1DGF,1QWL,1HBZ


Conserved Protein Domain Family
catalase_clade_3

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cd08156: catalase_clade_3 
Click on image for an interactive view with Cn3D
Clade 3 of the heme-binding enzyme catalase
Catalase is a ubiquitous enzyme found in both prokaryotes and eukaryotes, which is involved in the protection of cells from the toxic effects of peroxides. It catalyzes the conversion of hydrogen peroxide to water and molecular oxygen. Catalases also utilize hydrogen peroxide to oxidize various substrates such as alcohol or phenols. Clade 3 catalases are the most abundant subfamily and are found in all three kingdoms of life; they have a relatively small subunit size of 43 to 75 kDa, and bind a protoheme IX (heme b) group buried deep inside the structure. Clade 3 catalases also bind NADPH as a second redox-active cofactor. They form tetramers, and in eukaryotic cells, catalases are located in peroxisomes.
Statistics
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PSSM-Id: 163712
View PSSM: cd08156
Aligned: 52 rows
Threshold Bit Score: 742.812
Threshold Setting Gi: 25026780
Created: 25-Apr-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:heme binding pocket [chemical binding site]
Evidence:
  • Structure:1DGF: Human erythrocyte catalase binds heme, contacts calculated at 4A
    View structure with Cn3D
  • Comment:these residues are conserved in all heme-catalases

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               #                                        #                               
1DGF_A        64 RIPERVVHAKGAGAFGYFEVTH--DITKYSKAKVFEHiGKKTPIAVRFSTVAGESGSADTVRDPRGFAVKFYTEDGNWDL 141 human
O93662        51 RIPERVVHAKGAGAGGYFEVTA--DVTKYTKAKFLSEiGKRTEVFVRFSTVGGEKGSADSARDPRGFAVKFYTEDGNYDL 128 Methanosarcina ...
Q27487        64 RIPERVVHAKGAGAHGYFEVTH--DISKYCKADIFNKvGKQTPLLIRFSTVGGESGSADTARDPRGFAIKFYTEEGNWDL 141 nematode
Q9XZD5        57 RIPERVVHAKGGGAFGYFEVTH--DITRFCKAKLFEKiGKRTPVFARFSTVAGESGSADTRRDPRGFALKFYTEEGNWDM 134 Toxoplasma gondii
O77229        47 RIPERVVHAKGAGAHGYFEVPSs-DVPKWCKAKFLNKvGKRTPIFTRFSTVGGEKGSSDSERDPRGFAVKFYTEEGNFDM 125 Dictyostelium d...
CAC28086      49 RIPERVVHAKGTGAYGYFEVTN--DLSKYTRAKFLSEvGKKTEVFIRFSTVGGERGSADAKRDPRGTAMKYYTEEGNYDL 126 Methanobrevibac...
XP_786217     66 RIPERVVHAKGAGAFGYFETTH--DISKYCKAAPFESvGKKTPVAIRFSTVGGESGSADTARDPRGFAVKFYSEDGNWDL 143 purple urchin
XP_001752199  46 RIPERVVHAKGAGAHGYFEVTH--DVTDLCKAKLFDEvGKKTPVFARFSTVTGESGFPDTARDPRGFALKFYTEEGNWDM 123 Physcomitrella ...
ABX46064      52 RIPERVVHAKGAGAFGFFEVTHd-TATKYTIAKLFSSvGKRTPVAIRFSTVGGEQGSADTVRDPRGFAIKFYTEEGNWDL 130 buckeye rot agent
EEC45690      73 RIPERVVHAKGAGAFGVFQVTSpePIRSVCKAQVFQS-MEPTPVAVRFSTVGGETGSADTARDPRGFAVKFYTTEGNWDL 151 Phaeodactylum t...
Feature 1          #    #       #                                                                
1DGF_A       142 VGNNTPIFFIRDPILFPSFIHSQKRNPQTHLKdPDMVWDFWSLRPESLHQVSFLFSDRGIPDGHRHMNGYGSHTFKLVNA 221 human
O93662       129 VGNNTPVFFIRDPLKFPDFIHTQKRNPATNCKdPDMFWDFLSLTPESIHQVTILFSDRGTPATYRNMNGYSSHTYKWYNE 208 Methanosarcina ...
Q27487       142 VGNNTPIFFIRDPIHFPNFIHTQKRNPQTHLKdPNMIFDFWLHRPEALHQVMFLFSDRGLPDGYRHMNGYGSHTFKMVNK 221 nematode
Q9XZD5       135 VGNNTPIFFVRDAIKFPDFIHTQKRHPQTHLHdPNMVWDFFSLVPESVHQVTFLYTDRGTPDGFRHMNGYGSHTFKFINK 214 Toxoplasma gondii
O77229       126 VGNNTPVFFIRDPSKFPDFIHTQKRNPQTNCKdPNMFWDFLGQTPESTHQVSILFSDRGTPKSYRHMHGFSSHTLKFVNA 205 Dictyostelium d...
