Conserved Protein Domain Family
MPN_2A-DUB
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cd08067: MPN_2A-DUB (This model is not part of the current CDD release)
MPN domain of histone H2A deubiquitinase
This family includes histone H2A deubiquitinase (Histone H2A DUB;MYSM1; myb-like, SWIRM and MPN domains 1; 2ADUB; 2A-DUB; KIAA19152ADUB, or KIAA1915/MYSM1), a JAMM/MPN+ deubiquitinase (DUB) protein, with possible Zn2+-dependent ubiquitin isopeptidase activity. It contains the SWIRM (Swi3p, Rsc8p and Moira), and SANT (SWI-SNF, ADA N-CoR, TFIIIB)/Myb domains; the SANT, but not the SWIRM, domain can bind directly to DNA. 2A-DUB is specific for monoubiquitinated H2A (uH2A), regulating transcription by coordinating histone acetylation and deubiquitination, and destabilizing the association of linker histone H1 with nucleosomes. 2A-DUB interacts with p/CAF (p300/CBP-associated factor) in a co-regulatory protein complex, where the status of acetylation of nucleosomal histones modulates its deubiquitinase activity. It is a positive regulator of androgen receptor (AR) transactivation activity on a reporter gene; it participates in transcriptional regulation events in androgen receptor-dependent gene activation. In prostate tumors, the levels of uH2A are dramatically decreased, thus 2A-DUB also serves as a cancer-related marker.
Links
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Statistics
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PSSM-Id: 501536
Aligned: 71 rows
Threshold Bit Score: 205.518
Created: 22-Jul-2009
Updated: 30-Oct-2024
Structure
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Aligned Rows:
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Zn binding siteMPN+ (JAMM)
Feature 1: Zn binding site [ion binding site], 3 residue positions
Conserved feature residue pattern:H H DClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on related metal-binding MPN domains with structure
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
Q5VVJ2       571 KQEPFQVKVASEALLIMDLHAHVsmaEVIGLLGGRYsevdKVVEVCAAEPCNSLstglQCEMDPVSQTQA-SETLAVRGF 649 human
NP_001096446 231 KFQPFHVSVSSNALLLLDFHSHLtrsEVVGYLGGRWdtnsQLLSVLRAFPCRARl--rDTESAAAIEEEI-YQSLFLRGL 307 western clawed ...
Q08CH3       223 RFQPFNVAVSSNVLLLMDFHCHLtssEVVGYLGGRWdtntQLLTVLRAFPCRTRl--aDKDAAPAVEEEI-CQNLFMRGL 299 zebrafish
Q8N594       266 KFQPFNVAVSSNVLFLLDFHSHLtrsEVVGYLGGRWdvnsQMLTVLRAFPCRSRl--gDAETAAAIEEEI-YQSLFLRGL 342 human
XP_014342601 223 KFQPFNVAVSSNVLLLVDFHCHLttsEVVGYLGGRWdtntQLLTVLRAFPCRTRl--gDKESASTVEEEI-CQNIFMRGL 299 coelacanth
XP_042198775 245 RFQPFNVAVSSNVLLLVDFHCHLtrsEVVGYLGGRWdtstQLLTILRAFPCRVRl--gDKDSASAVEEEI-CQNLFLRGL 321 elephant shark
XP_040509568 246 KFQPFNVAISSNVLLLLDFHSHLtrsEVVGYLGGRWdtntQLLTVLHAFPCRSRl--gDAEAAGAVEEEI-CQSLFLRGL 322 chicken
XP_029650673 585 KFQPFSVSVTTNSMFLIDFHCHLtssEVLGYLAGKWdqntQHLNILQAFPCLSRl--gDKENAPLIEAEI-RHRMNKSGL 661 East Asian comm...
XP_014680492 245 KIQPYSITVSSSCLFLMDFHCHLtgsEVVGYLAGTWepliHRLTIQRAFPCRCRl--gDKDNALIIEEEI-RQNMTKETL 321 Priapulus caudatus
XP_021963044 339 RLQPFYVKITSEALALADFHCNItgtESLGYISGRWnsdeNSLSMEIAHPCKVLmp-nSSSIDCDIERNRiALEIQRLGH 417 Folsomia candida

