Conserved Protein Domain Family
threonine_DH_like

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cd08234: threonine_DH_like 
L-threonine dehydrogenase
L-threonine dehydrogenase (TDH) catalyzes the zinc-dependent formation of 2-amino-3-ketobutyrate from L-threonine, via NAD(H)-dependent oxidation. THD is a member of the zinc-requiring, medium chain NAD(H)-dependent alcohol dehydrogenase family (MDR). MDRs have a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit. Sorbitol and aldose reductase are NAD(+) binding proteins of the polyol pathway, which interconverts glucose and fructose.
Statistics
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PSSM-Id: 176196
View PSSM: cd08234
Aligned: 113 rows
Threshold Bit Score: 373.4
Threshold Setting Gi: 4980797
Created: 4-Feb-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative NAD(P)catalytic Zn
Feature 1:putative NAD(P) binding site [chemical binding site]
Evidence:
  • Comment:MDR family binds NAD(P) as a cofactor
  • Comment:defined by comparison to MDR alcohol dehydrogenase like family

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                            ###  #                   
ACL70060    1 MKSLVFYGPgnVKIEDKEIPkid-------------------enEVLVKVkAAGICGTDRHIYRGEAPArTQVILGHENA 61  Halothermothrix or...
EDK02200    8 MKALQYSKPkeFAVVDVPLPelr-------------------ddDVLVKVkACGVCGTDLHIHEGEFIAkFPLIPGHETV 68  Magnaporthe grisea...
EDN22252    7 MKALRYSKPeeYGIVEVPLPklr-------------------dnDVLVKVkACGVCGTDLHIHEGEFIAkFPLIPGHETV 67  Botryotinia fuckel...
ABB55877    7 MKALRYDKPesYAVVEVPLPtlr-------------------dnDVLIKVkACGVCGTDLHIHEGEFIAkFPLIPGHETV 67  whitish truffle
EAL88173    9 MKALRYEKPevHSVVQVPLPtlr-------------------enDVLIKVkACGVCGTDLHIHEGEFIAkFPLVPGHETV 69  Aspergillus fumiga...
EAA66542    9 MKALLYDKPevHKIAEIPVPtlrendvlvgvksrrsqyawltqlVIQIKVkACGVCGTDLHIHEGEFIAqFPLVPGHETV 88  Aspergillus nidula...
EAW08271    9 MKALRYEKPevHGIVQVPLPtlr-------------------dnDVLIKVkACGVCGTDLHIHEGEFIAkFPLVPGHETV 69  Aspergillus clavat...
EDU42565   19 MKALQYSGPetFAVVEIDVPdig-------------------ddDVLVKIsACGVCGTDLHYHKGEFLAkWPLIPGHEAT 79  Pyrenophora tritic...
ABK71633    1 MKAVLYEAPktWSVTDVPTPqpg-------------------kgEVRIRVaQVGVCGTDLHIHDGEFGAvFPLIPGHELV 61  Mycobacterium smeg...
EAQ86669    1 MGSLSKLPQe-MKALRYNKPedf------------------eivNVPLPV-LREDDVLVKHIHEGEFIAeFPLIPGHETV 60  Chaetomium globosu...
Feature 1                                                                                     
ACL70060   62 GEIIETGrqvrsLKKGDKVCIDPNIFCGQCYYCHRGEVHLCkelqAIGVTRNGGFAEYLVAPatnVYKVKEnVSYKEMAL 141 Halothermothrix or...
EDK02200   69 GVVAAVGkdvkdFKVGDRVSADNAELCGHCFYCRRGESLLCenwaGHGTTLSGGFAEYCAYPqgkVFKFNN-MTDVEATL 147 Magnaporthe grisea...
EDN22252   68 GVIAATGpkvkgFNVGDRVVADNSELCEECFYCRRGQLLLCenfnAHGVTMDGGFAEYCAYPaakVFKIEN-LSDVDATL 146 Botryotinia fuckel...
