2ZVI,3FK4,2OEM


Conserved Protein Domain Family
RLP_DK-MTP-1-P-enolase

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cd08209: RLP_DK-MTP-1-P-enolase 
Click on image for an interactive view with Cn3D
2,3-diketo-5-methylthiopentyl-1-phosphate enolase
Ribulose bisphosphate carboxylase like proteins (RLPs) similar to B. subtilis YkrW protein, have been identified as 2,3-diketo-5-methylthiopentyl-1-phosphate enolases. They catalyze the tautomerization of 2,3-diketo-5-methylthiopentane 1-phosphate (DK-MTP 1-P). This is an important step in the methionine salvage pathway in which 5-methylthio-D-ribose (MTR) derived from 5'-methylthioadenosine is converted to methionine.
Statistics
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PSSM-Id: 173974
View PSSM: cd08209
Aligned: 12 rows
Threshold Bit Score: 598.535
Threshold Setting Gi: 251772169
Created: 7-Jan-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:2OEM, Geobacillus kaustophilus 2,3-diketo-5-methylthiopentyl-1-phosphate enolase with bound Mg and 2,3- diketohexane-1-phosphate, contacts 4A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
2ZVI_A        24 LLATYLLtepgadteKKAEQIATGLTVGSWtdlplvkqEQMQKHKGRVIKVEeregta-------asekqaVITIAYPEI 96  Bacillus subtilis
3FK4_A         4 IIATYLIhddshnleKKAEQIALGLTIGSWthlphllqEQLKQHKGNVIHVEelaehehtnsylrkkvkrgIIKIEYPLL 83  Bacillus cereus...
2OEM_A         4 VMATYLLhdet-dirKKAEGIALGLTIGTWtdlpaleqEQLRKHKGEVVAIEelgeservnayfgkrlkraIVKIAYPTV 82  Geobacillus kau...
YP_003011206   5 CVATYRCfdekadfdKKALSIAVGLTVGSWtelpearkAEMEKHLGKVLSVDvheeag--------seryaDIRIAYPDI 76  Paenibacillus s...
YP_002774371   6 ILVTYLTqak--dlnKKAQAIAVGMTVGSWtdlplakqAMLAPYLGEAVSATpiatle-------ngetrgLITVSYPTR 76  Brevibacillus b...
YP_003183549  12 VVATYRLrdrkdkleARAEGIAVGLTIGTWtdlpaarkSEVAKHCGRVEGIRvlderp-------dgdvvaEIDIAYPVA 84  Alicyclobacillu...
A8YER2         3 IIVDYRFppai-naeKQAKTIAIGQTAGTWserhshrqKQLQQHLAEVVGIReead------------gykVARVRFPQI 69  Microcystis aer...
ZP_05291875   19 IEVDYRFppga-dgaRQAQMLAVGQTAGSWharhshreKELRSHLGEVRSLAlqed------------ggtVATIAFPRG 85  Acidithiobacill...
EDZ40332       4 IVVTYRFgpga-dpaKEARIIAVGQTAGTWderwssrsADLGRHLGKVQDVRsve-------------ggfEADVAFPAL 69  Leptospirillum ...
B1YIY2         4 ITATYQLgttd-qlpKRAEQIALGLTVGSWtdlnhleqQQLESFKGQVVHTEehd-------------gkgYITIRYPEH 69  Exiguobacterium...
YP_002885808   3 IIATYEIkhtd-hieRVAEKIAHELTVGTWtelnhleqYQLQAFRGEVIATSqqe-------------ttsRFSIRYPLH 68  Exiguobacterium...
EES52739      12 IRVLYEFpqgv-dpkRQGQILALGQTVGSLspgmakqiGDYQGILESFEVLPdg---------------rgQAWVGYPLR 75  Leptospirillum ...
Feature 1                       #                                              # #               
2ZVI_A        97 NFsqdiPALLTTVFGKLSLDGKIKLIDLHFSEAFkralpGPKFGVYGIRKLLGefeRPLLMSIFKGvIGRDLSDIKEQLR 176 Bacillus subtilis
3FK4_A        84 NFspdlPAILTTTFGKLSLDGEVKLIDLTFSDELkkhfpGPKFGIDGIRNLLQvhdRPLLMSIFKGmIGRNIGYLKTQLR 163 Bacillus cereus...
