Conserved Protein Domain Family
MPN_eIF3h

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cd08065: MPN_eIF3h 
Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in eIF2h
Eukaryotic translation initiation factor 3 (eIF3) subunit h (eIF3h; eIF3 subunit 3; eIF3S3; eIF3-gamma; eIF3-p40) is an evolutionarily non-conserved subunit of the functional core that comprises eIF3a, eIF3b, eIF3c, eIF3e, eIF3f, and eIF3h, and contains the MPN domain. However, it lacks the canonical JAMM motif, and therefore does not show catalytic isopeptidase activity.Together with eIF3e and eIF3f, eIF3h stabilizes the eIF3 complex. Results suggest that eIF3h regulates cell growth and viability, and that over-expression of the gene may provide growth advantage to prostate, breast, and liver cancer cells. For example, EIF3h gene amplification is common in late-stage prostate cancer suggesting that it may be functionally involved in the progression of the disease. It has been shown that coamplification of MYC, a well characterized oncogene involved in cell growth, differentiation, and apoptosis, and EIF3h in patients with non-small cell lung cancer (NSCLC) improves survival if treated with the Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor (EGFR-TKI), Gefitinib. Plant eIF3h is implicated in translation of specific mRNAs.
Statistics
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PSSM-Id: 163696
View PSSM: cd08065
Aligned: 41 rows
Threshold Bit Score: 193.637
Threshold Setting Gi: 145474959
Created: 21-Jul-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
O15372        37 KQVQIDGLVVLKIIKHYQEegqgteVVQGVLLGLvve-drLEITNCFPFPqhtedda----------------------- 92  human
Q7S9Y9        11 KSVQVEALVVMKIVKHCSTsf--ptVATGSIVGMdnn-gaIEVTNSFQFPsvdvsssdshsdas--------slaaaapr 79  Neurospora cras...
Q9UT48        18 ERVELESLLVMNIIKHCRDsfp-nmGTIGQLVGIdid-gvLQVSSSFESPsvleneesavn---------------ksvs 80  fission yeast
EEQ39553      16 TSIEIEGSVLLSVLRHTSEny--psLYSGSLLGFeddngsIDITHAYPFPypdqyeggs-------------------lr 74  Clavispora lusi...
XP_001423502  11 SNVKLDTIAAMKIIKQANDnp--tvNQYGYLLGIieg-etIEVTNCFPTIdiee-------------------------- 61  Paramecium tetr...
XP_002140525 106 NTVEIDVSVLLRIIKHCMEsyq-tmNASGQLLGMeyg-nkLEITTSFQLPtredllsslashyhnnkidkydkidieeri 183 Cryptosporidium...
XP_001611795  50 TYVEIDSLALIKALKHCKDny--pvPVNGQLLGLdvg-dkLEVTNCLPYPqkrdiynslnrdsnttn---ltekeleera 123 Babesia bovis T2Bo
EEE23316     252 RVVEVDSLVLMKVLKHCKEny--ptPVNGQLLGIdcr-drLEVTNCFPLPqkkdimaqvqrekgi------sekdleeri 322 Toxoplasma gond...
CAY71009       1 MSYELNASVALKIARSGAEhw--phPASGPLFGFpetpdsVKISHVFSFPtnnnhhnqnee--------------gfsfr 64  Pichia pastoris...
XP_001778153  18 RTVQIEGSVALKIVKRCKEcm--paLVTGQLLGLhig-siLEVTNCFPFLks---------------------------- 66  Physcomitrella ...
O15372        93 dfdevqYQMEMMRSLRHVNI--DHLHVGWYQSTy-YGSFVTRALLDSQFSYQHAIEE------------------SVVLI 151 human
Q7S9Y9        80 akanivYQNEMIRHLKEVNV--DANNVGWYTSAt-MGNFINMSFIENQYHYQKENEK------------------TVALV 138 Neurospora cras...
Q9UT48        81 gkarqaHTEAMLNRLQYIGA--VTGHVGWYLGAyvSSFLSSPFFVETQYAYQKANPN------------------SIAFL 140 fission yeast
EEQ39553      75 srsgskYQQEILETLKTLGQ--GVEFQGWFQSTi-SGNFVTSSLIEALAQQQLANKN------------------TFILI 133 Clavispora lusi...
XP_001423502  62 ---eqdQQYEYLDYAKKHHL--DFHKLGLYVITd-QNRHFTLDQFEDINRLQFYVKY------------------AFVLV 117 Paramecium tetr...
XP_002140525 184 leeidkYQTSMVELMHEMRS--DCLVLGWYQIIr-LDDFQDPGIVSTLLSYHSNAECk----------------sAIFLG 244 Cryptosporidium...
XP_001611795 124 ddefvkYQDKMIDLLHDIRV--DCFAIGWYQTLh-FGDVQSKEVIDNLVIYQEAVDK------------------AIMLG 182 Babesia bovis T2Bo
EEE23316     323 deefdkYQDKMAELMHDVNV--DCFTVGWYQTLs-FGDLKNKDIIDSLVLYQEAIDK------------------AIVLG 381 Toxoplasma gond...
CAY71009      65 snvnldFQERTLQELNKAKI--GAQFSGWYLCSq-GGRFITQSVLETMLQFHNQRAKsldr-----------qpeLVLVV 130 Pichia pastoris...
XP_001778153  67 -----cWDVITVGGLVSLGVdsSSYQVQMYQSTy-MGSFQTVELIETLMNYQPRSVGvesieasgrfhgallhpkFFLGG 140 Physcomitrella ...
