5L4K,3JCK,5GJQ,5VFP,6EPC,6FVT,7QVG


Conserved Protein Domain Family
MPN_PSMD7

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cd08062: MPN_PSMD7 (501531 is an unknown moldel)
MPN domain of 26S proteasome non-ATPase regulatory subunit 7
26S proteasome non-ATPase regulatory subunit 7 (PSMD7; also known as 26S proteasome regulatory subunit RPN8, 26S proteasome regulatory subunit S12, Mov34 protein homolog, or proteasome subunit p40) is one of the non-ATPase subunits (Rpns) that are involved in recognizing substrates and deubiquitylating them before unfolding and degradation. Rpns are part of the regulatory particle (RP) of the 26S proteasome holocomplex. RPN8 forms a dimer with deubiquitylating enzyme (DUB) Rpn11, which plays a role in projecting the active site of Rpn11. RPN8 shows a typical MPN metalloprotease fold, but lacks the canonical JAMM motif, and therefore does not show catalytic isopeptidase activity.
Statistics
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PSSM-Id: 501531
Aligned: 87 rows
Threshold Bit Score: 371.819
Created: 29-Jul-2009
Updated: 30-Oct-2024
Structure
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Program:
Drawing:
Aligned Rows:
 
oligomer
Conserved site includes 164 residues -Click on image for an interactive view with Cn3D
Feature 1:oligomer interface [polypeptide binding site]
Evidence:
  • Structure:5L4K: human 26S proteasome lid complex, contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           #   ### ### ### ##                               ### # #     #### ##   ### ####
5L4K_U           7 QKVVVHPLVLLSVVDHFNRigk-vgnQKRVVGVLLGSwqk-----kvLDVSNSFAVP-----FDEDDKDd-sVWFLDHDY 74    human
XP_649261       11 KKVIVHPLVLLSISDHQTRas---keGKRVVGVLLGFirk-----giVDVMNSFAVP-----FDEDEKDn--IWYLDHQY 75    Entamoeba h...
XP_001318214    10 KRVAVHPIVLLSIADHHNRivn--nrTKRVIGILLGDvyq-----gqVNVLQCFAIP-----FEEDIDNp-nIFFVDTNF 76    Trichomonas...
XP_005539405    10 TNAVIHPVVLLGIVDHYNRack--ntRKRAVGILLGTidr----rghAEVLNSFAVP-----FEEDERNp-tVFFFDHDY 77    Cyanidiosch...
XP_009494636    34 TSVVVHPLVLLSVVDHYNRvak--gtTKRVVGVLLGQwng-----stIDVSNSYAVP-----FEEEGQDs-sIWFFDHGY 100   Fonticula alba
KNH08991        18 TEVRMHPLVLLSAVDHYNRlnnaitsGKRVVGILLGTqte-----rfIDINNSYAVP-----FEEDESNk-nVWFLDGNY 86    Perkinsela ...
KRZ39473     16604 TKVIVHPLVLLSVIDHFNRvyk-itkSPRVVGILLGTvsg-----ktVDVTNCFAVP-----FEQDYTAlppVWFLDHEY 16672 Trichinella...
CAD2216411      41 ARVEVHPLVLLSLVDHFARmntsalqKKRVVGLLLGRykrgaegqpvLDINNSFAVP-----FDEDASNp-eVWFFDTNY 114   Angomonas d...
KAH7814913       4 KKASVHPLVLLFAVDHYNReak-gslTKRVCGILLGTmns-----giLDISNCFAVP-----FEENLENg--TWFLDSQY 70    Monocercomo...
KAI0981626      26 QKVIVHPIVLLSAADHYLRvsk-gtkHRRVAGVLLGSv---------WQKGQVLDITnsfavPFDEDKD---VWFMDEDY 92    Pomphorhync...
Feature 1            ##  ## ###             ##  ###      #                          ###      ### # 
5L4K_U          75 LENMYGMFKKVNARERIVGWYHTGPKL--HKNDIAINELMKRYc--------------PNSVLVIIDVkpk-dlGLPTEA 137   human
XP_649261       76 LETVYRMTQRVTAKEVLVGWYSTSSSI--KPCDIQIHSVINKYt--------------AHPVYLTVDVsatvshDLPVHS 139   Entamoeba h...
XP_001318214    77 IDEMFKLHKKVTLKEKIIGWYSSLSTI--SPNDLEIHKVISKYn--------------PTPIFLTTDVgasdphEIPTCA 140   Trichomonas...
XP_005539405    78 VENMAAMFRKVTARERIIGWYSTGPQI--RPADMGVHEIVQGFcs------------sGHALYVICQVdpk-etGLPTEA 142   Cyanidiosch...
XP_009494636   101 LEEMWHMFRKINAREKIIGWYHTGPAL--RSSDLAIHSVMSRFc--------------PNPVLVTIDVnpe-cvGLPTES 163   Fonticula alba
KNH08991        87 LDEMFLMFKKVWSRANIVGWYSSGPKI--AACDLAIHRMIRRYc--------------ANPVYCIIDVspe-vqGIPATC 149   Perkinsela ...
KRZ39473     16673 LESMHMMFGKVNAREKIVGWYHSGPHL--YSTDISINSVLKSFv--------------MHPVLCVVSVkk---hGIPADA 16733 Trichinella...
