Conserved Protein Domain Family
MPN_RPN7_8

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cd08062: MPN_RPN7_8 
Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in 19S proteasomal subunits Rpn7 and Rpn8
This family includes lid subunits of the 26 S proteasome regulatory particles, Rpn7 (PSMD7; proteasome 26S non-ATPase subunit 7; p44), and Rpn8 (PSMD8; proteasome 26S non-ATPase subunit 8; p40; Mov34). Rpn7 is known to be critical for the integrity of the 26 S proteasome complex by establishing a correct lid structure. It is necessary for the incorporation/anchoring of Rpn3 and Rpn12 to the lid and essential for viability and normal mitosis. Rpn7 and Rpn8 are ATP-independent components of the 19S regulator subunit, and contain the MPN structural motif on its N-terminal region. However, while they show a typical MPN metalloprotease fold, they lack the canonical JAMM motif, and therefore do not show catalytic isopeptidase activity. It is suggested that Rpn7 function is primarily structural.
Statistics
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PSSM-Id: 163693
View PSSM: cd08062
Aligned: 35 rows
Threshold Bit Score: 394.642
Threshold Setting Gi: 67466227
Created: 29-Jul-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
NP_002802       7 QKVVVHPLVLLSVVDHFNRigkvgnQKRVVGVLLGSwqk-kvLDVSNSFAVPFDEDDKDdsVWFLDHDYLENMYGMFKKV 85   human
EER00836     1597 TTVVVHPIVLLSIVDHYNRaar-gtARRVVGTLLGQmld-gkLHVTNSFALPFEEDLRDpqVWFVDHNYHEKMYAMFKKV 1674 Perkinsus mar...
XP_002365616   34 KTVVVHPIVLLSVVDHYNRvar-gtSRRVVGTLLGEisd-geIHVTNSFALPFEEDPKDpnVWYLDRNYHEHLYHMFKKV 111  Toxoplasma go...
XP_001015934   13 KLVAVHPLVLLSVVDHFNRvaksskNKRVVGVLLGQksq-gkADVTNCYAIPFDEDPKQpnIWFVDHIYHETMFNMFKKV 91   Tetrahymena t...
XP_001609871   14 KKVVLHPIVMLSVVDHYNRaaa-gtSRRVVGTILGEmie-gdIHITNSYAVPFEEDTKNplVWFFDHNYHERMFTMFKKI 91   Babesia bovis...
XP_666968      23 KNIIIHPIVLLSIVDHYNRiak-gtSKRVVGTLLGElhdedgIHVTNSYALPFEEDSRDptVWYLDHNYHEQMYLMFKKI 101  Cryptosporidi...
XP_002291391   22 IDVTIHPLVLLSAADHYHRvar-gtRKRAVGVLLGSssr-grIDAVNSFAVPFEEDSKNseVFYLDHNYLENMLGMFKKV 99   Thalassiosira...
XP_001443542    8 PLVIIHPLVLISVVDHYNRiisktqQPRVVGALLGErkadgvIDITNSYALPFEEDPKDqnIWYLDHIYNETLFELHRKI 87   Paramecium te...
XP_001352001   20 KHVVVHPIVLLSVVDHYNRias-ntKKRVLGTILGEkid-gvVHITNSYALPFEEDIKDinIFYIDDNYNENLFNMIRKI 97   Plasmodium fa...
XP_002176574   25 DEVVIHPLVLLSVADHYHRvar-gtRKRVVGVLLGQshr-gkIDVLNSFALPFEEDIRNpsVFYFDHNFLEEMIRLFRKV 102  Phaeodactylum...
NP_002802      86 NARERIVGWYHTGPKLHKNDIAINELMKRYc-----PNSVLVIIDVkpk---dlGLPTEAYISVEEVHDDgtp------- 150  human
EER00836     1675 SQKEVVVGWYSSGPRIKPSDLAINEIFRRYc-----PEPVFLIMDVtg----gnNFPMQAYYSAEEASADpl-------- 1737 Perkinsus mar...
XP_002365616  112 NTRERVLGWYSTGPQVRMTDLEIHEIFRRYt-----PNPVYVIVDInpk---dsVVPTKAYYSFEQPTSDrt-------- 175  Toxoplasma go...
XP_001015934   92 NAREKVLGWYTTGKHFKQHDIQINEVFKKYc-----PNPILLIVDVqhe--dklALPTETYCAVEEVSKNge-------- 156  Tetrahymena t...
XP_001609871   92 NTKEKVLGWYSTGPKCKPADLEIHELYRKYc-----PNPIYIIVDInq----keEVPIEAYVSVEEPTSDrr-------- 154  Babesia bovis...
XP_666968     102 NTKEKIVGWYSTGPKTKVVDIDIHELFRRYc-----PDPLYLIADVtaddfeylSSPISAYFSMDEPNSVl--------- 167  Cryptosporidi...
XP_002291391  100 HAKERVVGFYSTGPQIRPNDLRIHDLVSRFvpkgtvTPPVFVIIDVrpg---reSIPTTAYHVVEEVDSNvpsaggsdgg 176  Thalassiosira...
