Conserved Protein Domain Family
ribitol-5-phosphate_DH

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cd08237: ribitol-5-phosphate_DH 
ribitol-5-phosphate dehydrogenase
NAD-linked ribitol-5-phosphate dehydrogenase, a member of the MDR/zinc-dependent alcohol dehydrogenase-like family, oxidizes the phosphate ester of ribitol-5-phosphate to xylulose-5-phosphate of the pentose phosphate pathway. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability.
Statistics
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PSSM-Id: 176199
View PSSM: cd08237
Aligned: 8 rows
Threshold Bit Score: 526.161
Threshold Setting Gi: 90962925
Created: 19-May-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative NAD(P)putative
Feature 1:putative NAD(P) binding site [chemical binding site]
Evidence:
  • Comment:MDR family binds NAD(P) as a cofactor
  • Comment:defined by comparison to MDR alcohol dehydrogenase like family

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                               ###  #                                   
YP_536840      5 IISHVYRLT-EPHKIEEQDIERnl-reGWVDVEPTMASVCHADTRYFAGnrrpeALKKKLPMALLHEGIGVVKKSNSKKF 82  Lactobacillus s...
YP_001272949   4 MINIIYRLV-APKFFEEAIEEIn---iDNVIVRPSYLSICQADQRYYQGkrasdVLEEKLPMALIHEGVGEVVFDNTGSF 79  Methanobrevibac...
YP_001812693   1 MINQVYQLV-APRQIEVTYDERsl-nsDRVVVRPTYLSICHADQRYFTGsrsaeVLAKKLPMAMIHEGIGKVVHDPSGTF 78  Exiguobacterium...
Q8RKJ0         1 MINQTYRLV-SARQFEVTYKDKvv-hsDKVVVRPTHLSICAADQRYYTGsrgkeAMDKKLPMALIHEGIGKVMFDPTGTF 78  Bacillus subtilis
YP_001922372   1 MINKVYRLIgRKKFKEVFIEEEik--eNSIFVRPSYLSICVADQRYYKFersieVLNKKLPMALIHEAIGQIVYDPKGEY 78  Clostridium bot...
NP_785377      1 MLNQVYRLV-SPRQFEVETVAEev-daDDLIVRPKFLSICHADTRYFFGqrsqaALRAKLPMALIHEAVGEVVYDPRNEY 78  Lactobacillus p...
NP_358741      7 MINQIYQLT-KPKFINVKYQEEaidqeNHILIRPNYMAVCHADQRYYQGkrdpkILNKKLPMAMIHESCGTVISDPTGTY 85  Streptococcus p...
YP_003143832   1 MLNNIYRLE-RPETFAVHTEELve-teGYATIRPTHLAICAADQRYWSGnrdpkALKKKLPMALIHEGIGVVVSDSTGTY 78  Slackia heliotr...
Feature 1                                                                                 #   #  
YP_536840     83 KEGDRVVVAPNVP--GYIYEgkeknscIPDNYNpDSHFLSSGYDGLAQSDIVHPdSCLVKIPDnvpdeIAIFSEVSTVGY 160 Lactobacillus s...
YP_001272949  80 DVGDKVVMIPNTP--TKEDEy------ISANYLpSSKFRGSGFDGFTSDLIQLNpDRLVKLPDnfnlkISAFIELISVIC 151 Methanobrevibac...
YP_001812693  79 KIGTLVAMVPNTP--SETDDi------IGENYLrTSRFRSSGYDGYMQDYVFIQpDRLVEVPAdldpeVAAFTELVSVSV 150 Exiguobacterium...
Q8RKJ0        79 KVGTRVVMVPNTP--VEEHEv------IAENYLrSSRFRSSGYDGFMQDYMFMApDRLVELPDsinphVAAFTELITIAV 150 Bacillus subtilis
YP_001922372  79 KEGEYVVLIPCIP--LEKDEi------IDENYLkSSLFRSSGYDGFLQEVINQPrERIVRLPSklfkpVMAFTELMSVSI 150 Clostridium bot...
NP_785377     79 KPGTLVAMVPNTP--VKKDSi------IQENYLpSSRFRSSGYDGFMQEYVCLRrDRAITVPSdfdphMAAFIEMVSVGV 150 Lactobacillus p...
NP_358741     86 EVGQKVVMIPNQSp-MQSDEe------FYENYMtGTHFLSSGFDGFMREFVSLPkDRVVAYDAie-dtVAAITEFVSVGM 157 Streptococcus p...
YP_003143832  79 APGTKVVMVPNMPdpDDPDKl------SKENYSrASKFCSSSMDGFMRDYVTIPtERLVPFGNnvdpmVAVMAELTSVAT 152 Slackia heliotr...
