Conserved Protein Domain Family
MDR_like

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cd08242: MDR_like 
Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family
This group contains members identified as related to zinc-dependent alcohol dehydrogenase and other members of the MDR family, including threonine dehydrogenase. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group includes various activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.
Statistics
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PSSM-Id: 176204
View PSSM: cd08242
Aligned: 22 rows
Threshold Bit Score: 379.281
Threshold Setting Gi: 126460187
Created: 13-May-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:putative NAD(P) binding site [chemical binding site]
Evidence:
  • Comment:MDR family binds NAD(P) as a cofactor
  • Comment:defined by comparison to MDR alcohol dehydrogenase like family

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                              ###  #                                    
YP_867429      8 MTGIWFNQGqaq--lrhDLPLPQPapHEALIHMQWVGLCHTDWDLLKGYKn---FTGIPGHEFVGRVIQCQdq---tWMG 79  Magnetococcus s...
YP_001736753   7 MRALVLHAPrdl--rleDVDERSPgnGWVKVRVRRVGICGTDKSIYLGDYaarkLPIILGHEISGEIVEVGegvderIIG 84  Candidatus Kora...
YP_002429089  31 VKALLLLGArdlrleevEEPRPAP--EWVLIKVERVGICGTDKAMYSGTYkllkKPLIPGHEVSGIVVDVGegvsrdLVG 108 Desulfurococcus...
YP_920916      1 MKAALLYGPgdl--rveDVPLPEKpeGWALVKTLAVGICGTDKAFYKGTYplfkKPLIPGHEVSGVVVEGPe----eLVG 74  Thermofilum pen...
YP_931439      1 MLAARLYGPrdl--rveEIPAPKPerGWALVRTLAVGICGTDKAFYRGTYrlfkTPLVPGHEAVGVAEGGE------LDG 72  Pyrobaculum isl...
ABV27365       1 MKALRLVNGqlq---laEIPRPDMp-EEAVIRVTYAGICATDAAIVRGYTg---FSGTLGHEFVGVVAAAPda---aWIG 70  Candidatus Chlo...
YP_822834      1 MLAVHLEKGavt---vrEVPMPARpeGFALLRMLAAGICNTDLELQRGYYg---FTGTPGHEFVAEVVEADtr---eLIG 71  Solibacter usit...
YP_001056465  29 VLAAVLEGPrrl--fvrEVAVPRVe-GYALVRSELVGICGTDKAFYVGTYplfkRPLVPGHEVVGIVVEGPp----hLVG 101 Pyrobaculum cal...
YP_002991955   1 MRAIYFENGkid---fvERDKPQLtsGEALLKVRLSGICNTDVELHKGYYg---FAGVPGHEFVAEVEECP------DRP 68  Desulfovibrio s...
YP_001615705   1 MRALVWDGTaar---viDRDPPSTtaGMAVVEVRCAGICNTDLEIIQGYMg---FRGTLGHEFVGDVVEGPa----aWLG 70  Sorangium cellu...
Feature 1                                                                             #   #      
YP_867429     80 KRVVGAINshCGHCRCC-LRGAVSHCEQRNVLGIlNRPGALAEFLTLPLeNLYELPHamrdkqAVFT--EPLAAAGRIVQ 156 Magnetococcus s...
YP_001736753  85 QRVTSEINlsCGECSFC-KRGLREHCLRREALGI-SLDGGMAEYVLTRAdLIHPIGDlsw-lqGAFI--EPLAAALKPFF 159 Candidatus Kora...
YP_002429089 109 HRVTTEINvyCGRCWYC-RSGMYTHCPYRETIGI-TRNGGMAEYMVTRRdLIHVVDDltp-lqAAFI--EPLAAVVEMIE 183 Desulfurococcus...
YP_920916     75 RLVVSEINfpCWRCEYC-RSGLYTHCPYKKTLGI-DFDGGLAEYFVAPAtALHAAEGldp-vvATEV--EPLAALLNALR 149 Thermofilum pen...
YP_931439     73 RVVVSEINfaCGRCEMC-RAGLYTHCPYKRTLGI-DFDGGMAEYFVAPLeALHPAEGld---pAAATqvEPLAAVLNALA 147 Pyrobaculum isl...
ABV27365      71 RRVVGDINiaCGTCETC-QSGNRHHCEQRTVIGIrQRDGAFAEYLALPLrNLYAVPDavsdldAVFA--EPLAAACRILD 147 Candidatus Chlo...
YP_822834     72 QRVSGEINlaCTHCEWC-LRGLGRHCPNRTVLGIvGHAGAFAEFLTLPErNLHILPDdlptnrAVFL--EPLAAACEILD 148 Solibacter usit...
YP_001056465 102 RRVVSEINfpDWSCDYC-RSGLYTHCPYKRTLGI-DFDGGMAEFFAAPPtALHVFDGpp--elGIFV--EPLAAVLNAFA 175 Pyrobaculum cal...
YP_002991955  69 ELVGKRVVa-DINCPVGaFKGDHRHAPNRTVIGIvNHDGAFAEYLKAPAeNLCVVADnvedraAVFA--EPLAAGLEVSQ 145 Desulfovibrio s...
YP_001615705  71 RRVVGEINfaCGRCESC-ARGLGRHCPTRTVMGIaGADGALAERVAVPVaNLHAVADgiddeeAVFA--EPLAAAFAILE 147 Sorangium cellu...
