7WWQ,7WWP,6JWH,6JWI,8DAR,6OA9,6CDD,6CHS


Conserved Protein Domain Family
MPN_NPL4

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cd08061: MPN_NPL4 (This model is not part of the current CDD release)
MPN domain of nuclear protein localization-4 (Npl4)
Npl4p (nuclear protein localization-4) is identical to Hmg-CoA reductase degradation 4 (HRD4) protein and contains a domain that is part of the pfam clan MPN/Mov34-like. Npl4 plays an intermediate role between endoplasmic reticulum-associated degradation (ERAD) substrate ubiquitylation and proteasomal degradation. Npl4p associates with Cdc48p (Cdc48 in yeast and p97 or valosin-containing protein (VCP) in higher eukaryotes), the highly conserved ATPase of the AAA family, via ubiquitin fusion degradation-1 protein (Ufd1p) to form a Cdc48p-Ufd1p-Npl4p complex which then functions in the recognition of several polyubiquitin-tagged proteins and facilitates their presentation to the 26S proteasome for processive degradation. This family of eukaryotic MPN-like domains lacks the key residues that coordinate a metal ion and therefore does not show catalytic isopeptidase activity.
Statistics
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PSSM-Id: 501530
Aligned: 95 rows
Threshold Bit Score: 149.743
Created: 30-Nov-2009
Updated: 30-Oct-2024
Structure
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Program:
Drawing:
Aligned Rows:
 
