Conserved Protein Domain Family
MPN_eIF3f

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cd08064: MPN_eIF3f 
Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in eIF3f
Eukaryotic translation initiation factor 3 (eIF3) subunit F (eIF3F; EIF3S5; eIF3-p47; eukaryotic translation initiation factor 3, subunit 5 epsilon, 47kDa; Mov34/MPN/PAD-1 family protein) is an evolutionarily non-conserved subunit of the functional core that comprises eIF3a, eIF3b, eIF3c, eIF3e, eIF3f, and eIF3h, and contains the MPN domain. However, it lacks the canonical JAMM motif, and therefore does not show catalytic isopeptidase activity. It has been shown that eIF3f mRNA expression is significantly decreased in many human tumors including pancreatic cancer and melanoma. EIF3f is a potent inhibitor of HIV-1 replication; it mediates restriction of HIV-1 expression through several factors including the serine/arginine-rich (SR) protein 9G8, and cyclin-dependent kinase 11 (CDK11). EIF3f phosphorylation by CDK11 is important in regulating its function in translation and apoptosis. It enhances its association with the core eIF3 subunits during apoptosis, suggesting that eIF3f may inhibit translation by increasing the binding to the eIF3 complex during apoptosis. Thus, eIF3f may be an important negative regulator of cell growth and proliferation.
Statistics
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PSSM-Id: 163695
View PSSM: cd08064
Aligned: 38 rows
Threshold Bit Score: 262.912
Threshold Setting Gi: 190345304
Created: 23-Jul-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
O00303        92 VRLHPVILASIVDSYERRNEga---aRVIGTLLGTvdk--hsVEVTNCFSVPHNESEd---EVAVDmeFAKNMYELHKKV 163 human
XP_001876563  31 ITIHPVALFSILDHYLRRGEsq---dRVIGTLLGTrfe--neVEVRSSFAVLHSETTe---QVAVDmdYHRTMYELHHKV 102 Laccaria bicolo...
Q4PI88        32 VHVHPVALFSILDHYLRRNDgq---hRVIGTLLGTrte--seIEIKNCFAVPHLEDAee-gQVQVDmeYHRSMYELCQKV 105 Ustilago maydis...
Q5KER5        27 ITVHPSVIAQILTHHSRHSAdse-stRVIGALMGNrsdngqeVDIRSCFAVPHTEQGq---QISVDrpFQQDMVNFLAKN 102 Cryptococcus ne...
Q6C4H1        20 VTVTAQALFQILDHALRREEeq---sKVIGTLVGIrsedgseVEVRNAYAVPHSESEq---EMTIDleYNPTMLALHRKA 93  Yarrowia lipoly...
A8PZS4        33 VKVHPVALFSILDHYLRRDVsq---pRVIGTLLGTrse--seVEVRNAFAVPHGESQdp-wQIHLDaeHHRRMLDLHLRV 106 Malassezia glob...
O43060        23 IVIEPAVLFSILDHSTRKSEnn---qRVIGTLLGTrsedgreIEIKSCFAVPHNESSe---QVEVEmeYHRAMYHLHLKA 96  fission yeast
Q9P748        31 VNIQPQAVFSIIDHAVRRDDrdtqstRVIGALVGVrsedgseVEVRSTFAIPHTENEd---QVEVDveYQKNMLALTLKA 107 Neurospora cras...
EDK37168      71 IKVHNVALFKILEIVAKQVHpd--hkRVIGTMLGYrsedgteFEIRDAFMVPCTETGe---SLAIDdqAHKTFYKLYKKA 145 Pichia guillier...
XP_002141269  39 CRISPLVILSILDSHVRRQLgh---qLVLGTLLGYvne-sgnILISDCFVDKHSFTDdgmlSIMID--THETMFELKQKV 112 Cryptosporidium...
O00303       164 SPNELILGWYATGhDITEHSVLIHEYYSREAp-----------NPIHLTVDTSLqng---rmSIKAYVSTLMGVpgr--- 226 human
XP_001876563 103 NPKEVIVGWYSTGsNLNTYSALIQNFYSQETap---------nQAIHVAVNTGVeeg--qepGVKAFISSPVGVfpk--- 168 Laccaria bicolo...
Q4PI88       106 RPDEVIVGWYATSpELNTYSALIQDFYSRETap---------hQAVHLTMDTTIdgskpsglGIKSYISSPLGAtpk--- 173 Ustilago maydis...
Q5KER5       103 GTKEVIVGWYASQkTVNSNSAIIQEYFSFETnp---------yPAVHLTVDTDIeesg-kglGVKGWVSQPLGLtsk--- 169 Cryptococcus ne...
Q6C4H1        94 FPKEVIVGWYATSsELNTFSGLIHDYYTQLDg----------tPAIHLTVEAANlad---tlLPRTYVASAVGIdpsk-- 158 Yarrowia lipoly...
A8PZS4       107 RPDEVVLGWYSTNtELNSNSALIQDHYSRETap---------hQAIHLTLNTNVadea-nglGVQCYVSALLGAmak--- 173 Malassezia glob...
O43060        97 NPREVVVGWYATSpDLDAFSALIQNLYASPAepgtaplgtyphPCVHLTVNTDVss----plAIKTYVSSPVGIterl-- 170 fission yeast
Q9P748       108 NPRETLLGWYTTShELNSFSALIQNFFASPEtgt------fphPAVHLTIGTEAga----tiDTKTYISAPVAVsper-- 175 Neurospora cras...
