1GEH,2CWX


Conserved Protein Domain Family
RuBisCO_large_III

?
cd08213: RuBisCO_large_III 
Click on image for an interactive view with Cn3D
Ribulose bisphosphate carboxylase large chain, Form III
Ribulose bisphosphate carboxylase (Rubisco) plays an important role in the Calvin reductive pentose phosphate pathway. It catalyzes the primary CO2 fixation step. Rubisco is activated by carbamylation of an active site lysine, stabilized by a divalent cation, which then catalyzes the proton abstraction from the substrate ribulose 1,5 bisphosphate (RuBP) and leads to the formation of two molecules of 3-phosphoglycerate. Members of the Rubisco family can be divided into 4 subgroups, Form I-IV , which differ in their taxonomic distribution and subunit composition. Form III is only found in archaea and forms large subunit oligomers (dimers or decamers) that do not include small subunits.
Statistics
?
PSSM-Id: 173978
View PSSM: cd08213
Aligned: 10 rows
Threshold Bit Score: 670.637
Threshold Setting Gi: 224821049
Created: 7-Jan-2010
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1GEH, Thermococcus kodakarensis ribulose-1,5-bisphosphate carboxylase with bound S04-2, contacts 4A
    View structure with Cn3D
  • Comment:annotation is based on homology to other subgroups
  • Citation:PMID 3681999

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                  #    ##                                               
1GEH_A        23 RDIIAVFRVTpaeGYTIEQAAGAVAAESSTGTWTtlypwyeqerwaDLSAKAYDFHdmg----dgsWIVRIAYPFHAFEe 98  Thermococcus ko...
2CWX_A        24 DELIVEYYFEp-nGVSPEEAAGRIASESSIGTWTtlwkl--pemakRSMAKVFYLEkhg-----egYIAKIAYPLTLFEe 95  Pyrococcus hori...
Q58632        13 GDLLSCMVIK---GENLEKLANEIAGESSIGTWTkvqtmk-sdiyeKLRPKVYEIKeigeengykvGLIKIAYPLYDFEi 88  Methanocaldococ...
Q8THG2        15 TDLICEFHIEpaaGISFEEASTHMAGESSIDSWTeistls-pelaaRLKPHVFYLDad-------tQTVRVAYSEDLFEl 86  Methanosarcina ...
O28635        20 DDIVAVFRITpaeGFTIEDAAGAVAAESSTGTWTslhpwydeervkGLSAKAYDFVdlg----dgsSIVRIAYPSELFEp 95  Archaeoglobus f...
YP_920628     22 KDVIVTFRVTpseGFTIEDAAGGVAAESSVGTWTtlyqwydksridRLKGKAYYMEslg----dgsYILRVAYPVELFEe 97  Thermofilum pen...
YP_001012710  22 DEVIAVFRVTpaqGISIKDAAGRIAAESSVGTWTtlsvk--pswfeKLKAKAYRFHdlg----dgsWLVWVAYPVELFEe 95  Hyperthermus bu...
YP_001404266  19 DDLVCLFYFEpaaGITDKEAAGRIASESSTGTWTtlatl--pprmkKLEAKAFEFDg---------HYVKVAYPLALWEe 87  Candidatus Meth...
ZP_03694170   24 TDLVCTFRIDpaeDMSMEAAASRVASESSNGTWAalhvd--edeltHLGAVAYGIDg---------DEITVAYPAELFEa 92  Natrialba magad...
YP_003239796  16 SDCLACFYVEpaeGVDIYEAAGAVASESSIGTWTdvatmk-priweELRARVYAIEg---------NVVKIAYPAALFEp 85  Ammonifex degen...
Feature 1                    #                                                 # # #             
1GEH_A        99 ANLPGLLASIAGNIFGMKrVKGLRLEDLYFPEKLIREfdGPAFGIEGVRKMLEikdRPIYGVVPKPKVGYSPEEFEKLAY 178 Thermococcus ko...
2CWX_A        96 GSLVQLFSAVAGNVFGMKaLKNLRLLDFHPPYEYLRHfkGPQFGVQGIREFMGvkdRPLTATVPKPKMGWSVEEYAEIAY 175 Pyrococcus hori...
Q58632        89 NNMPGVLAGIAGNIFGMKiAKGLRILDFRFPAEFVKAykGPRFGIEGVRETLKikeRPLLGTIVKPKVGLKTEEHAKVAY 168 Methanocaldococ...
Q8THG2        87 GSVPQVLSAVAGNIFSMKiVDNLRLQDITFPKSMLREfeGPNFGLPGVRDIVGvkdRPLVGTIVKPKVGLTSEMHAEVAY 166 Methanosarcina ...
O28635        96 HNMPGLLASIAGNVFGMKrVKGLRLEDLQLPKSFLKDfkGPSKGKEGVKKIFGvadRPIVGTVPKPKVGYSAEEVEKLAY 175 Archaeoglobus f...
