1U5U


Conserved Protein Domain Family
AOS

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cd08151: AOS 
Click on image for an interactive view with Cn3D
Allene oxide synthase
Allene oxide synthase converts a fatty acid hydroperoxide to an allene oxide, which is an unstable epoxide. In corals, the enzyme is part of a eiconaosid synthesis pathway that is initiated by a lipoxygenase, which generates the fatty acid hydroperoxides in the first step. The structure of allene oxide synthase closely resembles that of catalase, but allene oxide synthase does not have catalase activity.
Statistics
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PSSM-Id: 163707
View PSSM: cd08151
Aligned: 7 rows
Threshold Bit Score: 450.723
Threshold Setting Gi: 60593583
Created: 25-Apr-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
heme bindingdimer interface
Conserved site includes 21 residues -Click on image for an interactive view with Cn3D
Feature 1:heme binding pocket [chemical binding site]
Evidence:
  • Structure:1U5U: cnidarian Plexaura homomalla Allene oxide synthase binds heme, contacts calculated at 4A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                     # ##                                   #            
1U5U_A         36 VFGGLKLKLKKEKFKTLFTLGtTLKGFRRATHTVGTGGIGEITIVNDPK-FPEHEFFTaGRTFPARLRHANLKY------ 108  Plexaura homo...
CAE02881     1795 EEMDQAYKKIVGNLAANLAIT-TMNVKSRYFHRIGVSGRGVLRMYEEIPsFPRHKIFAsGKSFPVIVRHSNSLSa----- 1868 Oryza sativa ...
BAB77350       11 NLLDSESQKIMLELQAMFSAA-GLALRGRGTHTDGIIVKGNLTVLHSSD-VPSHSLFTpGKKYDVIFRHANIVGg----- 83   Nostoc sp. PC...
ABO97194       16 PPNAFGLLVMQLKIAFMFVFG-TLMQKRRPTHPVGVGAIGQFTVIENSK-VPKNAFFTkGKTMPIILRHSNAVGvklads 93   Ostreococcus ...
ZP_01906557    68 PARERELCRTERLAQTMFATR-TLLTGRRGTHFRGVAARGTIDVVAKPE-FPEHDFFTaGRRFPCRLRHANASF------ 139  Plesiocystis ...
ZP_01907093     6 FFEETGLAMHEAFLTTLFAAA-AKKTGGRSTHKIGIGAKGSVEVCAELP-IPEHAFWRpGRRFDLAMRHANLNN------ 77   Plesiocystis ...
YP_001516910    9 EHVDDEFKKLISNIARAFGRT-AQIKGRRATHSYGTVAKGVLKVLDTLD-IPQHQIFSaGKQYPVLLRHANIKGf----- 81   Acaryochloris...
Feature 1                    # #                        ###    # #     #                          
1U5U_A        109 --PDDAGADARSFSIKFADs----------DSDGPLDIVMNTGEANIFWNSPSLEDFVPve-egDAAEEYVYK-----NP 170  Plexaura homo...
CAE02881     1869 --DDDARLDARGAAVRILSdn--------dGEAPLLDLTLKSGKAFYARTIADFATWLVc---gLPAREEQVKr----SP 1931 Oryza sativa ...
BAB77350       84 -aKDDALINGRGSAIRIGNigd------dlSKPRLLDLVLNTGEVFGLPTARLYHQFFG-----SDFHQKSDMla--sGS 149  Nostoc sp. PC...
ABO97194       94 emYDDASLEIRGCALKFSNa----------VDESPFDLHLNTGEFAGFFNLDSFLPFVFq---mATFNDSAYKa---wGM 157  Ostreococcus ...
ZP_01906557   140 --DDDAVVQVRGCALKFADa----------DFDSPYDLVMNTGATAAFWCFWSFMDFAKarvlsLPYRWKAQErwfrrLP 207  Plesiocystis ...
ZP_01907093    78 --LDDLSADYRGAALRLFEpgae----ltdPDAGELDLLMNTGDSTVWCHVAMFAERMR-----LAVRGQLAKfy-erHP 145  Plesiocystis ...
