2QLC


Conserved Protein Domain Family
MPN_DUF2466
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cd08071: MPN_DUF2466 
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Mov34/MPN/PAD-1 family
Mov34 DUF2466 (also known as DNA repair protein RadC) domain of unknown function contains the signature JAB1/MPN/Mov34 metalloenzyme (JAMM) motif, EXnHS/THX7SXXD, which is involved in zinc ion coordination and provides the active site for isopeptidase activity. However, to date, the name RadC has been misleading and no function has been determined.
Links
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Statistics
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PSSM-Id: 163702
Aligned: 341 rows
Threshold Bit Score: -1
Created: 6-Oct-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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MPN+ (JAMM)Zinc-binding
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:MPN+ (JAMM) motif
Evidence:
  • Comment:Based on literature and mutation studies
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                         #                                                 # #       #  
2QLC_A         9 RDVFEYMKGRIpde-tkEHLFVLFLStkNQILRHETItigtltaslIHPREIFKAAIResahSIILVHNHPSGDVQPSNA 87  Chlorobium tepi...
Q3AF80       109 DDVYNYLRYKIghk-kqEQVVVLYLNtkNQLCGENIVaiggvnhagVSPGDIFREAVKigayAVIIAHNHPSGDPTPSKE 187 Carboxydothermu...
YP_001530796  33 QEVYNIMKPVFaetddvETLYCLYLDtkNRILAMEKMftgslsstaVYPREIIKRVIAlkssAVVITHNHPTGDPGPSVE 112 Desulfococcus o...
ZP_02083179   52 GMAAEMVWPLFema-drEMALVLSLNtkLEPQALEIAavgglnacsIDCRDIFKHAVLnnaaFIICFHNHPSGDPKPSME 130 Clostridium bol...
ZP_04668153   33 RESVELVKPLFdma-drEMVVVMSLStkLEPLALEIAavgglntcsVDVRDIFKHSLLnnaaYVICFHNHPSGDPEPGLA 111 Clostridiales b...
O67541       115 QEAFEFLKDKFde--rrESLIALYLDlsNRLLDWEVVaignvntvfSKPKDILFKAVKlsanGIIIAHNHPQGEPSPSNE 192 Aquifex aeolicu...
YP_001930821 116 FNYLKFLSKETq-----EHMVALYLNssNHLIAQEVIakgslnvvrVLPRDILYYAIKhncnGIIISHNHPNNDPTPSQE 190 Sulfurihydrogen...
ZP_02178620  108 EDAYTFLRESFdd--rkETLVALYLDlsHRVMHLEVVavgtlnavnANPKDVLRPAVElsayGVLIAHNHPQGLPEPSEG 185 Hydrogenivirga ...
ZP_03289040   51 EEAVDVIKKMIenf-drEMLLSIQLArsGEVINASICsvgsvdcayVFAGGIVRTAVMsgasSVILIHNHPSGNPRASKA 129 Clostridium nex...
YP_002731237 116 FKHIKWLSKEKq-----EKMLVLYTNtmNQLLGEEIVavgslnivnIKPRDIFIPALRynayGIILVHNHPEGSPEPSKE 190 Persephonella m...
Q3AF80       109 DDVYNYLRYKIghk-kqEQVVVLYLNtkNQLCGENIVaiggvnhagVSPGDIFREAVKigayAVIIAHNHPSGDPTPSKE 187 Carboxydothermu...
YP_001530796  33 QEVYNIMKPVFaetddvETLYCLYLDtkNRILAMEKMftgslsstaVYPREIIKRVIAlkssAVVITHNHPTGDPGPSVE 112 Desulfococcus o...
ZP_02083179   52 GMAAEMVWPLFema-drEMALVLSLNtkLEPQALEIAavgglnacsIDCRDIFKHAVLnnaaFIICFHNHPSGDPKPSME 130 Clostridium bol...
ZP_04668153   33 RESVELVKPLFdma-drEMVVVMSLStkLEPLALEIAavgglntcsVDVRDIFKHSLLnnaaYVICFHNHPSGDPEPGLA 111 Clostridiales b...
O67541       115 QEAFEFLKDKFde--rrESLIALYLDlsNRLLDWEVVaignvntvfSKPKDILFKAVKlsanGIIIAHNHPQGEPSPSNE 192 Aquifex aeolicu...
YP_001930821 116 FNYLKFLSKETq-----EHMVALYLNssNHLIAQEVIakgslnvvrVLPRDILYYAIKhncnGIIISHNHPNNDPTPSQE 190 Sulfurihydrogen...
ZP_02178620  108 EDAYTFLRESFdd--rkETLVALYLDlsHRVMHLEVVavgtlnavnANPKDVLRPAVElsayGVLIAHNHPQGLPEPSEG 185 Hydrogenivirga ...
ZP_03289040   51 EEAVDVIKKMIenf-drEMLLSIQLArsGEVINASICsvgsvdcayVFAGGIVRTAVMsgasSVILIHNHPSGNPRASKA 129 Clostridium nex...
YP_002731237 116 FKHIKWLSKEKq-----EKMLVLYTNtmNQLLGEEIVavgslnivnIKPRDIFIPALRynayGIILVHNHPEGSPEPSKE 190 Persephonella m...

