3JVO


Conserved Protein Domain Family
gp6

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cd08054: gp6 
Click on image for an interactive view with Cn3D
Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins
The bacteriophage HK97 gp6 protein is critical in the assembly of the connector, a specialized structure that serves as an interface for head and tail attachment, as well as a point at which DNA exits the head during infection by the bacteriophage. It forms a dodecameric ring structure that comprises the middle ring of the connector, located between the portal protein (attached to the head) and the gp7 ring (attached to the tail). It is a component of the mature phage and the absence of HK97 gp6 results in defective head-tail joining and the absence of mature phage particles. Although the crystal structure of HK97 gp6 shows an unexpected 13-mer ring, the biological form present in the mature phage is believed to be a dodecamer.
Statistics
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PSSM-Id: 153446
View PSSM: cd08054
Aligned: 242 rows
Threshold Bit Score: 36.9051
Threshold Setting Gi: 110800362
Created: 4-Dec-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
oligomerization
Conserved site includes 36 residues -Click on image for an interactive view with Cn3D
Feature 1:oligomerization interface [polypeptide binding site]
Evidence:
  • Structure:3JVO; Interface between monomers in the 13-mer structure of Bacteriophage HK97 gp6; contacts at 4A.
    View structure with Cn3D
  • Comment: The crystal structure of HK97 gp6 shows 13-mer ring, however, the biological form present in the mature phage is believed to be a dodecamer.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          #  ## #       ##  ## ##  ##  #                 ###  #  ### ### ###           
3JVO_A       10 SLSLFKQQIEFeEDDrDELITLYAQAAFDYCXRWCDEpawk----vaadIPAAVKGAVLLVFADXFEHRtaqs------e 79  Enterobacteria p...
ZP_02184667   5 VLKEMKAYLHVvTDDdDKNLIALSKTAHSTLKRWCGSfgldn--degkqLIFDYVRYMRAGASEYFYKNfe--------- 73  Carnobacterium s...
ZP_00789667   6 LLKPFKERMRVfHDFdDDNLSLILKSSESALKGLLGFdl---------mDYESGKELIMERSRYVFNDCle--------- 67  Streptococcus ag...
ZP_05663906   7 LLKDFKSRMRIfHNAdDDNLENILESSTAAIKRWCGSed---------iTKPEIRELIIERSRYVYNDSle--------- 68  Enterococcus fae...
ZP_03964708  12 TPEDMQQYLNLdTNGdASVLADMISTAEEAIIGAIDDtidv----giyrKYPLFNQAVRVLVDFMYYSRgals------d 81  Lactobacillus pa...
ZP_05923555  10 DLEEIKEAIREdFSDdNTGIKRSAAAAIAYIKGAIGQdkpsfy-etdndSTDLLNLSILMLTDHYYHARsatietanatg 88  Enterococcus fae...
ZP_05864919   2 DLTEFKNYLRVdFDDdDSVIEAYYTGAENYICLAIGKnvkp----tdleQYEQFKPATLLLGAFWYNAKmavqqtatvka 77  Lactobacillus je...
ZP_05246740   7 DVSRIKNHVRVdHDFdDESLQQFLEAAQITLQGMIGSdanfaafydveeNAKLFDIATLFLVDHWYKTRsatts-----l 81  Listeria monocyt...
ZP_02093273   5 DISNVKQALRIdTDAdDELLKALYSAASDYIKGAIGDeieg-----fydNNPRFNLAVLMLTDHYYKTRsatse-----k 74  Parvimonas micra...
NP_348514     3 TLDQLKLSLRIdTSDdDTLLTLFMQTASDYIKGSIGNgvtg-----fydSNPRFDTALILLTDHYYKTRsatde-----t 72  Clostridium acet...
Feature 1          ###### ##  ## 
3JVO_A       80 vqlYENAAAERXXFIHR 96  Enterobacteria phage HK97
ZP_02184667  74 --sQIQSFGFSLMEVPS 88  Carnobacterium sp. AT7
ZP_00789667  68 -lfYDSFKNEIARLAIE 83  Streptococcus agalactiae 515
ZP_05663906  69 -ffNENFLSELMAVSLS 84  Enterococcus faecium 1,231,501
ZP_03964708  82 qskAYPPSYAYMINSIR 98  Lactobacillus paracasei subsp. paracasei ATCC 25302
ZP_05923555  89 glrEYDLGFNSLILQLK 105 Enterococcus faecium TC 6
ZP_05864919  78 ntdEIPFGVSALITQLK 94  Lactobacillus jensenii SJ-7A-US
ZP_05246740  82 tfsEAPLSVKTIVLLLK 98  Listeria monocytogenes FSL N1-017
ZP_02093273  75 tlqEVPFGVTSLILALK 91  Parvimonas micra ATCC 33270
NP_348514    73 dlkKVPFGVTTLILQLK 89  Clostridium acetobutylicum ATCC 824

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