Conserved Protein Domain Family
2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_like

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cd08255: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_like 
2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members
This subgroup of the medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family has members identified as 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase and alcohol dehydrogenases. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability.
Statistics
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PSSM-Id: 176217
View PSSM: cd08255
Aligned: 72 rows
Threshold Bit Score: 130.083
Threshold Setting Gi: 21674023
Created: 16-Sep-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative NAD(P)
Feature 1:putative NAD(P) binding site [chemical binding site]
Evidence:
  • Comment:MDR family binds NAD(P) as a cofactor
  • Comment:defined by comparison to MDR alcohol dehydrogenase like family

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                      #        ##  #                                                    
BAA94034      28 DLVVDi---eYSGISt-------GTEKLlwsgrmpafpgmgyplVPGYESVGRVvqaga-nahhkVGERVFVPGarcyge 96  Rubrivivax gela...
YP_001634055  30 DVLIKt---aFTSISa-------GTERMlldgrlpq-pqllfpvVPGYETVGQVvqvgskapkelLGQWVYIGGarcfrg 98  Chloroflexus au...
YP_001277572  33 DVVVRt---aFTSISa-------GTERMllagrmph-pmlqfpvVPGYETVGRIvargtavpaeyDGRWVYVGGarcfrd 101 Roseiflexus sp....
YP_001997615  28 DVILEt---yWSAVSa-------GTEKMllngrlpsmqmtqypvVPGYETVGKIirrgkkvpesyEGKFVYVSGslgytd 97  Chloroherpeton ...
AAT90313      58 DVVVQv---sHSGISt-------GTENLlwsgtmppfpgmgyplVPGYEAVGEVihaek-gaalsPGDYVFVPGsngfkd 126 uncultured prot...
AAM48597      31 ECLVEs---qWSGISt-------GTERLmltgqmppfpglgyplIPGYETVGKIlespk-gskltPGTTVFAPGsvgftd 99  uncultured mari...
NP_662308     31 DVLVEt---wWSSISt-------GTEKMalnglips-ppfifpfIPGYETVGRIveagdhvnqglIGKFAYVAGsfgyed 99  Chlorobium tepi...
YP_002911735  36 SVISPg----TERAFllae-pntATRQLgf------------pyYPGYSNVGRVvgigkavsnvqIGDLLGTMCa----- 93  Burkholderia gl...
YP_001996296  34 KTILTtvapgLERMQitg---ksVTRRVikf-----------pvVPGSEMVGEVvwvgefvhgiePGELVYVRQgdrwag 99  Chloroherpeton ...
NP_662088     34 RTIASt---iTPGLDrllltnkpVSHKVlay-----------pvMPGSETIGQVmqvgpevtsvkEGDFVYAFKgdcwvg 99  Chlorobium tepi...
Feature 1                                                                  #   #                 
BAA94034      97 vrglfggAASRVVVAgs--------------------rvCNVSDslg--eqAVLL---ALAATAYHSVAGGgkr--tpiV 149 Rubrivivax gela...
YP_001634055  99 vnaawggQSEYITAEhe--------------------rvVPLGSldp--atGVLL---ALAATALHGIKIGqi----rrS 149 Chloroflexus au...
YP_001277572 102 vnpawggQAATLLVDyr--------------------riVPLDGmqp--ehGVLL---ALAATALHGVDLIagtgqnltG 156 Roseiflexus sp....
YP_001997615  98 vnaafggASQYIISPlhki-----------------tllDKLPDps----vAIAL---PLGATALHAVELGti-----sK 148 Chloroherpeton ...
AAT90313     127 alglfggSARLLVTPcd--------------------rtIKIDRnlg--eqGALF---ALAATARHAIAGMe------vR 175 uncultured prot...
AAM48597     100 aknlfggSAQHLVCRed--------------------klIALPEkla--sdGVLL---ALAATALHSLRRCes-----vG 149 uncultured mari...
NP_662308    100 -vnaafgGASQFIVCpv--------------------esLTVLDgianpqcGIAL---PLGATALHIVDLAev-----kN 150 Chlorobium tepi...
YP_002911735  94 -------HQSHVLVRppldhprqhghgalfdsvepsglaWRLPGrhpslppAALAt-fIIAAVALYGVTRAqi----kpG 161 Burkholderia gl...
YP_001996296 100 aeslfgcNANFVLTHfk--------------------hvIPLGTapm--qrAVLS---GLLAYAISSVKKInl----qeL 150 Chloroherpeton ...
NP_662088    100 idpyygcHAEVIPTSeenv-----------------lalGRKPIh-----rDLLTglvGYVLSAMEKVALDp-------S 150 Chlorobium tepi...
Feature 1              ######                     ##   #              #                      ## #
BAA94034     150 PPDLIVGHGVLGRLLARMTVVAGFpa-ptVWETNPt--RAQGATG----YAVLHPDedp--------rrDYRAIFDVSGD 214 Rubrivivax gela...
YP_001634055 150 DRVLVLGQGIVGQLAARLAKYAGAq---hVAVADRvavRLQASQA----DQVIDVTreslde--aigeaKVDVLIEATGS 220 Chloroflexus au...
YP_001277572 157 RRVLVLGQGPVGQFAARIARAQGAw----VAVSDRvasRLERSVAdl-rVDVTTDSlvaa------vqqPVDTIIEATGS 225 Roseiflexus sp....
YP_001997615 149 KKILVIGQGAVGLLVTEFAKALGAe---kVVATDLnafRLEKSRAdv-kINVSETAvgev-----laemELDVIIDSSGS 219 Chloroherpeton ...
AAT90313     176 LPDLIIGHGVLGRMLARLTLAAGGep-ptVWEIDEa--RRDGAVG----YEVVHPDidn--------rnNYRAIFDASGR 240 uncultured prot...
AAM48597     150 PPELIVGHGVLGQLLARLTRIIHGvs-ptVWERDPa--RRPSNLD----YTVYDADqdp--------ryDYGVVCDVSGS 214 uncultured mari...
NP_662308    151 RKVLVLGQGAVGILAAELAKRFGAs---lVAVTEPhqrRLDISTSd---IKVNPEKqdvsv---alaghEFDVLIDSTGI 221 Chlorobium tepi...
YP_002911735 162 DQVIVAGLGPIGLLAGQFARLSGGlpivgISATDA---RRKHAVSlg-fDEVYASIdafrqqranysyaAKTVVIEATGR 237 Burkholderia gl...
YP_001996296 151 NRVLVLGLGSVGMMAIEYLRYKGFt---dIDAVESfaiRGRMSSAs--aIGISLDDfted------fndRYDLVIEATGR 219 Chloroherpeton ...
NP_662088    151 MRVLLLGLGSVGLMVSEYLHYRGIr---hVDALENfplRGQLSHAenigIEIVDFTddf--------ndRYDLVIETTGR 219 Chlorobium tepi...
Feature 1                           ##                         ###                               
BAA94034     215 saiLDRLVERLAkgGEIVLAGf---------yTEPLHFNFAPAFMREAQircaaewqrp---dllavkelaETGRLSld- 281 Rubrivivax gela...
YP_001634055 221 mgaLSGALPLLAnhGRVVLLGy----------YDHINIPYAPVFMREAQilvarewefgpdgdlprvrdllANGDLKvd- 289 Chloroflexus au...
YP_001277572 226 maaLSDALPLLAndGTIILLGy----------YDELRLPYMPLFLKQARlltakewvtg---dlqrsrdllASGMLDaa- 291 Roseiflexus sp....
YP_001997615 220 mkaIEDNLRFLKmhGEIVFGGy----------YERVDLAYAQIFMKELKlicakqwal----gdldrvrdmMGTSLIdf- 284 Chloroherpeton ...
AAT90313     241 sdlLDQWIQRGQkgAEIVLAGf---------ySERINFAFPPAFMKEIKiriaaewsqs---dliavralvESGALSlg- 307 uncultured prot...
AAM48597     215 adaLNQMIARCKpgATAVLGGf---------ySSAVTFDFPPAFIREINllvsaewqpq---dlkeaarlaSDGTLDfs- 281 uncultured mari...
NP_662308    222 msaIETGLRFLKfhGKVIFGGy----------YQRMNIDYSQAFNKELSfiaarqwakg---dlhrvreliAAGKINae- 287 Chlorobium tepi...
YP_002911735 238 pdnVLTALTCCPtgATLLLLGssrgsvnevdfYTLLHRKAITVIGAHQPtrpaanplen---rwaqywdadTALRMIasg 314 Burkholderia gl...
YP_001996296 220 lllIEQVMRLLKpqGKVLLMGn----------YEVTKYDYRLIQDKEPVlitsslvqde---hlieakrilSDAEFPae- 285 Chloroherpeton ...
NP_662088    220 ilmVEKVMRLLKpkAKVLLMGs----------YEVLGYDYRLIQHKEPVivcssvtdkq---hlieakallETEAFEte- 285 Chlorobium tepi...
Feature 1                                             
BAA94034     282 -----gLITHHASPs-DAAAAYRTAfgd-pdcLKMVL 311 Rubrivivax gelatinosus
YP_001634055 290 -----gLLTHHVPLd-RIQAAYRLAled-pacLKVVV 319 Chloroflexus aurantiacus J-10-fl
YP_001277572 292 -----aLITHRAPVa-RFEEAYATAlnd-pecLKLVI 321 Roseiflexus sp. RS-1
YP_001997615 285 ----krIFTHRESIhgNIPKAYETAfsn-pncLKMIF 316 Chloroherpeton thalassium ATCC 35110
AAT90313     308 -----gLITHRSSAe-EADLAYRTAfet-adcIKMML 337 uncultured proteobacterium eBACred25D05
AAM48597     282 -----qLITDVLPVt-HAAQAYDRAfnd-sscLKMVI 311 uncultured marine proteobacterium
NP_662308    288 -----kIFTHQCTVddNLMEAYMQAfsd-sdcLKMII 318 Chlorobium tepidum TLS
YP_002911735 315 rldvapVINREFAVe-RIEEAYRFVcna-pdaLCVSL 349 Burkholderia glumae BGR1
YP_001996296 286 -----kFITNVFPA--HEYEHGLEValnaseaIKTVF 315 Chloroherpeton thalassium ATCC 35110
NP_662088    286 -----kFFTNVFPVs-QYELAYRIAlds-keaIKTVI 315 Chlorobium tepidum TLS

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