ABB55877   68 GVVAAIGkdvkgFTVGERVCADNSELCNECFYCRRGQLLLCekfeAHGVTMDGGFAEYCAYPagkVFKIHN-LSDVDATL 146 whitish truffle
EAL88173   70 GIVAAVGskvkgFEIGERVVADNSELCGECFYCRRGDELFCehfeAHGVTMNGGFAEYCAYPakrVFKIKN-LSDVDATL 148 Aspergillus fumiga...
EAA66542   89 GVVAAVGpkvkgFEIGDRVVADNSELCGECFYCRRGDELFCenfqAHGVTMNGGFAEYCAYPagrVFKIQN-LSDVDATL 167 Aspergillus nidula...
EAW08271   70 GVVAAVGpkvkgFEIGERVVADNSELCGECFYCRRGDELFCehfeAHGVTMNGGFAEYCAYPakrVFKIKN-LSDVDATL 148 Aspergillus clavat...
EDU42565   80 GTIVRTGanathFPPGTRIAADALEPCLTCFHCVRRKPQLCtsvtGFGGNVPGGLAQYCRYParlVFPISDrITDLEAVC 159 Pyrenophora tritic...
ABK71633   62 GVVDAVGegvtrFGIGEQVTVNPNVYCGQCPYCLAGRLGQCaamlGYGSNFPGFFAEYAIADhtlVFSTEG-LPLDTAVF 140 Mycobacterium smeg...
EAQ86669   61 GVVAAVGpkvtgFKVGDRVAADNSELCSHCFYCRRGEGLLCenwtGHGINLPGGFAEYCAYPqakVFQIHN-LTDIEATL 139 Chaetomium globosu...
Feature 1      #   #                    ######                  ##   #                 #      
ACL70060  142 VEPLACCLHGIDLAgi-rpGDFVVILGAGAIGLILLQLALHSGASeVIVSEPnsKKRKLALKLGAs---KVFDPFndnle 217 Halothermothrix or...
EDK02200  148 IEPASCACHGLDKIkp-rlGSSVLMFGAGPTGLMLAQLLRQNGCSqVTIAAPagLKMDLARSLDAa--dTYVDLSredsg 224 Magnaporthe grisea...
EDN22252  147 LEPASCAAHGLEKIap-kmGSSVLMFGAGPTGLVLAQLLRQNGGCkVVLAAPggLKMDLAKKLDAa--dIYIELSrdnpe 223 Botryotinia fuckel...
ABB55877  147 LEPASCAAHGLEKIap-kiGSSVLMFGAGPTGLCLAQLPHNGASH-VVIAAPegLKMDLAKKLDCa--dIYVPLSrsnpq 222 whitish truffle
EAL88173  149 LEPASCAAHGLDKIap-kmGSSVLLFGAGPTGLILAQMLRLNGGCkVTVVAPegLKMDLAKNLGAg--dEYVALSrkdps 225 Aspergillus fumiga...
EAA66542  168 LEPASCAAHGLDKIap-kmGSRVLLFGAGPTGLILAQLLRLNGGChVVVCAPegLKMELAKSLGAg--dEYIGLSrqdps 244 Aspergillus nidula...
EAW08271  149 LEPASCAAHGLDKIap-kmGSSVLLFGAGPTGLILAQMLRLNGGCkVTVVAPegLKMDLAKNLEAg--dEYIALSrkdps 225 Aspergillus clavat...
EDU42565  160 IEPAACALHGIERMgl-evGSRVLLFGCGPTGILLAQLIKLNGAAhLTIASKpgPKLDLARKMGIadtyICISDDaaadm 238 Pyrenophora tritic...
ABK71633  141 SEPTACAMHGLESLqm-rpGGSALVLGAGPTGLLLAQLIAAGGASsVTVAGPtqAKLDTASALGId---RTVRISrddpe 216 Mycobacterium smeg...
EAQ86669  140 IEPASCAAHGLDRIrprlgSSVPNRFINFPSTQMLAQLLRQNGVTnLTLAAPggLKMELAKQLDAa--dTYVELSrddpa 217 Chaetomium globosu...