CAC28086     127 VGNNTPIFFIRDAIKFPDFIHTQKRNPKNNLSdADMFWDFMSLTPESIHQATFLFTDRGTPQNYRHMDLFGSHSFMWYNE 206 Methanobrevibac...
XP_786217    144 VGNNTPIFFIRDPMFFPSFIHTQKRNPVTHLKdPDMFWDFITLRPEATHQVSFLFSDRGTPDGYRHMNGYGSHTFKLRNK 223 purple urchin
XP_001752199 124 VGNNTPVFFVRDALKFPDLIHSQKRNPQTHMKdPNAFWDFLSLVPESLHQVLITFSPRGVPDGHRHMHGYGSHTYKWINK 203 Physcomitrella ...
ABX46064     131 VGNNTPIFFIRDPILFPSFIHTQKRLPNTHLKdDNMMWDFFSLRPETLHQQTFLFSDRGILDGYRHMNGYGSHTFANVNA 210 buckeye rot agent
EEC45690     152 VGNNTPIFFIRDPMLFPSFIHTQKRNPATHLAdPDAFWDFIGLRPETTHQVTFLFSDRGTPDGYRHMNGYGSHTFKNVNS 231 Phaeodactylum t...
Feature 1                                                                                        
1DGF_A       222 NGEAVYCKFHYKTDQGIKNLSVEDAARLSQedpDYGIRDLFNAIATGKYPSWTFYIQVMTFNQAETFPFNPFDLTKVWPH 301 human
O93662       209 KGEYFWVQYHFKTDQGIKNLTLEEAEKIGGsdpDHATRDLYEAIKKGDYPSWTLEMQIMTPEQAEDYRFDIRDITKVWPH 288 Methanosarcina ...
Q27487       222 DGKAIYVKFHFKPTQGVKNLTVEKAGQLASsdpDYSIRDLFNAIEKGDFPVWKMFIQVMTFEQAEKWEFNPFDVTKVWPH 301 nematode
Q9XZD5       215 DNEAFYVKWHFKTNQGIKNLNRQRAKELESedpDYAVRDLFNAIAKREFPSWTFCIQVMPLKDAETYKWNVFDVTKVWPH 294 Toxoplasma gondii
O77229       206 QGKPYWVKLHFTSETGIQNYTAEEAAKMSMndpDSATRDLFETIAKGGEPAWKVSIQLMEFEDALKYRFNPFDVTKIWSH 285 Dictyostelium d...
CAC28086     207 KNEYVWVKYHFKTAQGIQNLTNDEAIKMCGenpDHATEDLFNAIEEGNYPEWNVYVQIMTPEEAEKYEFDPFDVTKVWFH 286 Methanobrevibac...
XP_786217    224 DGEYVFCKFHFKCDQGIKNLNRHRAGDLSAtdpDYAIRDLYNSIATGNFPSWSLHIQVMTQEQADKHRDNPFDLTKYWKL 303 purple urchin
XP_001752199 204 EGKAHWVKFHFISDQGIKNLTHERAVELAGinpDYSTEDLFQNIQKGNGPSWTFKVQVMPLEDAASYRYDPFDLTKVWPH 283 Physcomitrella ...
ABX46064     211 QGEVTYVKYHFKTDQGIRNLPVDEAADLASsdpDYAIRDLYNAIERQDFPTWTLYIQTMTPEQAKAESVNPFDVTKIWPH 290 buckeye rot agent
EEC45690     232 NGEAVYVKYHWKTDQGVANLDAEHAARLAAsdpDYATRDLYNAIATGNYPSWTLYVQIMTYAEAAAVDINPFDLTKVWPH 311 Phaeodactylum t...
Feature 1                                                              #   #                     
1DGF_A       302 kdyPLIPVGKLVLNR---NPVNYFAEVEQIAFDPSNMPPGIEASP---DKMLQGRLFAYPDTHRHRLGPNYLHIPVNCPY 375 human
O93662       289 gdfPTMKIGKLVLNR---NPTNYFAEVEQAAFSPANLVPGIGISP---DKMLQGRVFSYHDTHIHRLGPNYNLIPVNAPK 362 Methanosarcina ...
Q27487       302 gdyPLIEVGKMVLNR---NPRNYFAEVEQSAFCPAHIVPGIEFSP---DKMLQGRIFSYTDTHFHRLGPNYIQLPVNCPY 375 nematode
Q9XZD5       295 gdyPLIPVGKLVLDR---NPENYFQDVEQAAFAPAHMVPGIEPSE---DRMLQGRMFSYIDTHRHRLGANYHQIPVNRPW 368 Toxoplasma gondii
O77229       286 kdyPLIQIGRMVLNR---NPENYFAEVEQAAFSPSHMVPGIEPSP---DKMLQGRLFSYPDTHRHRLGVNYQQIPVNCPF 359 Dictyostelium d...
CAC28086     287 gdyPLIPLGKLVLNK---NPENFFAEVEQVAFAPSNFVPGIGPSP---DRLLQGRLFSYEDTQRHRLGPNHHQIPINRAK 360 Methanobrevibac...
