cd08060: MPN_EMC8_9-like (This model is not part of the current CDD release)
MPN domain of endoplasmic reticulum membrane protein complex subunit 8 and 9, and similar proteins
Endoplasmic reticulum membrane protein complex (EMC) is a protein transmembrane chaperone assembly that aids the membrane insertion of tail-anchored (TA) proteins. The membrane subunit EMC3 forms, together with six other integral membrane EMC subunits (1, 4, 5, 6, 7, and 10), a 12-transmembrane domain (TMD) complex. This complex associates with the cytosolic subunits EMC2, EMC8, and EMC9, which form the EMC cytoplasmic docking site. EMC8 and EMC9 are homologous subunits and seem to substitute for each other, since no complex containing both subunits has been detected so far. This family of eukaryotic MPN-like domains lacks the key residues that coordinate a metal ion and therefore does not show catalytic isopeptidase activity.
Jiyao W et al.(2023). "The conserved domain database in 2023.",