Feature 1              # #          #                                                            
Q5VVJ2       650 SVIGWYHSHPaFDPNPSLRDIDTQAKYQsyfs----rggAKFIGMIVSPYnr--nNPLPYSQITCLVISEEisp------ 717 human
NP_001096446 308 SLVGWYHSHPqSPALPSLQDIEAQMDYQlklqg-tensfQPCIGMICGPYfq--mNEGVESSICPFWVMPPaehr----- 379 western clawed ...
Q08CH3       300 SLVGWYHSHPrGPALPSLQDIDSQMDHQlrlqg-ssngfQPCLGIICGPYyh--gNQGVASTITPFWVVPPpeqr----- 371 zebrafish
Q8N594       343 SLVGWYHSHPhSPALPSLQDIDAQMDYQlrlqg-ssngfQPCLALLCSPYys--gNPGPESKISPFWVMPPpemll---v 416 human
XP_014342601 300 SLVGWYHSHPfSHAVPSLQDTDAQMDYQlklqg-snnnfQPCLALICSPYfh--gNPSIESKMAPFWVMPPpeqr----- 371 coelacanth
XP_042198775 322 SLVGWYHSHPfSQALPSLQDIDSQMDYQlklqg-stnsfQPCLALICAPYyh--gNAEVESKISPFWVMPPpeqr----- 393 elephant shark
XP_040509568 323 SLVGWYHSHPfGPALPSLHDIDTQMDYQlklqg-sgngfQPCLALICGPYya--gNPGVESKIAPFWVMPPpeqr----- 394 chicken
XP_029650673 662 SLVGWYHSHPhRSASPTLRDIDCQMTYQlkmkg-vgsvyHPCLGFIIAPYnk--sSKKKESTFRAFWVMPPlveq----- 733 East Asian comm...
XP_014680492 322 ALVGWYHSHPtAPAQPSLKDIDAQLDYQvkln---ltkyHPCIGVVCSSYnp--rSNEKDTAFSFFMAMPPetakvvngq 396 Priapulus caudatus
XP_021963044 418 DVVGWYHSHPkAPPQPSKDDISRQLDYQivmkgasessyIPCVGVIISPLcysnqEDLTTSPVQFFWVMPPpenr----- 492 Folsomia candida

Feature 1                                                    
Q5VVJ2       718 dgsYRLPYKFEVq-----qMLEEPQWGLVFektr---wiiEKYR 753 human
NP_001096446 380 pgdYGIPMDVEVt-----yTQDSFLTNDILhqmm---mlvEFYK 415 western clawed frog
Q08CH3       372 pndHGIPVAVEVt-----yVQDNFLTTDVLnemm---llvEFYR 407 zebrafish
Q8N594       417 efyKGSPDLVRLqe---pwSQEHTYLDKLKis------laSRTP 451 human
XP_014342601 372 pndYGIPMEVEMt-----qVQDGFLTNDVLhemm---lliEFYK 407 coelacanth
XP_042198775 394 sndYGIPMEVEMt-----fVQDAFLTPDVLhemm---lllEYYK 429 elephant shark
XP_040509568 395 pndYGIPMDVEVa-----yIQDGFLTNDVLqemt---llvEFYR 430 chicken
XP_029650673 734 pldYGIPMEIQFs-----iYQNPSLTEELLsemk---alvDFYK 769 East Asian common octopus
XP_014680492 397 trnRRRTNERAVs-----mVTPQKWLADFHfrapdlvkfsETWK 435 Priapulus caudatus
XP_021963044 493 pldIGRPMNIEYdtysptnVNLKQLLEEMAsl-------iQFYK 529 Folsomia candida

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