2C0C,2WEK


Conserved Protein Domain Family
Mgc45594_like

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cd08250: Mgc45594_like 
Click on image for an interactive view with Cn3D
Mgc45594 gene product and other MDR family members
Includes Human Mgc45594 gene product of undetermined function. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES.
Statistics
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PSSM-Id: 176212
View PSSM: cd08250
Aligned: 20 rows
Threshold Bit Score: 481.757
Threshold Setting Gi: 260827096
Created: 1-May-2009
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
NADP bindingdimer interface
Conserved site includes 30 residues -Click on image for an interactive view with Cn3D
Feature 1:NADP binding site [chemical binding site]
Evidence:
  • Structure:2C0C: Human Mgc45594 protein binds NADP, contacts at 4A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                      ###                               
2C0C_A        23 MMQKLVVTRLSPNFREAVTLSrdcPVPLPG---DGDLLVRNRFVGVNASDINYSAGRYDps-vKPPFDIGFEGIGEVVAL 98  human
P42865         6 NFKKLQVVSLSKDFRSSTSVV---EAHLPEevpEGMVRVSVKYAGVNASDLNFTNGSYFkn-vQPPFDCGFEAAGTVVQI 81  Leishmania amaz...
XP_002108666   8 TFRRILCEKFSPDFRQATRIVd-tPMVNPG---AKELLIKNRYLGINASDINFTAGRYFngdeQPPFGVGFEAIGEIVAL 83  Trichoplax adha...
XP_001640786   9 TFRKLVVSRLSTNFREAVETVs-aKMLEPG---PEEVLVKTRYAGINATDINHTAGRYKpw-nKPPFDAGLEGLGEVVAT 83  starlet sea ane...
EEC03943       6 EYKKLVCTKTSPNFREAVSVV---TVPAPAalnANEVFLKTKYAGVNASDINATAARYGgt-tKPPFDIGFESVAEVVAV 81  black-legged tick
XP_823179      1 MQRKIVAKRLSSNFREATEVL---SSPIPSylkSTELLVKNRFVGINASDINFTSGKYLpg-tVPPFDCGFEALGEVVAV 76  Trypanosoma bru...
XP_001563197  10 TYRHIVARELSTDFRAITSIV---EAPFPTelhPKAILVKNKYLGINASDINFTAGIYQpe-vRPPFACGFEAVGEVVDV 85  Leishmania braz...
EEY64648       3 QSRKIVCQKLSTNFRECTAIV---PFTVPTl-kHGEVLVQTKYCGINASDINYTNGAYLpg-vQPPFDCGFEALGVVLEV 77  Phytophthora in...
EEY62162       3 SFKSVQVHTKSKDFRAATKIVdvpEIPTPS---ASNVVVKNQFLGINATDINLTAGAYTga-lPPPFGCGLEAAGIVHAI 78  Phytophthora in...
EEY66359       3 SFRRVQVHTWSTNFRKATKIEvdqELPKPS---AGNVVVKNHFLGINATDINITNGGYGr--tSLPINCGLEGVGVVESV 77  Phytophthora in...
Feature 1                                                          #   #                    #  ##
2C0C_A        99 GlsasarYTVGQAVAYMa---pGSFAEYTVVPAsiATPVPSVKPEYLTLLVSGTTAYISLKELGglseGKKVLVTAAAGG 175 human
P42865        82 Gagv-anVKVGDHVVLMq---yGCFAEFLDAPAerCIPVPELKPEYSVLPVSALTAAVALGEVGrvkkGDVALVTAAAGG 157 Leishmania amaz...
XP_002108666  84 GnecqrhFKVGNHVAYMq---nGSFAEYMVVPAreAFPIPSCNPEYIPFMVSGLTASISLDQLGdlksGETVLVTAAAGG 160 Trichoplax adha...
