Conserved Protein Domain Family
Fe-ADH-like
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cd08194: Fe-ADH-like 
Iron-containing alcohol dehydrogenases-like
This family contains iron-containing alcohol dehydrogenase (Fe-ADH) most of which have not been characterized. Their specific function is unknown. The protein structure represents a dehydroquinate synthase-like fold and belongs to the alcohol dehydrogenase-like superfamily. It is distinct from other alcohol dehydrogenases which contain different protein domains. Alcohol dehydrogenase catalyzes the reduction of acetaldehyde to alcohol with NADP as cofactor. Its activity requires iron ions.
Links
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Statistics
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PSSM-Id: 341473
Aligned: 50 rows
Threshold Bit Score: 433.496
Created: 3-Aug-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative activemetal binding
Feature 1:putative active site [active site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                      #                                                 
CBL05708       7 PSKILSGVGAinELGANIk-gKGNKALIVTDKFmvqfGNVAKVTNALdacNIEYVVYDGIsgEPTDKMVAEGVKLYQene 85  Megamonas hyper...
YP_885778      8 PRFAKIGAGAadTLGEVIadlGISRPVLVTDRYlvetGQAERLAKTLhaaGSTAAVFSDTvpDPTVESLSAGLELVRahr 87  Mycobacterium s...
YP_001342188   8 PRIMEIGAGAinKLPSIVrslGGSRTLIITDRMmvqlGYVQKIQDLLsvdGFEVDVFDGTepEPTAASIEAGVQCVIdns 87  Marinomonas sp....
OGQ57482       8 PRIMEVGADAseRLPEVLgalGCNHPLIVTDKMmvklGQAQRLQSILeakGISCEIFDDTvpEPTAASIQNGVTRIRegd 87  Deltaproteobact...
ACB93831       8 PRLLRIGAGAsrELASVLqslGLSRPFIVTDAYlqesGRADGLVQGLeasGLTAAVFSHTvpDPTVRSVDAALEAFRqgd 87  Beijerinckia in...
EBA04652      12 PRIIRIGGGValETAEVLqqlGLSRPLIVTDTNlialGHVDTVTDVLanvGIGWGTFDAVveDPTDTCVDEGLAAFNagd 91  Rhodobacterales...
NP_356418      8 PREMLIGGGSrfRLPAVVkslGVHRPLLVCDPVlqklGHADALLQALaeeGIEAAVFSDVveDPTDISIATLVKRISdgg 87  Agrobacterium t...
CEP00319       5 PRLLCIRGGArrEIGSALdqfGIRRPLLITDKFmvkaGHAGELVELAp-aVANMDVFDETvpEPTSYCLEHALNVFRqgg 83  Plasmodiophora ...
EEX12460       7 TGDVRMTPGIsaEAGPILadlGAKRPLVVVDPVvhqlGLADKMLSGLgdaGMTPQIFSAFspDPTDAEAMEAVQIARtvd 86  Citricella sp. ...
EKV30154       8 PRFMLVGGGTagRIAEVLgrmRVDRPLLVTDAAlaetPMFNAALQTLrdsGRCVQVFADTvsTPTDGVVAKGLEMLKagd 87  Caenispirillum ...

