Conserved Protein Domain Family
MPN_UPF0172

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cd08060: MPN_UPF0172 
Mov34/MPN/PAD-1 family: UPF0172 family of unknown function includes neighbor of COX4 (Noc4p)
This family includes Noc4p (neighbor of COX4; neighbor of Cytochrome c Oxidase 4; nucleolar complex associated 4 homolog) which belongs to the family of unknown function, UPF0172, with MPN/JAMM-like domains. Proteins in this family are homologs of the NOC4 gene which is conserved in eukaryotic members including human, dog, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.pombe, K.lactis, E.gossypii, M.grisea, N.crassa, A.thaliana, and rice. NOC4 highly expressed in the pancreas and moderately in liver, heart, lung, kidney, brain, skeletal muscle, and placenta. This nucleolar protein forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits. This family of eukaryotic MPN-like domains lacks the key residues that coordinate a metal ion and therefore does not show catalytic isopeptidase activity.
Statistics
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PSSM-Id: 163691
View PSSM: cd08060
Aligned: 41 rows
Threshold Bit Score: 132.419
Threshold Setting Gi: 224001820
Created: 30-Nov-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
NP_998535      5 LTTQAYCKMLLHAAKYPHCAVNGLLVAekhkkkdnprdsVLCVDCVPLFHg--aLALAPMlEVALTLIDTWCken---ky 79  zebrafish
EEH51239       7 LADKAYVKMLLHALKHPTRAVCGVLLGspae----dgaaVVVTDVVPMLHaatsGCATPSvEIALEHAATHAsssg--ag 80  Micromonas pusi...
NP_001052342   9 VAQVAYVKLALHALKHPAAAVNGLLVGrlldgaaspaavVSIADAVPLSHhphhLPLLPTlELALTLVEDHFaaq---gl 85  Japanese rice
XP_002500662   5 LSDRAYCKLILHALKHPLRSVCGALVGrcd------gdvVQVIDAIPYLHt--tVATAPNaEIALEQSCAYAgsg---gn 73  Micromonas sp. ...
XP_001764026   6 LRQTAYVKLVLHALKHTSCAVNGVLIGrigkg--dgestVEVTDCVPLFHg--qLGLLPMlELALSLVDEHLaagqdrsl 81  Physcomitrella ...
XP_001697758   7 ADQTALLKILAHAAKYPSNSVNGVLVGtake-----ggsVEILDAIPLCHt--tLTLAPAlEIGLAQVESYThitg--sv 77  Chlamydomonas r...
Q8LBG0        11 ISQNAYIKLVLHSLRHKTAAVNGVLVGrispk---ddgvVEISDSVPLFHs--nLALLPPlEISLIMIEEHYvaq---gl 82  thale cress
EEY62434       5 VSTQTYVKLVLHAAKRPANSVCGLLLGteq------gqgFSISDAVPLFHh--eAPLAPLlEVACAMVDAHCqksq--kl 74  Phytophthora in...
XP_001742808   4 ITSDAYFKLLAHACKYPFDTCLGLLVGqrga-----dgsVTVQDVVPVLHs--qHQLAMVmHAALAQVDMHYqds---pv 73  Monosiga brevic...
XP_001836039   9 VASKAYLKIYFHAAKHLHQTINGVLLGnqt------ggkIVVEDAIPLLHh--wTSLSPMmEIGLDLAEQYAaea---nl 77  Coprinopsis cin...
NP_998535     80 vIAGYYQANErik----etRPNQVAEKVAARISENfs------eAAMIMMDNSRftmecfvpv-------lfiydhhdnK 142 zebrafish
EEH51239      81 tLVGYYHGNElag----deTLGHGARKIADAVAAVarergvdarALLISAEKLAaatannadasigpvavaafkrggggG 156 Micromonas pusi...
NP_001052342  86 aVVGYYHANArrd----daDLPPVAKRVGDHVFRNfp------rAAVLLLDNKKleeavkgksrep--vvqlytrdsskS 153 Japanese rice
XP_002500662  74 aLVGYYHANErmd----ddRMSKHAAKIADCVERNggap--ggsACALLVDASAlaeatergtgr---aavrllvkkgaG 144 Micromonas sp. ...
XP_001764026  82 qIVGYYHANEqfd----nlELSSIAKKIGDQIVRYcs------qGAILLLDNKRlqalakentna---pvvqlyvkegsS 148 Physcomitrella ...
XP_001697758  78 aIVGYYQSDArfg----pgDLPPLGRKIADKVSEHqa------qAVVLVLDNKRleqfckaqadn---pfelfskdgskG 144 Chlamydomonas r...
Q8LBG0        83 sIVGYFHANErfd----dvELCGVAKNIGDHISRYfp------qAPILLLNNKKlealskgkersp--vmqlcvkdaskN 150 thale cress
EEY62434      75 qIVGFYYAGNgyspsdssnGLSHFAEKVADKVEQNss------rACVLVLDGQQlnseaktgl-------qillkdvkrG 141 Phytophthora in...
XP_001742808  74 sLVGLYQVHDrvd---aklQMDAVARKIAARLRQHnp------hAVALVFDSQNlqrtsepaa-------alftpqekdE 137 Monosiga brevic...
XP_001836039  78 kIVGYYQGRAavg----dvGLGPVGEKITQRIKEKfa------dAFALTLDGEDfgtekaal---------vvwtytenQ 138 Coprinopsis cin...
NP_998535    143 WKCRepstdcfedw----------------leaqkitaalLENKSYESLVDFDNHLDDLRNDWTN 191 zebrafish
EEH51239     157 WERVgdqegalrvs----------------avaragvarcHAAGVAAAIVDFDDHFDDVAADWRN 205 Micromonas pusilla CCMP1545
NP_001052342 154 WRQAgsdgssqltlk--------------epstnmvladhVTTKKWQQVVDFDDHLDDISKDWLN 204 Japanese rice
XP_002500662 145 WERAsdqgdlrvgg-----------------ganaklaalARDGRAKAVFDFDDHLDDITADWRN 192 Micromonas sp. RCC299
XP_001764026 149 WKLGgsgselrlke----------------tmansilndyRKEKREVRVVDFDEHLDDVSKDWLN 197 Physcomitrella patens subsp. p...
XP_001697758 145 WKRAsadggelalkna------------dwkklreeffvmFKQLKHRTLHDFEEHLDDAGKDWLN 197 Chlamydomonas reinhardtii
Q8LBG0       151 WRVVgadggsklllk--------------epsanvvlsdyISSEKWKDVTDVDDHLDDVTKDWLN 201 thale cress
EEY62434     142 WTKVenrlkvadg-------------------atktvtqgMKQNVQNDVVDFEEHLEDPSKDWRN 187 Phytophthora infestans T30-4
XP_001742808 138 WMHMynglipmnlapitrsqtplqftdsdegsrgqrlskmLESRSYEQIHDFEEFLADGTSDYLN 202 Monosiga brevicollis MX1
XP_001836039 139 WRRIgssgasppftsgssi------qldspdlpqkalsyvRDKSLHLQFGDFDDHLEDVKIDWIH 197 Coprinopsis cinerea okayama7#130
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