1H29,1Z1N,19HC,2E84,2E84,2A3M,1H29,1QN0,1WR5,1I77,1Z1N,1H29,2CY3,1AQE,1GYO,2BQ4,1H29,1Z1N,3CAO,3H4N,3BXU,1OS6,3H33,3H34


Conserved Protein Domain Family
Cytochrom_C3

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cd08168: Cytochrom_C3 
Click on image for an interactive view with Cn3D
Heme-binding domain of the class III cytochrome C family and related proteins
This alignment models heme binding core motifs as encountered in the cytochrome C3 family and related proteins. Cytochrome C3 is a tetraheme protein found in sulfate-reducing bacteria which use either thiosulfate or sulfate as the ultimate electron acceptors. C3 is an integral part of a complex electron transfer chain. The model also contains triheme cytochromes C7 which function in electron transfer during Fe(III) respiration by Geobacter sulfurreducens (PpcA, PpcB, PpcC, PpcD, and PpcE) and four repeated core motifs as found in the 16-heme cytochrome C HmcA of Desulfovibrio vulgaris Hildenborough which plays a role in electron transfer through the membrane following periplasmic oxidation of hydrogen (resulting in sulfate reduction in the cytoplasm).
Statistics
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PSSM-Id: 173979
View PSSM: cd08168
Aligned: 102 rows
Threshold Bit Score: 33.7512
Threshold Setting Gi: 153006300
Created: 30-Sep-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
heme-binding
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:heme-binding residues [chemical binding site]
Evidence:
  • Structure:1H29: a tetraheme unit from the Desulfovibrio vulgaris Hildenborough 16-heme cytochrome C HmcA binds 4 hemes
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               #  #       #  ###                   #                       #            
1H29_C       260 MKPVAFDHKAHEAKa-nDCRTCHHv--------------rIDTCTachtvngt--adskfvqLEKAMHQpds-----mrS 317 Desulfovibrio v...
YP_002990523  42 GGRVIFTHFVHADEygyECSDCHHddig---------qerPISCGschpv--------afdaKFRAEHQksfp---seeA 101 Desulfovibrio s...
YP_012003     43 GGKVVFDHKKHAADyavPCERCHHesat--------prenVKPCGtchgv--------tfddAFRKNHAaain---dgaS 103 Desulfovibrio v...
YP_460143     42 KFQAAFNSSVHGSN---GCRSCHAdirnldrhmtgqdkpvPVSCAschqq--------iageYRANFHYlqe-----dfR 105 Syntrophus acid...
YP_387076     42 GGKVIFDHKTHAENygiECQTCHHeset--------arpdPMACGdchgv--------avtdEFRKEHVasy----sdeA 101 Desulfovibrio d...
YP_001474443  39 SKPVEFDHLRHTQV---ECTQCHHkneer------gmsftSYKCAschstakk--dksidssYFKAIHGrkalpgdlgtR 107 Shewanella sedi...
2A3M_A        37 KMPVIFNHSSHSSY---QCADCHHpvdg---------kenLAKCAtagchdvfdkkdksvhsYYKIIHDrkat---tvaT 101 Desulfovibrio d...
1WR5_A        16 KQPVVFNHSTHKAV---KCGDCHHpvng---------kkdYQKCAtagchdnmdkkdksakgYYHAMHDkgt----kfkS 79  Desulfovibrio v...
1AQE_A        23 KGDVTFNHASHMDI---ACQQCHHtvpd---------tytIESCMtegchdni-kerteissVERTFHTtkd----sekS 85  Desulfovibrio d...
YP_002991522  44 GIGVVFNHSSHENY---ECIDCHHnikk---------sgePTSCAtchdnysa-mptkgyksYFKAMHYkrnn--akrpS 108 Desulfovibrio s...
Feature 1        #  ##                             #    ## 
1H29_C       318 CVGCHNTRvqqptcagch-----gfikptksdAQCg--VCHV 352 Desulfovibrio vulgaris
YP_002990523 102 CLRCHDDVptgplaeedkpdtesiplraeafhAQCm--DCHE 141 Desulfovibrio salexigens DSM 2638
YP_012003    104 CVTCHHSEyaaakwdh--------dahaqgysPSCt--DCHH 135 Desulfovibrio vulgaris subsp. vulgaris str. Hildenbor...
YP_460143    106 CVDCHRDIhnrqragr---------dikrrtiEQCt--ACHS 136 Syntrophus aciditrophicus SB
YP_387076    102 CVTCHHVEftgvdws----------heehtgyDDCt--ACHH 131 Desulfovibrio desulfuricans subsp. desulfuricans str....
YP_001474443 108 CLSCHVNEqktrsk-------------dkpslTGCtnsSCHK 136 Shewanella sediminis HAW-EB3
2A3M_A       102 CMSCHLEAagsdkd-------------lkkelTGCkksKCHP 130 Desulfovibrio desulfuricans subsp. desulfuricans str....
1WR5_A        80 CVGCHLETagadaa-------------kkkelTGCkgsKCHS 108 Desulfovibrio vulgaris
1AQE_A        86 CVGCHRELkrqgp---------------sdapLACn--SCHV 110 Desulfovibrio desulfuricans
YP_002991522 109 CLGCHVKEfgnd-----------------kemTGCinsACHP 133 Desulfovibrio salexigens DSM 2638

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