Conserved Protein Domain Family
MPN_NPL4

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cd08061: MPN_NPL4 
Mov34/MPN/PAD-1 family: nuclear protein localization-4 (Npl4) domain
Npl4p (nuclear protein localization-4) is identical to Hmg-CoA reductase degradation 4 (HRD4) protein and contains a domain that is part of the pfam clan MPN/Mov34-like. Npl4 plays an intermediate role between endoplasmic reticulum-associated degradation (ERAD) substrate ubiquitylation and proteasomal degradation. Npl4p associates with Cdc48p (Cdc48 in yeast and p97 or valosin-containing protein (VCP) in higher eukaryotes), the highly conserved ATPase of the AAA family, via ubiquitin fusion degradation-1 protein (Ufd1p) to form a Cdc48p-Ufd1p-Npl4p complex which then functions in the recognition of several polyubiquitin-tagged proteins and facilitates their presentation to the 26S proteasome for processive degradation. This family of eukaryotic MPN-like domains lacks the key residues that coordinate a metal ion and therefore does not show catalytic isopeptidase activity.
Statistics
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PSSM-Id: 163692
View PSSM: cd08061
Aligned: 40 rows
Threshold Bit Score: 165.61
Threshold Setting Gi: 219116761
Created: 30-Nov-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
NP_001080427 216 TLNRQKYRHVDNIMFENHTiadrfld-----fwrktgnQRIGYLYGRYtehkdi-plglraEVAAIYEPPQigtqnslql 289 African clawed ...
XP_001321763 158 IRIPQNKILLPFQQKALMTgy---------------ktHRIMFLFGRIdkyt------gkvTVHCSCEPQQknfv----- 211 Trichomonas vag...
XP_001763312 117 RIERQEKSHCSALSFDREAanafqlyv---heslafsiKRGGIMYGSVnea-------geiKVDVIYEPPQqgse----- 181 Physcomitrella ...
XP_002505182 122 RIETQESPNVESLSLDGHAanafqayv---ngtlgfnqMRFGWMYGTCsdd-------gevRVHAIYEPEQegte----- 186 Micromonas sp. ...
NP_191859    120 RVGRQEKAHCDSVSFDRDCanafqhfv---neslafavKRGGFMYGNVsed-------gqvEVNFIYEPPQ--------- 180 thale cress
CBH09764     185 LVRVDVTSLNLFQSFVRQSgw---------------avQRCGILYGKYdsae------stiEVHAVYEPEQeggl----- 238 Trypanosoma bru...
CAL51738     120 RIERQEAPHCVSVSFDANAanvfqsyv---nytlgfkqVRFGWLYGTRdde-------nkvRVEAIYEPEQegte----- 184 Ostreococcus tauri
XP_002186415 166 KIQRQEKATTSKVSLDVPSisnfqtyl----qrfqfqrKRCGFLYGKFvkedesdekptkvLVEAIYEPPQeinpd---- 237 Phaeodactylum t...
XP_001707270 215 NIERQKKALVACLSVSETQmmevrklv----eesmynrNFYGVMYGRYeylseanrleanvFIEWIYIPPQecia----- 285 Giardia lamblia...
XP_001301870 132 SLIPQVINQTESSTYAIRVgveaikrfqivslnehfknHRMMFLFGRVdkit------gkvTVHCGMEPPQfnspdhf-- 203 Trichomonas vag...
NP_001080427 290 lddpkaKVVDEia----------------akLGLRKVGWIFTDlvsedtrkgtvrysrnkdtyfLSAEECITAGyfqnky 353 African clawed ...
XP_001321763 212 ---dhvEILEEfnmdld--------rniaheFGMECVGMAISRpepteks--------edykheMTEYMVRLAAkyq--- 269 Trichomonas vag...
XP_001763312 182 ---eglLLMRDmdeekra-------dviaagLGLRKVGFIFTQtitqn-----------qggytLSNAEIRQTAefha-- 238 Physcomitrella ...
XP_002505182 187 ---dafVVVEDadedara-------eaiaesLGMTRVGMVFNVtttke-----------rpdytMSAFEIRQMAkyq--- 242 Micromonas sp. ...
NP_191859    181 ------QGMEDnlilmrdseeekrvdaialgLGMRRVGFIFNQtvtqd-----------kkeytLSNVEVLLAAqlha-- 241 thale cress
CBH09764     239 ---qkfVCLRDsrvgtv--------drlaerLGLRRVGMVCTHqardp-----------dkmvlSGYELLLCAReqs--- 293 Trypanosoma bru...
CAL51738     185 ---ddvEVLENtqedhna-------eclassMGLTRVGCIISTpkde-------------rdftLSAKEVARIArlq--- 238 Ostreococcus tauri
XP_002186415 238 --saegFTLEDdpqeeev-------nqlaewLGLQRVGWVFGHaprq--------------gyvLSAAETILAAefqlea 294 Phaeodactylum t...
XP_001707270 286 ---gtvVVLSDpcskaknk----aaekianaFGLINMGHTFTHfndr--------------gfiLSGAEIGSLAvrtakl 344 Giardia lamblia...
XP_001301870 204 tivpefEMLRPcqi--------------aqsFGMQCVGMAVAHnygp--------------klpLPGYLLKLAAhfq--- 252 Trichomonas vag...
