Conserved Protein Domain Family
MPN_CSN6

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cd08063: MPN_CSN6 
Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in COP9 signalosome complex subunit 6
CSN6 (COP9 signalosome subunit 6; COP9 subunit 6; MOV34 homolog, 34 kD) is one of the eight subunits of COP9 signalosome, a highly conserved protein complex with diverse functions, including several important intracellular pathways such as the ubiquitin/proteasome system, DNA repair, cell cycle, developmental changes, and some aspects of immune responses. CSN6 is an MPN-domain protein that directly interacts with the MPN+-domain subunit CSN5. It is cleaved during apoptosis by activated caspases. CSN6 processing occurs in CSN/CRL (cullin-RING Ub ligase) complexes and is followed by the cleavage of Rbx1, the direct interaction partner of CSN6. CSN6 cleavage enhances CSN-mediated deneddylating activity (i.e. cleavage of ubiquitin-like protein Nedd8 (neural precursor cell expressed, developmentally downregulated 8)) in the cullin 1 in cells. The cleavage of Rbx1 and increased deneddylation of cullins inactivate CRLs and presumably stabilize pro-apoptotic factors for final apoptotic steps. While CSN6 shows a typical MPN metalloprotease fold, it lacks the canonical JAMM motif, and therefore does not show catalytic isopeptidase activity.
Statistics
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PSSM-Id: 163694
View PSSM: cd08063
Aligned: 35 rows
Threshold Bit Score: 217.891
Threshold Setting Gi: 71649286
Created: 27-Aug-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q7L5N1        39 VSVALHPLVILNISDHWIRMRSQegr--------------------pvQVIGALIG--KQEGRn-IEVMNSFELLShtve 95  human
XP_001758955   7 LTFKLHPLVIVNISDHHTRSKAQtgra-----------------grppRVYGCVLG--VQTGRt-VEIFNSFELRYdpv- 65  Physcomitrella ...
Q8W206         9 LTFKLHPLVIVNISDHYTRVKTQlnppasicasghgsnngeamfqqnpRVYGCVIG--VQRGRt-VEIFNSFELLYdps- 84  thale cress
ABC49916      13 LEWKLHPLVLINISDHHTRTRANtpgata-------------pgvpapAVMGCLLG--SQSGRs-VDIRNSFEVRYaagp 76  Chlamydomonas r...
Q54C92        26 LEVDLHPLVLINISDHFTRTKVQsnyq------------------dncRVIGVILG--VQNGRn-VEICNSFEMVYatvd 84  Dictyostelium d...
ACO62709       2 EAYKLHPLALVNISDHYIRFKAQlppe-----------------eeppRVLGCLLG--FQEGNrdLEICNSFELIWtpee 62  Micromonas sp. ...
XP_001745862  15 LSALLHPLVILNISDHLTRRRAEaks-------------------hnvTAYGALFG--KQAGRv-VEIFNSFELLLad-- 70  Monosiga brevic...
EEY65928      31 RQIQIHPLVIVNIADHQTRQKCNsqlsq----------------teapQVIGALFG--IQKGLd-VDVYDSFEMKYdvcn 91  Phytophthora in...
XP_503337     12 VAVALHPLPLLNISNFYTRAVATs-----------------------tEFAGALLG--TQDGRq-VSIDTSFEFKIed-- 63  Yarrowia lipoly...
XP_813372     24 MPIRLQPLVILNITQHATRVWQHsats------------------ttaTALGVLLGrpTVDGG--TEIMSSFEVVGyetg 83  Trypanosoma cru...
Q7L5N1        96 --ekiIIDKEYYYTKEEQFKQVFkelEFLGWYTTGGp---PDPSDIHVHKQVCEII-----ESPLFLKLNPmt------- 158 human
XP_001758955  66 ---eeLLDRAFLETKQEQYKKVFpkyDVLGWYSTGSd---VQDSDMLIHKALMDIN-----ESPVYVLLNPtin------ 128 Physcomitrella ...
Q8W206        85 ---tqTLDRSFLEKKQELYKKVFpdfYILGWYSTGSd---AEESDMHIHKALMDIN-----ESPVYVLLNPain------ 147 thale cress
ABC49916      77 -dgtlDIDITYLLKKQEQYKQVFknlDVVGWYATGAa---ITEGHRLAHRKISEVV-----ESPVFLLLDPavd------ 141 Chlamydomonas r...
Q54C92        85 --kqlVLDIEYLRKKYEQLFPLY---DLLGWYSTGSq---VSKDDILLHKQISEHN-----ESPLYLMLDTdsp------ 145 Dictyostelium d...
ACO62709      63 gtgrvIVDAEYLAGQKVRYKTVYpkmEVVGWYSTGQa--vDHEHDLAIHKAICDAS-----EAPVYLLFDPfrvgagegt 135 Micromonas sp. ...
XP_001745862  71 ----gIWDLDFLNTRTEAFKRIFkdqDCLGWYATGSh---VTADHLALHRQLLGLN-----EAPFFLLLDDqaq------ 132 Monosiga brevic...
EEY65928      92 --gdiQIDKEFLTSRIQQFSQVFpgfELLGWYTVGAk---ALPSDLAVHRVVMEFN-----ESPLFMILDPeskg----- 156 Phytophthora in...
XP_503337     64 ----gVIDKELVTRRLAQFQQVMpelHFVGWFYVSKdhtsPTDEVTHLQKQLMEFD-----EAPLVLLIQPgs------- 127 Yarrowia lipoly...
XP_813372     84 ntaarSVDWRAVRSKKERLAEVFaelVVVGWYGVGRtredAVQCSSIMHVPLLDVFgdvpnGVMLALMVDRapp------ 157 Trypanosoma cru...
Q7L5N1       159 -------khTDLPVSVFESVIDIing-----------eatMLFAELTYTLATEEAERIGVDHVARmta------------ 208 human
XP_001758955 129 ------haqKDLPISIFESELHVide-----------vpsLIFVNASYTIETVEAERISVDHVAHikp------------ 179 Physcomitrella ...
Q8W206       148 ------htqKDLPVTIYESELHVidg-----------ipqLIFAHTSYTIETVEAERISVDHVAHlkp------------ 198 thale cress
ABC49916     142 ------htrKDLPVSLYETELHLspet---------gapgMVFVKSPYSIETSDAERIGVDQVARila------------ 194 Chlamydomonas r...
Q54C92       146 -------ksKDLPVIIYESELHIvnd-----------eptTIFVKTPYKIQTGEAERIGVNHIAKvt------------- 194 Dictyostelium d...
ACO62709     136 stsrhklrgAKLPIDIVEAVVHVgadg----------qsqTSFRPAKYAIETTEVERIATDTLARaqe------------ 193 Micromonas sp. ...
XP_001745862 133 ------atrEQLPITIFETIVELkdd-----------eqhIHFAPTPYKLASEEAERIGVDHIANvsa------------ 183 Monosiga brevic...
EEY65928     157 -----pstkKKLPISLFESELHMlng-----------vpkMIFVKAPFKIETSETEGIAIDHISKiap------------ 208 Phytophthora in...
XP_503337    128 -------dsQQLPLHVYEPIIDSg---------------eTKYREATVVIETGEAERVAVEDLVRet------------- 172 Yarrowia lipoly...
XP_813372    158 ------aslATLPVHLFEATTSRdgvrhtageeqrgqeaiQRHRSHNYNSEISPCTAAHGSRILChnegaprttvclrnv 231 Trypanosoma cru...
Q7L5N1       209 --------------------------tgSGENSTVAEHLIAQHSAIKMLHSRVKLILEYVKASEAGev-----pfNHEIL 257 human
XP_001758955 180 -------------------------sdgSSAATQLAAHLTGMHSAIKMLNSRIRVLYHHLASIQKGda-----eyEHSLL 229 Physcomitrella ...
Q8W206       199 -------------------------sdgGSAATQLAAHLTGIHSAIKMLNSRIRVLYQNLAAMQKGdk-----scDNSVL 248 thale cress
ABC49916     195 -------------------------ggkATGSEQLSAQLVSLHSAIKMLLERLRVIHGAMGKVAGAdgaaaeaayPHSLL 249 Chlamydomonas r...