Feature 1        #                                  
2QLC_A        88 DKQVTSILKKAGDLlqIELLDHVIVGn-nDWFSFR 121 Chlorobium tepidum TLS
Q3AF80       188 DIDFTGRVKKASEIlgIKLLDHIILGe-nKYISMK 221 Carboxydothermus hydrogenoformans Z-2901
YP_001530796 113 DTRITIRLLVALKSmnVDLHDHIIVGe--GYYSFA 145 Desulfococcus oleovorans Hxd3
ZP_02083179  131 DRKLTKRLEECGKIlgIPLIDHIIVGegpCCYSFK 165 Clostridium bolteae ATCC BAA-613
ZP_04668153  112 DKQITRKIEDGGQLlgIPLIDHIIVGe-tGFYSFR 145 Clostridiales bacterium 1_7_47_FAA
O67541       193 DLNFTERLKKACELlgFELLDHLILSe-gRYFSFR 226 Aquifex aeolicus VF5
YP_001930821 191 DIEFTKKLQTLANElgFDLLDHIIVGk-kDFYSFA 224 Sulfurihydrogenibium sp. YO3AOP1
ZP_02178620  186 DVMFTERLKRACEIlgFELVDHIVVSp-eGYVSFR 219 Hydrogenivirga sp. 128-5-R1-1
ZP_03289040  130 DWDVTKRLAIACKIfnLELLDHIIIGannQKISLK 164 Clostridium nexile DSM 1787
YP_002731237 191 DIKFTGLIKDLSIKmgFELLDHIIVGk-kGYFSFS 224 Persephonella marina EX-H1
Q3AF80       188 DIDFTGRVKKASEIlgIKLLDHIILGe-nKYISMK 221 Carboxydothermus hydrogenoformans Z-2901
YP_001530796 113 DTRITIRLLVALKSmnVDLHDHIIVGe--GYYSFA 145 Desulfococcus oleovorans Hxd3
ZP_02083179  131 DRKLTKRLEECGKIlgIPLIDHIIVGegpCCYSFK 165 Clostridium bolteae ATCC BAA-613
ZP_04668153  112 DKQITRKIEDGGQLlgIPLIDHIIVGe-tGFYSFR 145 Clostridiales bacterium 1_7_47_FAA
O67541       193 DLNFTERLKKACELlgFELLDHLILSe-gRYFSFR 226 Aquifex aeolicus VF5
YP_001930821 191 DIEFTKKLQTLANElgFDLLDHIIVGk-kDFYSFA 224 Sulfurihydrogenibium sp. YO3AOP1
ZP_02178620  186 DVMFTERLKRACEIlgFELVDHIVVSp-eGYVSFR 219 Hydrogenivirga sp. 128-5-R1-1
ZP_03289040  130 DWDVTKRLAIACKIfnLELLDHIIIGannQKISLK 164 Clostridium nexile DSM 1787
YP_002731237 191 DIKFTGLIKDLSIKmgFELLDHIIVGk-kGYFSFS 224 Persephonella marina EX-H1

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