XP_786217    304 lhaFYEKRGIVSVNKshvTTHDQSYDQDSGIFKTGNMVKQCLXSPplfLTSLQGRLFSYSDTHRHRLGTNYLQIPVNCPF 383 purple urchin
XP_001752199 284 kdyPLREVGKLKLDR---NPTNHFAEVEQSSFSPAHMVPGIEASP---DRVLQARLFAYDDAGRYRLGSNHLQIPINQCP 357 Physcomitrella ...
ABX46064     291 ssyPLQEVGRLVLNR---NPKNYFAEVEQLAFSPSHMVPGIEPSP---DKMLQGRLFSYPDTQRHRLGPNYQQIPVNKPL 364 buckeye rot agent
EEC45690     312 srfPLHEVGRMTLNR---NPKDYFAEVEQLAFAPSHLVPGIEPSP---DKMLQARLFSYPDTHRHRLGTNYQAIPVNAPR 385 Phaeodactylum t...
Feature 1                                                                                        
1DGF_A       376 r---ARVANYQRDGPMCMQDNqggapNYYPNSfgapeqq------psalehsIQYSGEVRRFnta-----ndDNVTQVRA 441 human
O93662       363 y---SPENSYQRDGFMRVDANggsgpNYWPNSfggpspd------svyleppFGVSGLAARTlyt----hpnDDFVQAGN 429 Methanosarcina ...
Q27487       376 r---SRAHNTQRDGAMAYDNQqh-apNFFPNSfnygktr------pdvkdttFPATGDVDRYesg-----ddNNYDQPRQ 440 nematode
Q9XZD5       369 n--aRGGDYSVRDGPMCVDGNkgsqlNYEPNSvdgfpked----rnaavsgtTTVSGTVACHpqe----hpnSDFEQPGN 438 Toxoplasma gondii
O77229       360 av-kGGVKNYQRDGFMAVNGNggkgpNYQPNSfggpeph------pefaqhkFDVSGFAARQpyn----hpnDDFVQPGD 428 Dictyostelium d...
CAC28086     361 n---AEVNTYQRDGPMTVTDNggsgpNYYPNSfdgpevd------etvtpptIELKAEINRHprp----vedVDFFQTGE 427 Methanobrevibac...
XP_786217    384 a---ARTRSYQRDGPQCVTDNqggapNYFPNSftgptds------ksyeqtkFTCPGEAARYetg-----ddDNYTQAGI 449 purple urchin
XP_001752199 358 f---ARVQNYSRDGLMTVTENggskpNYYPNSfpdl-------------prpDASQPDVHPYktpprkwsmqDDYEQPRA 421 Physcomitrella ...
ABX46064     365 ----VETRTYQRDGFMTVDGNmndapNYFPNSvggpte--------taslryHSYQGDHSVVdkfs--taddDNFSQVGD 430 buckeye rot agent
EEC45690     386 nisaAQQHNYQRDGPMQVTENgagapNYFPNSfggvqpppatahgpelawhaDTVSGQVVRIdtg-----deDNVSQCRD 460 Phaeodactylum t...
Feature 1                                                             
1DGF_A       442 FYVnvlnEEQRKRLCENIAGHLKDa-QIFIQKKAVKNFTEVHPDYGSHIQALL 493 human
O93662       430 LYRdvmtDYDRENLVGNIVSHLSAa-QKRIQLRQTALFFKADRDYGSRVAKGL 481 Methanosarcina barkeri str. Fusaro
Q27487       441 FWEkvldTGARERMCQNFAGPLGEc-HDFIIKGMIDHFSKVHPDFGARVKALI 492 nematode
Q9XZD5       439 FYRtvlsEPEREALIGNIAEHLRQa-RRDIQERQVKIFYKCDPEYGERVARAI 490 Toxoplasma gondii
O77229       429 LYRlm-sEDAKSRFVSNLVGHMSGvtIKEIQVRAVSNFYKADKDLGARLCKGL 480 Dictyostelium discoideum
CAC28086     428 LWRrvlsDEDKDHLVYNIVAHLGNa-QERIQYRQCALFYKAEPEYGTRVAEGI 479 Methanobrevibacter arboriphilus
XP_786217    450 FWRdvlsEADREATVDNMASHIKDa-AEYLQKRTVVQWGKCDEDWGKRLEAKL 501 purple urchin
XP_001752199 422 LWQtm-sKEDQGQTAKNIAGHIQGa-QEFIIQRQMGIFKRCDPSLAQKVEEML 472 Physcomitrella patens subsp. patens
ABX46064     431 FYRktldAAARERLTNNIAGSLVNa-SKPVQARAVANFFKADPDYGQRVQDKL 482 buckeye rot agent
EEC45690     461 FYRnvldQAARARLTDNLAAHLCRa-QPFLRARAIHNFTQVDSTFGAQLKAAV 512 Phaeodactylum tricornutum CCAP 1055/1

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