2QLC


Conserved Protein Domain Family
MPN_YfjY-like
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cd08071: MPN_YfjY-like (This model is not part of the current CDD release)
MPN domain of UPF0758 protein YfjY and similar proteins
This family contains uncharacterized UPF0758 family proteins including Escherichia coli UPF0758 protein YfjY. They contain an MPN domain with a modified JAB1/MPN/Mov34 metalloenzyme (JAMM) motif, EXnHNHX7SXXD. The signature motif, EXnHS/THX7SXXD, is involved in zinc ion coordination and provides the active site for isopeptidase activity. Proteins in this family have been referred to as DNA repair protein RadC, however the name RadC has been misleading and no function has been determined.
Links
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Statistics
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PSSM-Id: 501540
Aligned: 86 rows
Threshold Bit Score: 129.112
Created: 6-Oct-2009
Updated: 30-Oct-2024
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Zn binding siteMPN+ (JAMM)
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 3 residue positions
Conserved feature residue pattern:H H DClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on related metal-binding MPN domains with structure
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                            # #         
2QLC_A         9 RDVFEYMKGRIPde--tkEHLFVLFLStkNQILRHETITIGtltaslIHPREIFKAAIResahSIILVHNHPSGDVQPSN 86  Chlorobium tepi...
B5Y6A0       118 EYAARYFSSMLMne--gkEHFWILLLDrkNRPIKHVEISVGssiqttVDPKEILKQVSLtsaqALILIHNHPSGDPSPSR 195 Coprothermobact...
A5FMW5       112 KDAFTIMQPIIGel--phEEFWVLFLNnsNKVISKAQLSKGgiagtiVDVRLVFKLGLEngatGLILCHNHPSGELNPSQ 189 Flavobacterium ...
ABP57311      28 RVSYDIFKEAYDecmqhhEECWVMFLNqaNRLLGLSCISKCgisqtvVDVRIILQTALLahasGIILSHNHPSGNMVASS 107 Bacteroides uni...
Q7MVX9       109 RMAYRTISPFLTdl--pqEEMWVLLLNqsGKIISMENLSRGgvsetsADVRLIMHKAVShlasAIILAHNHPSGTVRPSE 186 Porphyromonas g...
BAH22324     102 EELLKYFKAAIGqs--rkESLRVVYLDrsGHLIYEYIQDCGtidrvpLYVREIIKQGLLidasSIAISHNHPSGDTEPSK 179 Wolbachia endos...
OLP72913     176 QAVLDYCALTIRge---vERFHVLYLDkkNRLISDECLATGtvdhvpVYPREVLKRGLEfnatALILVHNHPSGDPEPSR 252 Symbiodinium mi...
WP_014452880  43 QYVIAEFSPYLRdk--kqEFFLIVLLDkkNKPIKTVEISKGsidtsiVDPKDVVKHATVnsasALILVHNHPSGETEPSD 120 Caldisericum exile
WP_008730550 107 KDLINYLIIKLGkl--kfETFSIICLDvnKRFISMEHIFRGtidsatIYPRDLVEKSLSlgasYVIISHNHPSGVSKPSK 184 Brachyspira ham...
WP_006928779 110 EELIKFCINKLGfk--keEEFWMISLDskYSIIEENLISRGltdkapVYPRKIIEQALQqkahAVLLLHNHPNGNPRASE 187 Caldithrix abyssi

Feature 1         #                                     
2QLC_A        87 ADKQVTSILKKAGDLlqIELLDHVIVGn--nDWFSFRDH 123 Chlorobium tepidum TLS
B5Y6A0       196 EDVAVTKQLKQACELvgAQLLDHIIVGk--nQHVSLARE 232 Coprothermobacter proteolyticus DSM 5265
A5FMW5       190 ADKQITKKIKTAGEIldVKILDHLIITe--tKYYSFVDE 226 Flavobacterium johnsoniae UW101
ABP57311     108 SDNALTSKLKKACEIldITLLDHIILSd--tGYLSYADE 144 Bacteroides uniformis
Q7MVX9       187 QDIQLTQRVQKAATLlgFRLNDHLIIGdd-gAYFSFADE 224 Porphyromonas gingivalis W83
BAH22324     180 EDEDNTLTLAATCENvgMKLIDHIIVTq--kSHFSFYDS 216 Wolbachia endosymbiont of Cadra cautella
OLP72913     253 ADITMTKEINKGCKVlgLTLHDHIIVGi--gRELSLRAL 289 Symbiodinium microadriaticum
WP_014452880 121 EDVFLTKRLIEALNFvnIKVLGHIILGknpeDYFSFASN 159 Caldisericum exile
WP_008730550 185 EDIEITKVLYQAFLMveIKMIDHIIVAg--nSFYSFRED 221 Brachyspira hampsonii
WP_006928779 188 HDITITRAIIIPAKVlnLKVYDHIIVAg--dNYFSFKEE 224 Caldithrix abyssi

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