3KRT


Conserved Protein Domain Family
crotonyl_coA_red

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cd08246: crotonyl_coA_red 
Click on image for an interactive view with Cn3D
crotonyl-CoA reductase
Crotonyl-CoA reductase, a member of the medium chain dehydrogenase/reductase family, catalyzes the NADPH-dependent conversion of crotonyl-CoA to butyryl-CoA, a step in (2S)-methylmalonyl-CoA production for straight-chain fatty acid biosynthesis. Like enoyl reductase, another enzyme in fatty acid synthesis, crotonyl-CoA reductase is a member of the zinc-dependent alcohol dehydrogenase-like medium chain dehydrogenase/reductase family. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES.
Statistics
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PSSM-Id: 176208
View PSSM: cd08246
Aligned: 9 rows
Threshold Bit Score: 627.522
Threshold Setting Gi: 220904600
Created: 17-Aug-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative NAD(P)
Conserved site includes 24 residues -Click on image for an interactive view with Cn3D
Feature 1:putative NAD(P) binding site [chemical binding site]
Evidence:
  • Comment:MDR family binds NAD(P) as a cofactor
  • Comment:defined by comparison to MDR alcohol dehydrogenase like family

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                              ###  #                    
3KRT_A        29 ESYRAitVHKdetemfagletrdkdprksiHLDDVpvpelgpgEALVAvMASSVNYNSVHTSIFEPLstFGFLErygrvs 108 Streptomyces co...
CAA22721      27 ESYRAitVHKdetemfagletrdkdprksiHLDDVpvpelgpgEALVAvMASSVNYNSVWTSIFEPLstFGFLErygrvs 106 Streptomyces co...
YP_002479912  19 VMRAVvlYKAedeklmaiadederlraaihVERDIpipvpgtgEVLVKvMAGALNFNTLWALKRKPVstFDRLArfakld 98  Desulfovibrio d...
AAB26986      23 GEIPPlgHVPakmyawairrerhgppeqshQLEVLpvweigddEVLVYvMAAGVNYNGVWAGLGEPIspFDVHKg----- 97  Methylobacteriu...
AAN47495      12 GTLPPlgQVPkkmyaqvvrperygdpitaiQEELIdvpeiapdEVLVAvMAAGVNYNNVWAALGFPVdvIGARNkkge-- 89  Leptospira inte...
CAJ89361      11 GDAPDmgTVPrkmyaslirrerygqpvdafRTEVVdvppvgrgQVLVKvMAAGINYNNVWAALGSPLdvIAARQkaga-- 88  Streptomyces am...
YP_002784402  21 GTLPPlgVVPksmhaqvvrperygdpatafVHEVVdtphlgtgEVLIAvMAAGVNYNNVWAARGYPVdqVATRQrrge-- 98  Rhodococcus opa...
AAC38656     161 SRKPMnqALTetmqaflirperygepqqaiQLEQVriptlgphQVLIEvMAAGLNYNNVWAAQGKPVdiIAARRkrnr-- 238 Pseudomonas syr...
YP_778099     23 GCAIPlgVVPrtmhawtirrenhgepqhafTKEIVdvptlgpnDVLILvMAAGVNYNGVWAALGQPFsvLDLHDd----- 97  Burkholderia am...
Feature 1                                                                                        
3KRT_A       109 dlakrhdlpYHVIGSDLAGVVLRTGpgvnawqAGDEVVahclsvelessd--ghndtmldpeqRIWGFETNFGGLAEIAL 186 Streptomyces co...
CAA22721     107 dlakrhdlpYHVIGSDLAGVVLRTGpgvnawqAGDEVVahclsvelessd--ghndtmldpeqRIWGFETNFGGLAEIAL 184 Streptomyces co...
YP_002479912  99 pdavrhnldYQIMGSDGAGIVVKVGegvtncrPGDHIVvypvvfnhqspe--amedylfddhsRIWGYETNFGSFSDYCL 176 Desulfovibrio d...
AAB26986      98 --------eYHIAGSDASGIVWKVGakvkrwkVGDEVIvhcnqddgddee-cnggdpmfsptqRIWGYETGDGSFAQFCR 168 Methylobacteriu...