Feature 1                             ######                     ##   #            #             
YP_536840    161 HASSHVKDLLmkp-nvkVALFGDGPVGYMAAAAIHFIWGidsenLVVFGAEkDRLDKIDFAEKRMVTeydfDNSPEEF-- 237 Lactobacillus s...
YP_001272949 152 HGIDRFEKIAikh-kncFGVWGDGNLGYITALLLKEFYPes--eVTVIGKHgENLNLFSFADKTYKF----HEVPDDLa- 223 Methanobrevibac...
YP_001812693 151 HAMTRFDQIAhsr-retFGVWGDGNLGFITALMLRKLYPea--kLLVFGKTqSKLDYFSFADETYYI----DQIPDDVs- 222 Exiguobacterium...
Q8RKJ0       151 HALSRFERMAhkk-rdtFGVWGDGNLGFIMTLLLKKKYPds--kVFIFGKTpYKLDHFSFVDAAYQI----NDIPEDVr- 222 Bacillus subtilis
YP_001922372 151 HAIERFNRIAhkr-rknIGVWGDGNVGFITALFLKQQYPec--kVHVFGKNsEKLDMFVFADEVHLI----SDDLSNIy- 222 Clostridium bot...
NP_785377    151 QALTKLESTMded-qrvIGIWGDGNLGYITATLVKQIFPds--qLLVFGRHqSKLDYFSFADKTYLV----DDIPADVk- 222 Lactobacillus p...
NP_358741    158 HAMNRLLTLAhsk-rerIAVIGDGSLAFVVANIINYTLPea--eIVVIGRHwEKLELFSFAKECYIT----DNIPEDLa- 229 Streptococcus p...
YP_003143832 153 NAVEAFNQVRhvdrnnvIGIWGDGAVGYLMAMVLHQEFPdt--hLILFGADeDKMAMNDFVDEKHNVr---IERTEDLpa 227 Slackia heliotr...
Feature 1              ## #                       ##                      ###                    
YP_536840    238 -DVIFEATGGRFSs-sAINEGIKVIKRTGSFVLMGVTEDLVPIDTRDVLEKGLTLHGTSRSTtsDFRIVVNALSRNdEYM 315 Lactobacillus s...
YP_001272949 224 iDHGFECVGSNASq-aAIDQIINTINPQGSIILFGVSEYPIPINTRLILEKGLTIQGISRSErkDFLKVVELLKNNpNLF 302 Methanobrevibac...
YP_001812693 223 fNHGFECVGGIGSq-yAINQMIDYIIPEGTMALLGVSEDPVSVNTRMILEKGLRVYGSSRSTpaDFARTMELYQMYpDIP 301 Exiguobacterium...
Q8RKJ0       223 lDHAFECVGGRGSe-sAIEQIIAHVHPEACVALLGVSEYPVEIETRMVLEKGITLIGSSRSGreDFARTVDFLAQYpEVV 301 Bacillus subtilis
YP_001922372 223 iDHAFECVGGRGSq-lAINQIIDIINPEGYIGLMGVSEENIEVNTRMTLEKGLLLVGNSRSTleDYEKTVGIIHKNpKLL 301 Clostridium bot...
NP_785377    223 vSQALECTGGQGSe-aAIQQIIQHIQPMGTAILMGVSENPVGIDTRSVLAEGLTLRGVSRSSreDFKRAVDILSSSpVTR 301 Lactobacillus p...
NP_358741    230 fDHAFECCGGDGTg-pAINDLIRYIRPQGTILMMGVSEYKVNLNTRDALEKGLILVGSSRSGriDFENAIQMMEVK-KFA 307 Streptococcus p...
YP_003143832 228 vDHAFECVGGVGGctsAINQIIDLIRPQGVIGLMGVSEMPVPINTRMVLEKGLTLQGNSRSSkgDFERAVELFARP-EVA 306 Slackia heliotr...
Feature 1                                                  
YP_536840    316 EALRKLLPKEKTIinnGRDLEDAFENIIanrqWEKAALKFEW 357 Lactobacillus salivarius UCC118
YP_001272949 303 DSLDKLISEVVTIk-sLNDLKEAFDKDYis-gFGKTILVWDK 342 Methanobrevibacter smithii ATCC 35061
YP_001812693 302 AYLSNLVSGVFQIr-qIEDIHQAFESDLtn-rFGKTVMEWCM 341 Exiguobacterium sibiricum 255-15
Q8RKJ0       302 DYLETLVGGRFPVr-sIEEITNAFEADLts-sWGKTVIEWEI 341 Bacillus subtilis
YP_001922372 302 GYLESIITSVQKVr-kINDINRAFEDDNak-iYGKTIIEWEI 341 Clostridium botulinum E3 str. Alaska E43
NP_785377    302 ERLQNLVGYVQKVs-sIQDITNFFDSALtn-yWGKEVMEWDV 341 Lactobacillus plantarum WCFS1
NP_358741    308 NRLKNILYLEEPVr-eIKDIHRVFATDLn--tAFKTVFKWEV 346 Streptococcus pneumoniae R6
YP_003143832 307 RQVRKIDKDVFPVa-gIDDAQEAFRFDMh--sPFKTVMLWDT 345 Slackia heliotrinireducens DSM 20476

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