oligomer
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:oligomer interface [polypeptide binding site]
Evidence:
  • Structure:8DAR: Saccharomyces cerevisiae Ufd1/Npl4/Cdc48 complex unbound but in the presence of SUMO-ubiquitin(K48polyUb)-mEOS and ATP, contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                     #                                  
7WWQ_A       119 TLNRQKYRHVDNIMFE----------NHTVADRFLDFWRKtg--nQHFGYLYGRYtehkdi-plgirAEVAAIYEPPQig 185 human
8DAR_G       228 TLQQQEFRMVDHVEFQ----------KSEIINEFIQAWRYtg--mQRFGYMYGSYskydnt-plgikAVVEAIYEPPQhd 294 brewer's yeast
CUI14692      82 VRVRWQPSRVSLIKAD----------STALNIFQSFVYSFdw-kmQRYGILYGRVvsdgadekapkqVEVHAIYEPEQig 150 Bodo saltans
OHT12190     127 AFFEHKNRLLPHIDFQdesscyafriGEECMKRFQSIAFQtnfstHRIGFLFGRInet------tgkVTAHVLMEPPQen 200 Tritrichomonas ...
OHT00455     132 IVEDQSESSCYAFRVG----------EEAIKRFQAIAFQErf-atHRIIFLFGRInei------tgkVTAHCSCEPEQvn 194 Tritrichomonas ...
CBH09764     174 SRVRWAPSRTKLVRVD----------VTSLNLFQSFVRQSgw-avQRCGILYGKYdsa------estIEVHAVYEPEQeg 236 Trypanosoma bru...
CCW63378      80 TRVKWVPSRTQLVKAD----------AQSLNIFQSFVAQVgw-nlQRYAILYGRYdsa------savVEVHAVYEPEQhg 142 Phytomonas sp. EM1
EPY35569       7 TRVRWAASRTSLVRAD----------AESLNIFQTFVQQMdg-kvNRYGILYGLYkae------ekiIEAHAVYEPEQig 69  Strigomonas cul...
XP_001321763 146 IFGVSSLTSTFAIRIPq---------NKILLPFQQKALMTgy-ktHRIMFLFGRIdky------tgkVTVHCSCEPQQkn 209 Trichomonas vag...
XP_001707270 215 NIERQKKALVACLSVSe--------tQMMEVRKLVEESMYn---rNFYGVMYGRYeylseanrleanVFIEWIYIPPQec 283 Giardia intesti...
Feature 1                                            #                         ##  #             
7WWQ_A       186 tqnsl----elledpKAEVVDEIAakLGLRKVGWIFTDlvsedtrkgtvrysrnkdtyfLSSEECITAGdfqnkhpnmcr 261 human
8DAR_G       295 eqdglt-mdveqvknEMLQIDRQAqeMGLSRIGLIFTDlsdagagdgsvfckrhkdsffLSSLEVIMAArhqtrhpnvsk 373 brewer's yeast
CUI14692     151 kensf----allddpREETVNKIAegLGLRRVGCVCTHaprde------------tavtLSGDELLLCAkeq-------- 206 Bodo saltans
OHT12190     201 nydrv----iitdntSLDCALEIAkdFGMKCVGMAISHqtds--------------kypMTSYMIEKAAyyq-------- 254 Tritrichomonas ...
OHT00455     195 aadhv----eispnfDISIPLSIAdnFGMKCVGMAISHaads--------------kypMTQYMIQLAAyyq-------- 248 Tritrichomonas ...
CBH09764     237 glqkf----vclrdsRVGTVDRLAerLGLRRVGMVCTHqardp------------dkmvLSGYELLLCAreq-------- 292 Trypanosoma bru...
CCW63378     143 nryrf----eviddpRIETVDAIArgLGLRRVGALCTHpprdp------------deivMSARELLLCAreq-------- 198 Phytomonas sp. EM1
EPY35569      70 neyaf----leqkdpFLDTVDAVAagLGLRRVGVVCTHpprdn------------dvmlLNSRELLLCAreq-------- 125 Strigomonas cul...
XP_001321763 210 fvdhv----eileefNMDLDRNIAheFGMECVGMAISRpepteks--------edykheMTEYMVRLAAkyq-------- 269 Trichomonas vag...
XP_001707270 284 iagtvvvlsdpcskaKNKAAEKIAnaFGLINMGHTFTHfndr--------------gfiLSGAEIGSLAvrtakl----- 344 Giardia intesti...
Feature 1                                                                                        
7WWQ_A       262 lspdghfGSKFVTAVATggpd--nqvhFEGYQVSNQCMALVRDECLlpckdapel------------------------- 314 human
8DAR_G       374 yseqgffSSKFVTCVISgnle--geidISSYQVSTEAEALVTADMIsgstfpsma------------------------- 426 brewer's yeast
CUI14692     207 ----skfGDHCVLVTMGpnles-gqihAQCWQASQQCVRYFQMGILsvnpdsiqsilskvple----------------- 264 Bodo saltans
OHT12190     255 ----nlfGEYFTTLVVMprge--edviIEAFQVSDAAMRCSKEKLFaetds----------------------------- 299 Tritrichomonas ...
OHT00455     249 ----nlfGEYFTTLVVMpqkddesnvvIEAFQVKDSAMKMDQGQYFvpsdn----------------------------- 295 Tritrichomonas ...
CBH09764     293 ----srfGDECVLLTMSpsitt-grieCQAWQASPQAVHFYRLGTLtekldadprnstvvtgtadgfcg------deips 361 Trypanosoma bru...
CCW63378     199 ----slhGDECVLLTIApnlsd-gvveCQAWQTSPQCVHLFRVGLLyepdekdldrkntdkkdtdkkdtekkdtekkdtd 273 Phytomonas sp. EM1
EPY35569     126 ----scfGDECVLLTIAkndkeggvleCQAWQASPQCVHLYRLGVLheraprrrpatgaataaaspynvde--eeeaegi 199 Strigomonas cul...
XP_001321763 270 ----veiTEYFTTIVVTek-------hAEPYQASDAAMKAYQQGLFlqsss----------------------------- 309 Trichomonas vag...
XP_001707270 345 -eargaeHAKFMTNLRGcidktrkelvLDAFAASRQLVNLARNNILvenkved--------------------------- 396 Giardia intesti...
Feature 1                           ## # #                   #                                   
7WWQ_A       315 ---------gyakessseQYVPDVFYKdvdkfgn---eitqlarPLPVEYLIIDITTtfpkdpvy------tfsisqnpF 376 human
8DAR_G       427 ----------yindttdeRYVPEIFYMksneygit--vkenakpAFPVDYLLVTLTHgfpntdtet----nskfvsstgF 490 brewer's yeast
CUI14692     265 -iaqddqdkpghtrvvikESSTLVDTRwmt-----------syiAVEAFTSTVIGNNfirisr-----------pgcapP 321 Bodo saltans
OHT12190     300 --------------dkiiKFNEPIFTCnik------------qnEADVNLFLCAVRVrlteskfln-----htfpslsqI 348 Tritrichomonas ...
OHT00455     296 --------------pheiKFKEDLVVYnlk------------krSCDVNFLLCAVRVrqthskfls-----hsfpcpsqF 344 Tritrichomonas ...
CBH09764     362 hfvyssislevaqeqtddKGRPQVITKapskeidt--rwftsyvAVDPFDSHVVKNLfvrisr-----------pgmdpP 428 Trypanosoma bru...
CCW63378     274 keadkveewmivskvaleVAQEDTDGKghrlcv-----tkepctRIDTRWFTSYIAVqqftsdvvrggflrisrpgmapP 348 Phytomonas sp. EM1
EPY35569     200 aqrsahlqnpeearlvysEVELEVAEEktdaaghrhfvsklpshTVDTRWFTSYVAVeqfqss-----------ivrglF 268 Strigomonas cul...
XP_001321763 310 --------------ptllKFKSEVKLGtak-----------hlkELDSNYAVATLRIrna----------------nshF 348 Trichomonas vag...
XP_001707270 397 ------------pgnfvrFSEKQIFELka-------------seLVDAVCFLVPVAVtthkdiitt----mktkicssdF 447 Giardia intesti...
Feature 1                                                                  
7WWQ_A       377 PIENRd------------vLGETQDfhslatylsq----ntssvfldtiSDFHLLLFL 418 human
8DAR_G       491 PWSNRq------------aMGQSQDyqelkkylfnvassgdfnllhekiSNFHLLLYI 536 brewer's yeast
CUI14692     322 TMTNAkifl------qdakRAKLPFle--------------------kiADFHLLIFL 353 Bodo saltans
OHT12190     349 PSPLDlkm---------yfVDKEFSptw------------------yqmFDFNLLTYL 379 Tritrichomonas foetus
OHT00455     345 PTNDD--------------LKLYFRdheysp-------------awvtlFDFNLLVFL 375 Tritrichomonas foetus
CBH09764     429 TITNL--------------RNYLKDpkradv------------pilqklADFHVLIFL 460 Trypanosoma brucei gambiense DAL972
CCW63378     349 TFENLrnymn-----dpkrRNETFAek---------------------iADFHVLIFL 380 Phytomonas sp. EM1
EPY35569     269 LRRNRpamapp---tmanlRNYMKDpkrqkd------------sfaeklADFHVLVFL 311 Strigomonas culicis
XP_001321763 349 PDTEPfp-----------pLSEYPSvmdvkkyfdd----mqycpmwyrlFNFNLLLYF 391 Trichomonas vaginalis G3
XP_001707270 448 PSLGSpcpptlhdvasyisIHKSQKlse-------------------vyANCNYLVYL 486 Giardia intestinalis

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