Conserved Protein Domain Family
MPN_euk_non_mb

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cd08057: MPN_euk_non_mb 
Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity (non metal-binding); eukaryotic
This family contains MPN (also known as Mov34, PAD-1, JAMM, JAB, MPN+) domains variants lacking key residues in the JAB1/MPN/Mov34 metalloenzyme (JAMM) motif and are unable to coordinate a metal ion. Comparisons of key catalytic and metal binding residues explain why the MPN-containing proteins Rpn7/PSMD7, Rpn8/PSMD8, CSN6, Prp8p, and the translation initiation factor 3 subunits f and h do not show catalytic isopeptidase activity. It has been proposed that the MPN domain in these proteins has a primarily structural function. Rpn7 is known to be critical for the integrity of the 26S proteasome complex by establishing a correct lid structure. It is necessary for the incorporation/anchoring of Rpn3 and Rpn12 to the lid and essential for viability and normal mitosis. CSN6 is a highly conserved protein complex with diverse functions, including several important intracellular pathways such as the ubiquitin/proteasome system, DNA repair, cell cycle, developmental changes, and some aspects of immune responses. It cleaves ubiquitin-like protein Nedd8 (neural precursor cell expressed, developmentally downregulated 8)) in the cullin 1 in cells. EIF3f s a potent inhibitor of HIV-1 replication as well as an important negative regulator of cell growth and proliferation. EIF3h regulates cell growth and viability, and that over-expression of the gene may provide growth advantage to prostate, breast, and liver cancer cells.
Statistics
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PSSM-Id: 163688
View PSSM: cd08057
Aligned: 24 rows
Threshold Bit Score: 85.5724
Threshold Setting Gi: 145510520
Created: 20-Oct-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
NP_002802      9 VVVHPLVLLSVVDHFNRigkv-----gnqkRVVGVLLGswq--kkvLDVSNSFAVPfdeddkdd--svwfldhdYLENMY 79  human
XP_001441193   4 TNVHPQVLLSISSQILTnkvnf----pgknIHAGILLGffnakinkTDILDSFEISysgkgel-----kpgeidFLKERQ 74  Paramecium tetr...
XP_001382816   3 LQLHSVTLLNIADHVTRes----------dTAFGVLVGrvs---dsCTVYTSFELLldstnt-------sidndYLYRRC 62  Pichia stipitis...
XP_002421204   3 VELHSDVLLHVSDLFARgv----------kNKFGLLLGygl--ddrLVVVKPIELAqvd-------------pqYLEKRY 57  Candida dublini...
XP_001528649  10 IKLRSKVLLNISDILARdi----------eHKFGCIIGyqd--gdnLIALTSFEILpdstgn-------sidteYLYKRY 70  Lodderomyces el...
XP_456385      7 VQLHSIALFNLSDHITRre----------kSKFGVLLGttd--katITVTTSFELLfdndl--------dinteFLKKRL 66  Debaryomyces ha...
XP_002546772   3 VDLHSVVLLNLADTLTRqs----------gNSTGLLLGyvl--pdkLVVVTSVELAhed-------------peYIQERF 57  Candida tropica...
EDK40827       4 VQISPTLLFHFSELVTRnf---------keHNYGIVLGrsdasegvKYAQTGFEIPtvsntasnnsgeiridmaYFQNRL 74  Pichia guillier...
XP_001327650   3 VFIHPQALLQIADHTTRskyfs----enikYICGVIYGrqe--gsdLELTSTIEINfieegye-----ikvnpkTYEPLN 71  Trichomonas vag...
XP_001308787   4 LYLHPQAALQMSQHCTLtkyinmkefpdisYFAGALYGied--adkIEVISTFQLAikndngk-----ivvnraAYEELD 76  Trichomonas vag...
NP_002802     80 GMFKKVna-----reRIVGWYHTGpk----------------lHKNDIAINElmkry----------------------c 116 human
XP_001441193  75 QLRLKGdkwnlfknlDIVGWYITDsnpheylk---vhkqlqtlSEAESTENQtsf------------------------- 126 Paramecium tetr...
XP_001382816  63 TQFTTVlp-----hySVVGLYHIGslssq---------nekmiQDMMNQFSQfiknfse-----------------nssk 111 Pichia stipitis...
XP_002421204  58 SLFKDVyp-----nlSLVGVYEIGgnnp------------drvNMLDISFEPr--------------------------- 93  Candida dublini...
XP_001528649  71 NQLKLVyp-----ecQLIGVYYLAnsgsgssgsggscldgntdTKVDNKVEYnlghhgsftlamcqeiqqfcatygiplp 145 Lodderomyces el...
XP_456385     67 DQFKAVlp-----qySMVGFYQLIndrvp----------nsatMSVLNQLQVfqrlis-------------------the 112 Debaryomyces ha...
XP_002546772  58 NLFKDVyp-----qsTILGRYNLQdkqpt----------ndlfLTIDESFQPqcyl-----------------------n 99  Candida tropica...
EDK40827      75 RQMLTVwp-----qkVVVGLYVLTsnsam----------evgtMKILHQLEAflknly-------------------gee 120 Pichia guillier...
XP_001327650  72 NHHLKLyp-----eeIPLAWYSCQdl----------------pESEISKINNafaeifkvyl-----------rihfkne 119 Trichomonas vag...
XP_001308787  77 KYELDIhk-----seKALGFYWIGn-----------------iPDKELDLITaelni----------------------f 112 Trichomonas vag...
NP_002802    117 pnsVLVIIDvkpkd-------------lglpTEAYISVEEvhddgtptsktfehvtseigaeEAEEVG 171 human
XP_001441193 127 -fkYLLCFDpystqan---------lyemeeNKMQVSQSKve------------------pqSEEMIG 166 Paramecium tetraurelia stra...
XP_001382816 112 nepVATVLCa--------------------sESENIASTTvanyk------------tyfttETDKAA 147 Pichia stipitis CBS 6054
XP_002421204  94 ---LYLSVDesiqf-------------ksfvEGNLVKTVIes-------------------sETEVIT 126 Candida dubliniensis CD36
XP_001528649 146 slfIYLIYQqqkwkfnegtlknlpfqgylceTSQPIATEIsi-------------------sETESIA 194 Lodderomyces elongisporus N...
XP_456385    113 mpiVFTLINmgsfhnaed----yepfksflsENEPIPLRTsil-----------------anETENIA 159 Debaryomyces hansenii CBS767
XP_002546772 100 gklVKTVIDs--------------------sETEAIATSTitnrke-----------dkkvdENLNEA 136 Candida tropicalis MYA-3404
EDK40827     121 tspAILLVDpeqlsqtggg---ilafstengSVQPAGLTLss-------------------dETEMIA 166 Pichia guilliermondii ATCC ...
XP_001327650 120 enpIDVFLLs--------------------eNETWIPTSYsyk-----------------teAPERIA 150 Trichomonas vaginalis G3
XP_001308787 113 ypvLCRIKFt---------------------GEDEHPIKLfaqedqkwk----eckysyrteNPEHIC 155 Trichomonas vaginalis G3
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