2OEM_A        83 NFsadlPALLVTTFGKLSLDGEVRLLDLEFPDEWkrqfpGPRFGIDGIRDRVGvhnRPLLMSIFKGmIGRDLAYLTSELK 162 Geobacillus kau...
YP_003011206  77 NFsrdiPALLVTIFGKLSMDGKIKLIDLNVSEQFqsafpGPKYGLEGVRQLLGvhdRPLLMSIFKSvVGHDLPNLQEQFY 156 Paenibacillus s...
YP_002774371  77 NFtadiPSLLTGIFGKLSMDGKIKLVDIVFPESFlqafpGPKFGIDGLRERLGahnRPLLMSIFKScLGLPFDDLKTQFR 156 Brevibacillus b...
YP_003183549  85 NLngtfASLLVTVFGKLSMDGEIRLERLQMPDELvrqfpGPKFGVEGVRRRLGaynRPLVMSIFKAcAGLTLDELVEAFG 164 Alicyclobacillu...
A8YER2        70 NVendiASLLTMIFGKYSMAGAGKVVGVYLPESYg---tKAKLGITGIRQRLGvydRPLVMAIFKPaLGLSAQDHADILR 146 Microcystis aer...
ZP_05291875   86 NLdgsmGALLTMIFGKYSLGGVARILALRLPADYg---lRPRFGLPGLRQRLDvhgRPLIMAIFKPaLGLDAAGHAEILA 162 Acidithiobacill...
EDZ40332      70 NVpdgvGALLTMIYGKYSLSGRSRIVDVRLPEEWg---lPPRFGIQGIRQRTGvrgRPLFMGIFKPsLGLSPSDLAKILG 146 Leptospirillum ...
B1YIY2        70 NVsrdfSAILTTVFGKLSLDGQIKLTDLQLPASFttdfpGAKFGIEGVRQLIQvhdRPLLMSIFKGvIGRDLTFLREQLE 149 Exiguobacterium...
YP_002885808  69 NVtpdfSSILTTTFGKLSLDPNVQLVDLSLPEELapdfpGAAFGVEGVRDILRvhdRPLAMSIFKGvIGRDLDFLATQLR 148 Exiguobacterium...
EES52739      76 NVsgdlGSLLVMVLGKYSLAGPAKIRKLDLPSNYg---tRGRWGFEGISRLAKvsgRPLFMAIFKPaLGLSPDELARILR 152 Leptospirillum ...
Feature 1                  ####                                                                  
2ZVI_A       177 QQALGGVDLIKDDEIFFETgLAPFETRIAEGKQILKETYEq--tGHKTLYAVNLTGrtaDLKDKARRAAELGADALLFNV 254 Bacillus subtilis
3FK4_A       164 DQAIGGVDIVKDDEILFENaLTPLTKRIVSGKEVLQSVYEt--yGHKTLYAVNLTGrtfDLKENAKRAVQAGADILLFNV 241 Bacillus cereus...
2OEM_A       163 KQALGGVDLVXDDEILFDSeLLPFEKRITEGKAALQEVYEq--tGKRTLYAVNLTGktfALKDKAKRAAELGADVLLFNV 240 Geobacillus kau...
YP_003011206 157 KQALGGVDLIKDDEILFENpLTPLEKRVEVCMEAARKAQQe--tGQKLLYAVNLTGptsQLASQARKAIAAGANALLFNV 234 Paenibacillus s...
YP_002774371 157 AQALGGVDLVKDDEIFFADdRAPFIERIKAFKQIAQETEAe--tGKPVLYAANLTGpvhELNEKAKRAVEAGADCLLFNV 234 Brevibacillus b...
YP_003183549 165 EQAEGGVDLVKDDEIFFTEaYATPEDRVRAYAAKADEIAQr--tGRRTAYAVNLTGpvhSLRERARRLAELGAGALLVNV 242 Alicyclobacillu...