Feature 1                ###  #  #                                  ## #                  ##     
CBL05708      86 CDFLIGLGGGSPMDSAKAIGVMvaSDAKKISDFMHksit--vnvPYLVAIPTTAGTGSEATQFTIIADtenNVKMLLAGp 163 Megamonas hyper...
YP_885778     88 ADGIIGFGGGSPMDTAKALAVLs-ANGGDIASYKApssy-tgpaLPIVAVPTTAGSGSEATQFTVITDgetDEKMLCPGl 165 Mycobacterium s...
YP_001342188  88 YDVIVALGGGSPIDSAKAIAILg-KNGGNIRDYKFprqv-netgIPIIAIPTTAGTGSEVTRFTIITDeknDEKMLCVGi 165 Marinomonas sp....
OGQ57482      88 FDAIVALGGGSPIDSAKAMAILa-RHGGVIRDYRFprqv-neagLPLIAIPTTAGTGSEVTRVTIITDettDEKLLCAGi 165 Deltaproteobact...
ACB93831      88 HDCIIGFGGGSPIDTAKAVAVLa-VHGGPMSQYKAphaq-dlpgVPIIAIPTTAGTGSEVTRFTIITDesnDEKMLCAGl 165 Beijerinckia in...
EBA04652      92 YDCIIGIGGGSVLDAAKAISFMs-VNAGHVRDYKAptqi-dkcgPPLILLPTTGGTGSELTRWCVITDtklTEKYNLSGl 169 Rhodobacterales...
NP_356418     88 HDSLVALGGGSAMDTAKAGAIVa-TSGEDLRALKVpriv-dfavMPVIAIPTTAGTGSEVTRAAVVTDtaaSEKMLILGt 165 Agrobacterium t...
CEP00319      84 YDGIVALGGGSPIDLAKAVSVIg-HDDLDLSKYRApnnp--apgYPVVALPTTAGTGSEVTKATVITDsktHEKILCMAp 160 Plasmodiophora ...
EEX12460      87 ADCVVGIGGGSAMDVAKAVALLs-VQTDSLRALSVpriv-dlpaLPILCVPTTAGTGSEVTRAAVITDattHEKLLLLGs 164 Citricella sp. ...
EKV30154      88 FDGIVAFGGGSVMDTAKAMNVLy-CGGGSLRDHALpdhladmrvLPLLCVPTTAGTGSEASRFCAVTEeasGEHLLLSGl 166 Caenispirillum ...

Feature 1                    #       #      #   #                                                
CBL05708     164 sVLPALAVVDPAFTMtaPPSVTAATGVDALCHAVEAYTSRKAQPLsdtFALSAIKKIHKNLPICFADGKneQARMQMALG 243 Megamonas hyper...
YP_885778    166 sFLPIAIVVDYELTVsmPARLTADTGVDALTHAIEAYVSRRAGGFsdaLALAAMQSISKHLRRAYVDGDdrEAREAMMLA 245 Mycobacterium s...
YP_001342188 166 gFMPFAAIVDVNLTLslPPRITADTGIDALTHAIEAYVSQKASPFsdcQALSAMRLIGPNLKEAYINGNniEAREAMMLG 245 Marinomonas sp....
OGQ57482     166 gFMPMAALIDYKLTLslPARTTADTGIDAVTHAIEAYVSRKANPYsdsQALAALTYLGPNLRRACRDGQdeNAREAMMIG 245 Deltaproteobact...
ACB93831     166 aYLPVAALVDYELTLtkPKRLTADTGIDALTHAIEAYVSKKANPFsstFALAAMRAIAPNLRRVFANPDdrPAREAMMLG 245 Beijerinckia in...
EBA04652     170 aCVATAALIDWTFTVtkPARITADTAVDSLTHAIEAFVSRRAFAYtdaFALSAMPLITQHVRTAYTDPEnaVAREGLMLA 249 Rhodobacterales...
NP_356418    166 aALPVAAIIDYELTLtcPYRVTVDTGIDALTHALEALVNRNGNAHseaLALSALKLIGANLEKVADNPDdrDAREAMMLG 245 Agrobacterium t...
CEP00319     161 aFQPVAALVDYEYTMscPKTLTSHTGLDALTHAIESYVSRKRNGFsdaLALAAMGAIGKHIRTACTEPTnrTAREAMMLG 240 Plasmodiophora ...
EEX12460     165 sLQPKVALLDVELTLscPYRVTVDSGLDALSHALEALVNRNATPYsdgLATQAMQLIGKSLETAARVPGdhAARSDMLLG 244 Citricella sp. ...
EKV30154     167 aCVPEGAVVDYELTLdlPRRQTIDAGLNALTHALEAYVSRSASTLsdaLALSALRLIGRALPKVVREPRdaKAREDMMLG 246 Caenispirillum ...

