Conserved Protein Domain Family
srpA_like

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cd08153: srpA_like 
Catalase-like heme-binding proteins similar to the uncharacterized srpA
Catalase is a ubiquitous enzyme found in both prokaryotes and eukaryotes involved in the protection of cells from the toxic effects of peroxides. It catalyses the conversion of hydrogen peroxide to water and molecular oxygen. Several other related protein families share the catalase fold and bind to heme, but do not necessarily have catalase activity. This family contains uncharacterized proteins similar to the Synechococcus elongatus PCC 7942 periplasmic protein srpA, of mostly bacterial origin. The plasmid-encoded srpA is regulated by sulfate, but does not seem to function in its uptake or metabolism.
Statistics
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PSSM-Id: 163709
View PSSM: cd08153
Aligned: 49 rows
Threshold Bit Score: 292.983
Threshold Setting Gi: 119718562
Created: 25-Apr-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative heme
Feature 1:putative heme binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                           #                                     #                      
Q55025        41 LSAIEGTFGV--NVGQRRNHIKGTCAVGNFVATTEAk-tYSRSPLFsGQSIPVVARFSLAGGnp--kAPDTAKNPRGLGL 115 Synechococcus e...
NP_860750     35 ADVFYRLNGNaiKPKQKINHTKGFCASGEFIPHKGIi-sSIDVPLLsQQSIPVEIRYSLGGA-----QQDDRSKPRGMAL 108 Helicobacter he...
NP_207282     28 ADIFYKLNAK--EPKMKINHTKGFCAKGVFLPNAQAkkdLDVPLLN-EKEIPASVRYSLGGV-----AMDDKSKVRGMAL 99  Helicobacter py...
YP_001763267  42 TPDSASREAG--KKVKLRNHAKGFCTSGSFIPNPKLh-nTLAIPFFkQAEIPITARFSLGGTn---pHASDRGAGRFMSL 115 Shewanella wood...
YP_001156828  31 VTGIEHQFGV--TPGQRRNHINGVCVAGSFVGNKAVq-pYSMSPLFsGKVIPVLGRFSLAGGsl--kIPDTAKNPRGMAL 105 Polynucleobacte...
YP_283750     34 VAAVEGVFGV--TPGERRNHIKGTCAAGEFVGTKEAa-kLSRSPLFsGKPVPVVARFSLSGGnp--kAPDVAKSARGMAL 108 Dechloromonas a...
YP_824692     30 LQAFDDVSGL--HPGYRPVHAKGILLSGRFRPSPSGm-sLTKAPHLhRSFTPVTVRFSDFAGvpavpDNDPNASPRGLAI 106 Solibacter usit...
YP_002754782  17 LQMFDQLFGL--HPGFRAAHAKGLMLTGSFTPSARAr-sLTRAAHIqRDSTPVTVRFSNSTGlpqipDNVGDANPRGLAI 93  Acidobacterium ...
YP_348097     47 LDALYATFGK--HPGFRATHAKGLLVNGTFTASLAAa-sLSRAAHLqGKPVPVVLRFSNFSGvpatvDGDPMASPRGVAV 123 Pseudomonas flu...
YP_002801871  37 VAALEDTFGV--TPGERRNHIKGTCASGEFVGLPAVa-aWSRSALFsGQPVPVVARFSLPGGnp--kVPDTARSVRGMAL 111 Azotobacter vin...
Feature 1                      #    #       #                                                    
Q55025       116 QFQlPNNRFLNMALLNTPVFGVASPEGFYENILAirpdpttgKPDPEKVKAFREkYPENKAQAAFLAsnnPPTSYANTSY 195 Synechococcus e...
NP_860750    109 KFQ-GDKDTWTMVMLNTEINFAKNPQEFGQFFEMripq-engKPDTEKIKRLTQkVSSYRNFEAYMKn-iGISSLEHTGF 185 Helicobacter he...
NP_207282    100 KLE-NQNASWTMVMLNTEINFAKNPNEFAQFFEMrip--kngKVDEARIKKLYEeVPSYRNFAAYTKtigISSSVANTPY 176 Helicobacter py...
YP_001763267 116 KID-GDKESLNFVTTNSPVFFASNLEEFFNFQTKv-------KQGAEGKQWLVDnQPNAKAFFDYIKtlpPSASFANSRY 187 Shewanella wood...
YP_001156828 106 EFRlPDGQVQHFTMLNVPVFGAATPESFYDGVVAntpdpatgKPDPEKMAAYKAsHPDAKALGEYLGknnPIASYANSDF 185 Polynucleobacte...
YP_283750    109 QFQlPKGQLHHITMLNTPMFGAANPQTFLDLMQAlqpdpatgKPDPEKMKAFKAsHPDNQAQAQYLAsnnPPASYASSSY 188 Dechloromonas a...
YP_824692    107 RFHlAEHVHTDIIAHSVDGFPARTVEEFVEFLRAiaas-rpeSPKPSPVEVFLAaHPAALAFVQANKp--VPCSFARENF 183 Solibacter usit...
YP_002754782  94 RFHlAEHVHTDIVSHSTNGFPTRDGYEFLDFLRAaaas-gpdVPSPKPIEQFLGtHPAALAFVQAPKp--FPASLARETY 170 Acidobacterium ...
