6WW7,6Y4L,8EOI


Conserved Protein Domain Family
MPN_EMC8_9-like

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cd08060: MPN_EMC8_9-like (This model is not part of the current CDD release)
MPN domain of endoplasmic reticulum membrane protein complex subunit 8 and 9, and similar proteins
Endoplasmic reticulum membrane protein complex (EMC) is a protein transmembrane chaperone assembly that aids the membrane insertion of tail-anchored (TA) proteins. The membrane subunit EMC3 forms, together with six other integral membrane EMC subunits (1, 4, 5, 6, 7, and 10), a 12-transmembrane domain (TMD) complex. This complex associates with the cytosolic subunits EMC2, EMC8, and EMC9, which form the EMC cytoplasmic docking site. EMC8 and EMC9 are homologous subunits and seem to substitute for each other, since no complex containing both subunits has been detected so far. This family of eukaryotic MPN-like domains lacks the key residues that coordinate a metal ion and therefore does not show catalytic isopeptidase activity.
Statistics
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PSSM-Id: 501529
Aligned: 79 rows
Threshold Bit Score: 115.81
Created: 30-Nov-2009
Updated: 30-Oct-2024
Structure
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Program:
Drawing:
Aligned Rows:
 
oligomer
Conserved site includes 37 residues -Click on image for an interactive view with Cn3D
Feature 1:oligomer interface [polypeptide binding site]
Evidence:
  • Structure:6WW7: Human ER membrane protein complex, contacts at 4A between EMC8 and other subunits
  • Structure:6Y4L: Human ER membrane protein complex subunits EMC2/EMC9 dimer, contacts 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                      ## ##  # #                                   #     ##### ##  ##  #
6WW7_H         4 VKLTTQAYCKMVLHGAKYPh-CAVNGLLVAekqkprkehlplggpgahhTLFVDCIPLFHg--tLALAPMlEVALTLIDS 80  human
XP_002290582   6 IYLSTLSQTKMALHSARHGfsNPIHGIVLGrrrssad-----dshssssLEVVDVIPVCHe---VPTKPIvDMALRLADA 77  Thalassiosira p...
XP_001442234  10 VDIQKIVYKKAMLHACKYSt-EDVIGILIGqin-------------dthVNIVDAYPLFHs--rVSLNTL-EVSLDIISS 72  Paramecium tetr...
XP_001013196   8 QAIELLAYKKAYLHALKYVk-DDVIGVLTGkie-------------ngqITVEDAYPLFHs---RVVSPTlETAFELIEG 70  Tetrahymena the...
XP_668252      3 IEFNQTSYEKILSHSMKYPq-SFIDGVLIGyssg------------qtnLIITDSFPLSHg---PKLPLMvTLGIQYAQG 66  Cryptosporidium...
XP_002139672   3 VSLSEKAFGKMAMHSLKYPk-CPVDGILLGyee-------------dqvIKVTDVIPLFHs---PRLYESiSLALLFIEE 65  Cryptosporidium...
KRZ44389      13 FSLSSKATCLMILHAAKYPh-CCVSGILLGkkdk-----------ngqvVDVVTVIPLFHr--wHQLSAMtEVALMQINI 78  Trichinella pse...
XP_003138399   4 SAFTLRGYAKMILHAYKYPh-RPVVGFLIGktrn------------nseLICTDAIPVLHe--sASLSMAlEAALICTDN 68  African eye worm
KAF8366141     3 IEVDSLPYATIVLHALKYPs-KAVYGLLLGeak-------------gskVKVNNVVPLAHe--aSPLSPSlEIALTLVSA 66  Pristionchus pa...
XP_002676963   5 IFSESSPYFKSLFHSFKFPf-APINGVFIGkrkd------------dktVEITDCVPLCHstssICTTPLvEMALIQIDR 71  Naegleria gruberi
Feature 1                                #####             ##                               #    
6WW7_H        81 WCKDh----------sYVIAGYYQANERVkda-------spNQVAEKVASRIAEGfs----------dTALIMVDNTKft 133 human