A8YER2       147 EVAFAGLDVIKDDEIMADLpVAPTHERLDCCRRVLEEVRQq--tGRNVLYAVNVTGkadELQRKARLLVKHGANALLLNV 224 Microcystis aer...
ZP_05291875  163 QAAMAGLDIIKDDEILPDLaEAPVLERWRACAPIIEARRDr--sGRDLLYAVNLSGdarSLQEQARRLVAEGANALLLNV 240 Acidithiobacill...
EDZ40332     147 ETAEAGLDIIKDDEIMPDLpGCTALDRIRACRPVLEKARQkrpgQGAMLYAVNLSGsgaGLHEKARLLVKEGANALLLSA 226 Leptospirillum ...
B1YIY2       150 AQLAGGIDLVKDDEILYDNpLTPALDRARIGRDVLNAHYEk--tGKRALYAITLSGsvfGLKDQTKRLIEAGATAFLLNT 227 Exiguobacterium...
YP_002885808 149 DQFAGGIDLVKDDEILYDNpLTPSLERARIGSSIIQEHKEl--tGRSVLYAVTLSGpvfTLRDQAKRLIEAGATALLFNV 226 Exiguobacterium...
EES52739     153 EVGEAGLDLIKDDEILPDTpASTALSRIKACRPVLDEIERt--qKRTMLYAVTLSGradTLIDSARRLRDAGANAYLLSP 230 Leptospirillum ...
Feature 1                               ##                                #                      
2ZVI_A       255 FAYGLDVMQGLAEDpeipVPIMAHPAVSGAFTSSpfygFSHALLLGKLNRYCGADFSLFPSPYGSvalPRADALAIHEEC 334 Bacillus subtilis
3FK4_A       242 FAYGLDVLQSLAEDdeipVPIMAHPAVSGAYSASklygVSSPLLLGKLLRYAGADFSLFPSPYGSvalEKEEALAISKYL 321 Bacillus cereus...
2OEM_A       241 FAYGLDVLQALREDeeiaVPIMAHPAFSGAVTPSefygVAPSLWLGKLLRLAGADFVLFPSPYGSvalEREQALGIARAL 320 Geobacillus kau...
YP_003011206 235 LSYGYDVLHELSKDseinVPIAAHPAMAGAFYPSphygISASVLLGKLMRLAGADLVLFPSPYGSvvmPKEENMAVKDAL 314 Paenibacillus s...
YP_002774371 235 LAFGFDALHRLAADpdvhVPIMAHPALAGAYYPSpdygIATPLLLGTLMRVAGADLVLFPSPYGNvalDKTEALQLAKHL 314 Brevibacillus b...
YP_003183549 243 VAYGYDVVADLARDpdvdVPILAHPAVSGALYGSpnygIAADIVLGQLMRLAGADIGIFPSMYGSvtlGREATDRLLQHL 322 Alicyclobacillu...
A8YER2       225 LTYGFSVLEALASDpaidVPIFAHPAFAGAMCAGsdtgLAYSVVLGTMMAHAGADAVLYPAAYGSlpfDPQEEGKIRDIL 304 Microcystis aer...
ZP_05291875  241 LTYGFAVLEALVRDpevaVPIFAHPAFAGALCGApehgLAYGVVLGTLMAHAGADAVLYPAHYGSlpfSAADETAIVAAL 320 Acidithiobacill...
EDZ40332     227 PAYGYALLEELASDpevgVPLFVHPAFAGAYSGAsdhgLDWGIVLGTLPVRAGADAVLYPAHYGSlpfSSSNERRIVGKL 306 Leptospirillum ...
B1YIY2       228 FTYGLDVLRELAADpdisVPIFNHPALSGALIASpeygIAAPVLLGTLPRLAGADLTLFPSPYGNvalAKDLARGIAVEA 307 Exiguobacterium...
YP_002885808 227 YTYGLDALRELAKDseihVPILAHPAFAGALTGS----IRHSLLFGKLIRLAGADLTLFPSPYGSlstPKDETQQIQTYA 302 Exiguobacterium...