YP_348097    124 RFKlPNGEFTDIVGHSFDGFPVATPLEFLGFLKGiaat-vatPPDPQPLQAFLAeHPRARHFLETPKp--APSSYTSIEY 200 Pseudomonas flu...
YP_002801871 112 EFRlPGGALQHMTMLDTPVFGAAQPKTFLDQILAlkpdpatgKPDPAKLAAFRAsHPDSRAQARFLAehnPPPSFANSSY 191 Azotobacter vin...
Feature 1                                                                                        
Q55025       196 FGLHAFKFINQ-TNQTRLVRWQFVPQDGEkrltdaELQAAPANFLEQKLIERTQDSPVKWDFWITLGQPGDAEDNPTIAW 274 Synechococcus e...
NP_860750    186 YSIHTFYFQAPhKKANIAARWKFVPKDGIkylseqELSKLDKDFLLSSFKSYTKNKPMEYDMYLIYPNKQDVTNDTTALW 265 Helicobacter he...
NP_207282    177 YSVHAFRFKDK-KGKLLPARWKFVPKEGIkylnpqELKQKDSNYLLSAFQQHLKTKPIEYQMYLVFANKNDATNDTTALW 255 Helicobacter py...
YP_001763267 188 FGVNSFLFSAN-NGDIKPGRWSFEPVDGVvnlsqnQLDKLPNNFLKDELLTLIQQKPAIWDLYIQLAEPGDEINDPTVLW 266 Shewanella wood...
YP_001156828 186 YSVHTFKFINK-NNKSTLVRWRFVPQDGVkrlsdeELKTAPTRFLDQDIMNKTQAGVVRWDMVLVIGDPMDEQTNPTIYW 264 Polynucleobacte...
YP_283750    189 WGIHTFKFVDK-KGKATLVRWQFVPQDGEkrlsddELKTAGANFLESALIERAKQGAVRWDMMVSIGQPGDSETDPTVLW 267 Dechloromonas a...
YP_824692    184 FSVSAYEFTDA-SGVSRFGRYRIRPADGAeyldaaAAASAPANFLFDEIRQRVGKGPLEFRIEVQLSAAGDRVDDSTVHW 262 Solibacter usit...
YP_002754782 171 YAVTAFAFTNA-EGHTRYGRYIITPGQGNeyltpeQVAAIGENYHYDELAQRVASQPIRFHLRVQLAEPGDAVDDATLHW 249 Acidobacterium ...
YP_348097    201 FGVNSLVFSNH-ENQEQIVRYRIEPLTGQsligdqQAARMPADYLQDEMTARLARGPAQMRLIAQLAASGDVVEDGSIPW 279 Pseudomonas flu...
YP_002801871 192 FGIHTFKFVDA-TGKATLVRWRFVPEDGEkslsdeELETLPADFLEERLIQRTAQGPVRWDMLVSIGQPGDPENDPTVAW 270 Azotobacter vin...
Feature 1                                                             #   #        
Q55025       275 PSdRQQVKVGTLTLTAa--sPQPg--aACEGINYDPLVLSDGIEPTNdPVLQFRSGVYALSYSKRT 336 Synechococcus elongatus PCC 7942
NP_860750    266 KGaHKETLVGTLKVQK----YNGt---KCNAEVYFPSDLPAGVQPPKdPLFDTRNATYALTFSRRQ 324 Helicobacter hepaticus ATCC 5...
NP_207282    256 KGkHKELLVGTLKVEK----YEGm---GCNKDVYFPADLPKGVEAPTdPLFQIRNEVYGITFSRRQ 314 Helicobacter pylori 26695
YP_001763267 267 PEtRQRLLVGQVLIDGsr-dSESat-mQCDRGIFNPVLLPEGIKPSAdPILNARTPAYIESFIRRQ 330 Shewanella woodyi ATCC 51908
YP_001156828 265 PVdRKEIKAGVLALTSa--sPQQg--gACEKINFDPLAMTSGIAPTNdPVLLFRSPAYANSYAKRL 326 Polynucleobacter sp. QLW-P1DM...
YP_283750    268 PAeRPRIKAGTLTIRS----AEAqkgaPCEPINFDPLVMAPGIQPTDdPVLRFRSPAYAVSFGKRL 329 Dechloromonas aromatica RCB
YP_824692    263 PKdRPQIEFGTIELTSv--vANNd--aEQRQIIFDPIPRVDGIGSSGdPLLEPRANVYLASGRRRR 324 Solibacter usitatus Ellin6076
YP_002754782 250 PEsREVLDLGMLELTAv--lPDSl--aQQKQIIFDPIPRLDGIEPSAdPLLELRAAIYLLSGRRRR 311 Acidobacterium capsulatum ATC...
YP_348097    280 PRnRREVELGLFTLDSlvpaEDQq--aAQQRLDFSPGRLLDGIALSRdPMTLARDRIYQRAVLRRQ 343 Pseudomonas fluorescens PfO-1
YP_002801871 271 PEnREQVKAGTLVLTAa--mPQKg--aACEKVNFDPLVMAEGIAPTDdPILRFRSPAYAVSFAKRQ 332 Azotobacter vinelandii AvOP

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