1VJ0


Conserved Protein Domain Family
MDR_TM0436_like

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cd08231: MDR_TM0436_like 
Click on image for an interactive view with Cn3D
Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH)
This group contains the hypothetical TM0436 alcohol dehydrogenase from Thermotoga maritima, proteins annotated as 5-exo-alcohol dehydrogenase, and other members of the medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family. MDR, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability.
Statistics
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PSSM-Id: 176193
View PSSM: cd08231
Aligned: 28 rows
Threshold Bit Score: 301.486
Threshold Setting Gi: 54025497
Created: 12-Jun-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 38 residues -Click on image for an interactive view with Cn3D
Feature 1:tetramer interface [polypeptide binding site]
Evidence:
  • Structure:1VJ0: Thermotoga maritima alcohol dehydrogenase (Tm0436) forms a homotetramer, contacts at 4A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
1VJ0_D        18 AHAMVLEKfn--qpLVYKEFEISDi-pRGSILVEILSAGVCGSDVHMFRGedpr-----vplPIILGHEGAGRVVEVNge 89  Thermotoga mari...
NP_772206     55 IRVCTHAGpg--sePVIRTVPWPKv-gRKAALIKIGACGVCGTDLHILKGhwpk----plpwPFTLGHELGGIIVECGde 127 Bradyrhizobium ...
AAR90167      17 ATAMVLEGfg--raMAPRTFPRVDp-dAGAVVVDVTHAGICGTDIHLQQGrla------ipvPVILGHEAVGRVHALGeg 87  Rhodococcus sp....
XP_001774227  10 NTCVLMNSdgsvnvVTEKQLKLSSm-ePGSVLLQLVLSEVCGTDVHLKHGrldi-----vpyPIIPGHVAVGRVFATVgs 83  Physcomitrella ...
YP_002764278  10 SRAAVITEfg--gdLEVREVPIPEl-ePGGALVRIEAATVCGSDVHVWDGslsaggirpivpPVIPGHEMTGRVVALGeg 86  Rhodococcus ery...
YP_890514     10 TQAAVVRNfg--epLTLEEVAVPQtvaPGGLLVEIVACSLCGTDVHCWEGslai----pvglPLILGHEMVGRIIAIGdg 83  Mycobacterium s...
YP_001471498   3 SRAMVLEKfn--hpLVLRNFDIPNl-pEGAILVKLLASGVCGSDLHMAKGedpr-----tplPIILGHEGVGQVVQINge 74  Thermotoga lett...
YP_002573933   3 AYAMVLEEfn--kpLKAKEFELIKp-sDGELLVKIEAAGVCGSDVHMFRGndpr-----tklPMILGHEGVGRVYAISgq 74  Anaerocellum th...
AAO23329       2 PLAAVMTApn--qpVEVQQLPDPVl-eKGGIILETLYSEVCGTDVHLLHGrleg-----vpyPIIPGHFSVGRVVETGga 73  Nostoc sp. ATCC...
YP_002250208   3 AKAAILEEfk--kpLVIRYVDIPPl-lEGGILVKMVSSGICGSDIHMVDGedpr-----vpvPIILGHEGVGEIVEINgd 74  Dictyoglomus th...
Feature 1                                  # ## ##    ###                                #       
1VJ0_D        90 krd-lngeLLKPGDLIVWNrg-itCGECYWCKVsk-ePYLCPNRKVYGinrgcs--eyphlrGCYSSHIVLDPETd---- 160 Thermotoga mari...
NP_772206    128 ftedfmskPLTVGSKVMIPpl-mpCGRCYYCIHypqtANKCLTPVYYGrylgfd--kaphmwGGWAEYVYVDLDMlpgtk 204 Bradyrhizobium ...
AAR90167      88 vttdargeELRVGDAVSWAsn-ipCGHCYYCEDqq-ePSLCETRKVYGinqssa--dwphlsGGWSEQIYLQPGSt---- 159 Rhodococcus sp....
XP_001774227  84 ivd-vegsPVVQGDIVTYLdvidtCNSCVTCLVdk-qTTRCPLRRVLGitcnadsnsirgllGGWSSYVYLPPNTk---- 157 Physcomitrella ...