XP_001640786  84 GkdykgkFSVGQPVMFMr---fGGFAEYTLTEKd-IVPVPRTNPIFLTLPISGMTAALSLEKLGelkkGETVLVTAAAGG 159 starlet sea ane...
EEC03943      82 Gagv-ghLKVGDAVATLnfpefGAFAEYQLTEAtkAFPIPAAVPEVIPLLVSGLTAAMGLDQQGrikeGETVLVTAAAGG 160 black-legged tick
XP_823179     77 Gdgi-kqFCAGDVVVTQa---fGAFCEYQVVPSrsAKKVPLLKCEYLPLDLSGTTASISIGEILkplrGELAVVTAAGGG 152 Trypanosoma bru...
XP_001563197  86 Gsgv-kdLKAGVAVVTQs---yGAFAEYQVVARrhAKPIPCLAREYLPLDLSATTASIALEHVLkpqpGERAVVTAAAGG 161 Leishmania braz...
EEY64648      78 Gpgv-tkFKKGDAVASTs---yGAFTEHLVAKErfLIKVPAAVPEVLPIIVCGLTASMALEYVGemkhGETVLITAAAGA 153 Phytophthora in...
EEY62162      79 Gdgv-tnVKVGDAVAYQk---fGAFAEYVEVPSanLIKTPKLSPAVVTMTVGGISASIALEQIGemktNETVFVSAAAGG 154 Phytophthora in...
EEY66359      78 Aegv-tdVSVGETVAYQh---lGAFAEYTEVPTakIVKTPELSPSVIPLTVCGVSASLALEKAGemksNETVFVSAAAGA 153 Phytophthora in...
Feature 1        #                  ###   #               #                        ##            
2C0C_A       176 TGQFAMQLSKK-AKCHVIGTCSSDEKSAFLKS-LGCDRPINYKte--pVGTVLKQEYPeGVDVVYESVGGAMFDLAVDAL 251 human
P42865       158 TGQIAVQLLKHvYGCTVIGTCSSEEKAEFLKS-IGCDHVINYKte--sLDGRLHELCPkGVDVVYECVGGHTFNDAVRHV 234 Leishmania amaz...
XP_002108666 161 TGQFAVQLAKA-AGCHVIGTCSSSEKAEFLRN-IGCDRPVNYKte--nLDQVLKKEYPkGIDVVYESIGAEMFNICLENL 236 Trichoplax adha...
XP_001640786 160 TGQFAVQLAKQ-AGCHVIGTCSTEAKCDFLKS-IGCDRPINYKte--sLDKVLNKEYPkGIDVIYESIGGEIFDTCVNRL 235 starlet sea ane...
EEC03943     161 LGHLAVQWAKA-AKCHVIGTCSSPDKEVYLKS-IGCDKVINYKtq--dLSTELQKVYPrGVDVVWETVGGKTFDTLLKRL 236 black-legged tick
XP_823179    153 TGQFAVQILKKvYDCTVVGVTSSCSKENMLKE-LGCDHVIVGEre--sVGEAMKQLMPtGVNVAYESVGGDMLDVVVDNI 229 Trypanosoma bru...
XP_001563197 162 TGQFAVQLLKHvYGCSVVGTCSSPSKEVFLTDtLKCDAVVNYRaegnnTAAAFMQCYPrGITIAYESVGGDLLEAVIQSL 241 Leishmania braz...
EEY64648     154 TGQFAVQLAKL-AGNHVIGTCSSPDKVEYLRS-IGCDRPINYRee--kVYDVLKKEYPrGVDLVFESVGGEMFEACVNNI 229 Phytophthora in...
EEY62162     155 TGQYVVQLAKL-AGNHVIGTCSSDEKAGHLKK-LGCDRVINYTke--dVGAVLKKEYPkGIDLVFETVGGDMFKAVTDNL 230 Phytophthora in...
