Conserved Protein Domain Family
STKc_Nek5

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cd08225: STKc_Nek5 
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Neks are involved in the regulation of downstream processes following the activation of Cdc2, and many of their functions are cell cycle-related. They play critical roles in microtubule dynamics during ciliogenesis and mitosis. The specific function of Nek5 is unknown. Nek5 is one in a family of 11 different Neks (Nek1-11). The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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PSSM-Id: 173765
View PSSM: cd08225
Aligned: 3 rows
Threshold Bit Score: 554.953
Threshold Setting Gi: 118084918
Created: 2-May-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:based on the binding of MgADP to human Nek2

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            ## ##   #            # #                              #                ##
Q6P3R8      3 KYDVIKaIGQGAFGKAYLAKGKsdSKHCVIKEINfekmpiqeKEASKKEVILLEKMkHPNIVAFFNSFQEngrLFIVMEY 82  human
XP_417075   3 RYEILKkIGEGSFGKIFLAKAKvdNEQCVIKEIDltkmpvkeKEASQKEVILLAKMkHANIVTFYASLQEenkLYIVMEY 82  chicken
Q7TSC3      3 NFHLIKiIGEGTFGKVYLAKDKseSSHCVIKEISlt----keKEASKNEVILLARMeHPNIVTFFSSFQEngrLFIVMEY 78  house mouse
Feature 1     #   #                                             # #                #          
Q6P3R8     83 CDGGDLMKRINrqrgvLFSEDQILGWFVQISLGLKHIHdRKILHRDIKAQNIFLSkngMVAKLGDFGIARVLNNSMELAR 162 human
XP_417075  83 CDGGDLMKRINmqhgvLFEEDQILSWFVQIALGLKHIHdRKILHRDIKSQNIFLSsngKVAKLGDFGIARQLNDTTEFAY 162 chicken
Q7TSC3     79 CDGGDLMQRIQrqrgvMFSEDQILCWFVQISLGLKHIHdRKILHRDIKSQNIFLSkngMVAKLGDFGTARTLNDSMELAQ 158 house mouse
Feature 1                                                                                     
Q6P3R8    163 TCIGTPYYLSPEICQNKpYNNKTDIWSLGCVLYELCtLKHPFEGNnlQQLVLKICQAHFAPISPgFSRELHSLISQLFQV 242 human
XP_417075 163 TCVGTPYYLSPEICENRpYNNKTDIWSLGCVLYELCaLKHPFEGNslHQLVLKICRGYFHPVSPnYSYDLRMLISQLFKI 242 chicken
Q7TSC3    159 TCAGTPYYLSPEICQNRpYNNKTDIWSLGCVLYELCtLKHPFESNnfHHLVLKICQGRVAPISPhFSRDLQSLIPQLFRV 238 house mouse
Feature 1                      
Q6P3R8    243 sPRDRPSiNSILKRPFL 259 human
XP_417075 243 sPRDRPSiTSILRKPFL 259 chicken
Q7TSC3    239 sPQDRPSvTSLLKRPFL 255 house mouse

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