YP_001516910   82 --RDDAILDGRGATVRVLAgdaqaplsdlnLDEGIVDILMSTGRSFILAEALSFARWAA-----GPMKSRAAMl---qEF 151  Acaryochloris...
Feature 1                                    ##                                                   
1U5U_A        171 YYYYNLVEALr---RAPDTFAHLYYYSQVTMPFKAK---DGKVRYCRYRALPGDVDIKEEdesgrlte-------eeqrk 237  Plexaura homo...
CAE02881     1932 HIRDAVWGSL----RSTDSYTVLHYYSNICRLLRFD---DGREMYAKFKLRPADPDVPEDsgkvvprg-------ilppe 1997 Oryza sativa ...
BAB77350      150 LRRYAVEAAL----RNPDSFTELYYHTQLCYEWVDS---KKKSRYARFRLLNPNQSTEGGllddsve----------igp 212  Nostoc sp. PC...
ABO97194      158 KYPTGIKAGIggvrRAPDSYCDLHYYSQTCREFHAL---DGKKRYCKFRLVPYGAGPGTDvgqepflpdeadqnliatth 234  Ostreococcus ...
ZP_01906557   208 VAWLGTIESLr---SLPTSYADMSYYSKIAYPFKAR---DGRRRYAKYRILRPELELESGqindee-----------qrl 270  Plesiocystis ...
ZP_01907093   146 AAEERYWGGLr---RAPDNYEGLAYYSKVTTKYVGV---DGVTRGCRYRLIPHVEGGEWDgvesglptq-----rdfdag 214  Plesiocystis ...
YP_001516910  152 PKIAPIFHEIi---RDPDSYTQLHYYSETTYSFTSLnqqSFFLRYRLVNRQNPSADTGWLkpeevk------------lp 216  Acaryochloris...
Feature 1                                                                                         
1U5U_A        238 iwiFSRHENEKRPDDYLRKEYVERLQKG-PVNYRLQIQIHEASPdd--taTIFHAGILWDKethPWFDLAKVSIKTPLS- 313  Plexaura homo...
CAE02881     1998 tgaIPRDEDDTRPLLFLADDFRRRVGSPdGVRYVFQLQLREVPTdaaardVALDCTRPWDEaefPYIDVGEVSIGRNLP- 2076 Oryza sativa ...
BAB77350      213 rlvLPRKRGDTREKNYLRNEFRQRLTDGnIVEYVLQAQFRSIED------VAVDCSNIWDPntyPWLDIAAIVLNQDESe 286  Nostoc sp. PC...
ABO97194      235 mmkYRRLPNEKRLPDYLRNEFCTKVAGE-AVRYRLQIQLYEATSsd--taEIFNPNKAWGT---EFLDVGVVRLHAALP- 307  Ostreococcus ...
ZP_01906557   271 gyyQSRLPGNDGPYDLLGPEFIGRLSAPlEYRLQIQLWDWEQDRds---vEVLNLCRYWDEdahPWLDLATVTLTEPLP- 346  Plesiocystis ...
ZP_01907093   215 vefTERWPEEERPKDLLRAAYDARLQKE-VIQYRLQIVVRDVIEdw--shPVYDPCLPWDTdehPWVDLARVRAEAPLP- 290  Plesiocystis ...
YP_001516910  217 ldyLPRVASDTRPETYLQDDFRQQVRST-GVSYLLQIQLQPVSDdaamneTAKDCTIPWEEedhPFHDVAVLDLGSILP- 294  Acaryochloris...
Feature 1                 #                             #  ##  ##  # 
1U5U_A        314 PDVLEKTAFNI-ANQPA--SLGLLEAkspeDYNSIGELRVAVYTWVQHLRK 361  Plexaura homomalla
CAE02881     2077 TEETEKLEFNPfLRCPEvdVIPATSCa---QSASIDHGRSLVYEICQRLRN 2124 Oryza sativa (japonica cultivar-group)
BAB77350      287 NDYYQEIAYNP-GNTHYdlKLPNSYSv--dDFASLGVSGALVHYFGSIVRA 334  Nostoc sp. PCC 7120
ABO97194      308 QHSVENLSFGM-NRTPA--CMPLTRPinsqDYNSLNWTRAVVYETSYKIRR 355  Ostreococcus lucimarinus CCE9901
ZP_01906557   347 SQEMEVTRVWL-GHQPPslGISAPTCt--rDYRSLAWARVGVYPHSQRASE 394  Plesiocystis pacifica SIR-1
ZP_01907093   291 HAQLEPLAFSI-AHAPEslGVFPADAa--dDYTSVGDLRSRLYAKAAAKRP 338  Plesiocystis pacifica SIR-1
YP_001516910  295 DELAEALEFNP-YNAPPelSLILAKTa--rETASVNHLRSVVYQISANMRK 342  Acaryochloris marina MBIC11017

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