XP_002290582  78 HLQLsdkeegvgggdkLQIVGWYTANSVAsdse----eqepNVSACRIASSMAESssndgfvllllsvSHMVTLLDSKgn 153 Thalassiosira p...
XP_001442234  73 ELQSd-----------RKIIGVYEARANArg--------imSEIAKEMLHNINQKq------------AIVLRISQVEvd 121 Paramecium tetr...
XP_001013196  71 ALKKk----------kQIIVGLYEALSHPyqa------kylSEISTRILEKIQKNls---------kqPIALRIYDEDkq 125 Tetrahymena the...
XP_668252     67 YCDIlnrld---kspkLEIIGFYSGLPDEkc--------lnSGGSKTYLDLISEKllan------nknSILVTFSGQKm- 128 Cryptosporidium...
XP_002139672  66 YCIEivqkg---llnkFQLIGYYYDEEFSqlqgalntesqvDTRCSLILEKILQNn-----------dAAVFVRMKRD-- 129 Cryptosporidium...
KRZ44389      79 MINEs----------qQQIVGYYQANELLndd-------slDATALRFGEKILSCfn----------dAVIVLLKNNNll 131 Trichinella pse...
XP_003138399  69 CTKGg-----------HALIGLYFCNQFLadn-------slDPHAMRVAEKIVSNyp----------nTFLVQIDNSLls 120 African eye worm
KAF8366141    67 RPNG------------EAIVGVYYAPQNLket-------gaSPTAIRLAQKIAAIng---------spATIVELQNVKle 118 Pristionchus pa...
XP_002676963  72 IIGDd-----------LTIVGYYFGTDYAelss----dftvPSIHTSIFTKISENfp----------gALLWMLEDKKl- 125 Naegleria gruberi
Feature 1                                                                                   # ## 
6WW7_H       134 mdc--------vaptIHVYEHHEN----RWRCRDPhhdycedwp-------------------eaqrisaslLDSRSYET 182 human
XP_002290582 154 ssn-------sntsiCAVFERDGNtktfTQKVDSSritnasstmgevvsralsaisnfspeygsmnggdvagGSSTEELV 226 Thalassiosira p...
XP_001442234 122 dapilnakivslnenVKYVINSSSt--lEWWVIQDc------------------------------------LKAGLHWK 163 Paramecium tetr...
XP_001013196 126 dq---------qeeiQEYHYLTCE----GYKFDLKdsknidanyekiqel-------npqngfakfeiikndISQNKHRF 185 Tetrahymena the...
XP_668252    129 --------------lFKESMNVYLl---RNKQLLLhtfiedp-----------------------lrpetkrLKDLDYYN 168 Cryptosporidium...
XP_002139672 130 ---------------QLFTRDCLTa--sKMKSKQQfenislsvc-------------------snssnilraVKDMQYFH 173 Cryptosporidium...
KRZ44389     132 nfs--------ntgcFKAFSWNGS----SWKVKSPtqfyfnevd-------------------kiqqvveacFEAKLYRS 180 Trichinella pse...
XP_003138399 121 agl--------lepaIRVYTLDSK----LWKSKRFtilneetv----------------------lpivssaVQMKLYLE 166 African eye worm
KAF8366141   119 ggc-------qneclTCRQSNDEG----KWKELSIsatqdtl------------------------ttvslaAQRRLYRE 163 Pristionchus pa...
XP_002676963 126 --------------nQLSKSMVFK----TYQLKSSklvpcdcdikgl--------------qesdfqtladhLEKSTFDS 173 Naegleria gruberi
Feature 1            # ### #####  
6WW7_H       183 LVDFDNHLDDIRNDWTN 199 human
XP_002290582 227 IYDYVDHVDGFKKREDL 243 Thalassiosira pseudonana CCMP1335
XP_001442234 164 IIDFDAHFENVQLNFRN 180 Paramecium tetraurelia
XP_001013196 186 IVDFDAHFEDISLDFTN 202 Tetrahymena thermophila SB210
XP_668252    169 LSDFEDHLCNIQPKLVN 185 Cryptosporidium hominis TU502
XP_002139672 174 LYDFEDHLLNPSLNWFN 190 Cryptosporidium muris RN66
KRZ44389     181 LCDFDDHLENVEFDFTN 197 Trichinella pseudospiralis
XP_003138399 167 IMDFENHLDNPVNDHWN 183 African eye worm
KAF8366141   164 VVDFENHLDSPESDFYN 180 Pristionchus pacificus
XP_002676963 174 LVDFEIHTDNPSLDYFN 190 Naegleria gruberi

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