Q54C92       195 --------------------------psGSEGSGLTSHLFTMHNAISMLNIRVKALSDYLQAVKEKrl-----pyEQNIL 243 Dictyostelium d...
ACO62709     194 --------------------------geGTMTGQYVSHLRNLGSATEMLNARVEAIVEYLRAADSGeie----rpDRAAL 243 Micromonas sp. ...
XP_001745862 184 -------------------------savGGQISAVRQQMQTHASALLMLQERIDVICDFLADIDAGkv-----qpSPALL 233 Monosiga brevic...
EEY65928     209 --------------------------vgDASKSSLHPYLGNVRDAVKMLDRQVDVLLRFLQTMKNGea-----plNHNLL 257 Phytophthora in...
XP_503337    173 --------------------------sqHAASERVRQHLVSQHAAVKIFNGRVKTVLDYVKGVNEGsi-----vpDQRLL 221 Yarrowia lipoly...
XP_813372    232 rfltgsddmaqigigaamstigpgnrsgGHEGGTVSSHPQRVKRSLLLLKRRVVLVLEHLRAIESGcva----cpAPDVL 307 Trypanosoma cru...
Q7L5N1       258 REAYALCHCLPvls-tdKFKTDFYD---------QCNDVGLMAYLGTITKTCNTMNQFVNKFNVLYDr------------ 315 human
XP_001758955 230 RQISSLVRRLPaid-spKFQDDFLM---------EYNDTLLMTYLATITKCSSTMNELVDKFNTAYD------------- 286 Physcomitrella ...
Q8W206       249 RQVSSLLRRLPame-seRFQDNFLM---------EYNDKLLITYLAMITNCSSNMNEMVDKFNTAYDrn----------- 307 thale cress
ABC49916     250 RQVSSLVHSLPacn-tdAFNREYLT---------EYNDTLLTLYLASMTRGTHAANEVVDKFCLAYD------------- 306 Chlamydomonas r...
Q54C92       244 RKASSLCNQLPtid-thDFKKSYLQ---------EYNDVLLVTYLASITKTSASLNDTIDKYLVSNE------------- 300 Dictyostelium d...
ACO62709     244 RAAAALVKSLPkhggsaRLRADMVR---------EYNDCLLTAYLATMTKGMAEMDVLQARFDAAGLdgsg------gga 308 Micromonas sp. ...
XP_001745862 234 RNIKGICSRLPvsq-dpRLRAALLM---------ESTDTETVNLLALMTQACDAIKQLTGKMQTIHP------------- 290 Monosiga brevic...
EEY65928     258 RHISSICNQLPamk-seHFDTAFAQ---------EYNDALLVSYLAALTKGATNANTVVDRFTTTQE------------- 314 Phytophthora in...
XP_503337    222 RSLRSILSQLSa-----SSNSELKDs-------lQESQALTAAFLATVFQGTQLTASLKAQGLLMDRpa----------- 278 Yarrowia lipoly...
XP_813372    308 RHVAKACAMLPvsthdaSLCPVAAViipttaadeEVCGALAITLLSLETKCALALCELVRAQEEGPAvgrlpgcagptei 387 Trypanosoma cru...
Q7L5N1       316 qGIGRR 321 human
XP_001758955 287 -KQNRR 291 Physcomitrella patens subsp. patens
Q8W206       308 tRRGGR 313 thale cress
ABC49916     307 -KAGRR 311 Chlamydomonas reinhardtii
Q54C92       301 -KQSKR 305 Dictyostelium discoideum AX4
ACO62709     309 gGGGRR 314 Micromonas sp. RCC299
XP_001745862 291 -GAGKT 295 Monosiga brevicollis MX1
EEY65928     315 -RHHQR 319 Phytophthora infestans T30-4
XP_503337    279 kKSLRR 284 Yarrowia lipolytica CLIB122
XP_813372    388 gVSGRR 393 Trypanosoma cruzi strain CL Brener
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