Feature 1                          ## #                   ##                        ###       
ACL70060  218 kei-----kiikregADVVIEAVGNihTFKQSIQLARKGGSVLLFGVPpkdkVIEINPFEIYKRELKLKGAYINPFVTDR 292 Halothermothrix or...
EDK02200  225 pqle--qlkkdnpygFDIVIEATGSvkILEDSINYCRRGGTLVVYGVYgdqdKVSWKPTKIFGDEIRIIGSFSEVFMFPQ 302 Magnaporthe grisea...
EDN22252  224 aqfq--qikdeykygFDIVVEATGSakILEDAINYVRRGGKLVVYGVYsssaRVTWPPSKIFGDEITILGSFSETYMFPA 301 Botryotinia fuckel...
ABB55877  223 aqfd--qiksdnpygFDIVVEATGSpkILEDAINYVRRGGKLVVYGVYsdaaRVSWPPSKIFGDEITIIGSFSETYMFPA 300 whitish truffle
EAL88173  226 aqfe--klksdnpygFDIVVEATGNlnILNDSINYVRRGGKLVVYGVYankdRVSWPPAKIFGDEINIVGSFSEVYKFPA 303 Aspergillus fumiga...
EAA66542  245 aqfn--klkadnpygFDIVVEATGNvkILEDSINYVRRGGKLVVYGVYankdRVSWPPSKIFGDEIQIIGSFSEVYKFPA 322 Aspergillus nidula...
EAW08271  226 aqfe--qlksanpygFDIVVEATGNlnILNDSINYVRRGGKLVVYGVYankdRVSWPPAKIFGDEINIVGSFSEVYKFPA 303 Aspergillus clavat...
EDU42565  239 aal-----haanphgFDIVVEATGApsVLEAAVDYVRKGGKLVVYGVYdeavKISWSPFRIWEREITILASFCSMSHIPH 313 Pyrenophora tritic...
ABK71633  217 gniaalmaasphgdgYDAVVEATGSpaVGDICVPLARRGGTVLIYGVTreddLVRFHPFDVFRREITIKGSFAEMTSFGA 296 Mycobacterium smeg...
EAQ86669  218 aqfe--qikrdnphgFDIVVEATGSvrILEDAINYCRRGGTLVVYGVYakaaRVTWPPSKIFGDELRIIGSFSEVYMFPQ 295 Chaetomium globosu...
Feature 1                                                 
ACL70060  293 AVRILESgmVNLKKLVTSQYTLEELPNVLDGnld-esnVKSLVI 335 Halothermothrix orenii H 168
EDK02200  303 TIDYLDNgkVKTKGIVNKTFKLEQFGEALESikn-ksaIKAAIV 345 Magnaporthe grisea 70-15
EDN22252  302 AIDYLDSgkVKVDGIVNKTFKLEQWGEALESikn-ksaIKAAIV 344 Botryotinia fuckeliana B05.10
ABB55877  301 TIGYLDTgkVKVEGIVNKTYKLEQWGECLEAmrn-ksaIKAAIV 343 whitish truffle
EAL88173  304 AIDYLDTgkVKVNGIVNKVFKIEEWEQCLESmrn-ksaIKAAIV 346 Aspergillus fumigatus Af293
EAA66542  323 AIDYLDSgkVKVSGIVNKVYKIEQWEECLQSmrn-ksaIKAAIV 365 Aspergillus nidulans FGSC A4
EAW08271  304 AIDYLDSgkVKVKGIVNKVFKLEEWEQCLESmkn-ksaIKAAIV 346 Aspergillus clavatus NRRL 1
EDU42565  314 VLEYVEAggLRLGGIADRTFRIEEWGECLEAvrr-qevVKAVVV 356 Pyrenophora tritici-repentis Pt-1C-BFP
ABK71633  297 AIDALRGgrVRTDGIITHRFALDDYGRALEAlrsdpavHKVVIV 340 Mycobacterium smegmatis str. MC2 155
EAQ86669  296 TVEYLDSgkIKTKGIVNKVFKLEQFGEALESirn-ktaIKAAIV 338 Chaetomium globosum CBS 148.51

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