EEY66359     154 TGQFVAQLAKL-AGNHVIGACSSDEKVEYLKS-LGVDRPINYKke--dLNEVLKKEYPaGINLAFESVGGELFKAVLDNI 229 Phytophthora in...
Feature 1                ##### #                              ###                                
2C0C_A       252 ATKGRLIVIGFISGYQTptglsp---vkagtLPAKLLKKSASVQGFFLNHYLskyQAAMSHLLEMCVsGDLVCEVDlgdl 328 human
P42865       235 AVHARVVIIGSISSYKSgevvpfs-dpsgtsVTMLLLVKSASLNGFFLPQFHdviPKYMANLLQYLKaGQVKLFVDkk-- 311 Leishmania amaz...
XP_002108666 237 AIKGRLIVIGYISGYQTakgvsk---srnliIPPRLLSKSSSLRGFLLFHYVkhyGKHFQKLANMYHrAELKSSVDlgq- 312 Trichoplax adha...
XP_001640786 236 ATKGRIIVIGFITAYKSqlgfnp---sktgtLLPKLLMKSGSLRTFMLFNYLsdmPTVFPRLISMLEtGQLRISIDrges 312 starlet sea ane...
EEC03943     237 ARRGRLVVIGAISGYQNsdkpfp--dvdlhdLPYKLLSRSTSVSGFLLSDYAhliPQYVAKLTQMLQeGRLVPKVDlgan 314 black-legged tick
XP_823179    230 SLRGRVLSIGGISGYSNggswdys-ekgkapLPMRLLSKSASLNTFFLPHYIkyaKLHFSRLCQMYEqGTLQSCIDps-- 306 Trypanosoma bru...
XP_001563197 242 TLRGRIVSLGCVSTYQNgsveav--rpshkpLPLQLLAKSASLSTFFLPHFAkygQQHFDRLCALHErGVVQSCIDpt-- 317 Leishmania braz...
EEY64648     230 ARRGRIIVIGAIAGYQDsstwkhkpnkattpLPSKLLAKSASVRGFFYNDYFresQAHTKKLTTLVQrGVLNAGVDps-- 307 Phytophthora in...
EEY62162     231 AVHARVIVFGYISGYHGdksaep---mlvnqLNPKLLMKSASVRGFLLHNHDkfiPSHIERLLKLMAeGKLSPGVDst-- 305 Phytophthora in...
EEY66359     230 AIFGRIIVFGNVSHYHGdagtdp---qygyqQNRKMQLRSASLRGFLLFHHAqhaHEHLQNLLSLINeGKLKAGIDpt-- 304 Phytophthora in...
Feature 1                          ## # # #     
2C0C_A       329 spegrFTGLESIFRAVNYMYMGKNTGKIVVE 359 human
P42865       312 ----vFHGLSSVADAVDHLYSGANYGKVLVE 338 Leishmania amazonensis
XP_002108666 313 --qthYKGLDSIAEAIDYMYSGKNKGKIIVE 341 Trichoplax adhaerens
XP_001640786 313 sprgpFCGLDSIYDAVEYLHDGKNRGKVVVE 343 starlet sea anemone
EEC03943     315 aeggeLLGLDGCFRGVEYLHSGKSVGKVVVK 345 black-legged tick
XP_823179    307 ----kFKGLEAVADAVEYMYERRNKGKVIVE 333 Trypanosoma brucei TREU927
XP_001563197 318 ----tFKGLEGVYDAIDWMWEQKNCGKVMVE 344 Leishmania braziliensis MHOM/BR/75/M2904
EEY64648     308 ----nFYGLEDIPNAIDYMYERKNIGKIVVD 334 Phytophthora infestans T30-4
EEY62162     306 ----eFRGLESIPEAIDYMYARKNIGKLVVK 332 Phytophthora infestans T30-4
EEY66359     305 ----eFRGLESIPDAIDRLYAQKNIGKLVIR 331 Phytophthora infestans T30-4

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