AAN47495      90 ------pekFHIGGSDASGIVYKVGadvknvkVGDEVVlhcgiwdkndpwvkagkdpmfapsqLIWAYETNWGSFAQFCK 163 Leptospira inte...
CAJ89361      89 ------tedFHIGGSDLSGIVWAVGedvrgvrLGDEVVvlanrwderaedvrlgadptwsagqRVWGYEENYGSFAQFAV 162 Streptomyces am...
YP_002784402  99 ------sedFHIGGSDASGIVYAVGegvsgiqIGDEVVihpgvwdqndpwisagrdqmiapsaKIWGYDTNYGSFGQFAR 172 Rhodococcus opa...
AAC38656     239 -----daepFHIGGSEASGYVKAVGdavthvkVGDTVVvscsvydataiesrvapdpmfcsnqEIYGYETSYGSFAEYTL 313 Pseudomonas syr...
YP_778099     98 --------pYHITGSDASGIVWAVGanvkkwkVGDEVVahcsqvdgddee-cnggdpmlspsqRIWGYETTHGSFAQFAC 168 Burkholderia am...
Feature 1                              #   #                      #### ##                 ##   # 
3KRT_A       187 VKsNQLMPKPDHLSWEEAAApgLVNSTAYRQLVSrnGAGMKQGDnVLIWGASGGLGSYATQFAlAGGANPICVVSSPQKA 266 Streptomyces co...
CAA22721     185 VKsNQLMPKPDHLSWEEAAApgLVNSTAYRQLVSrnGAGMKQGDnVLIWGASGGLGSYATQFAlAGGANPICVVSSPQKA 264 Streptomyces co...
YP_002479912 177 IRaTQVLPKPRHLSWAEAAAlpGANSTVYRMLISpnGAQIKIGEsVLIWGASGGIGSMAVQYAlRTGAFPVAVVSSEEKA 256 Desulfovibrio d...
AAB26986     169 VQsRQLMARPKHLTWEEAACytLTLATAYRMLFGhaPHTVRPGQnVLIWGASGGLGVFGVQLCaASGANAIAVISDESKR 248 Methylobacteriu...
AAN47495     164 VQdHQCLPKPKHLTWEESAAymLVGATAYRMLHHwkPNDVQKDDvVLIWGGAGGLGAMAIQIVkAAGGIPIAVVSEDDKI 243 Leptospira inte...
CAJ89361     163 VDdYMCHPKPARLSWAEAACymATAATAYRQLFGwpPHTVRPGDpVLIWGGAGGLGCIAIQLVrHVGGIPVAVVSSEERG 242 Streptomyces am...
YP_002784402 173 VQaHQVLPKAAHLSWAEAAAptLVGTTAYRMLHGwkGNTVTEGDlVLVWGGSGGLGTQACQLVrEAGGRAVAVVSDDDRG 252 Rhodococcus opa...
AAC38656     314 VEdYQCFPKPKFLSWEESATlmLNGPTAYKQLTHwaPNTVKPGDaVLIWGAAGGLGSMSIQLTrALGGLPVAVVSSPERG 393 Pseudomonas syr...
YP_778099    169 VQaTQLMPRPKHLTWAASACytLTLATAYRMLFGhkPHVLSPGQsVLVWGAAGGLGTMAIQLAaLAGARPVAVVSDDSKA 248 Burkholderia am...
Feature 1                     #                                                ## #              
3KRT_A       267 EICRAmGAEAIIDRNAEGYRFWKDe-------nTQDPKEWKRFGKRIRELTGge-diDIVFEHPGReTFGASVFVTRKGG 338 Streptomyces co...
CAA22721     265 EICRAmGAEAIIDRNAEGYRFWKDe-------nTQDPKEWKRFGKRIRELTGge-diDIVFEHPGReTFGASVFVTRKGG 336 Streptomyces co...
YP_002479912 257 ELVRAlGCRAVIVRPNEENEFVNDd-------gTPDMRRLVRFRREVLQANGgk-apDVVFEHPGRgTFYASVFVAANRG 328 Desulfovibrio d...
AAB26986     249 DYVMSlGAKGVINRKDFDCWGQLPtvns--peyNTWLKEARKFGKAIWDITGkgndvDIVFEHPGEaTFPVSTLVAKRGG 326 Methylobacteriu...
