2CD9,2B5W


Conserved Protein Domain Family
glucose_DH

?
cd08230: glucose_DH 
Click on image for an interactive view with Cn3D
Glucose dehydrogenase
Glucose dehydrogenase (GlcDH), a member of the medium chain dehydrogenase/zinc-dependent alcohol dehydrogenase-like family, catalyzes the NADP(+)-dependent oxidation of glucose to gluconate, the first step in the Entner-Doudoroff pathway, an alternative to or substitute for glycolysis or the pentose phosphate pathway. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossman fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability.
Statistics
?
PSSM-Id: 176192
View PSSM: cd08230
Aligned: 27 rows
Threshold Bit Score: 348.441
Threshold Setting Gi: 255925155
Created: 3-Feb-2009
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
Conserved site includes 24 residues -Click on image for an interactive view with Cn3D
Feature 1:NADP binding site [chemical binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                                  ###  #                                
2CD9_A         1 MKAIIVKPPNA----GVQVKDVDEkkldsyGKIKIRTIYNGICGTDREIVNGkltLSTLPKGKDFLVLGHEAIGVVEESY 76  Sulfolobus solf...
2B5W_A         1 MKAIAVKRGED----RPVVIEKPRpep-esGEALVRTLRVGVCGTDHEVIAGg--HGGFPEGEDHLVLGHEAVGVVVDPN 73  Haloferax medit...
NP_377677      1 MKAIVVTPKKSg--vEVKDIPMREsl--gkGKVLVKTLYTGICGTDRGIVNAkitFTYPPDGYNFLILGHEGLGMVEEVG 76  Sulfolobus toko...
NP_344511      1 MKAIVVNPPNKg--vHVKEINDIHrsl-taDEVLVKTIANGICGTDRGIVSGllkFSRPPNGKNDLVLGHENLGQVIDKG 77  Sulfolobus solf...
YP_001191383   1 MKAIIVRPPNEg--vEVKDITLREst---dGKIVVRTRLSGLCGTDRGLVTGrltFARPPPGYDFLILGHETLGEVVKGN 75  Metallosphaera ...
YP_002464770   1 MDALAVQPGSAg--iRLVQRPQPEit--rpDEVLVRIIRVGICGTDREIVSGg--RAKASDHATDLVIGHEMFGRVEAVG 74  Chloroflexus ag...
YP_023848      2 VRAIITNAPNGgvkiENVNINEPEh-----YEVKLRPVYTGLCGTDRGEVLGnlsFAYNEPGYNYLVLGHEAICQVIEAS 76  Picrophilus tor...
YP_023417      1 MKAIIVHPPGAg--vSIEDVNING------NGPGIKILENGICGTDREIVNGe--LSAATSLNGFLVLGHEALGILEEDT 70  Picrophilus tor...
NP_344353     19 MKAIVVKPPNPg--vEIKDVKDDEnklsniGLVKVKILENGICGTDREIVSGkrtSVKPPIGKDELILGHEAIGIVEVGG 96  Sulfolobus solf...
ACU40666       5 VRAAWAVPGEPdr-cAVVGLDAVEr----vGEVLVAGRLAGVCATDVEIVRDg--FGWLPPGRDGLVLFHESLGEVLSAP 77  Actinosynnema m...
Feature 1                                                                                        
2CD9_A        77 h---gFSQGDLVMPVNRRg--CGICRNClvgrPDFCETGeFGEAGIhKMDGFMREWWYDDPKYLVKIPKSIe-DIGILAQ 150 Sulfolobus solf...
2B5W_A        74 dt--eLEEGDIVVPTVRRppaSGTNEYFerdqPDMAPDGmYFERGIvGAHGYMSEFFTSPEKYLVRIPRSQa-ELGFLIE 150 Haloferax medit...
NP_377677     77 dgvkyLKKGDFVVPVVRRg--CGVCLNCrigrQDFCETGkFVEAGIrGKHGFMREEFVDDELWLVKVPDEIk-DIAVLTE 153 Sulfolobus toko...
NP_344511     78 pevhgLGKGDYVVSIVRRg--CGKCSNClagrQDFCETGeFVEAGIrGLDGFMREFYIDNASYLVKIPDEIv-DIAVLLE 154 Sulfolobus solf...
