Conserved Protein Domain Family
TAF7

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cd08047: TAF7 
TATA Binding Protein (TBP) Associated Factor 7 (TAF7) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
The TATA Binding Protein (TBP) Associated Factor 7 (TAF7) is one of several TAFs that bind TBP and are involved in forming the Transcription Factor IID (TFIID) complex. TFIID is one of seven General Transcription Factors (GTF) (TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIID) that are involved in accurate initiation of transcription by RNA polymerase II in eukaryotes. TFIID plays an important role in the recognition of promoter DNA and assembly of the preinitiation complex. TFIID complex is composed of the TBP and at least 13 TAFs. TAFs are named after their electrophoretic mobility in polyacrylamide gels in different species. A new, unified nomenclature has been suggested for the pol II TAFs to show the relationship between TAF orthologs and paralogs. Several hypotheses are proposed for TAFs functions such as serving as activator-binding sites, core-promoter recognition or a role in essential catalytic activity. Each TAF, with the help of a specific activator, is required only for expression of subset of genes and is not universally involved for transcription as are GTFs. TAF7 is involved in the regulation of the transition from PIC assembly to initiation and elongation. In yeast and human cells, TAFs have been found as components of other complexes besides TFIID. Several TAFs interact via histone-fold (HFD) motifs; the HFD is the interaction motif involved in heterodimerization of the core histones and their assembly into nucleosome octamers.
Statistics
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PSSM-Id: 173966
View PSSM: cd08047
Aligned: 63 rows
Threshold Bit Score: 100.806
Threshold Setting Gi: 269861212
Created: 2-Oct-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q15545        13 ESQFILRLPPey-----asTVRRAVQSGhvnlkdr---------------ltielhPDGRHGIVRVDRVp--LASKLVDL 70  human
XP_001346906   8 ENQLIIRFPPqi-----aeKIRESFANNqqlpit-----------------iepkiGKGMEFDVSINNLkyqDKGVLVDL 65  Paramecium tetr...
XP_652589     31 EQPILLRLPEde-----akVLREQIRSGdvdfn-------------------idipQGENSGKCIFNGKe--FCATLVRL 84  Entamoeba histo...
EFA85239      65 EDQLILRLPLnv-----adRVRRMIKQKhfdap------------------idvqfKSDRAMVFKIGDQe--FDASLFDL 119 Polysphondylium...
EEY69724       1 MEQYLLQLPK---------RLAQEVREGiangdsa--------------dvdmvagADNKHFTLHVNGKk--YPAKIAQL 55  Phytophthora in...
XP_645636     73 EDQILFRLPLhl-----adQVRNMIKQKqmdip------------------vdfhfKNDRQIQIKFGDQe--YNANLVDL 127 Dictyostelium d...
EES99980      14 QEQYIVELPD---------VVAEAARRNpdfafefv-------------fditgqsGEMHLLRQYDNLLr-vYPFRVFKT 70  Giardia intesti...
XP_001689875  11 EELFVLRVADeal----adKLHRVLREEatvhgh----------------veltfqDNNLDGVLSVEGVs--YPVKLLNL 68  Chlamydomonas r...
XP_001032001  68 ESTEKQKDPVadsntpqvsFLPKVVKDAet-------------------------gLEKLQFDVQVDDFr--SKATLIDL 120 Tetrahymena the...
XP_002180202   9 DRTLVLRILVpgl----etRLRDKKRESedaaamdgkeskdcyldlegvtceptaaRNRTLWNFHCDGAt--YPAKLVNL 82  Phaeodactylum t...
Q15545        71 PCVMESLKTIDKKtFYKTADICQMLVStvdgdlyppveepvas---------------------tdpkaskkkdkdkekk 129 human
XP_001346906  66 PTITESYKSKDYInLYKSNDISQMIWVgktsnt-----------------------------------------rqcgdk 104 Paramecium tetr...
XP_652589     85 PCVVETHKSYDDVaLYKTGDIGQAIIIhekdni-----------------------------------------pkidds 123 Entamoeba histo...
EFA85239     120 PCILESHKTLDKTtYYKTADIGQMIEVyetpqsdsn------------------------------------nqneipsd 163 Polysphondylium...
EEY69724      56 PTILETHKTYDDNfFYKSGEIGQIFVVtdkeeek----------------------------------------kllemr 95  Phytophthora in...
XP_645636    128 PCIVESHKTFDRVnFYKTADIGQMIIVndnppppppppppptqsdqddlmdtsnnnntttttttttttplpntaapntin 207 Dictyostelium d...
EES99980      71 PLTTESYVSADGDyYYKSADISDMIIVyepdkipklfvdyeisqk------------------vklicsaagnpvfdpsv 132 Giardia intesti...
XP_001689875  69 PTVVEAYKTYDEInMVKINDIGQAADGvtppmr-----------------------------------------narqrh 107 Chlamydomonas r...
XP_001032001 121 PCILETYKTEDTInIFKSNDTKQMIYVhkpeeddvpsdfaqk------------------------kqvidrdtnekvlk 176 Tetrahymena the...
XP_002180202  83 PCPVELHKTHDHAaYFKCSDIAQMLIVyeddmaleea----------------------------------eekaiegfp 128 Phaeodactylum t...
Q15545       130 FIWNHGITLPLKNVRKRRFRKTAKKKyi----esPDVEKEVKRLLSTDAEAVSTRWEII 184 human
XP_001346906 105 VVCDSGLTPPTYDIRKDFHRKQPQIDig----eiQRVEKELHSIQSEFMKQAEEEENGS 159 Paramecium tetraurelia strain d4-2
XP_652589    124 GRLKSGLTPPTNRIVNKFQKPMTHAE--------KERMKELHKEIKSKVNDLPKSEEDN 174 Entamoeba histolytica HM-1:IMSS
EFA85239     164 YKSTSGITPPTKEITKKRHRELSKDKvt----eiAKIEEELVRIIKPGYIEQEEVEFVT 218 Polysphondylium pallidum PN500
EEY69724      96 EEVPNGVTPPNTNVVKRKYEKTKKTTpfpk-pdvSRVEEDLVKIIAGGVVEDVHEELVD 153 Phytophthora infestans T30-4
XP_645636    208 NILQTGLTAATKDIVKRKFKTYNRDKit----elAKIEEELVRLIKPGYADSEEIEFVS 262 Dictyostelium discoideum AX4
EES99980     133 NMSPHGLTPPTAWAPFHLWPNIPTRPsy----fpPATDEVVVTFDEIHTDKKNQAGAKI 187 Giardia intestinalis ATCC 50581
XP_001689875 108 FKPVPKVDPGEVAAVERDLLALLSGFap-----aGMRITDVEEEFVVDAHSGAGSWQRD 161 Chlamydomonas reinhardtii
XP_001032001 177 YESHHGITPPTYYIKKRFYRKKPILDka----evQEVEKIMVKIQKEITKNDKEPERTK 231 Tetrahymena thermophila
XP_002180202 129 SYHHSGLTPPMKRVVERRFAAREQKAvappraavVDVEDELLQLMDKISKDEKTKRNKL 187 Phaeodactylum tricornutum CCAP 1055/1
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