YP_920628     98 GNMPAFLASVAGNIFGMRrVRSLRVEDIYLPEAFLKHfkGPSQGVEGVRGKLKiwgRPIIGTVPKPKVGYSPEEVEKLAY 177 Thermofilum pen...
YP_001012710  96 GSIPNFASSILGNIFGMKaIAGLRVEDVYFPPSYLETfpGPNKGIQGVREILGikdRPILATVPKPKLGYTPEEYGRVAY 175 Hyperthermus bu...
YP_001404266  88 GNAVQLLSGIAGNIFGMKaLKNLRLIDATLPSAYTREfkGPHFGMDGIRKMMGirgRPLTGAVPKPKIGFSAKEHAEIGY 167 Candidatus Meth...
ZP_03694170   93 GSMPQILSCIAGNIMGMKaVDAIRLEDCKWPESITSGfpGPQFGTSVAREKLDagdRPILATVPKPKVGLSTDAHVRVGE 172 Natrialba magad...
YP_003239796  86 GNIPQYLSSIAGNIFGMKaVKNLRLLDISFPPELVSGslGPAFGVQGVRETLGiygRPLVGTIVKPKLGLSPREQAEVVY 165 Ammonifex degen...
Feature 1                    ##                                                                  
1GEH_A       179 DLLSNGADYMKDDENLTSPWYNRFEERAEIMAKIIDKVENETGEKKTWFANITAD-LLEMEQRLEVLADlglKHAMVDVV 257 Thermococcus ko...
2CWX_A       176 ELWSGGIDLLKDDENFTSFPFNRFEERVRKLYRVRDRVEAETGETKEYLINITGP-VNIMEKRAEMVANeggQYVMIDIV 254 Pyrococcus hori...
Q58632       169 EAWVGGVDLVKDDENLTSQEFNKFEDRIYKTLEMRDKAEEETGERKAYMPNITAP-YREMIRRAEIAEDagsEYVMIDVV 247 Methanocaldococ...
Q8THG2       167 NAFAGGCDLVKDDENLTDQKFNGFEKRAELTLKIAEKAEAETGERKMYLCNITAPtCEEMIRRLHVLKDlgaSYAMIDIV 246 Methanosarcina ...
O28635       176 ELLSGGMDYIKDDENLTSPAYCRFEERAERIMKVIEKVEAETGEKKSWFANITAD-VREMERRLKLVAElgnPHVMVDVV 254 Archaeoglobus f...
YP_920628    178 EILVGGMDFVKDDENLAGPSYCRFEERAKAIMKAIDRAEKETGERKAWLANITAD-VREMERRLKLVAElgnTHVMVDVV 256 Thermofilum pen...
YP_001012710 176 EILIGGIDLVKDDENFASQPFCRFEARLKEVMKAIDRAEKETGERKGYLANVTAP-IREMEKRIKLVADygnKFIMIDFL 254 Hyperthermus bu...
YP_001404266 168 ETWMGGFDFVKDDENLTSTSFNRFDDRVKYMTKLRDKAEKETGEKKSAFLNISAD-VETMKKRADLLVEygwNYAMIDVV 246 Candidatus Meth...
ZP_03694170  173 EAWRGGVDLLKDDENLTDQDFNPFEDRLAESLAARDRVEEDVGERKDYLVNVTAE-TNEMLERVDLVDEhggGFVMVDII 251 Natrialba magad...
YP_003239796 166 EALVGGLDLVKDDENLTSQPFSPFEERVKRSLEACARAEAEAGEKKVYLPNVTAE-TEEMIRRAELVKReggRYVMVDIV 244 Ammonifex degen...
Feature 1                               ##                               #       ##              
1GEH_A       258 ITGWGALRYIRDLAAdygLAIHGHRAMHAAFTRNPYHGISMFVLAKLYRLIGIDQLHVGTAgAGKLEGgkWDVIQNARIL 337 Thermococcus ko...
2CWX_A       255 VAGWSALQYMREVTEdlgLAIHAHRAMHAAFTRNPRHGITMLALAKAARMIGVDQIHTGTA-VGKMAGnyEEIKRINDFL 333 Pyrococcus hori...
Q58632       248 VCGFSAVQSFREEDFk--FIIHAHRAMHAAMTRSRDFGISMLALAKIYRLLGVDQLHIGTV-VGKMEGgeKEVKAIRDEI 324 Methanocaldococ...
Q8THG2       247 PTGWTALQTLREAAAdegLALHAHRCMHSAFTRNPRHGVSMLLVAKLCRLIGLDQLHIGTV-VGKMHGdkDEVLSIRDEC 325 Methanosarcina ...
O28635       255 ITGWGALEYIRDLAEdydLAIHGHRAMHAAFTRNAKHGISMFVLAKLYRIIGIDQLHIGTAgAGKLEGqkWDTVQNARIF 334 Archaeoglobus f...
