Conserved Protein Domain Family
TAF4

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cd08045: TAF4 
TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
The TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and are involved in forming the Transcription Factor IID (TFIID) complex. TFIID is one of seven General Transcription Factors (GTF) (TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIID) that are involved in accurate initiation of transcription by RNA polymerase II in eukaryote. TFIID plays an important role in the recognition of promoter DNA and assembly of the pre-initiation complex. TFIID complex is composed of the TBP and at least 13 TAFs. TAFs from various species were originally named by their predicted molecular weight or their electrophoretic mobility in polyacrylamide gels. A new, unified nomenclature for the pol II TAFs has been suggested to show the relationship between TAF orthologs and paralogs. Several hypotheses are proposed for TAFs functions such as serving as activator-binding sites, core-promoter recognition or a role in essential catalytic activity. Each TAF, with the help of a specific activator, is required only for the expression of subset of genes and is not universally involved for transcription as are GTFs. In yeast and human cells, TAFs have been found as components of other complexes besides TFIID. Several TAFs interact via histone-fold (HFD) motifs; HFD is the interaction motif involved in heterodimerization of the core histones and their assembly into nucleosome octamers. The minimal HFD contains three alpha-helices linked by two loops and is found in core histones, TAFS and many other transcription factors. TFIID has a histone octamer-like substructure. TAF4 domain interacts with TAF12 and makes a novel histone-like heterodimer that binds DNA and has a core promoter function of a subset of genes.
Statistics
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PSSM-Id: 173965
View PSSM: cd08045
Aligned: 52 rows
Threshold Bit Score: 81.9918
Threshold Setting Gi: 67479875
Created: 2-Oct-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P47825       670 YGDDDINDVAa-MGGVNLAEESQRIlgctenigt------------qirsckdevFLNLPSLQARIRAITSEagld---- 732  fruit fly
XP_002507144 117 KNFPEADDVLt-LAGVDPNDEARLMlaqgshddqsfh-------grrakknssrkLTELCIFARVIGQLPRSgic----- 183  Micromonas sp....
EEQ82242      57 IKTEHLEDILq-YSGVDLKEENEKIleynisyandd---------yedvegqihsLLNVKLFKEYVQKLAKNrkl----- 121  Nosema ceranae...
XP_002650124 111 KEDDNIDDIMp-YTGVNLKDEADYInkymynnyaesys----gvdlqnvensfetLFNIKLFEKYLNNCCANrki----- 180  Enterocytozoon...
Q8STW9        64 MKTEHLQDIIq-YSGVDLKEEAEHIvretetninfge------yeeedvnnhigsLMNVPLFREFVSRIGNSrrv----- 131  Encephalitozoo...
XP_002052155   1 MSSYPIEVPMqpYAGRLLIIEHLIVpdvsddqrqgsgkk--aivgpkfsdmprpsFFEPKVIEKTLLKYCILegis---- 74   Drosophila vir...
XP_001993340   4 ITSHPIRVPMqpYAGKRLIIENLIVpdssddlkvepksgekpvsapkfmdmprptFLEKKWIERTLFTYCSLngls---- 79   Drosophila gri...
XP_002066370   2 SEKKKLNMIVqpYAGKLMIIQDILAppiqedd----------------pnqqpgsYFNFPKLVDTFRTFLKEagykt--d 63   Drosophila wil...
NP_523574     25 LPDSGSQDAS--KAKVSIKKNQRAS------------------------------FFDRSSIYKKIMKHLSQgnqaddin 72   fruit fly
XP_001962264   1 MTDSGIEVPLqpYAGQLLLIKDLVMpdtsssk-----------------skarpsFFERSCVLKRLLRVLAQeypneefn 63   Drosophila ana...
P47825       733 -epsQDVAVLISHACQERLKNIVEKLAVIAEHRidvi-kldpRYEPAKDVRGQIKFLEELDKAEQKRHEELEremllraa 810  fruit fly
XP_002507144 184 -kvdNKAYDLLEEALQIHLRCLIMKIFNRALQRndskpsvlgRSNTHSEPKQRIRQINVDAEVQKRERVDIErkallrvg 262  Micromonas sp....
EEQ82242     122 -mvsEDVYTLLFFILRRKLIDFIDKMDEMSKVRvecl-lldkNVQIKNDLTRQLWCLEQIEKTEMEKLNLKNtedkkt-- 197  Nosema ceranae...
XP_002650124 181 -kitEDGVNLIFLLLYRKIMNLIDRLDEASKIRsefg-itlnRIQIKNEHNKQIWYLNELEKNKFEKLNMQAdkdkk--- 255  Enterocytozoon...
Q8STW9       132 -gisEESFFLLFQVAKRKMLDIVEKMEESSKWRveyn-lsefIIRIKNDLSRQLWCLEQIEKAEIEKFTIRRgeeegrk- 208  Encephalitozoo...
XP_002052155  75 kdfkDELVDALLSAVETYMKYLVRTVIELCEHRsgnnlyndpRCVVQHNMRTTMMFLNDREVADYGCSDDDSayghrrrw 154  Drosophila vir...
XP_001993340  80 tvvnEELVEGLLAAAETFLKDMMQTVIEFSEHRsgnslyddpRCELHHDLRTTMRFLDDREVADYGCSDDDTayghrrrw 159  Drosophila gri...
XP_002066370  64 rgdyNQLIDGILCALETYMKHILQVIIKNCEFRvnfhlindkRCKFNHILRDKVNYLNEMKRGASDERYSRKmcrrrak- 142  Drosophila wil...
NP_523574     73 iseqEWLLDSFLAALETYMKHVVKKTIELCEHRtsyhlhndeRCVMKNDMRVTMMFLNDLEIADYGSSDDETgfyr---- 148  fruit fly
XP_001962264  64 iesdDPLIEGFMGGLETFMRFTVQKSIEQCEHRtgyflysddRCIMKNEMRSTMSFLNDLELADCGSSDDDNdfyrr--- 140  Drosophila ana...
P47825       811 ksrsrve---dpeqakmkarakemQRAEMEELRQRd--ANLTALQAIGPRKKLKldgetvssgagssggg----vlsssg 881  fruit fly
XP_002507144 263 esilskrrtragddshlkekvariRQEEEERIRATi--ANDAARSALGDAKYLKwfvssgg------------------- 321  Micromonas sp....
EEQ82242     198 -------------------kkkniQEREDLVVKKKl--SNTVAMQALGIQQKSWmsgeetivnknitkfks---iyspyd 253  Nosema ceranae...
XP_002650124 256 --------------------kkqiQEREDLLIKKKq--SNSIAMAAMGVKQKSWmnktekieevskyds-------iysp 306  Enterocytozoon...
Q8STW9       209 ------------------kvkktiQEREDLVIKKRl--SNTVALAALGIQQKSWmsaedvrvseestafns---iyspfd 265  Encephalitozoo...
XP_002052155 155 ----------------mklqrnrtNNSGENEMRLEs--TNSTALMALGARKPIGpggaggqltsga------------aq 204  Drosophila vir...
XP_001993340 160 m---------------klqrnrnpTNSFESEIRLEs--TNKTALLALGVRKPQSatatvglpntapglpaa--gagtaaq 220  Drosophila gri...
XP_002066370 143 -----------------vrqsdpgFRRYQNEKRLAc--INYTAMLALGVHKRVGtvlfdpfsapyprngrtyfgasnqnh 203  Drosophila wil...
NP_523574    149 --------------------krraENIDEERKVARlesVNDTALLAISGRKRPGeqlapesapsgskva------kltga 202  fruit fly
XP_001962264 141 -------------------rrypgSRDHKSHSMQMd-sINTTALNAIGAVRKRPgdgqgaepvlypg----------vvg 190  Drosophila ana...
P47825       882 sapttlrpriKRVNLRDMLFYMEQEREFCRSSMLFK 917  fruit fly
XP_002507144 322 ---keadresQRKPSRELTCKQNDEKDSEIRFLKRS 354  Micromonas sp. RCC299
EEQ82242     254 dkhiekkvnaRILNMKDFLCVLERDKRYNKSIFTIQ 289  Nosema ceranae BRL01
XP_002650124 307 vddkliggknRSIIFKDFLFILERDKRYNKSIFLLS 342  Enterocytozoon bieneusi H348
Q8STW9       266 ekalerkvvnRTITMKDFLYVLERDRRYSKSVFTIQ 301  Encephalitozoon cuniculi
XP_002052155 205 ppqrsfiiriKHMNVKDIIQFMEEEKRYNKSKLLYD 240  Drosophila virilis
XP_001993340 221 lpkrqffvriKHMKVRDIIQYMENEKRFNKSKLLYD 256  Drosophila grimshawi
XP_002066370 204 ykrlptvlhqKYIKVQDVLQLLEQDPRFKYSMLLYE 239  Drosophila willistoni
NP_523574    203 piqracaprfKHMNIRDVLQFMEEDRRYARSNMLFE 238  fruit fly
XP_001962264 191 nlnrpfglrcKYISIRDVMQFMEEDKRFSRSNLLFE 226  Drosophila ananassae
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