2WQM


Conserved Protein Domain Family
STKc_Nek7
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cd08229: STKc_Nek7 
Click on image for an interactive view with Cn3D
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 7
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek7 is required for mitotic spindle formation and cytokinesis. It is enriched in the centrosome and is critical for microtubule nucleation. Nek7 is activated by Nek9 during mitosis, and may regulate the p70 ribosomal S6 kinase. It is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Links
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Statistics
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PSSM-Id: 270866
Aligned: 4 rows
Threshold Bit Score: 574.286
Created: 15-Dec-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:based on the binding of MgADP to human Nek2
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                       ## ##   #            # #                         
2WQM_A         9 QGPPVPQFQPQKAlrpDMGYNTLANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQ 88  human
NP_001026435   9 QGPTAPPFQPQKAlrpDMGYNTLANFRIEKKIGRGQFSEVYRATCLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQ 88  chicken
AAT45117       9 QGPPVQQFHTQKAlrpDMGYNTLANFQIEKKIGRGQFSEVCRATCLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQ 88  African clawed ...
AAH77138       8 QQPPVPVYQPQKI---DMGYNSLANFAIEKKIGRGQFSEVYRATYVLDHTIVALKKIQIFDLMDAKARQDCIKEIDLLKQ 84  zebrafish

Feature 1              #                ###   #                                               # #
2WQM_A        89 LNHPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVF 168 human
NP_001026435  89 LNHPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVF 168 chicken
AAT45117      89 LNHPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPEKTVWKYFVQLCSALEHMHSRRVMHRDIKPANVF 168 African clawed ...
AAH77138      85 LNHPNVIKYHASFIEENELNIVLELADAGDLSQMIRHFKKQRRLIPEKTVWKYFVQLCSALEHMHSRRIMHRDIKPANVF 164 zebrafish

Feature 1                       #                                                                
2WQM_A       169 ITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCK 248 human
NP_001026435 169 ITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCK 248 chicken
AAT45117     169 ITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCK 248 African clawed ...
AAH77138     165 ITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCK 244 zebrafish

Feature 1                                                            
2WQM_A       249 KIEQCDYPPLPSDHYSEELRQLVNMCINPDPEKRPDVTYVYDVAKRMHACTA 300 human
NP_001026435 249 KIEQCDYPPLPSDHYSEELRQLVNMCINPDPEKRPDITYVYDVAKRMHAHTA 300 chicken
AAT45117     249 KIEQCDYPPLPSDHYSEELRMLVNTCINPDPEKRPDVTYVYEVAKRMHARTA 300 African clawed frog
AAH77138     245 KIEQCDYPPLPSDHYSQELRKLVDMCINPDPEKRPDITYVYSMAKHMHGRIA 296 zebrafish

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