YP_001191383  76 g---eFSPGDLVVPVVRRg--CGSCLNCmlgrQDFCETGrFTEIGIrGAHGTMREEFLEDPKYLVRVPRELg-DEGVLLE 149 Metallosphaera ...
YP_002464770  75 savqrVHVGDFAVFTVRRg--CTQCLPClmnrPDMCRTGnYRERGIwGLDGYQTELVLDTEAYVVKVPAELe-AVGVLLE 151 Chloroflexus ag...
YP_023848     77 enpykIKPGDYVVPVVRR---PGKCVNCrigrEDDCSDGdKHEAGItGLHGFMRDYFYDEAKNLVKINDKNmvKVAVLTE 153 Picrophilus tor...
YP_023417     71 k---nLRKGDLVMPINRRg--CGRCLNCmlgrPDFCETGeQLEAGIsGMHGFMREYINDDERYLVKVPDVIr-DIAIMAQ 144 Picrophilus tor...
NP_344353     97 y---gFKEGELVMPINKRg--CGKCLNCligrPDFCETGeGLVAGTkGLDGFMREYLYDDPKYLVKIPPAIk-DIAILAQ 170 Sulfolobus solf...
ACU40666      78 dg-sgFAPGDLVAGVVRRp-dPEPCAACaadaWDFCRNGrYRERGIkELDGYGAQRWSVPPRFAVKLDPALg-DAGVLLE 154 Actinosynnema m...
Feature 1           #                                  #####                    ###              
2CD9_A       151 PLADIEKSIEEILEVQKRvpvwt-cddgtLNCRKVLVVGTGPIGVLFTLLFRTYGL---EVWMANRrEPTEVEQTVIEET 226 Sulfolobus solf...
2B5W_A       151 PISITEKALEHAYASRSAf---------dWDPSSAFVLGNGSLGLLTLAMLKVDDKgyeNLYCLGRrDRPDPTIDIIEEL 221 Haloferax medit...
NP_377677    154 PLSNVVKAIDELLFVQRRmiwtc--edstFECRNAFIIGSGPIGTFFSLILTTLGF---NVYMINKrDPSPMEDYISKRL 228 Sulfolobus toko...
NP_344511    155 PLSNVVKAYSELMLVQRRmtwwc--kdgsYNCRNVAIVGSGPIGLMFSLMFSIQGF---NAFVLNKrDPFPIEAEIVEKS 229 Sulfolobus solf...
YP_001191383 150 PLSNVVKALTEMEYLQRRswwrc--ddstYSCRTAVVLGSGPIGLLFSMALRSMGF---RVIVANRrPPSQVESEITRDI 224 Metallosphaera ...
YP_002464770 152 PLSVAEKAIDEAIRIQQArlpdapatpnwLFGRRCLVAGIGPIGLLAALALRLRGA---EVYGLDIvDANTTRPRWLATI 228 Chloroflexus ag...
YP_023848    154 PTKNVMKAFEVFDTVSKRsifqg--ddstNLTKNCLIIGTGSEAFLYAFMAREYRF---NVFMTNRhPVGEEKLSIISRI 228 Picrophilus tor...
YP_023417    145 PLADLEKSIEEMISIQKRlhwpc--idgtYNCRKVLITGTGTIGILFAMLLKTYGF---SVYISNKrEPNDIESKIFDEL 219 Picrophilus tor...
NP_344353    171 PLADIEKSVESILTSQKRipiwt-cddgtLNCRKALVVGTGPTGILFSLVLRTYGF---QVWIANRrELLDNEKEILDEP 246 Sulfolobus solf...
ACU40666     155 PASVVAKAWAQAELLCSRa---------fVPARTALVVGAGPIGLLAALLGVQRGY---DVHVVDR-VADGVKPDLVRAL 221 Actinosynnema m...
Feature 1              #                    ####                    ###                          
2CD9_A       227 KTNYYNSsngydkl-kdsvgkFDVIIDATGAdvniLGNVIPLLgRNGVLGLFGFSTs-gSVPLD-YKTLQEIVHTNKTII 303 Sulfolobus solf...