YP_002764278  87 rvplvgggDVAVGDRIVFGpg--rCGSCYFCAVan-qPSLCANRKHYGdnceq----ypylvGSFSEYTYVYPSSr---- 155 Rhodococcus ery...
YP_890514     84 advdsagqPLQIGDRILWTha--vCGRCVMCAKk--rPTLCRNKIPYGqatmdq---wpnllGGLAQHSYVLPGSg---- 152 Mycobacterium s...
YP_001471498  75 kcd-lngkKIKTGDWIIWNrg-ivCNNCFWCKVsr-qPYLCPNRKVYGinlsck--dypyllGAYSEYMVLFRETe---- 145 Thermotoga lett...
YP_002573933  75 wrd-ingeKIQEGDLIIWDrg-vvCGRCYFCAVkk-eSYLCPHRWTYGisvsca--epphlrGCYSEYIYLHKDTk---- 145 Anaerocellum th...
AAO23329      74 vsd-vngkLIQPGAIATFLdvhetCYNCWYCLVak-aSTRCPKRKVYGvtysa----kdgllGGWSELIYLKPGVk---- 143 Nostoc sp. ATCC...
YP_002250208  75 krd-lngeILKKGDLIIWNrg-vvCGECYFCKVlk-mPYLCENRKIYGinrsfk--eyphlsGAFAEFIILEEKTe---- 145 Dictyoglomus th...
Feature 1                                ##             #                    ###                 
1VJ0_D       161 VLKVSEk-dDLDVLAMAmCSGATAYHAFDEYPes---faGKTVVIQGAGPLGLFGVVIARSLGAeNVIVIAG-SPNRLKL 235 Thermotoga mari...
NP_772206    205 IYKLPDd-mSLRLGALS-EPLTSCIRAFNRASraggfswGDTVVIQGSGPIGILAVAAAKEMGAgRVICVGApEEPRLKL 282 Bradyrhizobium ...
AAR90167     160 IVRIPSsvtPQQVIALG-CAGPTAVHAVNRIAkp---daGNVVVVQGSGPVGLACAMYATLAGAaKVIIVGG-PANRLEV 234 Rhodococcus sp....
XP_001774227 158 IIRLPEm-lPASVFMAGgCGLPTALHAVDRASir----lMDRVIVQGSGPVGLLAAILARLSGAlQVIVVGA-PAHRLKV 231 Physcomitrella ...
YP_002764278 156 KVLVPDn-vKSEWSSAGsCALRTVFNAYERLGri---qpWQTVVIQGAGPLGLFATALAAQSGAeRIIVVGA-PDARLKL 230 Rhodococcus ery...
YP_890514    153 RLRVPDg-vPDDLASMAsCALRSVVNAVEQAGrv---gpEHTVVVQGAGPLGILATGLFAQAGAgRVITVGA-PDTRLEI 227 Mycobacterium s...
YP_001471498 146 ILKIPQi-dPVCLVTAA-CSGATAMHAFDLISep---llSKTVVIQGAGPLGVFCVVAARTLGAsQVIMISG-SQQRLEL 219 Thermotoga lett...
YP_002573933 146 VIKIKEnvdPEILVSAS-CSGATCAHAFDIVSpd----fGDSVLIQGPGPIGLYAIIFAKLRGArNIIVIGG-TKERLKM 219 Anaerocellum th...
AAO23329     144 VLTLPEevsPKQFIAGG-CALPTALHAIDRAQiq----iGDVVVVQGCGPVGLSVAILALLSGAgKVIVIDK-FESRLVV 217 Nostoc sp. ATCC...
YP_002250208 146 ILRLSPntdPNVIVMAG-CSGATAVHAIDALEdn---llDKTVVVQGGGPLGIFALSLAKFQGAkNTILITG-SSFRKEI 220 Dictyoglomus th...
Feature 1                                            #                   # #    #         ####   
1VJ0_D       236 AEeIGADLTLNRretsveerrk---aimdithgrGADFILEATGDsrALLEGSELLRrGGFYSVAGvav-pqdPVPFKvy 311 Thermotoga mari...
NP_772206    283 AReFGAEATVNIdelkspqeri--arvreivggfGADLVMDCSGHptAGPEGIEMLRdGGTYVEMGqft-dagSIETSwh 359 Bradyrhizobium ...