Feature 1                     ######                   ##    #            #                      
YP_867429    157 QApvtPGEAALVIGDGKLGLLVAQVLAMHGAv--VRLVGRh-pQRWEPLHR-CGVEGVlvdei---------------tv 217 Magnetococcus s...
YP_001736753 160 LMpppPSSSIAVVGVGTIGLLSVQISALFAPk-rLVAISRrrgRKSELAEI-FGAESMtveeal--------------nl 223 Candidatus Kora...
YP_002429089 184 MEpvkPLSRVAVIGVGAIGLLAIQVLKLFEPe-lLVAVSRpgsPKARLARE-LGADLVvdyqglsevv------kkdtpe 255 Desulfurococcus...
YP_920916    150 LKppaPGDSVAVVGTGNLAVMLVQVLKDAGFr--PVVVSRagsSKAEILRS-LDVEVVtaeqasrlg--------gesgd 218 Thermofilum pen...
YP_931439    148 QVpppPGAKVAILGTGNVAYLAAQVLRGFDP---VVVARRg-sAKAHLFRG-LGLEVVelgelgey---------maena 213 Pyrobaculum isl...
ABV27365     148 QVscrPGQAVAVLGDGKLGQLIAQVLHAHGLv--VTLIGRh-aRKLAVAAE-AGIATRhadelr--------------sa 209 Candidatus Chlo...
YP_822834    149 QVaipPHEPIAVLGDGKLGLLISQVLNAHGYp--VHQFGRy-sEKLAIARR-AGITTEritgp---------------lp 209 Solibacter usit...
YP_001056465 176 IRpirPGDKVAVIGTGNVAQLAAQAARALGAsrvDGVVRRg-sRKAATLAKfVDAVVEepa------------------- 235 Pyrobaculum cal...
YP_002991955 146 QIhvtGDMRVMVLGDGKLGLLTALALKLYNPn--VLLVGKh-eDKLTIAAQ-QGVKIHcisdpeelt--------alsek 213 Desulfovibrio s...
YP_001615705 148 QVrvtPGASALVFGDGKLGLLIAQVLHQAGAr--VLAVGKh-eEKLALLRA-QGIATElvrpepsgqadagaspplgawa 223 Sorangium cellu...
Feature 1                 ## #                   ##                      ###                     
YP_867429    218 aplMDRVVVCGGGDAGLRMAQAMVRPTGLLMIKSTfdgvtglDLNDVVIRELRVMGSRCGd---FAPALAWLAQARVetD 294 Magnetococcus s...
YP_001736753 224 kgeFDLVIEASGSPNGLEIALNLTRPRGTIFAKSThgkevsfDYTRAVVNEITILGSRCGp---FDAAIELLRKGKVrvD 300 Candidatus Kora...
YP_002429089 256 gqgFDYVVEATGSSSGLEVALDVARPRGVVALKSThgspvsfDQTKAVVKELRLSTSRCGp---FDKAISLLRKRIVvvD 332 Desulfurococcus...
YP_920916    219 gvgFDVVFEVSGDPSALNLAVDLVKPRGTVHLKSTpgnpgsvNLTKAVVKEVAVIGSRCGtfreFREAIRLLREGRV--R 296 Thermofilum pen...
YP_931439    214 plgFDVVFEATGDPSAINTAIEIARPRGVIHLKSTpgspapaNLTPAVVKELRIVGTRCGtyreFRHAIKLIREGIV--K 291 Pyrobaculum isl...
ABV27365     210 trqFEIVVEASGRATGLADALRLVRPRGTVVLKSTsatpwmlPPAAVVVPEVTLVGSRCGd---MPKALALLAARKVnpQ 286 Candidatus Chlo...
YP_822834    210 vaaYDWVVDATGSTEGLRTAVGMTRPRGTLIMKSTvhglvpiDTAPIIVNELTLVGSRCGr---MELALPLIDHELIlvD 286 Solibacter usit...
YP_001056465 236 esaYDVVFEASGDPSALELAVRLAKPRGVVHLKSTpglpatfNATYFVVKEVAVVGSRCGtfreFREAIRLLLSGAV--K 313 Pyrobaculum cal...
YP_002991955 214 wdkFDLVVEATGSEKGINYALDFVRPEGTVVAKTTshlpssiNLAKLVVDEISIVGSRCGd---IALAMNVLEQGMIdvS 290 Desulfovibrio s...
YP_001615705 224 gepAELVVEATGTAEGFVRAVRATRPRGTLVLKSTvaglssvHLAELVIHEITVVGSRCGl---FGPALRALEARTVdvR 300 Sorangium cellu...
Feature 1                                        
YP_867429    295 FLIEGCFGLt-QAEQALAQAfrpGVLKILVQN 325 Magnetococcus sp. MC-1
YP_001736753 301 ELVTSVYKLe-DGVEAFIRSl--DPDELKVQL 329 Candidatus Korarchaeum cryptofilum OPF8
YP_002429089 333 KLVTSEYPLt-RGVEAFEKSferDQVKIHLVT 363 Desulfurococcus kamchatkensis 1221n
YP_920916    297 PVITSVYGGleKAREAFERSfrpGEVKVVVKP 328 Thermofilum pendens Hrk 5
YP_931439    292 PLITSVVTGihNAREAFERAlqpNEVKVVLKP 323 Pyrobaculum islandicum DSM 4184
ABV27365     287 TLIEAVYDLd-DGLRAFEHAttpGVLKVLLRC 317 Candidatus Chloracidobacterium thermophilum
YP_822834    287 EMITDCFSLs-EAPRAFARAaerGVLKVLLVP 317 Solibacter usitatus Ellin6076
YP_001056465 314 PTLDAVFPLa-EAREAFEYAvekSPTKVAVRV 344 Pyrobaculum calidifontis JCM 11548
YP_002991955 291 GLIEAEYDFa-DFNDAFERAmgkGALKVLVRM 321 Desulfovibrio salexigens DSM 2638
YP_001615705 301 SLVSARLPLe-RAAEALAAAaapGALKVLVTR 331 Sorangium cellulosum 'So ce 56'

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