2VN8


Conserved Protein Domain Family
RTN4I1

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cd08248: RTN4I1 
Click on image for an interactive view with Cn3D
Human Reticulon 4 Interacting Protein 1
Human Reticulon 4 Interacting Protein 1 is a member of the medium chain dehydrogenase/ reductase (MDR) family. Riticulons are endoplasmic reticulum associated proteins involved in membrane trafficking and neuroendocrine secretion. The MDR/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES.
Statistics
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PSSM-Id: 176210
View PSSM: cd08248
Aligned: 28 rows
Threshold Bit Score: 379.645
Threshold Setting Gi: 256083490
Created: 8-Sep-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
NAD(P) binding
Conserved site includes 22 residues -Click on image for an interactive view with Cn3D
Feature 1:NAD(P) binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                         #                              
2VN8_A        22 SMAWVIDKYGKne------vlRFTQNMMMPIIh-yPNEVIVKVHAASVNPIDVNMRSGYGa---tALNMKRdplhvk--- 88  human
Q54II4         1 MKGILLNGYGEsld-----llEYKTDLPVPKPi--KSQVLIKIHSTSINPLDNVMRKGYAs---sIVDLKLk-------- 62  Dictyostelium d...
XP_001893786   1 MSTWVTKQFGDn---------MEKVEMSIPTIe-kPNQLLLKVKAASVNLIDTVMRKGYGr----QLCSAVknlrncs-- 64  agent of lympha...
XP_002162145  25 MKCIQLESYAPti------sgLNISKIASTKTnlkPNEILVKVHAASVNPIDIEMSKGYGs---tAINFLRkten----- 90  green hydra
NP_001021512  18 MRAWVSENGSG----------VELKEVPLPVIn-kPGQVLLKVKAASVNPIDVDMSQGYGr---eFLGTWKkiescd--- 80  nematode
XP_001648233 111 MKSIACTSFRDpd-------nVAVCNTGVPQFe-sSSDILVRVRAAALNRIDRRIAFGYGr----TLRRMIknyds---- 174 yellow fever mo...
XP_002577976   9 ISAWQLMSFLPpgavditselHFTKTRRMPNIt-rPDQLLIKVKAASLNPVDSLLVYGYGs---sSFHSLRrftskygcf 84  Schistosoma man...
XP_001602224 132 MKAIVCHHYLGte------gvSMIEDADMPAIq-kSNELLIQVKAASIHEVDIKICSGYAkayrrLLNSGRyk------- 197 jewel wasp
EEB19102     127 MKAVVCMAYDGld------alSCIDDAIIPTVm-kPQQILIQVKAASIDIIDIKISCGFGr----FLRKNFysds----- 190 human body louse
XP_309456    111 MKSIASTSFRDpd-------nVVVCQTAVPQFq-sASDILVRVRAASLNRIDRRIAFGYGr----TLRRMIrtyns---- 174 Anopheles gambi...
Feature 1                                                                                        
2VN8_A        89 -------ikgeeFPLTLGRDVSGVVMECGLDVKy--------FKPGDEVWAAVPPW----KQGTLSEFVVVSGnEVSHKP 149 human
Q54II4        63 ------------LPIILGRECSGEIVEIGDSVWd--------YEIGDQVWSASPPF----SMGSHCEYITVDEsEISLKP 118 Dictyostelium d...
XP_001893786  65 ------mdstilLPFIGGRDCSGVVEQTGGNVKk--------FKKYDEVIAVVDPF----SSGTHAEFVVVNEsNCVLKP 126 agent of lympha...
XP_002162145  91 ---------ipeFPLILGRDCSGEIVAVGKQFHr--------LAVGSHVYCTRWVV----GQGTHAEYVIVNKnEISLKP 149 green hydra
NP_001021512  81 -------aaasrFPLIPGRDCTAVVESVGGDVHn--------LAPGDEVMAVVPVI----LPGTHAEFVVTDSkYCSKKP 141 nematode
XP_001648233 175 -------synpeLPLVLGRSCAGIVEAVGKTSKs-------gLEIGDEVWLASPWY----ESGTASELVVVPEtRISRKP 236 yellow fever mo...
XP_002577976  85 glpdattaenadFPFTPGRDFSGQIVDIGSKVAlsnltkgnkLIIGTNVAGATWPFlsstGSGSLAEYIVCPAdYVAPLP 164 Schistosoma man...