YP_920628    257 IAGWSSLTYVRDLAAdykLAIHGHRAFHAAFTRNPYHGVSMFTLAKLYRIIGVDQLHVGTPeVGKLEAkaVDVIRMARLL 336 Thermofilum pen...
YP_001012710 255 TAGWAALQHARELAEeydLAIHGHRAFHAAFTRNPKHGVSMFLVAKLARMAGVDHVHVGTPgVGKMDAktREVLEHTRIV 334 Hyperthermus bu...
YP_001404266 247 VAGTASVMTMRDYCSdlgLAIHAHRAFHSAFDRNKKHGMTMYFLAKLMRLIGVSQIHTGTA-VGKLTGtkTESILLADLL 325 Candidatus Meth...
ZP_03694170  252 TCGWSAVQSVRDRCEkhgLAIHAHRAMHAAFDRMDHHGVSMRVIAQISRLCGVDHIHTGTAgLGKLAN--EDTPGINDWL 329 Natrialba magad...
YP_003239796 245 TAGFSGLLSLRKANLg--LIIHAHRAMYASFARNRRHGISMLVLAKLARLAGVDQLHIGTV-VGKMEGdkEDVLRCHAAL 321 Ammonifex degen...
Feature 1                                     ###                     ##                         
1GEH_A       338 REshykpdendvfhleqkfysIKAAFPTSSGGLHPGNIQPVIEALGTDIVLQLGGGTLGHPDGPAAGARAVRQAIDAIMQ 417 Thermococcus ko...
2CWX_A       334 LSkw---------------ehIRPVFPVASGGLHPGLMPELIRLFGKDLVIQAGGGVMGHPDGPRAGAKALRDAIDAAIE 398 Pyrococcus hori...
Q58632       325 VYdkveadnen-kffnqdwfdIKPVFPVSSGGVHPRLVPKIVEILGRDLIIQAGGGVHGHPDGTRAGAKAMRAAIEAIIE 403 Methanocaldococ...
Q8THG2       326 VLdtvpadpeq-hvlaqdwggLKPMFPVASGGLAPTMIPDLYSIFGKEVIMQFGGGIHAHPMGTAAGAAACRQALEASLE 404 Methanosarcina ...
O28635       335 SEveytpdegdafhlsqnfhhIKPAMPVSSGGLHPGNLEPVIDALGKEIVIQVGGGVLGHPMGAKAGAKAVRQALDAIIS 414 Archaeoglobus f...
YP_920628    337 REqtykpdiedglhmqqpfpgIKPAFPVSSGGLHPGTLPAVIKAMGVDTVIQVGGGVVGHPDGPRAGAAAARQAVEAYLE 416 Thermofilum pen...
YP_001012710 335 REqyyrpkegdlfhleqpwsnIKPVFPVASGGLHPGTLPEVIRVMGKDIIMQVGGGVLGHPDGPEAGARAVRQAVEAAMK 414 Hyperthermus bu...
YP_001404266 326 RKqkiqevshq--claqdwgtIKTAFPVSSGGLHPGLVPDVLDIYGTDLVLLVSGGIHGHPKGTRAGAKATMQAIEAWQE 403 Candidatus Meth...
ZP_03694170  330 HGnc---------------hgLNPVLPVASGGLHPGVVDQLIDALGTDICVQAGGGIHGHPDGTHAGAKALRQATDASLD 394 Natrialba magad...
YP_003239796 322 GNaspvsgdl---lrpqdwgeIKPVLSVASGGLHPGHIPDLISIFGVDCVLQFGGGVHGHPRGTRAGASAVRAAVEAATS 398 Ammonifex degen...
Feature 1                               
1GEH_A       418 gipLDEYAKT--HKELARALEKW 438 Thermococcus kodakarensis
2CWX_A       399 gvdLDEKAKS--SPELKKSLREV 419 Pyrococcus horikoshii OT3
Q58632       404 gksLEEKAEE--VAELKKALEYW 424 Methanocaldococcus jannaschii
Q8THG2       405 gisLQDYAKD--HKELEAALGKW 425 Methanosarcina acetivorans
O28635       415 aipLEEHAKQ--HPELQAALEKW 435 Archaeoglobus fulgidus
YP_920628    417 gvpLQEYAKT--HRELARALEKW 437 Thermofilum pendens Hrk 5
YP_001012710 415 gisLDEYARE--HRELARALEKW 435 Hyperthermus butylicus DSM 5456
YP_001404266 404 gitLDEKAKK--AKELKEALAKW 424 Candidatus Methanoregula boonei 6A8
ZP_03694170  395 gvpLEEYAQDpaHAELATALKKW 417 Natrialba magadii ATCC 43099
YP_003239796 399 gqsFQEVARR--EKTLEEAIMHW 419 Ammonifex degensii KC4

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap