2KCQ,2KKS


Conserved Protein Domain Family
MPN_like

?
cd08070: MPN_like 
Click on image for an interactive view with Cn3D
Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding)
This family contains archaeal and bacterial MPN (also known as Mov34, PAD-1, JAMM, JAB, MPN+)-like domains. These domains contain the signature JAB1/MPN/Mov34 metalloenzyme (JAMM) motif, EXnHS/THX7SXXD, which is involved in zinc ion coordination and provides the active site for isopeptidase activity for the release of ubiquitin from ubiquitinated proteins (thus having deubiquitinating (DUB) activity) that are tagged for degradation. The JAMM proteins likely hydrolyze ubiquitin conjugates in a manner similar to thermolysin, in which the zinc-polarized aqua ligand serves as the nucleophile, compared with the classical DUBs that do so with a cysteine residue in the active site.
Statistics
?
PSSM-Id: 163701
View PSSM: cd08070
Aligned: 115 rows
Threshold Bit Score: 87.6974
Threshold Setting Gi: 145592281
Created: 6-Oct-2009
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
MPN+ (JAMM)Zinc-binding
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:MPN+ (JAMM) motif
Evidence:
  • Comment:Based on literature and mutation studies

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                         #                                                              
2KCQ_A         6 DILDQIRVHGAda-yPEEGCGFLLGTvtddg-----dnrvaALHRatnrrs-----eqrtrrYELTADDyRAADAAAQeq 74  Salinibacter ru...
YP_741998     14 ARERDRLARLGlarwPEEACGLMLGCdgrvrr----lvlcrNVAArra------------drYLVHARDfLRWDRAAHrl 77  Alkalilimnicola...
YP_342417      8 RPLVNQLLHQAqvkpQQEICGLISARnglpsr----cypinNIAPepq------------rhFFMDPQGqIAAMRRMRee 71  Nitrosococcus o...
YP_112633      4 RCLINQILRLAqaspEREVCGLVGAAagrrmr----cypvpNVAErpe------------crFLLDPKGqIDALRAMRer 67  Methylococcus c...
ZP_05061836   11 RPLAVHLMSLAqrspDAEICGLIGMQdgelst----cypidNIADnpa------------eaFLMDPEQqAAAMRSIKdk 74  gamma proteobac...
NP_294125      7 APLRRALWAQVrrelPRECVGALGGWvrgeqvqahalyplpNVAAdpe------------reYLADPGDlLRVVRAMQre 74  Deinococcus rad...
ZP_05105398   10 RPLVNQLLHQAqlspAQEVCGLIGQLgqqce-----cypieNVAMdas------------vlFALNASEqLAAFKSMKhk 72  Methylophaga th...
YP_074979     25 ENIYRRMINHCyeerPLEACGLLVGAagqvma----gyatdNQARsp-------------vlYRVDDYQlLAAAEEAErr 87  Symbiobacterium...
YP_001380775   5 PEVLDRLRALCeadpEREVCGFVVRRagale-----vvavpNVADryhahdprafprtsrdsYLMDPRAqLRVHEELAat 79  Anaeromyxobacte...
YP_003110342   6 DGVLDAIAAHClrtyPLEACGLLLGDdraive----afpgrNEAHsa-------------rvFTMAPEDvLRAEQRAEra 68  Acidimicrobium ...
Feature 1                # #       #  #                                               
2KCQ_A        75 glDVVGVYHSHPdhpARPSATDLEEATfp------gfTYVIVSvrdgapeaLTAWALapdrsefHREDI 137 Salinibacter ruber DSM 13855
YP_741998     78 glDILGVWHTHPdggARPSGTDREQAWrg-------wSYLIAAvdgraiteLRSWRLrgd--hfIEETL 137 Alkalilimnicola ehrlichei ...
YP_342417     72 geELFGIYHSHPetaPLPSKSDLAQAAyp------gaLYLIISlntkgvleMRGFRLqg----eVYEEI 130 Nitrosococcus oceani ATCC ...
YP_112633     68 geELFAIFHSHPtaaAIPSPADLEFAAyp------eaLHLIVSlgtkgvleMRGFRIgs---ssRPREV 127 Methylococcus capsulatus s...
ZP_05061836   75 neSLFAIYHSHPsspPVPSERDLREVSvn------daYYLIISlntkgvleLAAYQLqeg--avKSVEL 135 gamma proteobacterium HTCC...
NP_294125     75 glDLVALYHSHPhgpAAPSASDRRLAAyp-------vPYLIADpaa---evLRAYLLpg----gEEVEV 129 Deinococcus radiodurans R1
ZP_05105398   73 gqSLFAIYHSHPsspAMPSVIDIEDANys------daLYLIISlntkgvleMRGFYLte----gQTEEV 131 Methylophaga thiooxidans D...
YP_074979     88 grEITAIYHSHVssdPVPSQTDIRQATwp------eaYYIIISlkgr-rprARAWRIvdg--qvSEHRI 147 Symbiobacterium thermophil...
YP_001380775  80 ggEIAAVWHSHVevgAYFSAKDREDAVvdgvplvpgaDYLVLGvrrgrvdeVKRYRFegg--efVESPL 146 Anaeromyxobacter sp. Fw109-5
YP_003110342  69 glEIVGVFHSHThseAFPSPTDVRQAVdd------rwVYVIASlarp-rvdIRAYRIsr----gLVREE 126 Acidimicrobium ferrooxidan...

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap