Conserved Protein Domain Family
MPN_2A_DUB

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cd08067: MPN_2A_DUB 
Mov34/MPN/PAD-1 family: Histone H2A deubiquitinase
This family includes histone H2A deubiquitinase (Histone H2A DUB;MYSM1; myb-like, SWIRM and MPN domains 1; 2ADUB; 2A-DUB; KIAA19152ADUB, or KIAA1915/MYSM1), a member of JAMM/MPN+ deubiquitinases (DUBs), with possible Zn2+-dependent ubiquitin isopeptidase activity. It contains the SWIRM (Swi3p, Rsc8p and Moira), and SANT (SWI-SNF, ADA N-CoR, TFIIIB)/Myb domains; the SANT, but not the SWIRM, domain can bind directly to DNA. 2A-DUB is specific for monoubiquitinated H2A (uH2A), regulating transcription by coordinating histone acetylation and deubiquitination, and destabilizing the association of linker histone H1 with nucleosomes. 2A-DUB interacts with p/CAF (p300/CBP-associated factor) in a co-regulatory protein complex, where the status of acetylation of nucleosomal histones modulates its deubiquitinase activity. 2A-DUB is a positive regulator of androgen receptor (AR) transactivation activity on a reporter gene; it participates in transcriptional regulation events in androgen receptor-dependent gene activation. In prostate tumors, the levels of uH2A are dramatically decreased, thus 2A-DUB serving as a cancer-related marker.
Statistics
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PSSM-Id: 163698
View PSSM: cd08067
Aligned: 28 rows
Threshold Bit Score: 225.224
Threshold Setting Gi: 118400150
Created: 22-Jul-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
MPN+ (JAMM)Zinc-binding
Feature 1:MPN+ (JAMM) motif
Evidence:
  • Comment:Based on literature and mutation studies