2B5W_A       222 DATYVDSrqtpvedvpdvyeqMDFIYEATGFpk-hAIQSVQALaPNGVGALLGVPSd-wAFEVDaGAFHREMVLHNKALV 299 Haloferax medit...
NP_377677    229 GVTFINSmkegd-----klpeADLIVDTSGVps-aFIPLMSKMrPNSALILFGTLEg-eKYEIT-SDLVTFMVERNIIVI 300 Sulfolobus toko...
NP_344511    230 NAKFINTnkdr------lpntIDLLIDTSGYps-aFIPLMSRLnKNSAIILFGTTGg-eKFEVN-ADLITYLVENNILLF 300 Sulfolobus solf...
YP_001191383 225 GATFLNTsehe-------dlePDLIVDTSGHps-aVVPLLPRIrKNGAVILFGTTGl-eRYELT-AEEITMLVENNILIF 294 Metallosphaera ...
YP_002464770 229 GGHYLDGrtvppgqiaqiagmMDLILEATGVpa-iEFNLLDALaPDGMYVLTGIPGgdrPLQVAgAELMRRLVLNNQVMV 307 Chloroflexus ag...
YP_023848    229 NADFYDYtred------plkgIDLLIDTSGDpg-tIFRFVRKMnYNGVVILFGTNGrapATSID-GEDIDYIIERNISLV 300 Picrophilus tor...
YP_023417    220 SVKYKNLsnki-------desFDAIIEASGSgtdvIERTLPLLkNNGFYGIFGFEKt-gTLNLT-SEFLQGIVYKSINIT 290 Picrophilus tor...
NP_344353    247 RILFYNSakgyesl-vkdvdkFDLIIDTTGAsasiIQELVPLLqINGVLGLFGFPRy-dNFSLD-YKIVQDFVINNRIII 323 Sulfolobus solf...
ACU40666     222 GATYHRSvpd---------reVDVAIECTGV----AELAWECArRAAVVVLAGISGehgPAALD-RSVLDAAVLGNRALI 287 Actinosynnema m...
Feature 1         ###                                                          
2CD9_A       304 GLVNGQKpHFQQAVVHLASWKtlyPKAAKMLITKTVSIndekELLKVLREKeHGEIKIRILW 365 Sulfolobus solfataricus P2
2B5W_A       300 GSVNSHVeHFEAATVTFTKLP---KWFLEDLVTGVHPLs---EFEAAFDDD-DTTIKTAIEF 354 Haloferax mediterranei
NP_377677    301 GSVNASKrDFQGALNYLSIWKnryYDVLQRMITSKVSVe---QAPEVLMRKpSGEIKTVIVW 359 Sulfolobus tokodaii str. 7
NP_344511    301 GSVNASKkDFENGVNYLTIWKyryPSVLNRMITRVIKPe---QAPEVLYTKpKGEIKTVISW 359 Sulfolobus solfataricus P2
YP_001191383 295 GSVNASKaDFQAGVNLLVEWKaryPGVLQRMITKRVSVe---EAPQVLKEKvPGEIKTVIDW 353 Metallosphaera sedula DSM 5348
YP_002464770 308 GSVNAARdHFQLAVDDLLQAHyrwGSILNDLISHRYPYt---AFPDAFQQHdPHDIKIVLEW 366 Chloroflexus aggregans DSM 9485
YP_023848    301 GSVDGAKrHYLRAVEYLEKWNyseGSVINRLITGVFEP----EDVSIFTKKpENEIKSVIKW 358 Picrophilus torridus DSM 9790
YP_023417    291 GLINGQKpHMEMAMNHLIQWKkqfPKTTSMMITEKVSInnerRLKEVLSKKrPGEIKIKIIW 352 Picrophilus torridus DSM 9790
NP_344353    324 GLDNGQKpHFQQALIHLASWKslwPKTASKMITKIISInderEVISSLREKlPGEIKVKIVW 385 Sulfolobus solfataricus P2
ACU40666     288 GTVNAGPdDYREAAAALAGAD---LGWLRGLITRRVPLe---RFTEAFDRA-DGDVKVVVDL 342 Actinosynnema mirum DSM 43827

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap