1OI0,1R5X


Conserved Protein Domain Family
MPN_archaeal

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cd08072: MPN_archaeal (This model is not part of the current CDD release)
archaeal MPN domain
This family contains only archaeal MPN (also known as Mov34, PAD-1, JAMM, JAB, MPN+)-like domains. These domains contain the signature JAB1/MPN/Mov34 metalloenzyme (JAMM) motif, EXnHS/THX7SXXD, which is involved in zinc ion coordination and provides the active site for isopeptidase activity for the release of ubiquitin from ubiquitinated proteins (thus having deubiquitinating (DUB) activity) that are tagged for degradation. The JAMM proteins likely hydrolyze ubiquitin conjugates in a manner similar to thermolysin, in which the zinc-polarized aqua ligand serves as the nucleophile, compared with the classical DUBs that do so with a cysteine residue in the active site.
Statistics
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PSSM-Id: 501541
Aligned: 13 rows
Threshold Bit Score: 170.21
Created: 6-Oct-2009
Updated: 30-Oct-2024
Structure
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Program:
Drawing:
Aligned Rows:
 
Zn binding siteMPN+ (JAMM)
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 3 residue positions
Conserved feature residue pattern:H H DClick to see conserved feature residue pattern help
Evidence:
  • Structure:1OI0: Archaeoglobus fulgidus Af2198, a Jab1/MPN domain protein binds Zn2+

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
1OI0_A         6 ISRGLLKTILEAAKSAHPDEFIALLSGSkd----------------vMDELIFLPFvsg-svsAVIHLDMLPigmkVFGT 68  Archaeoglobus f...
1R5X_A        15 ISRGLLKTILEAAKSAHPDEFIALLSGSkd----------------vMDELIFLPFvsg-svsAVIHLDMLPigmkVFGT 77  Archaeoglobus f...
O27052        24 VDSEVMDEVLEIARRSHPHEFAALLEGRqege------------vlhVTGLIFLPSets-degAVMDVLMLPpftgAVGS 90  Methanothermoba...
CAF28694      20 LARQAADGVITYAKSCHPNEGILILQGKhken------------ttfITGLVIPPFsthgpfySGFSGYELPfdlsYIGT 87  uncultured cren...
ACF09673      14 LNRETRDGILSFCKMNHPNEGILILRGKskhg------------nvyIDGLVIPPFsetgsdfAGFPHNPLPldpsYVGI 81  uncultured mari...
BAE95226       9 IKKSALDSIISYCKMRHPNEAILLLCGKsskd------------tatVERLMIPPFsyfgpyySGFPTLLLPfdrsILGI 76  uncultured cren...
WP_019177987  10 IEADVLDMVNDAAKGSFPHEFAAVLRAEkg----------------iITEILLLPGsisteysATVTLHNLPidlsVVGT 73  Methanomassilii...
WP_086637100   7 IAESTLKMILGVGKSAMPNEMIGLLRAEdg----------------vINDVVFAPGtvtsevsSMVRIDQLPvglkTVGS 70  Methanonatronar...
D4GVJ3        12 IAADALDFALEASAETHPNEYMGLLRGEearrvgv------drdgyvVTDVLIIPGtvsdpysATVRNDLVPndfhAVGS 85  Haloferax volca...
WP_179260058  16 IAEETLEFALESSEATHPSEYMGFLRGTeadrlgm------dsdglvITDILVVPGtesnsvsATVKTNQIPndvkALGS 89  Natrinema halop...
WP_266087882  12 IADETLEFVLETCADSHPNEFMGLLRAEevssprlrfdgeepgsgrvITDVLVIPGttsgeamASVREEMVPanvgGVGT 91  Halorutilus sal...
WP_041909381   4 IKKGLIESLLLASKNVYPNEFFCLLGGKgg----------------tIEEFVVVPAifg-dgfASYSADLIPfdreIIGT 66  
WP_162898518  15 MSIELLNTIFEGAKYLHPKETILMLRGKkkkd------------tihISELVVPPLatyghgfANYPLHLLPmdfsLVGT 82  Candidatus Bath...
Feature 1         # #          #                                       
1OI0_A        69 VHSHPspSCRPSEEDLSLFTRFgkYHIIVCYPYde-nSWKCYNRKGEEVELEVV 121 Archaeoglobus fulgidus
1R5X_A        78 VHSHPspSCRPSEEDLSLFTRFgkYHIIVCYPYde-nSWKCYNRKGEEVELEVV 130 Archaeoglobus fulgidus DSM 4304
O27052        91 VHSHPgpVNLPSAADLHFFSKNglFHLIIAHPYtm-eTVAAYTRNGDPVDFEVV 143 Methanothermobacter thermautotrophicus st...
CAF28694      88 VHSHPsgSMRPSLEDLHNYFGV--VSLIISHPYdy-qTISAFDRNGNSLDLEIS 138 uncultured crenarchaeote
ACF09673      82 VHSHPvgSAEPSLTDLNNFFGL--VSIIVKSPYdn-dDIFAWDSDGKKILLDIV 132 uncultured marine crenarchaeote AD1000-20...
BAE95226      77 MHSHPngSSEPSLTDLNYDFIGy-ISMIVSYPYed-dDIHIYDSRWEKLEFSVE 128 uncultured crenarchaeote 31-F-01
WP_019177987  74 VHSHPgpSNRPSEEDLHLFGSFgnTHIITCLPFdm-kSWRAYDWKGDAVELEVL 126 Methanomassiliicoccus luminyensis
WP_086637100  71 VHSHPsgNPTPSGADREMFSKKgkCHIITANPFem-nDWVAYNKKSEPIELDVV 123 Methanonatronarchaeum thermophilum
D4GVJ3        86 IHSHPngVLRPSDADLDTFGSGr-VHIIIGSPYgp-dDWEAFDQSGEVRDLDVL 137 Haloferax volcanii DS2
WP_179260058  90 IHSHPngVISPSNADLDTFGRGs-VHVIIGAPYrr-tDWRAFDSQGKPTDLNVI 141 Natrinema halophilum
WP_266087882  92 VHSHPsgSIRPSEEDLRTFGSKgaRHIIVGRPYdr-dTWRCYSSEGEGVHLDVL 144 Halorutilus salinus
WP_041909381  67 MHSHPsiYNHPSEADLESFRKFgkVHIIISYPYdl-nTIRAFDNNGKTVQLKVI 119 
WP_162898518  83 VHSHPsgNKTPSDVDFNHFFGR--IMMIVGYPYtseqDVVVYNAQGEKLPLQLT 134 Candidatus Bathyarchaeota archaeon

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