NP_001080427 354 pnlcrlspdahfGSKFVTVVAtggpd-----nqvhFEGYQVSNQCMALVRDECLlpcrdapel----------------- 411 African clawed ...
XP_001321763 270 ---------veiTEYFTTIVVte----------khAEPYQASDAAMKAYQQGLFlqsss--------------------- 309 Trichomonas vag...
XP_001763312 239 ---------esdFEQWATAIVklevned-ggadvhFEAFQLSDQCVKLFKDGLFeenvpd-------------------- 288 Physcomitrella ...
XP_002505182 243 ---------skyGDKFVTAVVmmlededegtpqvsFEPFQVSNQCVRLYSEGWFhdepce-------------------- 293 Micromonas sp. ...
NP_191859    242 ---------eseLKEWVTAVVkleined-ggadvhFEPFQMSDMCVRLFKEGWFeteigpe------------------- 292 thale cress
CBH09764     294 ----------rfGDECVLLTMspsit----tgrieCQAWQASPQAVHFYRLGTLtekldadprnstvvtgtadgfcgdei 359 Trypanosoma bru...
CAL51738     239 ---------skyGQHFATAVMmtfeded-dnwqvsFEAFQLSDLAIKIYDRGWFtgkcavden----------------- 291 Ostreococcus tauri
XP_002186415 295 -------aggveETPFCTVTVapkld-----gqvaVEAFQVSQQCMAMVAEEALqvdpd--------------------- 341 Phaeodactylum t...
XP_001707270 345 ------eargaeHAKFMTNLRgcidkt---rkelvLDAFAASRQLVNLARNNILvenkved------------------- 396 Giardia lamblia...
XP_001301870 253 ---------vkfGEYFTTLVFmpngt-----nnieVNAYQVSDAVTKLENLGLIeepksysd------------------ 300 Trichomonas vag...
NP_001080427 412 -----------gyakessseQYVPDVFYKdidkfgn-eitqlarPLPVEYLII--------DITTTFPkdpvytfstssn 471 African clawed ...
XP_001321763 310 ----------------ptllKFKSEVKLGtak---------hlkELDSNYAVAtl-----rIRNANSH------------ 347 Trichomonas vag...
XP_001763312 289 --------------ldpkltRMKKEVIVLqkd----------tfDVDNDFFLVpv-----kILDHEGPmt---------t 330 Physcomitrella ...
XP_002505182 294 ---------------kpghtRLTKDVVVVdkvs-------kdvtEVDNDRWLVpv-----kILDHEGPwr---------t 337 Micromonas sp. ...
NP_191859    293 --------------ddpklsKLKKEVVVGvkd----------vkEVDNDFFLVlv-----kILDHQGPls---------c 334 thale cress
CBH09764     360 pshfvyssislevaqeqtddKGRPQVITKapskeidtrwftsyvAVDPFDSHVvk----nlFVRISRPgm---------d 426 Trypanosoma bru...
CAL51738     292 ------------gedlkgvsKLTNEVMVErkd----------vfDVDNDFFLVtv-----pILDHEGPls---------s 335 Ostreococcus tauri
XP_002186415 342 ----------------npqlCKVNETFTAiqeg-------kaspTVETAFFLTvv-----pIVQHTSEtfv--------a 385 Phaeodactylum t...
XP_001707270 397 --------------pgnfvrFSEKQIFELka-----------seLVDAVCFLVpvavtthkDIITTMKtkic------ss 445 Giardia lamblia...
XP_001301870 301 -------------qkeigliRFKKDVRVSgakkr-----fcnvnFCLCAVRVR--------KVNSKIPsh---------- 344 Trichomonas vag...
NP_001080427 472 lFPIENRd------------vLGETQDfhslatylsq--nlssvfleiiSDFHLLLFL 515 African clawed frog
XP_001321763 348 -FPDTEPfp-----------pLSEYPSvmdvkkyfdd--mqycpmwyrlFNFNLLLYF 391 Trichomonas vaginalis G3
XP_001763312 331 tFPIENRa------------pLATLQAlkthlerhr-----nkpyvkriADFHLLLLL 371 Physcomitrella patens subsp. patens
XP_002505182 338 sFPIENR--------------LHPVQTvedlkdavs----kggqycvklADFHLLLFL 377 Micromonas sp. RCC299
NP_191859    335 tFPIENRntq---------ttMRALKThmerars--------lpfvkriSDFHLLLFV 375 thale cress
CBH09764     427 pPTITNL--------------RNYLKDpkradv----------pilqklADFHVLIFL 460 Trypanosoma brucei gambiense DAL972
CAL51738     336 tFPVENR--------------LHPIQTvddlrealq----kdkpygdrlRDFHLLLFL 375 Ostreococcus tauri
XP_002186415 386 dFPRANRd------------lDDTAPNkdaltrqlrqagsngwtlvdrlADFNLLIYL 431 Phaeodactylum tricornutum CCAP 1055/1
XP_001707270 446 dFPSLGSpcpptlhdvasyisIHKSQKlse-----------------vyANCNYLVYL 486 Giardia lamblia ATCC 50803
XP_001301870 345 dFPSPNSkptk-------tdlIRYLDDneysp------------twrkfFDFNFLVYL 383 Trichomonas vaginalis G3
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