XP_001602224 198 -----------gLPVTLGRDCAGVVVDIGQSVId--------FDIGDKVFLAVPSW----SAGTMAEYIVVPEtRVAKMP 254 jewel wasp
EEB19102     191 ---------kneLPITLGRDCSGVIVEIGPKVNk--------FEIGDNVWVAVPFW----CSGTLAEYIIANEnMVSKMP 249 human body louse
XP_309456    175 -------tydpeLPLVLGRSCAGIVEAVGTGSKs-------gLEIGDEVWLATHWY----EPGVASEFVVVPEtRVSRKP 236 Anopheles gambi...
Feature 1                    ##  #                           # ####                   # #        
2VN8_A       150 KSLTHTQAASLPYVALTAWSAINKVGGLndk---nctGKRVLILGASGGVGTFAIQVMKAWDa--HVTAVCSq--DASEL 222 human
Q54II4       119 KNLTHQQSASIPFASLTAWNAIYNVLPTnkk---ittNTKILVNGGNGSVGFFILQLLKKHLnvnQVSTTCNi--KHFEK 193 Dictyostelium d...
XP_001893786 127 TNISYIDGAAFPYTACTAWSALVSVARInpy---naaSQRVLIHGGAGGIGTTAIQMLKAWNi-sKVVVTCSn--DCFNM 200 agent of lympha...
XP_002162145 150 KNLSYIEAASLAYVSCTAWNALVNSGAVsnnt--fkrKKRIFIPGGSGGLGSFATQLCMAYGh--DVVTSCSe--QNINA 223 green hydra
NP_001021512 142 SNLSFVSAAALPYVASTAYSAFTIARVSqrn----akQQRVLIHGGAGGVGSMAIQLLKAWGc-eKIVATCA---KGRLD 213 nematode
XP_001648233 237 FLIGFEGAASLPYSGCIALSLMDAHGLTeht----skGKRVLVQDACSPVGCVITQLANKWGa--NVAVTCHt--RSAPV 308 yellow fever mo...
XP_002577976 165 SNVSFISAAALGYAGLTAWSALVDAGGInpaiksspsAYSILITGATGGVGMIAAQLAKLWGw--RVHVTCPsdkKALDL 242 Schistosoma man...
XP_001602224 255 KILPFEASASLPYSGCIAWDALINGSVIkeg---nakGKRVLVYGGSTPVGCILIQLIKLWGg--HIVTICRp--QAAPV 327 jewel wasp
EEB19102     250 SHISFEEASSLPYSGCLAYNACVRAGIVendn--eknKKRVLIYSGVSPVGCIACQLAKYYNw--EVTVTCLa--KADPV 323 human body louse
XP_309456    237 FLIGFEGAASLPYSGSIALNLLDEHHLTeht----ckGRQILVQDACSPVGCVITQLVHKWGa--HVTATCHt--RSVPV 308 Anopheles gambi...
Feature 1                                      #                                  ##             
2VN8_A       223 VRKLGA-------------------DDVIDYksg--------------svEEQLKSLKPFDFILDNVGGs---------T 260 human
Q54II4       194 LKKLTLv------------------NETIDYnn----------------lKINDNDNNKFDLIFNCYDGgkn----qneN 235 Dictyostelium d...
XP_001893786 201 IQELGAip----------------iDYKSPRv------------------LEKLISEGPFDVVLDCVQSe---------L 237 agent of lympha...
XP_002162145 224 LHKLGI-------------------KNVLNYese--------------syFKDLSASGPYDVILDTLKEa--------fK 262 green hydra
NP_001021512 214 YLYLCNfsnkncsfdivkqlgaipvDYTSDQa------------------TQELIEHAPFEVILDTVDSq---------L 266 nematode
XP_001648233 309 IHELGA-------------------ADIIAFanehfrsnfidvnveksnlINELTPREKFDYIFLTTRIa--------yD 361 yellow fever mo...
XP_002577976 243 MNLLQV-------------------DEIFPH-------------------PTNIQTTTKYDLILDCIRPdyfntttsssT 284 Schistosoma man...
XP_001602224 328 IKALGA-------------------NEIILLnet--------------diAKELELRDKYDAIFYTGGQl--------iD 366 jewel wasp
EEB19102     324 AKKLKA-------------------DKVVAYen---------------iqMENELLQDQFDVVLNTVGGv---------T 360 human body louse
XP_309456    309 INNLGA-------------------ADIITFdnehfrsnfidvnveksnfINELTSRPKFHYIFLTTRLg--------yD 361 Anopheles gambi...
Feature 1                               ##                                                       
2VN8_A       261 ETWAPDFLKKw-----sGATYVTLVTPFLLNMDr------------------lGIADGMLQTGVTVGSKALKHFw----- 312 human
Q54II4       236 EKKCIDALKD-------GGNLIGFNGPLVKFSDkdg--------------vlsGLPMGMMNQLNSSERIKKQYSk----- 289 Dictyostelium d...
XP_001893786 238 AGWSSKVMGLw-----rNSVHVSLLSPLLSDTDr------------------yGIPFGIASAAVKYFLRVTLPTir---- 290 agent of lympha...
XP_002162145 263 EEFMNLLKKDq------SSFYISLSPTILGDVDq------------------lGLPFGLLKAAKNYFSTLACQInd---- 314 green hydra
NP_001021512 267 AKWSDNVMGVw-----rNCVHVSIVSPLMREMDk------------------nGVPLGLVTTAMKHFERSFQSHl----- 318 nematode
XP_001648233 362 HKFLEKFLTK-------QGIIIDAVEPELASDEy------------------gPLMRVLLAFLVKFRKMIAVVF------ 410 yellow fever mo...
XP_002577976 285 SSSSNTPLKQcnlsgclLPQLPSMLSYLNTSSSraryimlnppllylndhygpLVGSGIACSHFLYSNIAAVFSsnsvng 364 Schistosoma man...
XP_001602224 367 ERILKKHLAP-------HGSYVSTAPEHLISDSl-------------------GYISSSLFSGCIRVRLLLQYVf----- 415 jewel wasp
EEB19102     361 HESCLKLCKP-------EGLVVSTVPEHMYNDNf-------------------KFPWSLFQTVAVKIKCLWKKVf----- 409 human body louse
XP_309456    362 YKFLEKFLTK-------DGVIVDAVEPEQSTDDy-------------------GVVGRFFLGTYVRCRKVAAVLf----- 410 Anopheles gambi...
Feature 1                    ###                                           ###      
2VN8_A       313 -----kGVHYRWAFFma-sGPCLDDIAELVDAGKIRPVIEQTFPFSKVPEAFLKVErGHARGKTVIN 373 human
Q54II4       290 ------NVHLDYAIFsp-sGSTLKQISKLYENNILIPNIDKQFNLNQIKDAYTCFEnSNSNGKIIIN 349 Dictyostelium discoideum
XP_001893786 291 -----rGQWYSYAFFap-yPECMQQISEFLKDGKMKPVIDQIFEYDELPIAYEKVLkKKGRGKTIIN 351 agent of lymphatic filariasis
XP_002162145 315 -----gKGLYYWGFVnp-sGLILDNVRLLVEEGKILPLVDRVFKIDDGIESYKYLMeKKSCGKVVIG 375 green hydra
NP_001021512 319 -----rGRWFSYAFFrp-sSDLMSQLSRFAEDGKIVPVVEQVMGFEELEKAYEKVSqLNGRGKTVIK 379 nematode
XP_001648233 411 ------RTHPDWGGPhl-cHLVLERLAGFVNDETLKTVVDRVYTPNEVERALDHICsEKSIGSTIIT 470 yellow fever mosquito
XP_002577976 365 niftpnWKKIRWVFFkp-nSNVLDYLLNLVSSQQLVIPVDTVYNFSHVPDAFNRLYtKGKRGKIVIE 430 Schistosoma mansoni
XP_001602224 416 -----gASTCHWKEGskinTAYLQSLQELADADQLQPILDRVYAPHCIDQALAHVMdSNAIGSTVIK 477 jewel wasp
EEB19102     410 ------GNVNEWDDFni-sAETLDKLRILVEKGYLLPVVDEVYEPHDVIRALQHCDsVEAIGKTVIR 469 human body louse
XP_309456    411 ------RTSVDWGGPhl-cHFVLERLAGFVNDETLKTVVDRVYTPNEVERALEHICsEKSIGSTIIS 470 Anopheles gambiae str. PEST

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