O15372       152 YDPik---taQGSLSLKAYRLTPKlmevc-kekdFSPEALKKANITFEYMFEEVPIVIKNSHLINVLMWELEkksava-- 225 human
Q7S9Y9       139 HDVsr---ssQGALSLRAFKLSPEfmtay-keakFTTESLRNSKLTYKDIFVELPVNVHNSHLLTSFLHQIPappksaei 214 Neurospora cras...
Q9UT48       141 YDLsq---ssNGTLYMRAYQLTPEfmaah-eektWTASSLNSHNLTPSNVIRELPIVIHNSHLATCLLHSLSepptpast 216 fission yeast
EEQ39553     134 HNMa-----sIGKVDLKAIRLSENfltty-legkWKTKDLEAHKLSFFNIFEEIGITIHNQHLVNLYLASAEpevta--- 204 Clavispora lusi...
XP_001423502 118 YSLqla--ksGHSQPFQAFVINEKya------eiYSKDEIPVLNIKNDKIYRQLPLELLKTPLTQAFLYQYRasiee--- 186 Paramecium tetr...
XP_002140525 245 IDSell--iqGKQNAFKAYTLGNEylsr---ikeYDDNYSIIKGIEFEDILIEIPIYIKYPVLSEAFLLDWAtfdilqs- 318 Cryptosporidium...
XP_001611795 183 FDPms----sTGEISFKAYRASDQllel---yhsSNGDITNFNSLKGTQILVEVPIVVKNSILSECFLSQYVfdnpaqn- 254 Babesia bovis T2Bo
EEE23316     382 FDPml---nsMAKKAFKAYRVNPEfvqk---yheFEQDVSKYSKLRAKDILIEVPLVVVNPFLVEAFLMDWAvhdplqn- 454 Toxoplasma gond...
CAY71009     131 HETsk---arQGLVSFKAYILSPQliqtsqmrekFITKNLRTAELTFSNLLKEVPLTVRNLSLVGGALDGLIpddvs--- 204 Pichia pastoris...
XP_001778153 141 SESircrlcpHPCMSFRYIIHSNKysle--velhLSVIMLREKNSTLKDVFEEIPVKICNFALVSSMMTELEp------- 211 Physcomitrella ...
O15372       226 -------------------dkhelLSLAS------SNHLGKNLqllmDRVDEMSQDIVKYNTYMRN---TSKQQQQkh-- 275 human
Q7S9Y9       215 pmpaslddirrdpvqipahpgfesLDLSI------DPFLEKTCdlllDSIESHYTDLNNHQYYQRQ---LTREQFKit-- 283 Neurospora cras...
Q9UT48       217 ltaea-------aledcesnlpltETFSNfev-slGTRYRKNIelllESTDEFHYEQGNLGFHQRQ---LAREQAKiq-- 283 fission yeast
EEQ39553     205 -------------------nefdnLNFSSns--niTTQLLENLy---SQIDSFNFDQTNFNYYQRQ---LQKEHTKil-- 255 Clavispora lusi...
XP_001423502 187 -------------------kfkneETKFTs----nIQNYGRQLi---ETIEEQVTLSDKINSNTAN---KKEGDKQpell 237 Paramecium tetr...
XP_002140525 319 ------------------tidfieLPSSHkn---nLEFSDKSLlnlaDSIDILSIEQERFIKNHRD---YMKQQYLvk-- 372 Cryptosporidium...
XP_001611795 255 ------------------vsvfdiLDADH------NKYLAHNLefisHSLEALSDNQEKFFRYQRElakLTHQHKQ---- 306 Babesia bovis T2Bo
EEE23316     455 ------------------qadfdsLELDQ------SVYMEKNLsmlsLSLEALGDEQDKLQRYQREs--LKQQQLQk--- 505 Toxoplasma gond...
CAY71009     205 --------------------teseRILALgn---sTQGDLNTIeqllETVDHFNHNQGNFHYYQRL---LSREQQRis-- 256 Pichia pastoris...
XP_001778153 212 ------------------------DVQATqtrpihKSFHGKES----EIFDHVYGRSFHGAAEGMSfltIATMLTEn--- 260 Physcomitrella ...
O15372       276 qYQQRRQQENMQRQSRGEPPLPEED 300 human
Q7S9Y9       284 qWQAKRKAENAARLAAKQSPLPEDE 308 Neurospora crassa OR74A
Q9UT48       284 qWIAKRKAENANRAAENLQPLPLDD 308 fission yeast
EEQ39553     256 qWKQNRKLENAERAKIGESELDPEE 280 Clavispora lusitaniae ATCC 42720
XP_001423502 238 eYLISMNKLYYLAEAIKRETQYTLE 262 Paramecium tetraurelia strain d4-2
XP_002140525 373 qMAERKRIENEQRKLKGENPLPIDT 397 Cryptosporidium muris RN66
XP_001611795 307 -LVERRRLENEQGRLKGEPILPMPE 330 Babesia bovis T2Bo
EEE23316     506 qLLERRRLENDQRRLRGEPLLPADL 530 Toxoplasma gondii GT1
CAY71009     257 qWVSKREQENAATLKRNPNATESEL 281 Pichia pastoris GS115
XP_001778153 261 -AARRAAGEEPLPEEEPNNPIFKTR 284 Physcomitrella patens subsp. patens
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