Conserved Protein Domain Family
STKc_Nek3

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cd08219: STKc_Nek3 
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 3
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek3 is primarily localized in the cytoplasm and shows no cell cycle-dependent changes in its activity. It is present in the axons of neurons and affects morphogenesis and polarity through its regulation of microtubule acetylation. Nek3 modulates the signaling of the prolactin receptor through its activation of Vav2 and contributes to prolactin-mediated motility of breast cancer cells. It is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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PSSM-Id: 173759
View PSSM: cd08219
Aligned: 3 rows
Threshold Bit Score: 562.673
Threshold Setting Gi: 47937795
Created: 11-Apr-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:based on the binding of MgADP to human Nek2

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               ## ##   #            # #                             #                ###
P51956         3 DYMVLRmIGEGSFGRALLVQHesSNQMFAMKEIRLPksfsntQNSRKEAVLLAKMkHPNIVAFKESFEaegHLYIVMEYC 82  human
AAH72363       3 QYNILRvVGEGSFGRALLVCHvnSDQKYVMKEIRLPksshavEDSRKEAVLLSKMkHPNIVTFRESFEgdgHLYIVMEYC 82  African clawed ...
XP_001232686   3 KYEVLKvLGEGSFGRALLVQHklSDQKYAMKEIRLPvsssdvETSRKEAILLAKMkHPNVVAYKESFEadgHLYIVMEYC 82  chicken
Feature 1           #                                             # #               #            
P51956        83 DGGDLMQKIKqqkgkLFPEDMILNWFTQMCLGVNHIHKKRVLHRDIKSKNIFLTqnGKVKLGDFGSARLLSNPMAFACTY 162 human
AAH72363      83 QGGDLLQKIKlqrgrLFTEQTILQWFVQICLAVQHIHEKRVLHRDIKSKNIFLTqnCNIKLGDFGSARILTSPGAYACTY 162 African clawed ...
XP_001232686  83 DDGDLMQKIKdqrgkLFPEDTILCWFVQMCLGVKHIHDKRVLHRDIKSKNVFLTqnGKVKLGDFGSARLLAHPVSYACTY 162 chicken
Feature 1                                                                                        
P51956       163 VGTPYYVPPEIWENLpYNNKSDIWSLGCILYELCtLKHPFQAnsWKNLILKVCQGCISPLPshYSYELQFLVKQMFKRnP 242 human
AAH72363     163 VGTPYYVPPEIWENMpYNNKSDIWSLGCVLYELCtLKHPFQAgsWKNLILKICQGSYKPLPmqYSYELRSLITQMFRKnP 242 African clawed ...
XP_001232686 163 VGTPYYVPPEIWENMpYNNKSDIWSLGCILYELCtLRHPFQAnsWKHLILKVCKGSYNPLPshYSYELHYLIKQMFKRnP 242 chicken
Feature 1                       
P51956       243 SHRPSaTTLLSRGIV 257 human
AAH72363     243 RSRPSaSTILSRSSL 257 African clawed frog
XP_001232686 243 KNRPSaTTILARGCL 257 chicken

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