Conserved Protein Domain Family
LARP_7

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cd08032: LARP_7 
La RNA-binding domain of La-related protein 7
LARP7 is a component of the 7SK snRNP, a key factor in the regulation of RNA polymerase II transcription. 7SK functionality is dependent on the presence of LARP7, which is thought to stabilize the 7SK RNA by interacting with its 3' end. The release of 7SK RNA from P-TEFb/HEXIM/7SK complexes activates the cyclin-dependent kinase P-TEFb, which in turn phosphorylates the C-terminal domain of RNA pol II and mediates a transition into productive transcription elongation.
Statistics
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PSSM-Id: 153401
View PSSM: cd08032
Aligned: 4 rows
Threshold Bit Score: 153.172
Threshold Setting Gi: 41053963
Created: 30-Jul-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
RNA binding
Feature 1:RNA binding site [nucleic acid binding site]
Evidence:
  • Comment:by similarity to other members of this family

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                   #  ##    #  ## #                    ###                              
NP_001039168  32 RVKQLLADIAKQVDFWFGDVNLHKDRFLREQIEKTRDGYIDISLLASFNKMKKITTDsKLIARAVKNSs--vVEINLsgT 109 western clawed ...
CAG32359      32 RVKQVLADIAKQVDFWFGDVNLHKDRFLREQIEKSRDGYVDISLLVSFNKMKKLTTDgKLIARAVKSSsvveLDLEG--T 109 chicken
Q4G0J3        30 RVKQVLADIAKQVDFWFGDANLHKDRFLREQIEKSRDGYVDISLLVSFNKMKKLTTDgKLIARALRSSa--vVELDLegT 107 human
NP_956224     38 RVKQLLSDVKKQVEFWFGDVNLHKDRFMKSIIEQSRDGYIDIAVLTTFNRMKNLTADvKLIARALKNSt--iVEVNDegT 115 zebrafish
Feature 1            
NP_001039168 110 KIRR 113 western clawed frog
CAG32359     110 RIRR 113 chicken
Q4G0J3       108 RIRR 111 human
NP_956224    116 RIRR 119 zebrafish

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