EES52739     231 FAYGLSVMEALASHpdtnLPIFAHPAMAGALGGSpdygFDMSVLLGTLMVHGGADAVLYPTSAGNlpiSSETETNIRETL 310 Leptospirillum ...
Feature 1                      ###                     ##                                        
2ZVI_A       335 VReda-fnQTFAVPSAGIHPGMVPLLMRDFGIDHIINAGGGVHGHPnGAQGGGRAFRAIIDAVleaqpid--ekaeqcKD 411 Bacillus subtilis
3FK4_A       322 TEddasfkKSFSVPSAGIHPGFVPFIVRDFGKDVVINAGGGIHGHPnGAQGGGKAFRTAIDATlqnkpl----hevddIN 397 Bacillus cereus...
2OEM_A       321 TDdqepfaRAFPVPSAGIHPGLVPLIIRDFGLDTIVNAGGGIHGHPdGAIGGGRAFRAAIDAVlagrplr--aaaaenEA 398 Geobacillus kau...
YP_003011206 315 LApsdtlrTSFPVPSAGIHPGLVPLILRDFGTDVVVNAGGGIHGHPmGTAAGGKAFRSAITAAmngvplreaaaqpgnEP 394 Paenibacillus s...
YP_002774371 315 TDplngvrRSFPVPSAGIHPGLVPQLYQDFGLDQIVNAGGGIHGHPgGATAGAKAFVAAIEAVtagrtle--eassesQE 392 Brevibacillus b...
YP_003183549 323 RAegp-hkPVLPAPSAGIYPGLVPRLYQDFGVDLVLNAGGGIHGHPgGARMGGRAFFDAIWAVehgvple--eaakdrPA 399 Alicyclobacillu...
A8YER2       305 RDr-----NVFPVPSAGIRPGIVPQVLGDYGRNVILNAGTGIMDHPsGPASGVRAFFEALARIeagesfd--panlpeGA 377 Microcystis aer...
ZP_05291875  321 RAr-----AVAPVPSAGVHPGTLAQILGDYGCEVILNAGTGIMDHPdGIGPGVLAFFEAWERWqqgeslr--leavppGP 393 Acidithiobacill...
EDZ40332     307 RQg-----GVLPVPSAGIHPGILPRLMDDYGPDVALNAGTGIMDHPmGPAAGVRAFFEALDRWenkesfe--pgsipgGP 379 Leptospirillum ...
B1YIY2       308 TRige-tkTILPVPSAGIHPGLVAQLVHDFGTDSVINAGGGVHGHPqGAAAGVLAFRQALDAAlageslt--saatrqEE 384 Exiguobacterium...
YP_002885808 303 TEshw-tkPILAVPSAGIHPGLVPDLIRDFGTDVVINAGGGIHGHPdGAAAGARAFRQAIDQAigkt--------setDA 373 Exiguobacterium...
EES52739     311 RRg-----GLGPVPSAGVHPGALPRFLPDGNREIILNAGTGIMDHPqGPAAGVRAFHEAWKRWcdkdsfs--peaipdGP 383 Leptospirillum ...
Feature 1                 
2ZVI_A       412 LKLALDKWG 420 Bacillus subtilis
3FK4_A       398 LHSALQIWG 406 Bacillus cereus ATCC 14579
2OEM_A       399 LQKAIDRWG 407 Geobacillus kaustophilus
YP_003011206 395 LQAAIDAWG 403 Paenibacillus sp. JDR-2
YP_002774371 393 LAIALEKWG 401 Brevibacillus brevis NBRC 100599
YP_003183549 400 LRQALEKWG 408 Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446
A8YER2       378 LKQAILEWG 386 Microcystis aeruginosa
ZP_05291875  394 LHRALEKWG 402 Acidithiobacillus caldus ATCC 51756
EDZ40332     380 LKAAVGKWG 388 Leptospirillum sp. Group II '5-way CG'
B1YIY2       385 LRVALDAWG 393 Exiguobacterium sibiricum 255-15
YP_002885808 374 LSTALDAWG 382 Exiguobacterium sp. AT1b
EES52739     384 LKSAVLKWG 392 Leptospirillum ferrodiazotrophum

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