AAN47495     244 DFCKKlGAAGVINRKKFNHWGALTseinktekfIEWTKAAREFGKAIWDIAGkgnnpRIVFEHPGEtTIPTSMFVCETGG 323 Leptospira inte...
CAJ89361     243 EFCLKlGAEGWIDRRDFDHWGRLPdtsd-eeamGRWLSGARAFGRRLWDVLGerrgpRIVLEHSGAdTVPTSLYLCDNGG 321 Streptomyces am...
YP_002784402 253 AYAMKyGAIGYINRREFDHWGVPPlvdd-tegqKKWTAGARAFGKKLWEIAGsredpAIVFEHPGAsTIPTSIFVCQPGG 331 Rhodococcus opa...
AAC38656     394 RYACElGAVGYLLRTDYPHLGRLPdlns--dahSAWTKSFASFRRDFFMTLGkkelpKVVIEHSGQaTFPTSLQICDRSG 471 Pseudomonas syr...
YP_778099    249 EFVKRlGAVGVINRSNFSCWGAPPpvda-tneyAAYVDAVKKFGKAIWDALGerrdvDMVFEHPGRnTFAPSCYVVKRGG 327 Burkholderia am...
Feature 1            ##                       ###                                                
3KRT_A       339 TITTCASTSGYMHEYDNRYLWMSLKRIIGSHFanyREAWEANRLIakGRIHPTLSKVYSLEdtGQAAYDVHrn-lhQGKV 417 Streptomyces co...
CAA22721     337 TITTCASTSGYMHEYDNRYLWMSLKRIIGSHFanyREAWEANRLIakGRIHPTLSKVYSLEdtGQAAYDVHrn-lhQGKV 415 Streptomyces co...
YP_002479912 329 RIVTCGSTTGYDHLYDNRYLWMYGKRIIGSHCaswNEAARANDLIckGLIMPELSSAFSLDrfEDAVEELKnn--hVGKV 406 Desulfovibrio d...
AAB26986     327 MIVFCAGTTGFNITFDARYVWMRQKRIQGSHFahlKQASAANQFVmdRRVDPCMSEVFPWDkiPAAHTKMWknqhpPGNM 406 Methylobacteriu...
AAN47495     324 MVVICAGTTGYNATVDLRYLWMRQKRLQGSHFandENSKGLNDLVidKKVDPCLSKTFAWNetAHSHQLMKenkhpAGNM 403 Leptospira inte...
CAJ89361     322 MVVLCGGTTGYNGDVDLRFLWMRQKRLQGSHVataREAREVTRLIdqGIIDPCLSRTFDFDeiGLAHQLIHdnrhpAGNM 401 Streptomyces am...
YP_002784402 332 MVAICAGTTGFDAMVDLRYHWTRQKRLQGSHGtndEQAIAYNQLVvdGKIDPVVGRVLPMAdiPLSHAQMGrgeevFGNT 411 Rhodococcus opa...
AAC38656     472 MVVIVGGTSGYNCDFDVRHLWMHQKRIQGSHYaniRECQEFLQLVeqRRVVPTLNTLYRFEetPRAHQALLsg-evVGNA 550 Pseudomonas syr...
YP_778099    328 MVVFCAATSGYDLTCDARYVWMRQKRIQGSHFaslKEAAQANRLVmsGKIDPCLSEVFPWNrlPDAHAKIRanqhlPGNM 407 Burkholderia am...
Feature 1            
3KRT_A       418 GVLC 421 Streptomyces coelicolor
CAA22721     416 GVLC 419 Streptomyces coelicolor A3(2)
YP_002479912 407 AILC 410 Desulfovibrio desulfuricans subsp. desulfuricans str. ATCC 27774
AAB26986     407 AVLV 410 Methylobacterium extorquens AM1
AAN47495     404 SILV 407 Leptospira interrogans serovar Lai str. 56601
CAJ89361     402 AARV 405 Streptomyces ambofaciens ATCC 23877
YP_002784402 412 VHLI 415 Rhodococcus opacus B4
AAC38656     551 AVLV 554 Pseudomonas syringae pv. glycinea
YP_778099    408 AVLV 411 Burkholderia ambifaria AMMD

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