XP_001443542   88 NINEKIVGWYSTGSRFKPNDIQINQIFYKYt-----STPIFVIIDVhqf--dplSLPTEAYTSVDEISKSge-------- 152  Paramecium te...
XP_001352001   98 NTREKIVGWYTTGSNIKPNDIFINEIFYKYh-----HAPIFLLVNVhtd---qsIFPVNAYVAIEKAIHEnk-------- 161  Plasmodium fa...
XP_002176574  103 NTKETIVGFYSTGPSIRPNDLRIHDICKRYv-----RIPIFCIIDIrpd---rqELPVKAYKVVEQVHHAgqa------- 167  Phaeodactylum...
NP_002802     151 -----tsKTFEHVTSEIGAeEAEEVGVEHLLRDIKDttvgTLSQRITNQVHGLKGLnsKLLDIRSYLEKVatGKLPINHQ 225  human
EER00836     1738 -----trRTFVHLPSVVGAfEAEEVGVEHLLRDIRTqstsTLATRVESKMNALKTLvvKINEIAQYLGQVidGKLPPNAQ 1812 Perkinsus mar...
XP_002365616  176 -----frRTFVHVASTIGAlEAEEVGVEHLLRDLKNastsTLATRVADKLSALKLLigKIQEIYAYLQDAanKKIVANPN 250  Toxoplasma go...
XP_001015934  157 -----iiQNFVHLPSTVEAfEPEEIGVEHLLREIRDvsvnTLTNQVTDKIQALKGMmgKIQQIKLYIEAVlgGKVQAKND 231  Tetrahymena t...
XP_001609871  155 -----frRTFAHVPSEMGAfEAEEVGLEHLLRDLTNvttsTLSTKVDNKVLALKSLvlKLAEIVDYLKGVigGQYNLNPA 229  Babesia bovis...
XP_666968     168 ------kKKFAHVPCTIGAfEAEEVGVEHLLRDLKNtstsTLITQISDTINSCKILvsKLKESKNYLNDIveGRIPPNHR 241  Cryptosporidi...
XP_002291391  177 avqaqvrKSFAHVPSLIGAmEAEEVGVEHLLRDINDptvsTVANLVKAKMSGLSTLteKLVEMKDYLTAVseGRMKPNSE 256  Thalassiosira...
XP_001443542  153 -----iiQNFVHIPSTVQAfEPEEIGVEQLLREINNvdtqSLSAKAEQKINGVKGMnkKIAQIQQYLTLIqqGKVKPNQL 227  Paramecium te...
XP_001352001  162 -----frKTFIHIPVKIGAfEAEEVGVEFLLKELKSvstsTLATKVGDKLSSLKSLiaKLYEISAYLNDIlnGNIEMNIK 236  Plasmodium fa...
XP_002176574  168 -----vtRQFDHVSTQMGAmEAEEIGVAHLLRDINDptvsTVMSLIQGKLNGLQSLteKLLTAKKYLQACaeGKCKVNTE 242  Phaeodactylum...
NP_002802     226 IIYqLQDVFNLLPDVsl--qEFVKAFYLKTNDQMVVVYLASLIRSVVALHNLINNKIaNRDAEK 287  human
EER00836     1813 IIYnLQNIFNYLPGDsqedvELMRSFNVETNDSMLCIYLGSILRATVALHNLINNKIaNKAPEA 1876 Perkinsus marinus ATCC 50983
XP_002365616  251 IMYtIQDIFNLLPDLsd--pELIEAFTIQANDTMLNLYLGSVVRSVLALHNLINNKVeNKRASE 312  Toxoplasma gondii ME49
XP_001015934  232 ILFkIQEILNLLPNLnn--pEIIKSFASKNNDQMFVLYICSLSKSIISLHSLINNKLqNKEAEL 293  Tetrahymena thermophila
XP_001609871  230 IVYmLQDILNLFPSVds--dAIKEAFIINMNDTSLAIYLGSILRAILALHNLIDNMTeNKRIAK 291  Babesia bovis T2Bo
XP_666968     242 IISvLQDIFNLLPDLre--pEAIYAFSNRYADMILTIYGMSCLRSVLSMHDLVNNVSeNRTAFE 303  Cryptosporidium hominis TU502
XP_002291391  257 IIAnMQAIVNLLPNLnv--eELVRSMLVKNNDMHMVIYLSALIRCVIALHDLVLNKIaYNHETG 318  Thalassiosira pseudonana CCMP...
XP_001443542  228 IINnLQEILNYLPNLgs--qDVVQAFTTKNNDNMLTIYLASLMRSIIAYHNLINNQAqQEKKVK 289  Paramecium tetraurelia strain...
XP_001352001  237 ILYnLQNVFSLLPDIen--vDLVQAFMVKNNDLMLNIYIGSITRSVIALHNLINNKIeNKLNSE 298  Plasmodium falciparum 3D7
XP_002176574  243 IVDhLQTIVSLLPNLnt--pDLVHAMIVKTNDMHMAVYLASLIRSVIALHDLVNNKIrYGEDGM 304  Phaeodactylum tricornutum CCA...
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