EDK37168     146 HPKEYVLGWFGSGkQIDTTTGLIHDFYSKGAdsa------apyPAIHLNVDFVDddqnvtapSISTYIGAAIGRpasgki 219 Pichia guillier...
XP_002141269 113 NSKLQVVGWYSTGtSITPVSCAVHNWFRTDTfsskfqstplllDPIHILVDSSFsng---kiSVSAYTQIPLSWsss--- 186 Cryptosporidium...
O00303       227 --------tmgVMFTPLTVKYay-yDTERIGVDLIMKtcfspnrvigls----------------------------sdl 269 human
XP_001876563 169 --------penCVFVPVPVELrf-hDGERSGLDLLTSaanaststasqp---------------------------iadv 212 Laccaria bicolo...
Q4PI88       174 --------aenCVFLPLPTNLlh-sTPEHSSLSLLASqnisspltd---------------------------------l 211 Ustilago maydis...
Q5KER5       170 --------secSVFVPVPVSIky-aDSERAALDLLTApqptpspalp-------------------------------pl 209 Cryptococcus ne...
Q6C4H1       159 -------nsgnCVFVPISNEVkfndSADRAALEAISSarespersinlt----------------------------sdl 203 Yarrowia lipoly...
A8PZS4       174 --------pedCAFLSLPTHLlm-sTPEQTALRHLAApkpqnitdl---------------------------------- 210 Malassezia glob...
O43060       171 --------adsCAFVPTPFTIrd-dEAVRSGLKAVAApkndpsrlaslf----------------------------tdl 213 fission yeast
Q9P748       176 -------aaesCLFIEVPHKLlf-tDAERGALGSVAAaadaesrsapvv----------------------------sdi 219 Neurospora cras...
EDK37168     220 gwktssssnnsYIFTPIPHEIitgsVTEKLALNGLCEavqigtesgassvsg----------------------aaasdl 277 Pichia guillier...
XP_002141269 187 ---------siSAFQSIPLDIma-sTCERLHISHIIKplldkhhynalglppkilprtilgpedelctvlplnslatnpy 256 Cryptosporidium...
O00303       270 qqvggasaRIQDALSTVlqYAEDVLSGKvs--aDNTVGRFLMSLVNQVPkiv--pdDFETMLNSNINDLLMVTYLANLTQ 345 human
XP_001876563 213 eilersilTVSEMLDRVlsYVRDVLAGKqk--gDPAIGRYLMDTLGASTd-----dLEKGGFNASLQDTLMISYLANLVR 285 Laccaria bicolo...
Q4PI88       212 dalavslkQVQSQLDRVltYVRAVISGEke--gDKAVGRFLNDTISVVPagl-ddnKLETLFNAHLQDVLMVSYLANVVR 288 Ustilago maydis...
Q5KER5       210 ptlsnslsQLSSLIDQClaYVQSVNNGSqt--pDVEIGRYLLEGLGRWSas---gnEDEGGVKAGLQDTLTVEYLSSLVR 284 Cryptococcus ne...
Q6C4H1       204 anlensltQVLDMLERVqtYVARVISGEessekAQQVGKQLLSTLTLTPsld--aqNLEALFNSHLQDVLMVVYLANTVK 281 Yarrowia lipoly...
A8PZS4       211 dalkasleDVQAKLDRVltYVRRVLAGEve--gDKAVGRYLSDTIGVVPagl-desLLESLFQSHLQDVFMVSYLSKLVS 287 Malassezia glob...
O43060       214 qqlrrstlELLSMIERVsdYVQNVIDGSsp--aNVAVGRYLMKCFSLIPcve--gqDFEKIFSSHLQDVLVVVYLANTLR 289 fission yeast
Q9P748       220 enlaqaleTVSDLLERVsgFVGEVLDEErd--gNHALGQYLMNALSLAPkvs--nlAIENDFNNHIQDVLMVSYLANTIR 295 Neurospora cras...
EDK37168     278 sylssqlnAVSATITKLlhHIESPSTSDa----DVDLLRLLSNNLLTKPhfltdvsELKSHFMAHNQDVIMIEYLTKVVK 353 Pichia guillier...
XP_002141269 257 anlntlisKLLLMVQKClvYVQKVQKGEiv--aNSIIGRQIDQAIHMIYdfd--phAFNAAKQVGIQDSLIIGCLTELTK 332 Cryptosporidium...
O00303       346 SQIALNEKL 354 human
XP_001876563 286 SQAEVSSRL 294 Laccaria bicolor S238N-H82
Q4PI88       289 AQAEVSSRL 297 Ustilago maydis 521
Q5KER5       285 SQVELAGRL 293 Cryptococcus neoformans var. neoformans B-3501A
Q6C4H1       282 TQLQLSAKL 290 Yarrowia lipolytica CLIB122
A8PZS4       288 AQAEMSTRL 296 Malassezia globosa CBS 7966
O43060       290 TQVDIASRL 298 fission yeast
Q9P748       296 TQIELSQRL 304 Neurospora crassa OR74A
EDK37168     354 EQIELSARL 362 Pichia guilliermondii ATCC 6260
XP_002141269 333 VQLALAEKL 341 Cryptosporidium muris RN66
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