Feature 1                        #   #         #                                                 
CBL05708     244 ATEAGIAFNNSSVTIVHGMSRPIGAlFHIAHGVSNAVLLPACMEFAiqentARFAEIARIMEvatdetddmtAAKAFVAE 323 Megamonas hyper...
YP_885778    246 STQAGMAFSNSSVALVHGMSRPIGGhFHVAHGLSNAMLLPAVTRFSvesaiGRYADCARAMGivgaavadrdAASELVTE 325 Mycobacterium s...
YP_001342188 246 STLAGIAFSSASVALVHGMSRPIGAfFHVPHGLSNAMLLPSVTAFSipsapERYADCARAIGvatstdtteqANQKLLNA 325 Marinomonas sp....
OGQ57482     246 ATLAGIAFSSASVALVHGMSRPIGAfFHVPHGLSNAMLLPSLTAWSlnaapARYAQCARALGaahaadddaaAGQKLIEY 325 Deltaproteobact...
ACB93831     246 ATQAGIAFSNSSVALVHGMSRPIGAhFHVPHGLSNAMLLPAITAFSapvalPLYADCARAMGvareeegdqaSVARLIDE 325 Beijerinckia in...
EBA04652     250 ASQAGMAFSNASVALVHGMSRPIGAhFHVAHGLSNAMLLPAVTAFSvshapQRYAQCARIMGmaepadtdgkACEKLIAG 329 Rhodobacterales...
NP_356418    246 ATHAGLAVSNTSTALIHGLSRPVGAfFHVPHGMSNAMVLPLVTQFSlnsalPHYAAAARALGsaaatdsdqvSGAKLVEA 325 Agrobacterium t...
CEP00319     241 ATQAGMAFSNASVALVHGMARPLGAhFGIPHGLSNAMLLPVVTGFSvqadvARYAACARAMGidvqkgadlrAVELLLEE 320 Plasmodiophora ...
EEX12460     245 ACLAGMAVSHTSTALIHGMSRPIGAaFHVPHGMSNAMLMPLVTEWSaasapQAYGRAAKAMGla-------gDPAALIDA 317 Citricella sp. ...
EKV30154     247 AMEAGMAFSDVSSGLTDGMSRAMSLfFRVPQGIGSAMLLPAVASFGlamapERYALAARAMGiateddeddmAGAKLVGF 326 Caenispirillum ...

Feature 1                                                                         
CBL05708     324 VTRFCKELNIPSVeeilnKNGFTKDDflaqLDKMATDALdsgsPANTMRQPTk-EEIIEIYKKLF 387 Megamonas hypermegale ART12/1
YP_885778    326 LERLCADVEVPTPr----SYGIDEKDwearLPTMAEQALasgsPQNNPRVPTh-DEIVALYREIY 385 Mycobacterium smegmatis str. M...
YP_001342188 326 LETFNRELQVPTLa----EFGADKARfdslVGTMAEQALasgsPSNNPRIPSt-EEMITIYQQLW 385 Marinomonas sp. MWYL1
OGQ57482     326 LRAVNAELSVPTLa----EFGVDRARfdqvITIMAEQALasgsPGNNPQVPTv-PEMVELYRALW 385 Deltaproteobacteria bacterium ...
ACB93831     326 LRQLNADLQVPGPr----AYGIEETRwnslLPLMAEQALasgsPGNNPIVPTs-DQIQTLYRQAW 385 Beijerinckia indica subsp. ind...
EBA04652     330 LQQLNQDLQVPSPs----TNGLDHHAyhekLPLMAEQAMtsgsPQNNPRVPTa-AEIESLYREIW 389 Rhodobacterales bacterium HTCC...
NP_356418    326 FLGLNRRLKVPTPq----EFGIDRSRyldlVPEMVRQGLasgtPANNPRVPTv-AEMTRLYELAY 385 Agrobacterium tumefaciens str....
CEP00319     321 LVRLNHDLHIPTPk----QYGVDHERyfrlVPLMVDQAIasgsPGNNPRIATa-SEMFELYTDAY 380 Plasmodiophora brassicae
EEX12460     318 LKVLNARLEVPSLa----SLGISQETfraaIPEMARQAIasgtPDNNLRRAGe-AQISDLYLTFL 377 Citricella sp. SE45
EKV30154     327 LRRLCAELEVPSPr----AFGIDEEEy---MDALGRMANaalaPVPGAPAVAsaEQVEHLYRQAY 384 Caenispirillum sp. AK4

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