1OI0,1R5X


Conserved Protein Domain Family
MPN_archaeal

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cd08072: MPN_archaeal 
Click on image for an interactive view with Cn3D
Mov34/MPN/PAD-1 family: archaeal JAB1/MPN/Mov34 metalloenzyme
This family contains only archaeal MPN (also known as Mov34, PAD-1, JAMM, JAB, MPN+)-like domains. These domains contain the signature JAB1/MPN/Mov34 metalloenzyme (JAMM) motif, EXnHS/THX7SXXD, which is involved in zinc ion coordination and provides the active site for isopeptidase activity for the release of ubiquitin from ubiquitinated proteins (thus having deubiquitinating (DUB) activity) that are tagged for degradation. The JAMM proteins likely hydrolyze ubiquitin conjugates in a manner similar to thermolysin, in which the zinc-polarized aqua ligand serves as the nucleophile, compared with the classical DUBs that do so with a cysteine residue in the active site.
Statistics
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PSSM-Id: 163703
View PSSM: cd08072
Aligned: 21 rows
Threshold Bit Score: 148.173
Threshold Setting Gi: 20093654
Created: 6-Oct-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
MPN+ (JAMM)Zinc-binding
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:MPN+ (JAMM) motif
Evidence:
  • Structure:1R5X: Archaeoglobus fulgidus JAMM-like domain
    View structure with Cn3D
  • Comment:Based on literature and mutation studies

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                          #                                                 # #       #
1OI0_A        6 ISRGLLKTILEAAKSAHPDEFIALLSGskd----vmdELIFLPFvsg-svsAVIHLDMLPigmkVFGTVHSHPspscrPS 80  Archaeoglobus fu...
1R5X_A       15 ISRGLLKTILEAAKSAHPDEFIALLSGskd----vmdELIFLPFvsg-svsAVIHLDMLPigmkVFGTVHSHPspscrPS 89  Archaeoglobus fu...
O27052       24 VDSEVMDEVLEIARRSHPHEFAALLEGrqegevlhvtGLIFLPSets-degAVMDVLMLPpftgAVGSVHSHPgpvnlPS 102 Methanothermobac...
ZP_03608495  20 VDREVLESVIYYAKKAYPNEFLAFFDGkikdkilyitSLIFLPGetc-dvgAVVHTEMLPptlkYWGSVHSHPgpsaqPS 98  Methanobrevibact...
NP_613501     9 FDARLLDSLLEASDKNHPDEFFAMLGGsidae-titiDSLIVVPfeasdsgAIFDLLSVHtc-dVIGTFHSHPygdpvPS 86  Methanopyrus kan...
NP_142431     5 IRRELLEYLLELAKSFYPREVAGFLRMkdg----vfeEVLIVPKgffgessVYFDLTLMPhdesIKGTFHSHPspfpyPS 80  Pyrococcus horik...
EEW28067      3 IRRELIEALIEAAKETHPHEFFALLTGkrg----vieEFIFIPFesg-enfASFNLDLVPlgmkIYGTAHSHPssnpyPS 77  Ferroglobus plac...
YP_448170    22 IDEKVVEEIIKIAINADPKEFVALLSGdiensilkitGLIFLPFeas-dtsAVMQVFMMPmtvnAVGSVHSHPgpsnqPS 100 Methanosphaera s...
YP_876231    16 LTKDARDGILTFCKMNHPNEGILVLRGksrkgniridGLVVPPFsetgpafAGFPHSFLPldmsYVGVVHSHPgnsarPS 95  Cenarchaeum symb...
ACF09673     14 LNRETRDGILSFCKMNHPNEGILILRGkskhgnvyidGLVIPPFsetgsdfAGFPHNPLPldpsYVGIVHSHPvgsaePS 93  uncultured marin...
Feature 1         #                                      
1OI0_A       81 EEDLSLFTrfgkYHIIVCYPYdensWKCYNRKGEEVELEVV 121 Archaeoglobus fulgidus
1R5X_A       90 EEDLSLFTrfgkYHIIVCYPYdensWKCYNRKGEEVELEVV 130 Archaeoglobus fulgidus DSM 4304
O27052      103 AADLHFFSknglFHLIIAHPYtmetVAAYTRNGDPVDFEVV 143 Methanothermobacter thermautotrophicus str. Delta H
ZP_03608495  99 GADLKTFSknglFHMIVCLPYsletFMAYDKYGQPISYTVG 139 Methanobrevibacter smithii DSM 2375
NP_613501    87 EDDLMLFKrlgaVHAIAAYPYtpdrVEFYDKSGRNITPVVE 127 Methanopyrus kandleri AV19
NP_142431    81 EGDLMFFSkfggIHIIAAFPYdedsVKAFDSEGREVELEVI 121 Pyrococcus horikoshii OT3
EEW28067     78 SEDLRTFThg-kVHIIIHYPYckncWKAYDSRGNEVVLEVV 117 Ferroglobus placidus DSM 10642
YP_448170   101 NADLSFFGkngyFHMIICRPYsqatIQAYDAFGTPMTFTIK 141 Methanosphaera stadtmanae DSM 3091
YP_876231    96 LADLQNFFg--lISLIVKYPYedddIFAWDSGGREVEISVI 134 Cenarchaeum symbiosum A
ACF09673     94 LTDLNNFFg--lVSIIVKSPYdnddIFAWDSDGKKILLDIV 132 uncultured marine crenarchaeote AD1000-202-A2

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