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                   #                                                     
Q5VVJ2        571 KQEPFQVKVASEALLIMDLHAHVsmaEVIGLLGGRYSevDKVVEVCAAEPCNSLst-----glQCEMDPVSQTQASETLA 645  human
A0JMR6        542 KKAPFQVKVSCEAMLVLDLHAHVsmaEVIGLLGGRYTesESVVEICAVEPCNSLst-----glQCEMDPVSQTQASEALA 616  African clawe...
XP_001746392  794 HVCPFRVQVDGGALLLMEFHSHMattEIIGFLGGTYDakNQLLTVSLAVPCAAMeedafqreqSVEMAPESGDRARHLIE 873  Monosiga brev...
XP_001420724  195 RTQPFKVTVTSGAELVMDFHAHLcsdEIIGFLGGVYDddAKTLRITRALPARQLvqeh--agvEVELDPESVPAIVETLT 272  Ostreococcus ...
Q5RGA4        511 RQEPYSVIVCAEALIVMDIHAHVsmgEVIGLLGGTYEeeDKVLKICSAEPCNSLst-----glQCEMDPVSQTQASEVLG 585  zebrafish
XP_642011     772 NEQPFTIDVSSNTMIVMDIHSHIsstEVIGMLGGKFNpdTNHITILLAIPCNSIss-----diQCDMDPNSQIAAKEMVN 846  Dictyostelium...
EEY66643       35 LDPPFQVVVHPDAVFVADLHAHLatcEIIGFLGGKWDeaSKTLYIQAAFPCRSLeiegddgstDVEMDPGSEIELRGIIE 114  Phytophthora ...
ACO66887      434 GAQPFKLTVSPAAMLVMDLHAHLctnEVIGYLGGSWDpdTKSLTIERAFPGRGVas-----gmDVEMDPIAEVELKSQVE 508  Micromonas sp...
XP_002405603  173 NQEPFGIHVCVSALLQMDIHSHLletEVIGLLGGYYDehRSCLVVSAAEPCDSVst-----glECEMDSVSQTLSMECLM 247  black-legged ...
XP_972498     560 PEQKYKLRMHLTTLLLMDFHAHTsltEVMGLVAGTWNptKKILTISHYEPCRNIass----atHCDMCPISQSKAAELIH 635  red flour beetle
Feature 1                   # #       #  #                                                        
Q5VVJ2        646 VRGFSVIGWYHSHPaFDPNPSLRDIDTQAKYQsyfs-----------rggAKFIGMIVSPYnr-----------nNPLPY 703  human
A0JMR6        617 SRGYSVIGWYHSHPaFDPNPSIRDIDTQAKYQnyfs-----------rggAKFLGMIISPYnr-----------rNPHPQ 674  African clawe...
XP_001746392  874 KRGMTVVGWYHSHPaFCPNPSLRDIENQQSFQqfltk---------dtdnEPFVGIIAAPYhrlqsesasekharEAATL 944  Monosiga brev...
XP_001420724  273 AKGEGIVGWYHSHPvFATQPSIRDIQNQFEYQkmfarsd-----gesqtiAPFVGAIVGPYdv-----------rNDSQK 336  Ostreococcus ...
Q5RGA4        586 VKGLSVVGWYHSHPaFDPNPSLRDIDTQAKYQsyfs-----------rggAPFIGMIVSPYnp-----------sNSSPQ 643  zebrafish
XP_642011     847 SIGLDIVGWYHSHPnFEPIPSLRDIETQTSFQnlfatssnnnnnnnksmiEPFIGFIVNPYh-------------KNGLI 913  Dictyostelium...
EEY66643      115 NAQLEVVGWYHSHPaFAPDPSVRDIENQTSYQqlfqrpn-----asketlEPFVGLIVGTYdt-----------rRSTPV 178  Phytophthora ...
ACO66887      509 AQNMKVVGWYHSHPvFEPTPSGVDINNQLNYQrlfrd--------epvgvEPFVGFIVGPYdm-----------rLPNQV 569  Micromonas sp...
XP_002405603  248 GKGYDVVGWYHSHPtFVPNPSVRDVTTQRDYQamfs-----------gqgRPFVAAILSPYlp----------lnAAAPQ 306  black-legged ...
XP_972498     636 NRGLDVLGWFHSHPtFAPEPSQQDLETQQDVQmwi------------gskSPCLGVILSPFsa-----------hGALIA 692  red flour beetle
Feature 1                                                                                      
Q5VVJ2        704 SQITCLVISEEisp--------------dgsYRLPYKFEVqqmleep----------qwglvfeKTRWII---EKYR 753  human
A0JMR6        675 SQVACLIISDElsn--------------dgsYRIPYKFEIeymqgep----------qwelvfaKTRWII---EKYR 724  African clawed frog
XP_001746392  945 GDIRCFWVDRShatef-----------hgtaYGTPMHLDYevlvqeq----------iddhlfaDLINLC---NYYE 997  Monosiga brevico...
XP_001420724  337 SDVRMFHCVDFg------------------gEPEPYELKVehagced----------vspdvlrELKGLA---DRFR 382  Ostreococcus luc...
Q5RGA4        644 SQSTCLLVQEEpgp--------------sgsHKFPYQFNMqcsaepp----------dwsevmrRAEWVV---FKYR 693  zebrafish
XP_642011     914 SNFNCITITKQmde--------------tnqYRIPYQLSTsytpsln-----------nqylyqQIDNLF---EKYK 962  Dictyostelium di...
EEY66643      179 SLFRYFHTRGEkvsgg-----------alreIYMPYELLPgrrhfr-------------svlrdEEREKT---RFFP 228  Phytophthora inf...
ACO66887      570 SSVTAFCAQRLmka--------------gatEDVPFEVSYglsddkdvepltvgsmaavvvqnkSTEGRVnptELWR 632  Micromonas sp. R...
XP_002405603  307 ATIAKSLVTKAkwwvvgdghhgasvnasssgSSVPYGFSPkll-------------------ktDTSCIV---EVRR 361  black-legged tick
XP_972498     693 SPFRCMVVDKKenf---------------edQFVPYKFQVdvvaiea----------dfdrffsDLGRIF---HFSK 741  red flour beetle

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