgaag-------lehvQVPVPtpk----snEVCLKLeATSLNPVDWKIqkgmirpf-----lprkfpcIPATD 72  thale cress
XP_001903375   9 MKAHIYTNtsptlea--nlsistSVPTPtvs---gpnELLIQVlSASINPADHKVpelpgpvr----rlviktpaTPGMD 79  Podospora anser...
XP_002145726  24 LQTNLYKSdtay--------rpgQTLRPh--------QCLIKIsSTSLNPADYKVpedapsllw---kcvvsspaSPGMD 84  Penicillium mar...
EEU43570       5 MQIWQYSSpvekied--slaikdQVPIPphss-lgkdEMLIKViTASISPVDYKLpesgiigr-----imipnpaTPGLD 76  Nectria haemato...
XP_001394744   1 MQAWLYSTthptleq--nltltpSAPTPppp---kntQLLIRVhTCALNPADYKVptmpvist-----llirkpaSPCLD 70  Aspergillus nig...
XP_680796    419 MKSWLYSStqpsvis--nlsftaSAPSPplps--yanQLLIKVfTTSLNPADHKVpqhatipftggrtlicglpaSPGLD 494 Aspergillus nid...
XP_959388      9 MRAWQYSQttggleq--nlvlkdDVPVPtlsprvgdkELLIEVlSASINPSDYKIaelplnlg----ravvrtpaTPAWD 82  Neurospora cras...
EDP49534       7 MKAWLYSNttgglennlelstsaRTPGPpg-----hsQLLIKViSASINPADYKVpempivpr-----ffvsypaTPGMD 76  Aspergillus fum...
EEU34257       1 MQAWQYTTikgple---ssltlnEKATPpdaqslpkgHVLVEViTAGVNPVEYKLpeaplygk-----fmvqppaSPGLD 72  Nectria haemato...
EEU37991       1 MKAWRFHKavggae---kylkfeDVTLPtsfhslppqSSLIKVsIVSLNPVDIKFaetpfvgp-----ylhpmpaIPGLD 72  Nectria haemato...
Feature 1                                                                          #   #         
Q9SV68        73 VAGevvevg-sgvknfKAGDKVVAvlsh----lggGGLAEFAVAtek-ltVKRPQEVGaaeAAALPVAGLTALQALtnpa 146 thale cress
XP_001903375  80 FCGrvvqag-tkvdsiALGDIVYGrlgp----kqhGSLGEYIIApanavaVLPKEGVTvdeAAAIGVAGLTAYQAIqpn- 153 Podospora anser...
XP_002145726  85 FSGvvvatg-akvtnvRIGQRVFGclpl---prqyGTLAEYSVAdag-lvVPVPEGVDlddAATVGIAGQTALQVIkgq- 158 Penicillium mar...
EEU43570      77 FCGrvvhkh-ssitgfEEGQLVFGshag---hnqlGTLAQYTVVsaa-ccALLPEGIDpddGAAVGTAATTAYQSLmpdk 151 Nectria haemato...
XP_001394744  71 FAGeivstgpnvpstlTPGKLVYGtlpl---ptqfGPLAEYVVAeae-hvQIIPEGVEvdhAATVGVAGQTAWQAIapyv 146 Aspergillus nig...
XP_680796    495 FAGkivsvhpknrtefEPGQLVYGclar---prtfGTTGEYILAdan-dvAHLPEGVSvddAACLGVAVRTAYQSLknyl 570 Aspergillus nid...
XP_959388     83 FCGrvvktt-nivdnfRVGEIVFGrqap----tqhGACGQYIVAsan-acASLPSGVDvdeAASLPCAGLTAYQTIapn- 155 Neurospora cras...
EDP49534      77 FCGqvvaag-pgatafQPGQLVYGttaa---paqfGSLGEYLLCkte-hvALLPDGVApdhAATVGVAAQTAYQSIapy- 150 Aspergillus fum...
EEU34257      73 FCGrikain-dtddslKEGQLVFGalsitskfpkfGTLGQIIIApvs-qlTALPPGVSpddAAAVGTAGMTAYQSLpqdl 150 Nectria haemato...
EEU37991      73 GVGhvvkt---tdstlHVGQLVMFrlle---kqpeGALAEYVLVtse-gcVPIPSGVSpvqAATVGTCGVTACQAIapfv 145 Nectria haemato...
Feature 1                           #### ##                 ##  #              #                 
Q9SV68       147 glk---ldgtgkKANILVTAASGGVGHYAVQLAKLAnahVTATCGarNIEFVKSLGaDEVLDYKtpegaa-----lksps 218 thale cress
XP_001903375 154 ---------vkkGDKIFINGSSGGVGCFAVQIAKVLgchVTASCSpaKAELVKSLGaDEIIDYTttdvce-----ylrak 219 Podospora anser...
XP_002145726 159 ---------vqsGDHIFINGGSGGVGTYAIQIAKAYgchVTATCStrNVELLKSLGaDEVLDYTtvdvvd-----ylrkq 224 Penicillium mar...
EEU43570     152 ---------lppAANVFINGGSGGVGTWAIQLAKAMgakISTTCStkNLDLCQRLGaDHIIDYTkndvie-----flkdq 217 Nectria haemato...
XP_001394744 147 --------tpdaGDKVLIVGASGGCGIYGVQIAKALgceVTAVCSgkNVEFVKGLGaDEVIDYTvedvve-----vmkak 213 Aspergillus nig...
XP_680796    571 dls---kfeggsGPRVFINGGSGGCGVFAIQIAKMLgcqVTTTCSgrNIELVRDLGaDEIIDYTttnvte-----tlktk 642 Aspergillus nid...
XP_959388    156 ---------vkpGDKVFLNGGSGGVGSFGIQIAKALgchVTVSCSaaKAEQCKALGaDDIIDYTavdvcq-----alker 221 Neurospora cras...
EDP49534     151 ---------vsaGDRVFINGGSGGCGIFAIQIAKALgcsVTTTCStrNVPFCKELGaDEVIDYTqddvla-----vlrar 216 Aspergillus fum...
EEU34257     151 ---------ikpGTKIFINGGSGGVGSFTVQFAKALgatVTTTCStaNVELCRSLGaDEVIDYRkldvmv-----elkkk 216 Nectria haemato...
EEU37991     146 fkynsikpdgkePFKVFVNGGSGGTGTFQIQIAKAVgcyVVTSCStpNVDLCKSLGaDEVIDYRlgpaedalqemvqsgr 225 Nectria haemato...
Feature 1                 ##                       ##                              ###           
Q9SV68       219 GKKYDAVVHCAngiPFSVFEpnl---senGKVIDITPgpnamwtya-------vkkitmskkQLVPLLLipk--aenLEF 286 thale cress
XP_001903375 220 GKVFAQVLDNVg-tPDNLYKasddfliagGKFVQVGSplslgalrsaasrallpsflgggksKYEVYTIrds--aedLKV 296 Podospora anser...
XP_002145726 225 GPLFSLALDMIg-kPDDMYReshnfllpgKPYAQVGNeshlstagrl-----itprilgggqRPYQLVFfknr-yedMKE 297 Penicillium mar...
EEU43570     218 GAVYDLVIDNVg-nRPELYDnshlmlkagGTFVQVGVgesmslkgvast--mkkqiwpfgtpRFYFVNMkns--aefFQV 292 Nectria haemato...
XP_001394744 214 GKVYKLVVDHVg-ePWELYResekfmvrgGVFTQVGAnwmptfavrf------irpgflgggRMKYVPIfwksnkkdLTK 286 Aspergillus nig...
XP_680796    643 GLVYDHVIDHIg-lPGNLYAechhflkpsGVWVQVGAgsiltafwra-----itprflgggrRWFVPLMmans-kedLVE 715 Aspergillus nid...
XP_959388    222 GQVFKLSVDNVg-lPAELYKagddyllpdGKFVQVGGpvslaalsstmsrllrpsflgggkrKFQLYTLmgdq-hqdLAI 299 Neurospora cras...
EDP49534     217 GPVYAHAVDHIg-lPEALYSqshmfllpgKAFVQVGAlsmltfvrrvv----wpgflgggrrKYVIFMMksn--qrdIAT 289 Aspergillus fum...
EEU34257     217 GQIFDLAIDNVg-tPPGIYEqsqhflkpdGTFLQVAMqsslsgmlrrs----llpsflgggkRQYRLVRvnin-rkdLQQ 290 Nectria haemato...
EEU37991     226 SSPFDLVVDNVd-lPWSLYKaathymkpgGTYVQIGGdvswqgikelfcikllpaflgggprQWEFLAMkts--redAER 302 Nectria haemato...
Feature 1                                                   
Q9SV68       287 MVNLVkeGKVKTVIDSKHpls--kaEDAWAKSidghATGKIIV 327 thale cress
XP_001903375 297 LGQWIkeKKIKVVIEQTYefe--dvPKAFAKLrtgkSAGKLVI 337 Podospora anserina DSM 980
XP_002145726 298 IADLMqdGKVKPVIDTVFefd--daVKAFERLrtnrARGKVIV 338 Penicillium marneffei ATCC 18224
EEU43570     293 IGRWLaeGRVKPVIAAQFdwk--dvPEAFRLLregrSAGKIVV 333 Nectria haematococca mpVI 77-13-4
XP_001394744 287 VGELIaeGKVKVVLDSVFrfg--daPKAFEKLrggrARGKVVV 327 Aspergillus niger CBS 513.88
XP_680796    716 VGNLLkeGKLRTVKDGNRvwefgdvKKAYELLasgrARGKIVI 758 Aspergillus nidulans FGSC A4
XP_959388    300 LGQMVaeGKIKPVVEHAYdfe--dvPTAFRDLrkgkTHGKLVI 340 Neurospora crassa OR74A
EDP49534     290 LGEWMqqGKLRVEVDSTYele--daVKAFEKLrsgrARGKIII 330 Aspergillus fumigatus A1163
EEU34257     291 IGQWMaeAKVRAVIDQKFewk--eaPKAYEKLrlgrTVGKIVV 331 Nectria haematococca mpVI 77-13-4
EEU37991     303 VLGWMqeGKIRIPLDEEFgfh--evPDAYRRLkagrTRGKIIV 343 Nectria haematococca mpVI 77-13-4

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