CAD2216411     115 AEEMFLMYRRVLPQVKIVGWYSSGPTV--KPSDMLLHLLVADRf-------------cPNPVYCVVNTdan-nrGVPVLA 178   Angomonas d...
KAH7814913      71 IIVMKAMQRKVSAKEVIVGWYSAFPGAkiRPSDLSIQRMVTQFc--------------PNPLYLVIDVep--kgEFPASA 134   Monocercomo...
KAI0981626      93 LDTMWQMFRKVNARERIVGWYHTGPKL--RPSDIAITERIQKYfvnavlvvidtserlSDRIPIVRNTnrekyvGSPIEA 170   Pomphorhync...
Feature 1          #     # ##              ### #  ###   ###############     ################  #####
5L4K_U         138 YISVEEVHDDgtp---------tsKTFEHVTSEIGAeEAEEVGVEHLLRDIKDttvgTLSQRITNQVHGLKGLnsKLLDI 208   human
XP_649261      140 YVSAESIDSSenill----qpelsLRFIHVPTDVGS-DESEVGVERLLRDLQKptgtVLKHEVELKMDSLRALddKIKLM 214   Entamoeba h...
XP_001318214   141 YIGTERERVDglp---------lvTTFKTLPTVVDFlEVEEIGVEHLLRDIKDvdvsEIGTTLTNSMHGLAALehRLKAI 211   Trichomonas...
XP_005539405   143 YVSLEEDSVAlegsa----pgqprRIFEHVPNSIGAlEAEEVGTEHLLRDVRNwsvsTLTGEVRAKLDALQSLraRLENI 218   Cyanidiosch...
XP_009494636   164 FVAIEEVDDSinastssesgpssrKTFTQVSTEVRAtEAEEIGVEHLLRDVKDnavsSLATQVTEKVSSMRSLhnHLKDI 243   Fonticula alba
KNH08991       150 YIARESESRNseg---------ekYCFYHLRTVIDSiEAESIGVDQLLRDLTTsttqTMETKIEDKKFSLQKFneSLKVI 220   Perkinsela ...
KRZ39473     16734 YIEVEEVQDDgsv---------plRTFELLSCCIQSeEAEAVGVEHLLRDIKDqsagTLAQMTTRRVVGLRGFveMLRCI 16804 Trichinella...
CAD2216411     179 YTTTQGREGSr------------tLEFRNIPTHLGAeEAEEVGIEHLLRDLTDstvsTLSTQIGERELSLQHLcqILQQI 246   Angomonas d...
KAH7814913     135 YLSNVDPKYDgte---------ltLTFRHVPSEMGAqEAEEIGVEHLLRDVMDtnmtSLSSKISQRATSFATFtkHISVI 205   Monocercomo...
KAI0981626     171 YILTEEIHSDgap---------atKTFDHVPAIIEAeEAEDVGVEHLLRDINTdscgTLSQKVMNQVHAVRGFhqSLNLM 241   Pomphorhync...
Feature 1          # #####   ########## ###########    #####################################       
5L4K_U         209 RSYLEKVatGKLPINHQIIYqLQDVFNLLPDVsl-qEFVKAFYLKTNDQMVVVYLASLIRSVVALHNLINNKIa------ 281   human
XP_649261      215 RNYLELVesGKIPVNQKIIQnIQDIFNLSPNIe---KYTQQFAVNTNDVMVTIYLSQLVKSVLAVHDLIRNKNd------ 285   Entamoeba h...
XP_001318214   212 SDYLNDVieGKLPIENEIIGvIQSIFNLLPNLtl-kETVDSLATKADDETFMIFISQLCRSVVSLHDLVNTRHp------ 284   Trichomonas...
XP_005539405   219 RRYLEEVasGNLPLHQEILHaLQLVLKGLPRNaassELTQAFAVCSNEQTLLIYVATLLRSVLVLHDLVNNKTe------ 292   Cyanidiosch...
XP_009494636   244 ATYLQMVadGRIQPNPVVLTnAQALLAGRPDIsgsdALSAAFTSAGNDAMLVLHIAAMCRSLTALHDLIRNRQ------- 316   Fonticula alba
KNH08991       221 KNYLEVIqqKHVEGDQNILRkVQKILWIATSIqq-fKNSASLKRNHNDSAIVRYVTSLMKSFMDVVDLIDRKEe------ 293   Perkinsela ...
KRZ39473     16805 KCYLEEVseGSLPINNNILYhLQEIFYILPSLq--aSLSESYLSETTDELMGLFLGSLSRAVCGLHNLIDNLVk------ 16876 Trichinella...
CAD2216411     247 EEYLNDVaaGNMPVSEDVLEvLQELISLQPEMyv-qKKSTDMIRFANDSAISTFLASIGRCICALHEVILNRRtlarelr 325   Angomonas d...
KAH7814913     206 QQYLRDVleHKLPMNQQIFAlLQEIFNLIPDVns-pEIQRALIEHSNDSSLVLLMSNLMRTTLSMHSLIQNKIelq---- 280   Monocercomo...
KAI0981626     242 VLYVDSVikERLPRNQLVLQhIQNVLNSLSRLs--yVEEGQQLSVLNDQMAVIYVAMLCRTIVALHDLINNKIq------ 313   Pomphorhync...
Feature 1               ## #  
5L4K_U         282 -----NRDAEK 287   human
XP_649261      286 -----YEIKLK 291   Entamoeba histolytica HM-1:IMSS
XP_001318214   285 ----pLAEKEK 291   Trichomonas vaginalis G3
XP_005539405   293 -----LLETER 298   Cyanidioschyzon merolae strain 10D
XP_009494636   317 -----NVASSE 322   Fonticula alba
KNH08991       294 ----gERNASS 300   Perkinsela sp. CCAP 1560/4
KRZ39473     16877 -----YREAEK 16882 Trichinella pseudospiralis
CAD2216411     326 eikakREEAQE 336   Angomonas deanei
KAH7814913     281 --tkkEKEAEE 289   Monocercomonoides exilis
KAI0981626     314 -----NRQSER 319   Pomphorhynchus laevis

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