1GGE,1U5U


Conserved Protein Domain Family
catalase_like

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cd08150: catalase_like 
Click on image for an interactive view with Cn3D
Catalase-like heme-binding proteins and protein domains
Catalase is a ubiquitous enzyme found in both prokaryotes and eukaryotes involved in the protection of cells from the toxic effects of peroxides. It catalyses the conversion of hydrogen peroxide to water and molecular oxygen. Several other related protein families share the catalase fold and bind to heme, but do not necessarily have catalase activity.
Statistics
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PSSM-Id: 163706
View PSSM: cd08150
Aligned: 4 rows
Threshold Bit Score: 359.565
Threshold Setting Gi: 60593583
Created: 24-Apr-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
heme binding
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:heme binding pocket [chemical binding site]
Evidence:
  • Structure:1GGE_A: Escherichia coli catalase HPII binds heme, contacts calculated at 4A
    View structure with Cn3D
  • Comment:these residues are conserved in all heme-catalases
  • Citation:PMID 9931255

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          #                                         #                                
1GGE_A    123 PERIVHA-RGSAAHGYFQPYksl--sdiTKADflsdpNKITPVFVRFSTVQggagSADTVRDIRGFATKFYte------- 192 Escherichia coli
1U5U_A     62 FRRATHT-VGTGGIGEITIVndpk-fpeHEFFt---aGRTFPARLRHANLKy---PDDAGADARSFSIKFAdsd------ 127 Plexaura homomalla
P55495     30 GLRGQHFkQHGCVFATFEVLadlperlrVGLFa---ePKVYTAYIRFSNGAq---IDDTKPDIHGMAIKLTgvagrkile 103 Rhizobium sp. NGR234
Q55025     53 GQRRNHI-KGTCAVGNFVATteaktysrSPLFs----GQSIPVVARFSLAGgnpkAPDTAKNPRGLGLQFQlp------- 120 Synechococcus elon...
Feature 1                 #    #        #                                                     
1GGE_A    193 ----eGIFDLVGNNTPIFFiq-dAHKFPDFVHavkpephwaipqgqsahDTFWDYVSlQPETLHNVMWAmsdrgIPRSYR 267 Escherichia coli
1U5U_A    128 ---sdGPLDIVMNTGEANIfw-nSPSLEDFVPve-------------egDAAEEYVYkNPYYYYNLVEAlr--rAPDTFA 188 Plexaura homomalla
P55495    104 geedaATHDFVLADKPVFFir-nTSDYVRFMAefarsap----rgepplAFIAWLKEnRPEDLPVLLGFrq--qVQDSPL 176 Rhizobium sp. NGR234
Q55025    121 ---nnRFLNMALLNTPVFGvaspEGFYENILAirpdpt-----tgkpdpEKVKAFREkYPENKAQAAFLas-nnPPTSYA 191 Synechococcus elon...
Feature 1                                                                                     
1GGE_A    268 TMEGFGIHTFRLINA---EGKATFVRFHWKPLagkaslvwde---------------aqkltgrdpDFHRRELWEAIEAg 329 Escherichia coli
1U5U_A    189 HLYYYSQVTMPFKAK---DGKVRYCRYRALPGdvdikeedesgrlteeeqrkiwifsrhenekrpdDYLRKEYVERLQKg 265 Plexaura homomalla
P55495    177 AARYWSQVPYAYGLGnahACRYSVVPSKDNLVssips------------------------eargpGYLREAMTDHLTRa 232 Rhizobium sp. NGR234
Q55025    192 NTSYFGLHAFKFINQ---TNQTRLVRWQFVPQdgekrltd------------------aelqaapaNFLEQKLIERTQDs 250 Synechococcus elon...
Feature 1                                                                                     
1GGE_A    330 -dFPEYELGFQLIPEedefkfdfdLLDPTKLIPEelvPVQRVGKMVLNR--NPDnffaENEQAAFHP-GHIVPGLDFTNd 405 Escherichia coli
1U5U_A    266 --PVNYRLQIQIHEAspdd--tatIFHAGILWDKethPWFDLAKVSIKT--PLSp--dVLEKTAFNI-ANQPASLGLLEa 336 Plexaura homomalla
P55495    233 arPAVFDFRVQLNDDtsa----ttIDNPTVEWAT---PVEAVARITIPP--QTFts-aAQLAFGDNLsFTPWHALLEHRp 302 Rhizobium sp. NGR234
Q55025    251 --PVKWDFWITLGQPgd------aEDNPTIAWPSd-rQQVKVGTLTLTAasPQPg--aACEGINYDP-LVLSDGIEPTNd 318 Synechococcus elon...
Feature 1                 #   #        
1GGE_A    406 -------PLLQGRLFSYTDTQISRL 423 Escherichia coli
1U5U_A    337 kspedynSIGELRVAVYTWVQHLRK 361 Plexaura homomalla
P55495    303 l-----gEINEVRRRVYLSSSGLRH 322 Rhizobium sp. NGR234
Q55025    319 -------PVLQFRSGVYALSYSKRT 336 Synechococcus elongatus PCC 7942

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