AAR90167     235 ARtAGIGDIHIDifaetdraarldrilaettggrGADVVIEAAGVptAVSEGIDIARrGGKYLVVGqyt-dhgTTPINph 313 Rhodococcus sp....
XP_001774227 232 VKeFGIDHTISIeefpdpskrl--aqvqdltsghLGDVVIEATGRpeAVTEGMMLCRdGGTYVVVGqyt-dngEVALNph 308 Physcomitrella ...
YP_002764278 231 ATaWGAHDVVSVedasssedrv--aavreltgghGAEIVQEWSGGrtAFAEGLDMVRrGGRFLIGGqvgpqlaEIQPSk- 307 Rhodococcus ery...
YP_890514    228 ASeFGAHDVISLaahpdpddrl--amirdatdglGADLVAEFSGHpaAFAEGVEMAApDGRYLVVGqlgagvtTIAPGt- 304 Mycobacterium s...
YP_001471498 220 AKkAGADIVLNRhdineeertk---kilsitgnrGADIVIEASGNskALLEGFRLVRrGGMYMITGvav-pqeSIPLDvy 295 Thermotoga lett...
YP_002573933 220 CEeFGATHVLDRnsttacqrqe---iimditngrGVDLAIEAVGHpsAVSEGIKLVRnGGSYLSLGfgd-pngSVTLDcy 295 Anaerocellum th...
AAO23329     218 AKsFGVDETLAIkaddprqhie---rvleltnghGADVTIEATGIpiAVKEGLNMTRnGGRYVIVGhyt-ntgEILINph 293 Nostoc sp. ATCC...
YP_002250208 221 AEkIGIDMILDRntsaeerln----kilditygrGADVVIEATGTnkAVPEGLRFLRkGGTYIIAGvas-pqeKVPIDfy 295 Dictyoglomus th...
Feature 1           ## ########       ##  ##  #                                          
1VJ0_D       312 ewlVLKNATFKGIWVSdtsHFVKTVSITSRn-----YQLLSKLITHRLPLkEANKALELmesreaLKVILYP 378 Thermotoga maritima
NP_772206    360 -riCTKDLNVLGSWGF---TGNDLPLGVDM------LYRTAGKYPWLKMQ-TIYPFTEEg-----VAQAVRD 415 Bradyrhizobium japonicu...
AAR90167     314 -yiTKKQLQVLGSWAFsphNHLEYVESLPRla---aRFDLASMVTEYPLG-KAEEAMGDmrdgrsLKSVLVT 380 Rhodococcus sp. DK17
XP_001774227 309 qmiNRKHLTIKGCWGSdfsHFYRGVQFLTKha---tSLPWHLLVSQIFELkDADKAIAAverlevFKALVKP 377 Physcomitrella patens s...
YP_002764278 308 --iMRNHLDIIGSMSAsesHYWQAMKFLSStq---dRFDFDQMLTGRYGLhQVSNALRAmqdlsaIKPVIDP 374 Rhodococcus erythropoli...
YP_890514    305 --iTKKNLNVIGSFSGdlsHYRTALTILERya---dRLPFDRLITGHYPLrDIDSVMGRmqsfqeIKPVLLP 371 Mycobacterium smegmatis...
YP_001471498 296 hdlVFKNIHIQGVWVSdakHLVQAVDLIAKh-----PEIFERIVTHRLPLsQANEALKLieertaLKVAITF 362 Thermotoga lettingae TMO
YP_002573933 296 ydiVRKNLRYQGVWVSdtkHLYMAVNVVLQn-----RELFKKMITNVYKLtDATKALEDmenkntIKSVLKP 362 Anaerocellum thermophil...
AAO23329     294 leiNLKHIDIRGTWGIdfsHFYRMIELLKRhsdsskNIAWSSIISRSYTLqQINQALADveqgsvLKAVIQP 365 Nostoc sp. ATCC 53789
YP_002250208 296 -evSSKNITIKGVWVSdaeHFKKAVSFVEKh-----QDLFATLITHKISLdEINYGLDLvrerkaGKVVITY 361 Dictyoglomus thermophil...

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